LOCUS       NM_152660               3579 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 76 member A (FAM76A),
            transcript variant 3, mRNA.
ACCESSION   NM_152660
VERSION     NM_152660.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3579)
  AUTHORS   Salichs,E., Ledda,A., Mularoni,L., Alba,M.M. and de la Luna,S.
  TITLE     Genome-wide analysis of histidine repeats reveals their role in the
            localization of human proteins to the nuclear speckles compartment
  JOURNAL   PLoS Genet 5 (3), e1000397 (2009)
   PUBMED   19266028
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL020997.1 and BC025768.1.
            
            On Jun 2, 2019 this sequence version replaced NM_152660.2.
            
            Transcript Variant: This variant (3) lacks an in-frame coding exon
            in the 5' region, and encodes a shorter isoform (3), as compared to
            variant 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025768.1, SRR3476690.109590.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373954.11/ ENSP00000363065.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL020997.1         16196-16213
            19-1426             BC025768.1         1-1408
            1427-3579           AL020997.1         51199-53351
FEATURES             Location/Qualifiers
     source          1..3579
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..3579
                     /gene="FAM76A"
                     /note="family with sequence similarity 76 member A"
                     /db_xref="GeneID:199870"
                     /db_xref="HGNC:HGNC:28530"
     exon            1..201
                     /gene="FAM76A"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1044
                     /gene="FAM76A"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein FAM76A"
                     /codon_start=1
                     /product="protein FAM76A isoform 3"
                     /protein_id="NP_689873.1"
                     /db_xref="CCDS:CCDS309.1"
                     /db_xref="GeneID:199870"
                     /db_xref="HGNC:HGNC:28530"
                     /translation="MAALYACTKCHQRFPFEALSQGQQLCKECRIAHPVVKCTYCRTE
                     YQQESKTNTICKKCAQNVQLYGTPKPCQYCNIIAAFIGNKCQRCTNSEKKYGPPYSCE
                     QCKQQCAFDRKDDRKKVDGKLLCWLCTLSYKRVLQKTKEQRKHLSSSSRAGHQEKEQY
                     SRLSGGGHYNSQKTLSTSSIQNEIPKKKSKFESITTNGDSFSPDLALDSPGTDHFVII
                     AQLKEEVATLKKMLHQKDQMILEKEKKITELKADFQYQESQMRAKMNQMEKTHKEVTE
                     QLQAKNRELLKQAAALSKSKKSEKSGAITSP"
     exon            202..266
                     /gene="FAM76A"
                     /inference="alignment:Splign:2.1.0"
     exon            267..321
                     /gene="FAM76A"
                     /inference="alignment:Splign:2.1.0"
     exon            322..474
                     /gene="FAM76A"
                     /inference="alignment:Splign:2.1.0"
     exon            475..632
                     /gene="FAM76A"
                     /inference="alignment:Splign:2.1.0"
     exon            633..719
                     /gene="FAM76A"
                     /inference="alignment:Splign:2.1.0"
     exon            720..855
                     /gene="FAM76A"
                     /inference="alignment:Splign:2.1.0"
     exon            856..957
                     /gene="FAM76A"
                     /inference="alignment:Splign:2.1.0"
     exon            958..3579
                     /gene="FAM76A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2046..2051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM76A"
                     /note="hexamer: AATAAA"
     polyA_site      2067
                     /gene="FAM76A"
                     /note="major polyA site"
     regulatory      3557..3562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM76A"
                     /note="hexamer: AATAAA"
     polyA_site      3579
                     /gene="FAM76A"
                     /note="major polyA site"
ORIGIN      
        1 gcctgcgccc gcccgcctgc cgcagccagc agcctgcagc cgccgccggg ttgtgcctca
       61 gactgtcaga taaatcggcg ggccgggccg gcgggtcggt gagcgcggcc cgggccggac
      121 atggcggcgc tctacgcctg caccaagtgc caccagcgct tccccttcga ggcgctgtct
