LOCUS       NM_152450               3458 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens family with sequence similarity 81 member A (FAM81A),
            mRNA.
ACCESSION   NM_152450
VERSION     NM_152450.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3458)
  AUTHORS   Kaizuka,T., Hirouchi,T., Saneyoshi,T., Shirafuji,T., Collins,M.O.,
            Grant,S.G.N., Hayashi,Y. and Takumi,T.
  TITLE     FAM81A is a postsynaptic protein that regulates the condensation of
            postsynaptic proteins via liquid-liquid phase separation
  JOURNAL   PLoS Biol 22 (3), e3002006 (2024)
   PUBMED   38452102
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3458)
  AUTHORS   Zhang,Q., Sun,S., Xie,Q., Wang,X., Qian,J., Yao,J. and Li,Z.
  TITLE     FAM81A identified as a stemness-related gene by screening DNA
            methylation sites based on machine learning-accessed stemness in
            pancreatic cancer
  JOURNAL   Epigenomics 14 (10), 569-588 (2022)
   PUBMED   35574683
  REMARK    GeneRIF: FAM81A identified as a stemness-related gene by screening
            DNA methylation sites based on machine learning-accessed stemness
            in pancreatic cancer.
REFERENCE   3  (bases 1 to 3458)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3458)
  AUTHORS   Pineau,C., Hikmet,F., Zhang,C., Oksvold,P., Chen,S., Fagerberg,L.,
            Uhlen,M. and Lindskog,C.
  TITLE     Cell Type-Specific Expression of Testis Elevated Genes Based on
            Transcriptomics and Antibody-Based Proteomics
  JOURNAL   J Proteome Res 18 (12), 4215-4230 (2019)
   PUBMED   31429579
REFERENCE   5  (bases 1 to 3458)
  AUTHORS   Dosemeci,A., Loo,H.K., Toy,D., Winters,C.A., Reese,T.S. and
            Tao-Cheng,J.H.
  TITLE     FAM81A protein, a novel component of the postsynaptic density in
            adult brain
  JOURNAL   Neurosci Lett 699, 122-126 (2019)
   PUBMED   30735723
REFERENCE   6  (bases 1 to 3458)
  AUTHORS   Kapoor,M., Wang,J.C., Wetherill,L., Le,N., Bertelsen,S.,
            Hinrichs,A.L., Budde,J., Agrawal,A., Almasy,L., Bucholz,K.,
            Dick,D.M., Harari,O., Xiaoling,X., Hesselbrock,V., Kramer,J.,
            Nurnberger,J.I. Jr., Rice,J., Schuckit,M., Tischfield,J.,
            Porjesz,B., Edenberg,H.J., Bierut,L., Foroud,T. and Goate,A.
  TITLE     Genome-wide survival analysis of age at onset of alcohol dependence
            in extended high-risk COGA families
  JOURNAL   Drug Alcohol Depend 142, 56-62 (2014)
   PUBMED   24962325
REFERENCE   7  (bases 1 to 3458)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   8  (bases 1 to 3458)
  AUTHORS   Wang,K.S., Liu,X.F. and Aragam,N.
  TITLE     A genome-wide meta-analysis identifies novel loci associated with
            schizophrenia and bipolar disorder
  JOURNAL   Schizophr Res 124 (1-3), 192-199 (2010)
   PUBMED   20889312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC022537.1, AC091748.3 and AC092754.4.
