LOCUS       NM_001394396            3887 bp    mRNA    linear   PRI 25-NOV-2024
DEFINITION  Homo sapiens family with sequence similarity 83 member A (FAM83A),
            transcript variant 5, mRNA.
ACCESSION   NM_001394396
VERSION     NM_001394396.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3887)
  AUTHORS   Yuan,Y., Hao,L., Huang,J.S., Zhao,F.Y., Ju,Y.H., Wang,J.M.,
            Zhang,T., Li,B.Q. and Yu,Z.W.
  TITLE     Promotion of stem cell-like phenotype of lung adenocarcinoma by
            FAM83A via stabilization of ErbB2
  JOURNAL   Cell Death Dis 15 (6), 460 (2024)
   PUBMED   38942760
  REMARK    GeneRIF: Promotion of stem cell-like phenotype of lung
            adenocarcinoma by FAM83A via stabilization of ErbB2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3887)
  AUTHORS   Zhao,C., Li,X., Zhang,R., Lyu,H., Xiao,S., Guo,D., Ali,D.W.,
            Michalak,M., Chen,X.Z., Zhou,C. and Tang,J.
  TITLE     Sense and anti-sense: Role of FAM83A and FAM83A-AS1 in Wnt, EGFR,
            PI3K, EMT pathways and tumor progression
  JOURNAL   Biomed Pharmacother 173, 116372 (2024)
   PUBMED   38432129
  REMARK    GeneRIF: Sense and anti-sense: Role of FAM83A and FAM83A-AS1 in
            Wnt, EGFR, PI3K, EMT pathways and tumor progression.
            Review article
REFERENCE   3  (bases 1 to 3887)
  AUTHORS   Fei,W., Yan,Y., Liu,G., Peng,B., Liu,Y. and Chen,Q.
  TITLE     High-risk histological subtype-related FAM83A hijacked FOXM1
            transcriptional regulation to promote malignant progression in lung
            adenocarcinoma
  JOURNAL   PeerJ 11, e16306 (2023)
   PUBMED   37904848
  REMARK    GeneRIF: High-risk histological subtype-related FAM83A hijacked
            FOXM1 transcriptional regulation to promote malignant progression
            in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3887)
  AUTHORS   Zou,W., Wang,H., Wu,D., Wu,Y., Zhou,K., Lian,Y., Chang,G., Feng,Y.,
            Liang,J. and Huang,G.
  TITLE     ncRNA-mediated upregulation of FAM83A is associated with poor
            prognosis and immune infiltration in pancreatic cancer
  JOURNAL   Front Endocrinol (Lausanne) 14, 1093042 (2023)
   PUBMED   37065746
  REMARK    GeneRIF: ncRNA-mediated upregulation of FAM83A is associated with
            poor prognosis and immune infiltration in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3887)
  AUTHORS   Zhou,C., Zhu,X., Liu,N., Dong,X., Zhang,X., Huang,H., Tang,Y.,
            Liu,S., Hu,M., Wang,M., Deng,X., Li,S., Zhang,R., Huang,Y., Lyu,H.,
            Xiao,S., Luo,S., Ali,D.W., Michalak,M., Chen,X.Z., Wang,Z. and
            Tang,J.
  TITLE     B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates
            pancreatic tumorigenesis through interacting with beta-catenin
  JOURNAL   Signal Transduct Target Ther 8 (1), 66 (2023)
   PUBMED   36797256
  REMARK    GeneRIF: B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation
            elevates pancreatic tumorigenesis through interacting with
            beta-catenin.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3887)
  AUTHORS   Olden,M., Corre,T., Hayward,C., Toniolo,D., Ulivi,S., Gasparini,P.,
            Pistis,G., Hwang,S.J., Bergmann,S., Campbell,H., Cocca,M.,
            Gandin,I., Girotto,G., Glaudemans,B., Hastie,N.D., Loffing,J.,
            Polasek,O., Rampoldi,L., Rudan,I., Sala,C., Traglia,M.,
            Vollenweider,P., Vuckovic,D., Youhanna,S., Weber,J., Wright,A.F.,
            Kutalik,Z., Bochud,M., Fox,C.S. and Devuyst,O.
