LOCUS       NM_001010872            6244 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 83 member B (FAM83B),
            mRNA.
ACCESSION   NM_001010872 XM_294139
VERSION     NM_001010872.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6244)
  AUTHORS   Wang,J., Li,P., Sun,L., Zhang,J., Yue,K., Wang,Y. and Wu,X.
  TITLE     FAM83B regulates mitochondrial metabolism and anti-apoptotic
            activity in pulmonary adenocarcinoma
  JOURNAL   Apoptosis 29 (5-6), 743-756 (2024)
   PUBMED   38478170
  REMARK    GeneRIF: FAM83B regulates mitochondrial metabolism and
            anti-apoptotic activity in pulmonary adenocarcinoma.
REFERENCE   2  (bases 1 to 6244)
  AUTHORS   Zhang,J., Wang,J., Yue,K., Li,P., Shen,W., Qiao,X., Wang,Y. and
            Wu,X.
  TITLE     FAM83B promotes the invasion of primary lung adenocarcinoma via
            PI3K/AKT/NF-kappaB pathway
  JOURNAL   BMC Pulm Med 23 (1), 32 (2023)
   PUBMED   36690987
  REMARK    GeneRIF: FAM83B promotes the invasion of primary lung
            adenocarcinoma via PI3K/AKT/NF-kappaB pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6244)
  AUTHORS   Cirello,V., Grassi,E.S., Pogliaghi,G., Ghiandai,V., Ermellino,L.,
            Muzza,M., Gazzano,G., Persani,L., Colombo,C. and Fugazzola,L.
  TITLE     FAM83B is involved in thyroid cancer cell differentiation and
            migration
  JOURNAL   Sci Rep 12 (1), 8608 (2022)
   PUBMED   35597845
  REMARK    GeneRIF: FAM83B is involved in thyroid cancer cell differentiation
            and migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6244)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 6244)
  AUTHORS   Xiong,H., Wang,N., Chen,H., Zhang,M. and Lin,Q.
  TITLE     MicroRNA-199a/b-5p inhibits endometrial cancer cell metastasis and
            invasion by targeting FAM83B in the epithelial-to-mesenchymal
            transition signaling pathway
  JOURNAL   Mol Med Rep 23 (5) (2021)
   PUBMED   33649801
  REMARK    GeneRIF: MicroRNA199a/b5p inhibits endometrial cancer cell
            metastasis and invasion by targeting FAM83B in the
            epithelialtomesenchymal transition signaling pathway.
REFERENCE   6  (bases 1 to 6244)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   7  (bases 1 to 6244)
  AUTHORS   Cipriano,R., Bryson,B.L., Miskimen,K.L., Bartel,C.A.,
            Hernandez-Sanchez,W., Bruntz,R.C., Scott,S.A., Lindsley,C.W.,
            Brown,H.A. and Jackson,M.W.
  TITLE     Hyperactivation of EGFR and downstream effector phospholipase D1 by
            oncogenic FAM83B
  JOURNAL   Oncogene 33 (25), 3298-3306 (2014)
   PUBMED   23912460
  REMARK    GeneRIF: Suppression of PLD1 activity prevents FAM83B-mediated
            transformation.
REFERENCE   8  (bases 1 to 6244)
  AUTHORS   Cipriano,R., Miskimen,K.L., Bryson,B.L., Foy,C.R., Bartel,C.A. and
            Jackson,M.W.
  TITLE     FAM83B-mediated activation of PI3K/AKT and MAPK signaling
            cooperates to promote epithelial cell transformation and resistance
            to targeted therapies
  JOURNAL   Oncotarget 4 (5), 729-738 (2013)
   PUBMED   23676467
  REMARK    GeneRIF: ablation of FAM83B decreased p110alpha and AKT membrane
            localization, suppressed AKT phosphorylation, and diminished
            proliferation, AIG, and tumorigenicity in vivo.
REFERENCE   9  (bases 1 to 6244)
  AUTHORS   Varjosalo,M., Sacco,R., Stukalov,A., van Drogen,A., Planyavsky,M.,
            Hauri,S., Aebersold,R., Bennett,K.L., Colinge,J., Gstaiger,M. and
            Superti-Furga,G.
