LOCUS       NM_152548               1542 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 81 member B (FAM81B),
            mRNA.
ACCESSION   NM_152548
VERSION     NM_152548.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1542)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1542)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC034772.1, BM560335.1, AK058062.1 and AC090071.3.
            
            On May 17, 2019 this sequence version replaced NM_152548.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034772.1, AK058062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283357.10/ ENSP00000283357.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-810               BC034772.1         23-832
            811-846             BM560335.1         638-673
            847-1538            BC034772.1         869-1560
            1539-1541           AK058062.1         1544-1546
            1542-1542           AC090071.3         72614-72614
FEATURES             Location/Qualifiers
     source          1..1542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..1542
                     /gene="FAM81B"
                     /note="family with sequence similarity 81 member B"
                     /db_xref="GeneID:153643"
                     /db_xref="HGNC:HGNC:26335"
     exon            1..148
                     /gene="FAM81B"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1383
                     /gene="FAM81B"
                     /codon_start=1
                     /product="protein FAM81B"
                     /protein_id="NP_689761.2"
                     /db_xref="CCDS:CCDS43341.1"
                     /db_xref="GeneID:153643"
                     /db_xref="HGNC:HGNC:26335"
                     /translation="MQLQFLGTLASSEKRKKSQRLFFKNIKSTKNKAGKASIMSSDTN
                     VNKSASPTATAEEQPVEPDGPLPGSDNNQEKKVRLSPAKMSTKNSTDLVEYVDKSHAF
                     LPIIPNTQRGQLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLL
                     ESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVA
                     RCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSE
                     QTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINE
                     CLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQME
                     KQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIVELQ
                     EV"
     exon            149..252
                     /gene="FAM81B"
                     /inference="alignment:Splign:2.1.0"
     exon            253..317
                     /gene="FAM81B"
                     /inference="alignment:Splign:2.1.0"
     exon            318..561
                     /gene="FAM81B"
                     /inference="alignment:Splign:2.1.0"
     exon            562..680
                     /gene="FAM81B"
                     /inference="alignment:Splign:2.1.0"
     exon            681..810
                     /gene="FAM81B"
                     /inference="alignment:Splign:2.1.0"
     exon            811..917
                     /gene="FAM81B"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1053
                     /gene="FAM81B"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1249
                     /gene="FAM81B"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1542
                     /gene="FAM81B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1521..1526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM81B"
                     /note="hexamer: AATAAA"
     polyA_site      1542
                     /gene="FAM81B"
                     /note="major polyA site"
ORIGIN      
        1 agaaacagga agaccttagt taggatgcaa ttacaattcc ttggtacatt ggcttcctca
       61 gaaaaaagaa aaaaatcaca gagattgttt ttcaaaaata tcaaatctac aaaaaataaa
      121 gctggaaaag caagcatcat gagttcagat acaaatgtaa acaaaagtgc ctctccaact
      181 gcgactgcag aggaacagcc agttgaacct gatggccccc ttcctggctc agacaataac
      241 caagaaaaga aagtaagatt atctccagcc aaaatgtcaa ccaagaattc tacagatcta
      301 gttgaatatg ttgacaagag tcatgctttt ctccccatca ttccaaacac ccagagaggt
      361 cagctagaag acagactgaa caaccaggcg cgtaccatag ctttccttct tgaacaagcc
      421 ttccgcatca aggaggacat ctctgcttgc ctgcagggga cccatggctt tcgaaaagag
      481 gaatcgctcg ccaggaagtt actggaaagc cacatccaga ccatcaccag catcgtcaaa
      541 aaactcagcc aaaatattga gattttagaa gaccaaataa gagctcgaga tcaggcggcc
      601 acaggaacta actttgcagt acacgagata aacatcaaac acctacaagg agttggagat
      661 cttcgaggaa gagtagccag atgtgattca agcattgtga agctttctgg agacattcac
      721 ttattcaggc aagagcaccg gcaaattgag aaagccattc aagaattcgt gcccgccctg
      781 gaaactcttt ccaagaactt ggacatgaag gtgatgcagc tcttaggaaa gatagaaact
      841 gccagttctg agcaaacctc gaatttaaag atggtccagg gggattatcg ccacgaaatg
      901 aaccttttgg aattcaaatt tcattcactt tcaagtaatc tgtacgaaga agttgagaat
      961 aataaaaaat ggacagaaaa ccaatttctc aaatatagaa aagaccacct gggccatata
     1021 aatgaatgtc tgaaggtcct acaggagaaa ctggaaaagt ctgaaaataa aatggaagaa
     1081 aaactgctgc agctttcaag caaagtagag aatttcatta acacacagaa acaggaaaca
     1141 caactaagta aagtaaagca tatggaaaat aaattgtcca aaaagatgga acaaatggaa
     1201 aagcagatct ggggtgaatt agagacaatg cagaatgaat atcaatcagg atttaaatca
     1261 attcatgact ctctcagctc cctccaacaa atacagaaaa caaagatgga tttagagaaa
     1321 tataaagtac agaaagacct aaagaaatta cagcgcaaga tagtggaact ccaggaagta
     1381 taaacctttt cagtcatctt ctttttcatc agccaatgga gtgatttgtt ggaaaaagtt
     1441 ctgaagaaga aagttactat ctctgggatg tttactgctt ctaatgtctc cttttaagga
     1501 gacgaatgta ccagaaaaat aataaagcaa agaagcttcg ga
//