  TITLE     Common variants in UMOD associate with urinary uromodulin levels: a
            meta-analysis
  JOURNAL   J Am Soc Nephrol 25 (8), 1869-1882 (2014)
   PUBMED   24578125
REFERENCE   7  (bases 1 to 3887)
  AUTHORS   Lee,S.Y., Meier,R., Furuta,S., Lenburg,M.E., Kenny,P.A., Xu,R. and
            Bissell,M.J.
  TITLE     FAM83A confers EGFR-TKI resistance in breast cancer cells and in
            mice
  JOURNAL   J Clin Invest 122 (9), 3211-3220 (2012)
   PUBMED   22886303
  REMARK    GeneRIF: FAM83A interacted with and caused phosphorylation of c-RAF
            and PI3K p85, upstream of MAPK and downstream of EGFR.
REFERENCE   8  (bases 1 to 3887)
  AUTHORS   Liu,L., Liao,G.Q., He,P., Zhu,H., Liu,P.H., Qu,Y.M., Song,X.M.,
            Xu,Q.W., Gao,Q., Zhang,Y., Chen,W.F. and Yin,Y.H.
  TITLE     Detection of circulating cancer cells in lung cancer patients with
            a panel of marker genes
  JOURNAL   Biochem Biophys Res Commun 372 (4), 756-760 (2008)
   PUBMED   18514066
  REMARK    GeneRIF: The diagnostic value of BJ-TSA-9 was explored in
            combination with other known lung cancer markers for the detection
            of circulating cancer cells in lung cancer patients.
REFERENCE   9  (bases 1 to 3887)
  AUTHORS   Macaulay,I.C., Tijssen,M.R., Thijssen-Timmer,D.C., Gusnanto,A.,
            Steward,M., Burns,P., Langford,C.F., Ellis,P.D., Dudbridge,F.,
            Zwaginga,J.J., Watkins,N.A., van der Schoot,C.E. and Ouwehand,W.H.
  TITLE     Comparative gene expression profiling of in vitro differentiated
            megakaryocytes and erythroblasts identifies novel activatory and
            inhibitory platelet membrane proteins
  JOURNAL   Blood 109 (8), 3260-3269 (2007)
   PUBMED   17192395
REFERENCE   10 (bases 1 to 3887)
  AUTHORS   Li,Y., Dong,X., Yin,Y., Su,Y., Xu,Q., Zhang,Y., Pang,X., Zhang,Y.
            and Chen,W.
  TITLE     BJ-TSA-9, a novel human tumor-specific gene, has potential as a
            biomarker of lung cancer
  JOURNAL   Neoplasia 7 (12), 1073-1080 (2005)
   PUBMED   16354590
  REMARK    GeneRIF: Over-expression of BJ-TSA-9 is associated with lung cancer
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068228.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052300.1, SRR14038195.968416.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000690554.1/ ENSP00000509471.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-672               AC068228.8         110259-110930
            673-840             AC068228.8         119397-119564
            841-965             AC068228.8         121618-121742
            966-3887            AC068228.8         134751-137672
FEATURES             Location/Qualifiers
     source          1..3887
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..3887
                     /gene="FAM83A"
                     /gene_synonym="BJ-TSA-9"
                     /note="family with sequence similarity 83 member A"
                     /db_xref="GeneID:84985"
                     /db_xref="HGNC:HGNC:28210"
                     /db_xref="MIM:621022"
     exon            1..672
                     /gene="FAM83A"
                     /gene_synonym="BJ-TSA-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1497
                     /gene="FAM83A"
                     /gene_synonym="BJ-TSA-9"
                     /note="isoform a is encoded by transcript variant 5; tumor