  TITLE     Interlaboratory reproducibility of large-scale human
            protein-complex analysis by standardized AP-MS
  JOURNAL   Nat Methods 10 (4), 307-314 (2013)
   PUBMED   23455922
REFERENCE   10 (bases 1 to 6244)
  AUTHORS   Cipriano,R., Graham,J., Miskimen,K.L., Bryson,B.L., Bruntz,R.C.,
            Scott,S.A., Brown,H.A., Stark,G.R. and Jackson,M.W.
  TITLE     FAM83B mediates EGFR- and RAS-driven oncogenic transformation
  JOURNAL   J Clin Invest 122 (9), 3197-3210 (2012)
   PUBMED   22886302
  REMARK    GeneRIF: FAM83B expression was significantly elevated in cancer and
            was associated with specific cancer subtypes, increased tumor
            grade, and decreased overall survival.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK055204.1, BC101628.1, AL049555.6 and AK024927.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001010872.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK055204.1, DRR138516.426114.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306858.8/ ENSP00000304078.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1161              AK055204.1         2-1162
            1162-3227           BC101628.1         1121-3186
            3228-5936           AL049555.6         26071-28779         c
            5937-6244           AK024927.1         1422-1729
FEATURES             Location/Qualifiers
     source          1..6244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1"
     gene            1..6244
                     /gene="FAM83B"
                     /gene_synonym="C6orf143"
                     /note="family with sequence similarity 83 member B"
                     /db_xref="GeneID:222584"
                     /db_xref="HGNC:HGNC:21357"
     exon            1..56
                     /gene="FAM83B"
                     /gene_synonym="C6orf143"
                     /inference="alignment:Splign:2.1.0"
     exon            57..560
                     /gene="FAM83B"
                     /gene_synonym="C6orf143"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..3152
                     /gene="FAM83B"
                     /gene_synonym="C6orf143"
                     /codon_start=1
                     /product="protein FAM83B"
                     /protein_id="NP_001010872.1"
                     /db_xref="CCDS:CCDS34479.1"
                     /db_xref="GeneID:222584"
                     /db_xref="HGNC:HGNC:21357"
                     /translation="METSSMLSSLNDECKSDNYIEPHYKEWYRVAIDILIEHGLEAYQ
                     EFLVQERVSDFLAEEEINYILKNVQKVAQSTAHGTDDSCDDTLSSGTYWPVESDVEAP
                     NLDLGWPYVMPGLLGGTHIDLLFHPPRAHLLTIKETIRKMIKEARKVIALVMDIFTDV
                     DIFKEIVEASTRGVSVYILLDESNFNHFLNMTEKQGCSVQRLRNIRVRTVKGQDYLSK
                     TGAKFHGKMEQKFLLVDCQKVMYGSYSYMWSFEKAHLSMVQIITGQLVESFDEEFRTL
                     YARSCVPSSFAQEESARVKHGKALWENGTYQHSVSSLASVSSQRNLFGRQDKIHKLDS
                     SYFKNRGIYTLNEHDKYNIRSHGYKPHFVPNFNGPNAIRQFQPNQINENWKRHSYAGE
                     QPETVPYLLLNRALNRTNNPPGNWKKPSDSLSVASSSREGYVSHHNTPAQSFANRLAQ
                     RKTTNLADRNSNVRRSFNGTDNHIRFLQQRMPTLEHTTKSFLRNWRIESYLNDHSEAT
