LOCUS       NM_144664               3932 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 76 member B (FAM76B),
            transcript variant 1, mRNA.
ACCESSION   NM_144664
VERSION     NM_144664.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3932)
  AUTHORS   Wang,J., Zhao,X., Wang,Q., Zheng,X., Simayi,D., Zhao,J., Yang,P.,
            Mao,Q. and Xia,H.
  TITLE     FAM76B regulates PI3K/Akt/NF-kappaB-mediated M1 macrophage
            polarization by influencing the stability of PIK3CD mRNA
  JOURNAL   Cell Mol Life Sci 81 (1), 107 (2024)
   PUBMED   38421448
  REMARK    GeneRIF: FAM76B regulates PI3K/Akt/NF-kappaB-mediated M1 macrophage
            polarization by influencing the stability of PIK3CD mRNA.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3932)
  AUTHORS   Wang,D., Zheng,X., Chai,L., Zhao,J., Zhu,J., Li,Y., Yang,P., Mao,Q.
            and Xia,H.
  TITLE     FAM76B regulates NF-kappaB-mediated inflammatory pathway by
            influencing the translocation of hnRNPA2B1
  JOURNAL   Elife 12, e85659 (2023)
   PUBMED   37643469
  REMARK    GeneRIF: FAM76B regulates NF-kappaB-mediated inflammatory pathway
            by influencing the translocation of hnRNPA2B1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3932)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3932)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3932)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3932)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 3932)
  AUTHORS   Zheng,X., Li,Y., Zhao,J., Wang,D., Xia,H. and Mao,Q.
  TITLE     Production and Characterization of Monoclonal Antibodies against
            Human Nuclear Protein FAM76B
  JOURNAL   PLoS One 11 (3), e0152237 (2016)
   PUBMED   27018871
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3932)
  AUTHORS   Salichs,E., Ledda,A., Mularoni,L., Alba,M.M. and de la Luna,S.
  TITLE     Genome-wide analysis of histidine repeats reveals their role in the
            localization of human proteins to the nuclear speckles compartment
  JOURNAL   PLoS Genet 5 (3), e1000397 (2009)
   PUBMED   19266028
REFERENCE   9  (bases 1 to 3932)
  AUTHORS   Vasilescu,J., Zweitzig,D.R., Denis,N.J., Smith,J.C., Ethier,M.,
            Haines,D.S. and Figeys,D.
  TITLE     The proteomic reactor facilitates the analysis of affinity-purified
            proteins by mass spectrometry: application for identifying
            ubiquitinated proteins in human cells
  JOURNAL   J Proteome Res 6 (1), 298-305 (2007)
   PUBMED   17203973
REFERENCE   10 (bases 1 to 3932)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG718983.1, BX647586.1, AP001877.5 and AW118814.1.
            
            On Nov 23, 2018 this sequence version replaced NM_144664.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.88706.1,
                                           SRR1660809.174327.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358780.10/ ENSP00000351631.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               BG718983.1         14-296
            284-987             BX647586.1         1-704
            988-988             AP001877.5         58682-58682         c
            989-1285            BX647586.1         706-1002
            1286-3910           AP001877.5         48042-50666         c
            3911-3932           AW118814.1         19-40               c
FEATURES             Location/Qualifiers
     source          1..3932
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..3932
                     /gene="FAM76B"
                     /note="family with sequence similarity 76 member B"
                     /db_xref="GeneID:143684"
                     /db_xref="HGNC:HGNC:28492"
     exon            1..391