                     antigen BJ-TSA-9; tumor-specific gene expressed in
                     prostate protein; protein FAM83A"
                     /codon_start=1
                     /product="protein FAM83A isoform a"
                     /protein_id="NP_001381325.1"
                     /db_xref="CCDS:CCDS6340.1"
                     /db_xref="GeneID:84985"
                     /db_xref="HGNC:HGNC:28210"
                     /db_xref="MIM:621022"
                     /translation="MSRSRHLGKIRKRLEDVKSQWVRPARADFSDNESARLATDALLD
                     GGSEAYWRVLSQEGEVDFLSSVEAQYIQAQAREPPCPPDTLGGAEAGPKGLDSSSLQS
                     GTYFPVASEGSEPALLHSWASAEKPYLKEKSSATVYFQTVKHNNIRDLVRRCITRTSQ
                     VLVILMDVFTDVEIFCDILEAANKRGVFVCVLLDQGGVKLFQEMCDKVQISDSHLKNI
                     SIRSVEGEIYCAKSGRKFAGQIREKFIISDWRFVLSGSYSFTWLCGHVHRNILSKFTG
                     QAVELFDEEFRHLYASSKPVMGLKSPRLVAPVPPGAAPANGRLSSSSGSASDRTSSNP
                     FSGRSAGSHPGTRSVSASSGPCSPAAPHPPPPPRFQPHQGPWGAPSPQAHLSPRPHDG
                     PPAAVYSNLGAYRPTRLQLEQLGLVPRLTPTWRPFLQASPHF"
     exon            673..840
                     /gene="FAM83A"
                     /gene_synonym="BJ-TSA-9"
                     /inference="alignment:Splign:2.1.0"
     exon            841..965
                     /gene="FAM83A"
                     /gene_synonym="BJ-TSA-9"
                     /inference="alignment:Splign:2.1.0"
     exon            966..3887
                     /gene="FAM83A"
                     /gene_synonym="BJ-TSA-9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3864..3869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM83A"
                     /gene_synonym="BJ-TSA-9"
                     /note="hexamer: AATAAA"
     polyA_site      3887
                     /gene="FAM83A"
                     /gene_synonym="BJ-TSA-9"
                     /note="major polyA site"
ORIGIN      
        1 aggagttctg agaagcattg ctcaggacag cggtaaatca cttcttggag gtgccctgca
       61 cgccggtcct gggagcaggc ggcctcccgg gggtgcggga gccccactcc tccgtggtgt
      121 gttccatttg cttcccacat ctggaggagc tgacgtgcca gcctccccca gcaccaccca
      181 gggacgggag gcatgagccg gtcaaggcac ctgggcaaaa tccggaagcg tctggaagat
      241 gtcaagagcc agtgggtccg gccagccagg gctgacttta gtgacaacga gagtgcccgg
      301 ctggccacgg acgccctctt ggatgggggt tctgaagcct actggcgggt gctcagccag
      361 gaaggcgagg tggacttctt gtcctcggtg gaggcccagt acatccaggc ccaggccagg
      421 gagcccccgt gtcccccaga caccctggga ggggcggaag caggccctaa gggactggac
      481 tccagctccc tacagtccgg cacctacttc cctgtggcct cagagggcag cgagccggcc
      541 ctactgcaca gctgggcctc agctgagaag ccctacctga aggaaaaatc cagcgccact
      601 gtgtacttcc agaccgtcaa gcacaacaac atcagagacc tcgtccgccg ctgcatcacc
      661 cggactagcc aggtcctggt catcctgatg gatgtgttca cggatgtgga gatcttctgt
      721 gacattctag aggcagccaa caagcgtggg gtgttcgttt gtgtgctcct ggaccaggga
      781 ggtgtgaagc tcttccagga gatgtgtgac aaagtccaga tctctgacag tcacctcaag
      841 aacatttcca tccggagtgt ggaaggagag atatactgtg ccaagtcagg caggaaattc
      901 gctggccaaa tccgggagaa gttcatcatc tcggactgga gatttgtcct gtctggatct
      961 tacagcttca cctggctctg cggacacgtg caccggaaca tcctctccaa gttcacaggc
     1021 caggcggtgg agctgtttga cgaggagttc cgccacctct acgcctcctc caagcctgtg
     1081 atgggcctga agtccccgcg gctggtcgcc cccgtcccgc ccggagcagc cccggccaat
     1141 ggccgcctta gcagcagcag tggctccgcc agtgaccgca cgtcctccaa ccccttcagc