            
            On Nov 23, 2018 this sequence version replaced NM_152450.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.133066.1,
                                           SRR1660805.171246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288228.10/ ENSP00000288228.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BC022537.1         14-51
            39-97               AC091748.3         144550-144608
            98-233              BC022537.1         111-246
            234-468             AC092754.4         20204-20438
            469-491             BC022537.1         482-504
            492-587             AC092754.4         52526-52621
            588-1188            BC022537.1         601-1201
            1189-3455           AC092754.4         81518-83784
            3456-3458           AC092754.4         83785-83787
FEATURES             Location/Qualifiers
     source          1..3458
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.2"
     gene            1..3458
                     /gene="FAM81A"
                     /note="family with sequence similarity 81 member A"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
     exon            1..97
                     /gene="FAM81A"
                     /inference="alignment:Splign:2.1.0"
     exon            98..194
                     /gene="FAM81A"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1281
                     /gene="FAM81A"
                     /codon_start=1
                     /product="protein FAM81A"
                     /protein_id="NP_689663.2"
                     /db_xref="CCDS:CCDS45269.1"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
                     /translation="MENMHLRRVRTMPRHSQSLTMAPYSSVSLVEQLEDRILCHEKTT
                     AALVEHAFRIKDDIVNSLQKMQNKGGGDRLARLFLEEHIRNITAIVKQLNRDIEVLQE
                     QIRARDNISYGTNSALKTLEMRQLSGLGDLRGRVARCDASIARLSAEHKTTYEGLQHL
                     NKEQQAAKLILETKIKDAEGQISQLLNRVDLSISEQSTKLKMSHRDSNHQLQLLDTKF
                     KGTVEELSNQILSARSWLQQEQERIEKELLQKIDQLSLIVKENSGASERDMEKKLSQM
                     SARLDKIEEGQKKTFDGQRTRQEEEKMHGRITKLELQMNQNIKEMKAEVNAGFTAVYE
                     SIGSLRQVLEAKMKLDRDQLQKQIQLMQKPETPM"
     exon            195..468
                     /gene="FAM81A"
                     /inference="alignment:Splign:2.1.0"
     exon            469..587
                     /gene="FAM81A"
                     /inference="alignment:Splign:2.1.0"
     exon            588..717
                     /gene="FAM81A"
                     /inference="alignment:Splign:2.1.0"
     exon            718..824
                     /gene="FAM81A"
                     /inference="alignment:Splign:2.1.0"
     exon            825..960
                     /gene="FAM81A"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1156
                     /gene="FAM81A"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..3458
                     /gene="FAM81A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2420..2425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM81A"
                     /note="hexamer: AAGAAA"
     polyA_site      2441
                     /gene="FAM81A"
                     /note="major polyA site"
     regulatory      2653..2658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM81A"
                     /note="hexamer: AATAAA"
     polyA_site      2690
                     /gene="FAM81A"
                     /note="major polyA site"
     regulatory      2865..2870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM81A"
                     /note="hexamer: AATAAA"
     polyA_site      2900
                     /gene="FAM81A"
     regulatory      3428..3433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM81A"
                     /note="hexamer: AATAAA"
     regulatory      3440..3445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM81A"
                     /note="hexamer: AATAAA"
     polyA_site      3454
                     /gene="FAM81A"
     polyA_site      3458
                     /gene="FAM81A"
ORIGIN      
        1 gcagccgggc gccctgctca gccagcgcca gcggccgccg cacccagccg cgccggcgag
       61 gacatgggca gccgcggcgc gcccaccccc cgcgccgatg tgaattatta aaaagaaaat