                     /gene="FAM76B"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..1324
                     /gene="FAM76B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM76B"
                     /codon_start=1
                     /product="protein FAM76B isoform 1"
                     /protein_id="NP_653265.3"
                     /db_xref="CCDS:CCDS41700.1"
                     /db_xref="GeneID:143684"
                     /db_xref="HGNC:HGNC:28492"
                     /translation="MAASALYACTKCTQRYPFEELSQGQQLCKECRIAHPIVKCTYCR
                     SEFQQESKTNTICKKCAQNVKQFGTPKPCQYCNIIAAFIGTKCQRCTNSEKKYGPPQT
                     CEQCKQQCAFDRKEEGRRKVDGKLLCWLCTLSYKRVLQKTKEQRKSLGSSHSNSSSSS
                     LTEKDQHHPKHHHHHHHHHHRHSSSHHKISNLSPEEEQGLWKQSHKSSATIQNETPKK
                     KPKLESKPSNGDSSSINQSADSGGTDNFVLISQLKEEVMSLKRLLQQRDQTILEKDKK
                     LTELKADFQYQESNLRTKMNSMEKAHKETVEQLQAKNRELLKQVAALSKGKKFDKSGS
                     ILTSP"
     exon            392..456
                     /gene="FAM76B"
                     /inference="alignment:Splign:2.1.0"
     exon            457..511
                     /gene="FAM76B"
                     /inference="alignment:Splign:2.1.0"
     exon            512..667
                     /gene="FAM76B"
                     /inference="alignment:Splign:2.1.0"
     exon            668..867
                     /gene="FAM76B"
                     /inference="alignment:Splign:2.1.0"
     exon            868..915
                     /gene="FAM76B"
                     /inference="alignment:Splign:2.1.0"
     exon            916..996
                     /gene="FAM76B"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1132
                     /gene="FAM76B"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1234
                     /gene="FAM76B"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..3932
                     /gene="FAM76B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2505..2510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM76B"
                     /note="hexamer: ATTAAA"
     polyA_site      2527
                     /gene="FAM76B"
                     /note="major polyA site"
     regulatory      3912..3917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM76B"
                     /note="hexamer: AATAAA"
     polyA_site      3932
                     /gene="FAM76B"
                     /note="major polyA site"
ORIGIN      
        1 ggatccacgg ccgcacagct aaacagcaac cccctacccg cttcgtctcc ctccgccgct
       61 atcggggcct aagcgggagc ggctggcacg gcgtcactgg gtgggctggg gcggaagtgg
      121 aggcggaggg agacggtggc gtcgtccgcg gggccctggg ctctcgcggc gaggccctgg
      181 tgggcgcgag gcagggggag ggggaggagg aggagcccgc ggcccgggcg gcggcggctc
      241 tcgggttctc cgtagggccc cgcctcggag cgggcggcgg cggaggagga gactgaggag
      301 caggatggcg gcctcggccc tgtacgcctg caccaagtgt acccagcgtt atcctttcga
      361 ggagctctcc cagggccagc agctctgcaa ggaatgtcgg attgcacatc ctattgtaaa
      421 atgtacttac tgcagatcag aatttcaaca agagagcaaa actaacacaa tttgtaagaa
      481 gtgtgctcaa aatgtgaagc aatttgggac gcccaagcct tgtcagtact gtaacataat
      541 tgcagcattt attggtacca agtgtcagcg ttgcacaaat tcagaaaaaa agtatggacc
      601 acctcagacc tgtgaacagt gcaaacagca atgtgctttt gatcggaagg aggaaggaag
      661 aagaaaggtt gatggaaagt tattatgctg gctctgtact ttatcgtaca aaagagtttt
      721 acagaagacg aaagaacaaa ggaagagcct gggatcttca cattcaaatt catcttcttc
      781 atctcttact gagaaagacc agcatcatcc aaaacatcat caccaccatc atcaccatca
      841 ccatcgtcac agcagtagcc atcacaaaat cagcaatcta agtccagaag aagagcaggg
      901 actgtggaaa cagagccata aatcctctgc aacaattcag aatgaaactc caaagaaaaa
      961 gcccaaattg gaatctaagc catctaatgg agatagtagc tctataaatc agtcagcaga