     1201 ggccgctcgg caggcagcca ccccggtacc cgaagtgtgt ccgcgtcttc agggccctgt
     1261 agccccgcgg ccccacaccc gcctccaccg ccccggttcc agccccacca aggcccttgg
     1321 ggagccccga gtccccaggc ccacctctcc ccgcggcccc acgacggccc gcccgccgct
     1381 gtctacagca acctgggggc ctacaggccc acgcggctgc agctggagca gctgggcctg
     1441 gtgccgaggc tgactccaac ctggaggccc ttcctgcagg cctcccctca cttctgaagg
     1501 tcccatcccc tgctgccctc cgcaggccca gggctgggca ctccctgaga cccaaagacc
     1561 cacctcaacg acgagtggcg ttgagccact tccctttgaa aagacactca aaatcactgc
     1621 catggttcaa tgttcccagg ccccaggcca tccacttgcc ggcccccacc agttcttggg
     1681 ttccccgctc tagtttgacc tgtgcagcac attccagaag gttccaggga ggttgtgggg
     1741 cagctagagg acaaaatcat gaaaacagag tccctgtctt ccagagatca tccggggctt
     1801 taatattaat ggcccccaaa actccgtaag aagcaggaaa tgcagcccaa gttttacaaa
     1861 tgggtaaaca gaggcactga gagatagatg gtagtttggt acttctggtt cccagtgccc
     1921 aggaatggtc cactcccaag aaattcagga aagaaagact gaggagaagg tgtgggaaca
     1981 ttctggatgt ttcgggagag ttggggaaac tcctcctctt aggaaaggct aatactaggg
     2041 tatccttggg cccaatgaat taggggtgag gccccagaac ccgttatcta tgagttgtat
     2101 gggggagcca tctgaagctg tagccaccag ggatgcagct agctgaggag tttggggtgt
     2161 tgggttggac aaggcaggtt agtagactca gattcttgct tcaaagagcc ttgggctggc
     2221 ctggaggtcc ctggagtcta gactggacct aggagcttga gttgtcaggg gccaggactg
     2281 gccccactgc agtgcccagg ccagtcttga gcagcaggga gggctcagct gtccccagat
     2341 ccaggtgcct ctgaccagcc tggtcacctc ctgaggaata aatgctgaac ctcacaagcc
     2401 ccatcattca tttcttctca attcacagtg cccctctttg tttctggggt ggaactaggt
     2461 cctgagggca cagcctagct gagtgcaaag aaatatagga tgcttagaaa gcatacagga
     2521 ggggccaggc gtggtggctc atgcctgtaa tcccagaact ttgggatgcc aaggtggttg
     2581 gattacctga gatcaggtgg attacctggt ctcgagacca gcctgaccaa tatggtgaaa
     2641 ccccgtctct actaaaaata caaaaattag gctgagacag gagaattgct tgaacccagg
     2701 aagcagaggt tgcaatgagc tgagattgca tcactgcact ccagcatggg caacaaagca
     2761 agactccgtc acagaaaaaa aaaaaaaaaa gagagagagc atagaggagg gttggccagc
     2821 cctgtggtgg gtgggatgtc agagacactt cccagataaa gtaagagtta accctgcacc
     2881 tcaggtgtga tagtggggtc agtggtatgt gatccaggct ggggagccag aggggagcag
     2941 gtgccaactc cacatccttc tcctgtttct aggccctctc ctcccttgtc ggtttttggc
     3001 ggggaagctc agccttcgct gtggagggac gagagcacag agctcttcct cctggtggcc
     3061 tctgacccct gacggcctgt ggcatcctcc ctagtcccct ctgcccatcc atccctctgt
     3121 tccaattctc cactgctccc agcatgatct ggggcatctt ggcttctggt ttcttttatt
     3181 attattatta ttattaatta ttgtattcct gtccttcact tttttcctcc ttagttcctg
     3241 aaagtaaaca aaacaaaaca aaaacaaaaa aacaaacaac actttggttc ctgatggctt
     3301 tctgaaccca gccctgacct tgttgtttca cagctgacgg ctgagatgag gttagaatga
     3361 ctgggcccgg ctgaacattc caaattggat ttcaccatct gctgagaaag tttaaggaag
     3421 gcaaagcttg ccaggtcaca gaagctccca agcccagctt tccaaaggcc tcagcctgtg
     3481 cctgtgtcga gctcagtcct gggagatagg ggagaacctg caggcaggaa caagcccccc
     3541 tactcctgac caccctccat cagcagtctc ccctccgtgg tcgtctttgt tgacaaaggt
     3601 gcagtttctc ctctcctggg cacctgtaac atgtgatgcg ctgcctgctg ggaggttagg
     3661 tcggggctgc cccggcgagt ggagcatgag cagaaccgcc gagggtcact tctgggcaga
     3721 agctttgaga gcctgggtcc aggttgccac atagaagcag ctctccagtt gaaaccctcc
     3781 tctgccagcc tggggtccta agcgatgagc agaatccccc actcccaccc caccaaccca
     3841 caatggatat gtagtgagca agaaataaac ctttgttgtt taagcca
//