      121 ggcccaacgg agcactgtat ttccttctcg tgtcaccaag gaaaggtata atatatggaa
      181 aatatgcatc taaggcgagt gagaaccatg ccccgacaca gccagtccct gaccatggca
      241 ccatactcat ctgtaagcct cgtggagcag ctggaagaca ggatcctctg ccatgagaaa
      301 accaccgccg ccctcgtaga gcacgccttt cggattaaag atgacattgt caacagtttg
      361 cagaaaatgc aaaacaaagg gggaggtgac cgcttggcca ggcttttctt ggaggagcat
      421 atcagaaaca taactgccat agtgaagcaa cttaatcggg atatcgaggt actccaggag
      481 cagattcgtg cccgggacaa cattagctat ggaactaatt ctgccttaaa gaccctggag
      541 atgcgccagc tctccggttt gggagatctt cgaggaagag tggcaagatg tgatgccagc
      601 atagctagac tttctgcaga gcacaaaacg acctatgagg ggctccagca cttgaacaaa
      661 gaacagcagg ctgccaaact tatcttggaa acgaaaatca aagatgcaga gggacagatt
      721 tctcagcttt tgaacagagt ggacttgtca atatcagagc agagcaccaa actgaagatg
      781 tctcacagag acagtaacca ccagcttcag cttttggaca ctaaatttaa aggtacagtt
      841 gaggaactca gtaaccagat attatctgca cggagttggt tgcaacagga acaagaacgg
      901 atagaaaaag agcttttaca gaaaattgat cagctttcct tgattgttaa ggaaaacagt
      961 ggagccagtg aaagggatat ggagaagaag ctcagccaga tgtcagccag gcttgacaaa
     1021 atagaagagg gtcaaaagaa gacttttgat ggtcagagaa caaggcaaga agaggagaag
     1081 atgcacgggc gaatcaccaa gctggagtta cagatgaacc agaacatcaa ggaaatgaaa
     1141 gcagaagtta atgctgggtt tacagccgtc tatgaaagca taggatccct caggcaagtt
     1201 ctcgaggcca agatgaagct ggacagggac cagctacaga agcaaatcca gctgatgcag
     1261 aagccagaga cccccatgtg aagggagctg ggacaaggtc ctaaaagaca gttttgccag
     1321 tggggctagg agccggatac ctctgtagcc aggccatcgc tgcattcagg attgttccat
     1381 ccatggcgtg catgtgccaa gaaatgtgtt tttatgggtc taaatgttta ccttgagtct
     1441 tgaaaatact cttttgttaa aagtatgaaa tacagttttt accagtttat ttcacttctc
     1501 taaattcaat ggaaatcccc cgccctggat tttgaaaggc ttttatcttc ttcattttac
     1561 gaatggaaag acgacaattt ttcttcaatg cttgatgcac taatgaagac tgtttactat
     1621 tttgaaaaat gtcatgggga ttttttttta attaagaaac taatgaatca tcacaggaat
     1681 gtgttgctcc tcaccctaaa ttaagagaat gtcccagtag attagacttc aacctttgag
     1741 tccaatttgg attttattat cgttgtctat gcacttctta tattggttat cttcttgtaa
     1801 atcttctgtc ttttgtaagg ggaaaggatt taacatttag aataaacccc accatttatg
     1861 taatggaaat agtttaaaaa ttgctaactg ccatgtggat tgcaaattaa atggaaactt
     1921 atttagataa cgtaaggctc aatatctgcg ttgaccacct agatattaca ggttttaata
     1981 tttaaaacta tttttgaatt atccacaacc tgtatagtga tagccatata tttaataatg
     2041 gaatggtggt taacagtcta tttactgcac aattaattgt tcactaatca aatagaatgt
     2101 ggtaattttt cagactttat gatctgtttc caaaattggc acaaagtgct agggtttata
     2161 tacacttatc gtaactgtat ttttgtgcct tggttttatc atgtcaatgc actgtactct
     2221 gtaaaagttt tgcagacaaa atagaaagta tgataatccg tcagaagtat gatgtaaaac
     2281 tggaatcctc tgtatttttt aaatgttcta aaaattttat cgctgttaag gtattaatca
     2341 ttcagtatta ctaatggaat agaaattcat acttttgtat ggacaacaat tcaaattgat
     2401 attgcattta tagcactgta agaaactttc atcttgagca actttgtaga tgatgggtgt
     2461 tttattttca atcgccatat ttgatcagtc attgaaaatt ggccccagtg ctgtttgttc
     2521 atctctgtat gtaaaaactg acagtgagac acaacgttct gaactgtgag ggtgtcccag
     2581 gaaaaagaaa aacaggaata ctttaacaat taaaaagaaa aaaatgtttt ttgtttgcca
     2641 aggactcagg aaaataaaaa gcattttcta tttttaggac aaatcacaaa tgaagtgtct
     2701 aactggctat tactgtttac ccatataaaa tatgctgcta aagtacatat tttgctgtca
     2761 atggcttgac aatttttttt ttcaaatttg gacatgagag gttatatagg gactatatta
     2821 tccaacacat attttcttat tttgccacaa atttccactt aacaaataaa aaaaggcgaa
     2881 tgctgttttg caatcagaaa gtgaatttct tttgtggtag cgtacacgtg gttcatgtgg
     2941 ttctccacgt ttaagcacaa accacagcac aggaagccac accccctcca gcatctctgt
     3001 cttgtggggt ctttgaggag aaggaatcag aacatcgaca cctgggaaga gggaggcggg
     3061 gaacaccagc tggactctgg ccaaggagtg atgtaagcag gtgacacttg gctgtcagct
     3121 gagcttctca ggtgcttctg acattgccag ccccttgaga tgagccaccg caggtgtgct
     3181 caccttggct acatgttgaa atcatccaga ggagttggga aatctactga tgccccgctg
     3241 tgcctcccag accgattaag tcagaacctc tgggaggtgg gtcgcaggca tcagtgcgtg
     3301 cccgaggcct ccgcgtgttt gggtgtgcag ccgaggtggt gagctgtcga gccacagtgc
     3361 agttctcttc tcaccaaagc tcaaatgaga atcagcttcc atgttctttc ctttaccaga
     3421 aatttgcaat aaaaagaaaa ataaaatttt cacataaa
//