                     PDSNGSALGDRFEGYDNPENLKANALYTHSRLRSSLVFKPTLPEQKEVNSCTTGSSNS
                     TIIGSQGSETPKEVPDTPTNVQHLTDKPLPESIPKLPLQSEAPKMHTLQVPENHSVAL
                     NQTTNGHTESNNYIYKTLGVNKQTENLKNQQTENLLKRRSFPLFDNSKANLDPGNSKH
                     YVYSTLTRNRVRQPEKPKEDLLKSSKSMHNVTHNLEEDEEEVTKRNSPSGTTTKSVSI
                     AALLDVNKEESNKELASKKEVKGSPSFLKKGSQKLRSLLSLTPDKKENLSKNKAPAFY
                     RLCSSSDTLVSEGEENQKPKKSDTKVDSSPRRKHSSSSNSQGSIHKSKEDVTVSPSQE
                     INAPPDENKRTPSPGPVESKFLERAGDASAPRFNTEQIQYRDSREINAVVTPERRPTS
                     SPRPTSSELLRSHSTDRRVYSRFEPFCKIESSIQPTSNMPNTSINRPEIKSATMGNSY
                     GRSSPLLNYNTGVYRSYQPNENKFRGFMQKFGNFIHKNK"
     exon            561..725
                     /gene="FAM83B"
                     /gene_synonym="C6orf143"
                     /inference="alignment:Splign:2.1.0"
     exon            726..850
                     /gene="FAM83B"
                     /gene_synonym="C6orf143"
                     /inference="alignment:Splign:2.1.0"
     exon            851..6244
                     /gene="FAM83B"
                     /gene_synonym="C6orf143"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6223..6228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM83B"
                     /gene_synonym="C6orf143"
                     /note="hexamer: AATAAT"
     polyA_site      6244
                     /gene="FAM83B"
                     /gene_synonym="C6orf143"
                     /note="major polyA site"
ORIGIN      
        1 aaaccttcgg cggccggcgc tgtgcggcgg gcgcggttgc gcgcggcttg gggcaaatac
       61 ttctcaccac tgcatgaatg gacatttgaa agtgccatag ccaaacactt gcaagcatgg
      121 agacctcatc aatgctttcc tcattgaatg atgagtgtaa atctgacaac tacattgagc
      181 ctcactacaa ggaatggtat cgagtagcca ttgatattct gattgaacac gggttagaag
      241 cataccaaga atttcttgtc caggaacgag tttcagactt tcttgctgag gaagaaatta
      301 attatatttt gaaaaatgtc cagaaagttg cacaaagcac agcacatggt actgatgatt
      361 cctgtgatga taccttatct tcagggacct actggcctgt tgagtctgat gtggaagctc
      421 caaatcttga cttaggctgg ccatatgtga tgcccggact cttagggggc acccatatag
      481 atctcctttt tcatccacca agagcacatc tacttacgat aaaagaaact attcggaaga
      541 tgataaaaga agcaagaaag gtcattgctt tagtgatgga tatatttaca gatgtggaca
      601 ttttcaaaga aatcgttgag gcatcaactc gaggagtatc tgtttacatt ctgcttgatg
      661 agtccaattt taatcatttt ctaaatatga ctgagaaaca aggttgttca gttcagcgtc
      721 tcaggaatat tcgagtgcga acagtaaaag gccaagatta tctttcaaaa acaggggcaa
      781 aattccatgg aaaaatggaa cagaaatttt tgttagttga ctgccagaaa gtgatgtacg
      841 gttcttacag ttatatgtgg tcatttgaga aagctcacct cagcatggtt cagataatta
      901 caggacaact tgttgagtcc tttgatgaag aatttagaac tctctatgcc agatcctgtg
      961 tccctagttc atttgctcag gaagaatcag caagggtgaa gcatggaaaa gccctctggg
     1021 aaaatggcac ttaccagcat tcggtgtctt cattagcatc tgtttccagc cagagaaacc
     1081 tttttggtag acaagacaag attcataaac tagattccag ttacttcaaa aacagaggga
     1141 tatatacttt aaatgaacat gacaaatata acataagaag tcacggatac aaacctcatt
     1201 ttgttcctaa ctttaatggt ccaaacgcaa tacgtcagtt tcaacccaat cagataaatg