      181 caggggcagc agctgtgcaa ggaatgtcgg attgcacacc ctgttgtgaa gtgcacctac
      241 tgcaggactg agtaccagca ggagagtaaa accaatacaa tatgcaagaa atgtgctcag
      301 aacgtgcagt tgtatggaac gcccaaacct tgtcagtatt gcaacataat tgcagcattt
      361 attgggaata aatgccagcg ctgcacaaat tcagaaaaga agtatggacc accctattct
      421 tgtgaacagt gcaagcagca gtgtgcattt gacaggaaag atgatagaaa gaaggtagat
      481 gggaaattgc tgtgctggct gtgcacactt tcatacaaac gggtccttca gaagaccaaa
      541 gagcagagga aacacctgag tagctcttct cgtgctggcc accaggagaa ggagcagtat
      601 agtcgcctga gtggtggtgg ccattataac agccagaaaa cactttctac atcttcaatt
      661 caaaatgaaa tcccaaagaa aaagtccaag tttgagtcaa tcacaactaa tggagacagc
      721 ttctccccag acctggctct ggactcacca ggcactgacc actttgtcat cattgcccaa
      781 ctgaaggaag aagtggctac cctgaagaag atgttgcatc aaaaggatca aatgatttta
      841 gagaaagaga agaagattac agagttgaag gctgattttc agtaccagga atcgcagatg
      901 agagccaaaa tgaaccagat ggagaaaacc cacaaagaag tcacagaaca actgcaggcc
      961 aaaaaccgag agctcctgaa gcaggcagct gctttgtcca agagcaagaa gtcagagaag
     1021 tcaggagcta taacctctcc atgacagacc tcaaggaggc tccctagcaa cagcaaatgg
     1081 agttgtccag ggttagggtt ggagacctgg ctgttctgtg ggaattgcaa gctttcttaa
     1141 gaaatctcta ttttattaca gttatccttc tttgtgcgat tgcagtgggc tgaatggaaa
     1201 cacctggttt gtgctgtgtt agactgcatg cttgagtgtt tgggatttca agctcgctct
     1261 ctttctctca ctattaggac ttttcttttt cttcttcctc ttctctctat tttggttcta
     1321 ttcttttttt ttcttttttc tttttttttt tttttttttt tttgtggtgg tcactgctca
     1381 gtgtaatgtg cagaatgatt tgttttttgt tttttttttt ttttttggtc cttcattgca
     1441 tcctgccata cccatgagca aacagtttgg cattaattat atatcactgc caccctctga
     1501 actttgaaaa ctgccatctt cagacttggt ataatggaag aggctttctc tctccaataa
     1561 accttttgct tcagggtata ctcttcggtt tttttccaga tgtattatgt atgaactttg
     1621 tactatgtat agccagagtt ttatttattt tttaaaaaag aaactttttc ttgataaagg
     1681 aataatggtg gtctagctag ttcttgtaaa agtgatgcct cttgaaaaaa aaacagtcct
     1741 attcactagc ttttagtaaa agaatcagat cttttctttc ttgttacctt ggagtcttaa
     1801 aaactgattg ctaaggtgaa acaattcaat gcataagtat ggagctaagt gccttttgga
     1861 ggatttcttg gaagagcatt tatggagata cttaagggag gtagcaaaga tttgaaccgt
     1921 ctgtcttttt aagtaagggc agaaagcaag gttgtccagg ttgtactgga cacttctctc
     1981 cccacccctt tcctgattgt tttatgtgat tgattttaaa ttctcacact gccacttctt
     2041 taaaaaataa aatcctttat ttgcttatat cagttgtcat actgggctgc tgtcagagaa
     2101 tgttttttta catgaatgaa cagattaaaa atggaataat atggtcgggt gcggtggctc
     2161 acgcctgtaa taccagcaat ttgggaggcc aaggcgggtg gatcatttga ggttaggagt
     2221 ttgagaccat cctggccaac atggtaaaac cccatctgta ctaaaaaaat acaaaaatta
     2281 gccgggcctg gtggcatgca cctgtaatcc cagctaccca ggaggctgag gcaggagaac
     2341 tgctcgaatc ccgggaggca gaggttgcaa tgagctgaaa tcgcaacact gcactgcagc
     2401 ctgggcaatg gagtgagact ccgtctcaaa aaaaaaaaaa aaaggaataa tatttgaact
     2461 acagagcatt tttggggtca gcatgagctg ctctagtaag gactcttgag tctgggaaaa
     2521 gtggtatcac tataccttct ccccactcct cacccacccg agcccataca ctccctgctt
     2581 ttcatggata tgtattgaaa acaggtgctt ctcagaagca ctttgcctca accagagtta
     2641 tgtatgccct gcctatcttc ccttcttaac cctgtaggaa tatggattta cttttccagg
     2701 aaaggggata gatttacatt tctaggcata ctctcaggtc ctctatgtga tgtttgtgaa
     2761 aggaattagg gtgtgtcatg tgtgccatga aacaacaaaa ccaactaccc tagaatcatt
     2821 tatgcagggg gtactagagt tagaaataat aatgagggca gataacattt gtacctcagt
     2881 ctaccaaaaa attatagtac taaatttaac ttctaggcgt ttcctggaag cagatgctct
     2941 ataatttgtg atagcattct cataaatgga gtcctacaca taattggaca gagatgtgga
     3001 aatggtggtt tccttctgat aagggataca gtggaccatg tcgcttatat atcaccctac
     3061 taggggatat aattttccct tctaagcaag ggaaatggca gtgctaaata gttttgtaaa
     3121 gtttttgaat gagaagcttt taggtaaaga taaactgtca taatattttt cagatgcatt
     3181 tgcattgact atgggagaaa aattaggggg aaatgacagt catggtgttt ttttttaatt
     3241 ttaaggactg aaattctgtt acatgatgta tgacaatata aaaacatact tagttttata
     3301 ctaaatcttt ttttaaggtc ttggcattta atataaagca aattcacacg ttttctaact
     3361 ttccataagt tccaaaaagg gaaagaagaa acctcagtct tgaaattttg atttttaaaa
     3421 atcatgacac tgttttacca tgaaattgag tagctaactt ttggtaacac cttttgtttc
     3481 tttgtatgtt tgtaataatg gacattttaa aacacaggaa tgttttggtt tgtacagact
     3541 ttgacaaatg tgtgttaata aaaattcata ttgactcaa
//
