LOCUS       NM_001017961            2481 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 78 member B (FAM78B),
            transcript variant 1, mRNA.
ACCESSION   NM_001017961 XM_097622
VERSION     NM_001017961.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2481)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2481)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur J Hum Genet 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2481)
  AUTHORS   Cheung,C.L., Chan,B.Y., Chan,V., Ikegawa,S., Kou,I., Ngai,H.,
            Smith,D., Luk,K.D., Huang,Q.Y., Mori,S., Sham,P.C. and Kung,A.W.
  TITLE     Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible
            genetic association with bone mineral density variation
  JOURNAL   Hum Mol Genet 18 (4), 679-687 (2009)
   PUBMED   19064610
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596087.11, AB593134.1, AK299946.1, AL626787.9 and BM663586.1.
            
            On Aug 31, 2019 this sequence version replaced NM_001017961.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL580399.3, ERR4352441.89009.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354422.4/ ENSP00000346404.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               AL596087.11        46701-46996         c
            297-1016            AB593134.1         51-770
            1017-1856           AK299946.1         301-1140
            1857-2218           AL626787.9         19442-19803         c
            2219-2481           BM663586.1         18-280              c
FEATURES             Location/Qualifiers
     source          1..2481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.1"
     gene            1..2481
                     /gene="FAM78B"
                     /note="family with sequence similarity 78 member B"
                     /db_xref="GeneID:149297"
                     /db_xref="HGNC:HGNC:13495"
     exon            1..1016
                     /gene="FAM78B"
                     /inference="alignment:Splign:2.1.0"
     CDS             754..1539
                     /gene="FAM78B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM78B"
                     /codon_start=1
                     /product="protein FAM78B isoform 1"
                     /protein_id="NP_001017961.1"
                     /db_xref="CCDS:CCDS30931.1"
                     /db_xref="GeneID:149297"
                     /db_xref="HGNC:HGNC:13495"
                     /translation="MGCIQSITCKARIRRENIVVYDVCATIDQCPTRIEETSPIVLRY
                     KTPYFKASARVVMPPIPRHETWVVGWIQACNQMEFFNTYSDLGMSSWELPDLREGRVK
                     AISDSDGVSYPWYGNTTETVTLVGPTNKISRFSVSMNDNFYPSVTWAVPVSDSNVPLL
                     TRIKRDQSFTTWLVAMNTTTKEKIILQTIKWRMRVDIEVDPLQLLGQRARLVGRTQQE
                     QPRILSRMEPIPPNALVKPNANDAQVLMWRPKRGPPLVVIPPK"
     exon            1017..2481
                     /gene="FAM78B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM78B"
                     /note="hexamer: AATAAA"
     polyA_site      1761
                     /gene="FAM78B"
                     /note="major polyA site"
     regulatory      1876..1881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM78B"
                     /note="hexamer: ATTAAA"
     polyA_site      1897
                     /gene="FAM78B"