     1261 aaaattggaa aaggcatagt tatgctgggg aacagccaga aacagtgcca tacctcctgc
     1321 ttaatagggc tctgaataga accaataatc cacctggtaa ttggaaaaag ccatctgata
     1381 gtctcagtgt ggcgtcctca tcacgggaag gctatgtaag ccaccacaac acacctgccc
     1441 agagttttgc caatcggctt gcgcagagaa aaacaacaaa tcttgcagac aggaattcaa
     1501 atgttcggag gtcttttaat gggacagata accatatccg ctttttgcaa caacgaatgc
     1561 caacccttga acataccaca aagtcattcc tacgtaactg gagaattgaa tcctacttaa
     1621 atgatcattc agaagctaca ccggactcaa atggatcagc tttaggtgac cgatttgagg
     1681 gctatgataa tcctgagaat ttgaaggcca atgcccttta tactcattct cggcttcgtt
     1741 cctctttagt atttaaaccc actttacctg agcaaaagga agttaacagt tgtacaactg
     1801 gctcctcaaa ttcaactatc attggttctc agggaagtga gacacctaaa gaggtcccag
     1861 acacccctac gaatgtacag catttgacag acaaaccctt gccagaatca atccccaagc
     1921 tcccattgca gtcagaggca ccaaaaatgc acaccttgca ggttcctgaa aaccactcag
     1981 tagccttaaa ccaaactaca aatggccata ctgaatcaaa taactatata tataaaacct
     2041 tgggtgtaaa taagcagaca gaaaatctaa agaatcaaca gactgagaat ctacttaaaa
     2101 ggcgaagttt cccgttattt gacaactcaa aagccaactt agatcctgga aatagtaagc
     2161 attatgtata tagtacactt accaggaatc gagttagaca accagaaaag cccaaagaag
     2221 atttgctgaa aagttctaaa agcatgcaca atgtgactca taacttggag gaggatgagg
     2281 aggaagttac caagagaaac tctccaagtg gcactactac caaatcagtt tccattgctg
     2341 ctttacttga tgtgaataaa gaggaatcta acaaagaact tgcttcaaag aaggaagtta
     2401 agggttcccc aagttttttg aaaaaggggt ctcagaagtt aaggtcatta cttagcctta
     2461 ccccagataa gaaagaaaat ctatccaaaa ataaagcacc tgccttttat agattgtgta
     2521 gtagctctga cacattagtt tctgagggtg aagaaaatca aaaaccaaag aaatcagaca
     2581 caaaagttga ttcatctcct agaagaaagc attcttcctc atcgaattct caaggcagca
     2641 tccacaagag taaggaagat gtaacagtta gcccatctca agagataaat gctccaccag
     2701 atgaaaataa aagaacacct tctccaggtc cagttgaaag caagttcttg gaaagggcag
     2761 gagatgcctc tgccccaaga tttaacactg aacagatcca ataccgagat tcaagggaga
     2821 ttaatgcagt tgttacccct gaaagaagac ctacttcttc tccaaggcca acgtccagtg
     2881 agcttctacg atctcattca actgatcggc gtgtttacag tcgttttgag ccgttttgta
     2941 agattgagag ctctattcag ccaacaagca acatgccaaa taccagtata aatcgcccag
     3001 aaataaaatc tgcgactatg ggcaacagtt atggcaggtc tagtccattg cttaattaca
     3061 acactggtgt ttatcgctca tatcaaccca atgagaacaa gtttcgagga tttatgcaaa
     3121 agtttggaaa ctttatacac aaaaataaat agctattaaa atgcaaaatg aatgaggcta
     3181 tcaatatttg tccaaagaaa attgtggaca gtctttgtaa catgccaata gattttccta
     3241 aggacagaat tatgggtatg atgtatatgt tcaccagtgt cctagtataa agttattttt
     3301 ctgtgtgata aagttagggt ctgctgtaga tagaatttct ctgtaaacac attatttgta
     3361 agtggtaatg gtaaaaataa tagatgtatt taaatcattt tctttagact gaagatttta
     3421 agtctcactt agaaattttt gtggacgatg tatggtgtat ggtgtatggt gtatggattt
     3481 taaccatttc cttttaaaaa ggtcatacta ccctcagtaa ccctttataa catgtgttta
     3541 tagtgttttc atatcttcaa aaatataagc aaatgggaca aagccctttt ttaagattaa
     3601 cttgaagttc tacgggataa cttgttatat tttattaata ttattttttc tgtggatcat
     3661 tgtacagctg tttgggcaac agcagtacct tttacatttt ttatttttta tttttttttc
     3721 tgcctgaagt gtttgcaaag tatcagcctc atgtagtata atgacattcg taggaattta