     1021 tagtggggga acagacaatt ttgtccttat aagtcaattg aaagaagaag tgatgtcact
     1081 taagcgtctc ttacagcaga gagaccagac cattttagaa aaagataaaa agttaactga
     1141 actaaaggca gactttcagt accaagagtc aaatttgaga acaaaaatga acagtatgga
     1201 aaaagcccac aaagaaactg tggaacaact tcaggccaaa aacagagaac tactcaaaca
     1261 ggtcgcagca ttatcaaagg gtaaaaaatt tgacaaaagt ggaagcatac taacatctcc
     1321 ttgagaaagt catttgttta gcatttcttc ttacaatgta aatttgggga aaaaaaattc
     1381 tgtgaagccc ttaaattctg tgtagtagaa aaatattttt gcacaccaaa tgaattggtg
     1441 tgtttcctgt tcacttttgt aattgatata cagcattttt taagttgtaa aacattcaaa
     1501 taaaacttca actggtttga agtaactttt taattatttg atatccagga acttttttgc
     1561 cagcaatagt attaaacagt tgtaaaggag tgcatgagta gtgctcttta tgaaacgcaa
     1621 catgcaataa tagagtaggt atggtttcag aagtcagagc agcagggttt ttttgttttg
     1681 tttttgtttt acactatgct aatttcagac aaacagtttt caatttagaa atacaaaaac
     1741 ttttaaactc gaaaaatggc gaacactggt tttttgggaa ttgtgttttt actttgcatc
     1801 aagatgaatt taggagaaaa tcacggtgct tttattaaat gaacttcaga tatatgtaaa
     1861 tttgtttttt aaagttacat cattaacatt agtaacctag cattttcatt attggtatag
     1921 gaattaatgt ttattgtaca gtatctaagg taaaatgtgt ttctgttttg taaaaactac
     1981 tgtagatttt tacttacaag tgcctttttg ccacctaatg tttttattta taggaatgct
     2041 gatcttttgt acatacattt tgttttaaaa tcatgtttaa taaatgtttg tatataaatg
     2101 catatgtaca gaagcctatt tcaaaaggaa atcaaagttg ctagtaaaat gtttgagatt
     2161 acatttagaa ctaactgata atgcatatag attgtagaaa attttgtgat ttgtttctgt
     2221 gtgataaggg aagctgttgg tctttgaatt catttaatta tgtcaaaata gttccccaaa
     2281 gatttaattt taagttgctt cttaaagagt aattttattt tttatgtcat gtggcttcat
     2341 attagtattg tgtgagttac atgttttgct ttatatttta taaaattttt taaaaatttt
     2401 aatgtttctg caatgatcca tgtatctgct ttccctatgt gtggttatct aagttaatat
     2461 ttatgtacaa tgtaatttgt aaatttaaag caaatctgaa aaaaattaaa tgatcttttt
     2521 aatccaatct gtgataatct ttgaataaat tggaatctac tataagattc aggcattata
     2581 agtaaattgt cctaaagtct ttaaaattgt ctataaaagg ttaaggtagg gtgggatagg
     2641 ttatatgaag ttattgacta tattctgatc cagcggtttt cagcctgaaa tagaatttat
     2701 ctcctagtta ttatcagttc agagttttag tttgatttta aagtattgct agatacactg
     2761 tatagagtga gttgcttctc ttaataattt atgggcaaag ataaatttgc ttcatgtaaa
     2821 actgttacta aatttataag ttttaaaggt tttgttttat acaagcattg attgtgaatg
     2881 tcatatcaaa gattggcttt cttaagaaca catgattgaa acaatttttt tttaacatga
     2941 cgtgtttcaa tagactgttc tcatagttca ttataaagtg aataccaaat aattctttgt
     3001 ccattttgaa agcataatat agggtaattt tcaagtgata caaaaagatt cagttagaat
     3061 cttgtaaact aaaccagttt atttttatgg gatcttcatg taataatttt cttaaattta
     3121 gtactctcaa ccatgataga taatgcctta acatggattt taacgtttgc aggatttgct
     3181 aaattcataa gatagttatt acctttcttt gaaatttgta atgttttata ttcttgtttc
     3241 atagccattt gtcagtccac agtggtcatt atggttttac tttttgatag ttcttacacc
     3301 ttgttggaga aactacaaaa gaaagttgtc ctcgtccttc cccttagcta acatcaaaat
     3361 taaaaagttg aatattaata ttagctaaca ttaaaatgga aggtaattca gttttagtgt
     3421 tagctaacat taacagtcta ataatttagc tttgtaaatt ccaaggctaa aaccctttca
     3481 tgggcttcac agtatttagt cctaattaaa tacccttctt tattccatga ccttatttta
     3541 taacttaaat ttttttgcaa ttgtataaat tagtaattca gtcccagtcc tggatctctg
     3601 tagtgttttg acataataaa ctgatattct ttaaatgtgg acctgtaagg agatactatg
     3661 gtgtggtgta ttgtgctttt agcctgtttt ccactattaa ttagcattta ccagtaaggg
     3721 tcattttgac tcaagttatt tatgtattaa tagcctgtga atattgcagt cctttttaga
     3781 ttatattggt ctaaatatgc attctgcagt gaacctgtta agctgttcac atgtatagac
     3841 tattgaaata ctgtacttgt acacatctga ctgttgacat tttgtacttt tttctagatc
     3901 caatatttca caataaaaaa cttgtcaaag gc
//