     regulatory      2458..2463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM78B"
                     /note="hexamer: AATAAG"
     polyA_site      2481
                     /gene="FAM78B"
ORIGIN      
        1 atggcgtaca gccagtttcc tccgcggagc acgtcctgtg ctgctccagc cgttggggct
       61 ctccaccccg ggccacagcc tcctggcgcc ccccgggccg aggcagccgg gccgaggagt
      121 gtcggtgtgg tccggctacg gggcggggcc ggcgggagct ccggtcgccg ccgccgccgc
      181 tgctgcctcc gcctgcctct tgggccgccc gctcgcccgc cgctgggtgc gctgcacgcg
      241 gggggcagcc gtggtgcaga ggttcatgca gcggcggcgg cggcggcggc tgctgctgct
      301 gccgccgcgg aggcagacag accgggcgct gccaccgccg ccctcccccg gctccatgcc
      361 gccgccgctg ccgcctcctc ctctccggcg aggggcgggg ggctccggcc cggggtgggc
      421 accattcctc gcagcgccgc tcccctccct gccctccgcc cgggcgctgg agccggcgag
      481 ggcacccgcc gcctcctagg agtgcaccct ccgcgcgccc tgccggagcg agggggcggg
      541 cgtgggcgga cgtcggggca gcggggaccc cgcgcggctg caagaggagg gggcttcccc
      601 aaggatgccc ggcggctccc cgctcctagg tgcgagctga gtctgaccgg gagcgagcgg
      661 cgcgtcgcca tgccggcgtg acgggcgccc ccggctgccc gcgcgggccc ccgcgctgcc
      721 ccacgccgcg ccgtgccggc accgggctgc aggatgggct gtatccaaag catcacctgc
      781 aaggcgcgga tccggcgcga gaacatcgtg gtgtacgatg tgtgcgccac catcgaccag
      841 tgccccacgc gcatcgagga gacctcgccc atcgtcctgc gctacaagac cccctacttc
      901 aaagcctccg cccgcgtggt catgcccccc atcccccgcc acgagacctg ggtggtgggc
      961 tggattcagg cgtgcaatca gatggagttc ttcaacacct acagcgacct gggcatgtca
     1021 agctgggaac tgcctgactt gagggaaggg agagtaaaag ccatcagtga ctcagatggg
     1081 gtgagctacc cttggtacgg gaacaccaca gaaactgtga ccctggttgg ccccaccaac
     1141 aagatctcca ggttctccgt cagcatgaat gacaacttct accccagtgt gacatgggca
     1201 gtgcctgtga gtgacagcaa tgtgccactg ctcacaagaa tcaagagaga ccaaagtttc
     1261 acgacctggc tggtggccat gaacaccacc acaaaggaga agatcattct gcagaccatc
     1321 aagtggagga tgagggtgga cattgaagtg gaccctcttc agctcttggg gcagcgggcc
     1381 cggctggtgg gcaggactca gcaggagcag ccccggatcc tgagccggat ggaacccatc
     1441 ccccctaatg cactagtgaa acccaatgcc aatgatgccc aggtcctcat gtggaggccc
     1501 aagcgggggc cacctctggt tgtgatccct cctaagtaga agcagactgg cctgactgtg
     1561 tgtggatcac acgcctctga gacatgcagt gagggtgcca ggggtggcag gagccaaaca
     1621 gagtttctga gccaaagcag acctctcggt ttgccagcct ttgcagccac ttttgaagag
     1681 tagggctgct ccttgggtgg tagaaccata atccttagga aaaatccctt cctcttagga
     1741 ataaagaaat cactgatttg acagacttgc tgtgattacc atgcaagtag ccatattttg
     1801 gagctgacca ggatgattct tttatctgaa ctattgacca tttctttcct gtgagatgca
     1861 ggggatggaa acgaaattaa acagtgcctg tggcaaatgc tgcttcccag ccaattagaa
     1921 gtaggagtga aaacatccac accaggtggt cgtaagacag actcctgctg tctgactgga
     1981 gggtgctggg gaaatgggtg gtgaaagaat gggtgatggg gagaggaaag aataaggttt
     2041 tatgacacat taatacttct gcatttatta gttgataatc agatcaacac actcaatgga
     2101 atgaatgctt agaaaactag acaaatactg atatttgctc ctttctgagg gagaaagcct
     2161 ccttggaact gtccaaggtg ctgatgtgaa ctaacggaaa cacttcatta gttccgtcta
     2221 cccacctctt tccaaaaaga ttgcttattc agagtatttt taatcacagt atttggcttt
     2281 gtaattccca cattctgcaa tagttatgat atttggggcc ctgtccatgt tttagtgaaa
     2341 tcctaactaa cttgattttg tttacagctg cttattctgt tcccatgatt agccctaaat
     2401 ttatatttaa aaagttatga gccatgaatc catgtaaggt tcaagaacat ttcagcaaat
     2461 aagaacagca ttttcattct g
//