     3781 ttttcctcag cctttgaaaa cggtctggga tgtgcttctt tctacactgg acccagggag
     3841 ctgtccccct cttacccata ggctgctgat tttttatagt cattccttac ttcacattta
     3901 ggacaaacca gtaggaattt agaaaatctg aatgattccc cctccttttt ctattgtata
     3961 aaagctttta gaaatgtaaa tttctgccta aatttttgtt agattggcat gacaatgcta
     4021 aggggtcttg cttgcgaaaa ttcttgctct tttttttttt cttttgagat ggagtctcgc
     4081 tctgtcaccc aggctagagt gcagtggcgc aatcttggct cactgcaacc tctgcctccc
     4141 aagttcaaac gattctcctg cctcagcctc ctgagtagct gggattacag gtgcgcacca
     4201 ccacacccgg ctaatttttg tattttcaga agagatggga tttcaccatg ttggccagtc
     4261 tagtctcaaa ctcctgacct cgtgatcctc ccgcctcggc ctcccagagt gctgggatta
     4321 caggtcttgc tcttctttaa gttgtgccaa atatgatatg actgcatagt gtttttgtaa
     4381 gaataccatt gggaaaatga gaagttttac tgggctagtt cttccatgat ttgaggatga
     4441 tattcagatt ataagatacc ctttgtcttt cttacagtaa tgaagtataa gctccatatc
     4501 tgttccagag actttaactt gactttgctt cattcacaaa gaacagagtt caagaagcag
     4561 tgcatcctgt gagaagtgtg aagtgtttgt acatcacttt aaatatatta cttaatatat
     4621 tctaagttgc tgtgtggagc agtatactgt tgttttaaaa atgcaagatt cagacaaatt
     4681 ttaatattgt ctcattaaaa taatttaaat aatggtataa aatatctata tcattaaaat
     4741 aattttccat agtgtttaga aaccatgaaa aagaaaacat agcaggagaa aatatgacag
     4801 gaaaagaaaa cctaacaaag cccagaaccc acagttaacc aaactagact gactttgtta
     4861 ttacccattc tttgttagta ttggataggg aattaggata atgagccatt aggcagttct
     4921 gaaatggaaa gccctgaaat ttagtgcaat gtaactttaa aactgaaatt atataaagag
     4981 tagaagttta atcatgttta attacaacca aaagcctgtt gcctttttgt acagaaatct
     5041 ccttaatttc aggacatgta gatagcttat agaaacatcc ttttaaatag tttgtgagct
     5101 cttcctcttc agtggaattg aggaatacag aatgctttat ttcatcatcc cctgacaggt
     5161 gacttaggct ttgcacagca gatttatttt tctctgcgtt ttttaaaaat tgtttttctt
     5221 gtatcttttt tcttcaaaaa tatctatatt tgagaatatg tacataacaa ctttccaaag
     5281 tctctgtggc caaaacctct ccagggataa gactgagcaa gaatataata cttcaaaaaa
     5341 tgtacagcta ctgtttaagt tttaaacaga caccatcaca gtttgtggat gaaatagttt
     5401 taagccatat actttctgtc tttttttccc catattaata ttggggggcg gataatatca
     5461 ctttgatgta cattgatatt aaagtttggt aatgcagctt ttactgtcta catggtactg
     5521 tacattagtt tttaagcaga aacacaagaa aaatgggtat aatttcaaag tagttcttgg
     5581 cagatggcta gagaatactg caagtgaccc tgtatcccga atacacagat atccctctat
     5641 tacaagtttg ggattagcca taattctgac atggtgtgtt caggtatggg tatatgttgt
     5701 cagtctacac ttgtggaagc aaatatcttg tttaatcaag atgatgtcta gtgtcaccta
     5761 aataatgcaa aaagtttaat tctggatgaa ttcagcttta ctcaagatcc acatattcaa
     5821 gtatcattcc acagatattc acagaacaca gaaatatctg tgttctgcct tatgcctgtg
     5881 gctaagggat gcaaagtaga attgctttac attgactata tatgtgacat gtacgttgct
     5941 gtttttttta aaataacttt atcatgatat tcaggtagat cctgggttct agaatattta
     6001 aaacaaaagg ataaaatgat aaaccaaaga gtcaacttgt taacttttct tttttaagag
     6061 atgggttttc actagtatgc ccagtctgga ctccaagtcc tgggctcaaa cgatcctcca
     6121 gcctcaggtt cctgagtagc tcaacatttt atgtatgtac gatattataa agaaatattc
     6181 ttccaaatga acttttgttt ttagatcaat aaatgaataa taaataattt tgtacaaaca
     6241 tcaa
//
