LOCUS       NM_001100910            2396 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 72 member B (FAM72B),
            transcript variant 1, mRNA.
ACCESSION   NM_001100910 XM_930579 XM_935476 XM_935477
VERSION     NM_001100910.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2396)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2396)
  AUTHORS   Kutzner,A., Pramanik,S., Kim,P.S. and Heese,K.
  TITLE     All-or-(N)One - an epistemological characterization of the human
            tumorigenic neuronal paralogous FAM72 gene loci
  JOURNAL   Genomics 106 (5), 278-285 (2015)
   PUBMED   26206078
  REMARK    GeneRIF: An epistemological characterization of the human
            tumorigenic neuronal paralogous FAM72 gene loci (FAM72A, FAM72B,
            FAM72C, FAM72D).
REFERENCE   3  (bases 1 to 2396)
  AUTHORS   Nehar,S., Mishra,M. and Heese,K.
  TITLE     Identification and characterisation of the novel amyloid-beta
            peptide-induced protein p17
  JOURNAL   FEBS Lett 583 (19), 3247-3253 (2009)
   PUBMED   19755123
  REMARK    GeneRIF: this study provides an additional possible mechanism of
            neurotoxicity in Alzheimer's disease, the induction of p17(FAM72B),
            through which Abeta acts to induce apoptosis and exhibit other
            Alzheimer's disease characteristics.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244453.2.
            
            On Apr 16, 2021 this sequence version replaced NM_001100910.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1099084.1,
                                           SRR7410570.28762.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369390.7/ ENSP00000358397.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1003              AC244453.2         26290-27292
            1004-1081           AC244453.2         29282-29359
            1082-1206           AC244453.2         33298-33422
            1207-2396           AC244453.2         41795-42984
FEATURES             Location/Qualifiers
     source          1..2396
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p11.2"
     gene            1..2396
                     /gene="FAM72B"
                     /gene_synonym="p17"
                     /note="family with sequence similarity 72 member B"
                     /db_xref="GeneID:653820"
                     /db_xref="HGNC:HGNC:24805"
                     /db_xref="MIM:614711"
     exon            1..1003
                     /gene="FAM72B"
                     /gene_synonym="p17"
                     /inference="alignment:Splign:2.1.0"
     CDS             852..1301
                     /gene="FAM72B"
                     /gene_synonym="p17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     amyloid-beta peptide-induced protein p17; protein FAM72B;
                     RP11-439A17.6"
                     /codon_start=1
                     /product="protein FAM72B isoform 1"
                     /protein_id="NP_001094380.1"
                     /db_xref="CCDS:CCDS72848.1"
                     /db_xref="GeneID:653820"
                     /db_xref="HGNC:HGNC:24805"
                     /db_xref="MIM:614711"
                     /translation="MSTNICSFKDRCVSILCCKFCKQVLSSRGMKAVLLADTEIDLFS
                     TDIPPTNAVDFTGRCYFTKICKCKLKDIACLKCGNIVGYHVIVPCSSCLPSCNNGHFW
                     MFHSQAVYDINRLDSTGVNILLWGNLPEIEESTDEDVLNISAEECIR"
     exon            1004..1081
                     /gene="FAM72B"
                     /gene_synonym="p17"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1206
                     /gene="FAM72B"
                     /gene_synonym="p17"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..2396
                     /gene="FAM72B"
                     /gene_synonym="p17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcaggaa aagcggaaga gggagcgaaa accaacgtgt tcggtgacag accccagcgc
       61 cgactgagcc tctaaagcga cttcagctct gccccaccaa caccaccgcg cgcccgggaa
      121 cagccgctcc gggaagaaac ctgaggggac tgcggggggc acgagggaca gctgagggaa
      181 gggaggacgc gagagaaaca gcgcaagcac gctgagggcc gggggttgcc aggagagggg
      241 cccgcggacc cgcagagcgg aggaaggtcc gggagaaaag gggcgggacg gaggagaatc
      301 cgggatcgcc tggcagaaaa agagaaggga gtttctgaat cctgggaaga ggaggcgtgg
      361 gtagggatgc ttagcccgag atccgacagc agggaaccgg agcgctccgg gggaggggct
      421 taatgctggg gaagggatgt cttaaaagag gagaagcttt aaattagacg atcggagaag
      481 gctgagggaa ttgctatgaa ggggcgggag ctgaagtgta gaggactcct ttagacagca
      541 gaaagggaaa gccgttgaga agttcccttc aaactccacc tgcctcctct ccaattcaaa
      601 ctccactccc ttctccaaaa gttaaaagga aagccaagtt tgccacgctc ccctgttcct
      661 actcaataaa tacttcttct actccgccac cgggaaaaca gaaaaaaaaa actaatttcc
      721 ttcccaatat taggacttag aaaagctcta ggtcccgcaa cttgaatttt agcctagggg
      781 aatcaaaata gtaggagcat tactcttgtt tcctttttca aaatcccaca cctcatcctt
      841 cctgcgacgc catgtctacc aacatttgta gtttcaagga caggtgcgtg tccatcctgt
      901 gttgcaaatt ctgtaaacaa gtgctcagct ctaggggaat gaaggctgtt ttgctggctg
      961 atactgaaat agaccttttc tctacagaca tccctcctac caacgcagtg gacttcactg
     1021 gaagatgcta tttcaccaaa atctgcaaat gtaaactgaa ggacatcgca tgtttaaaat
     1081 gtgggaacat tgtaggttat catgtgattg ttccatgtag ttcctgtctt ccttcctgca
     1141 acaacggaca cttctggatg tttcacagcc aggcagttta tgatattaac agactagact
     1201 ccacaggtgt aaacatccta ctttggggca acttgccaga gatagaagag agtacagatg
     1261 aagatgtgtt aaatatctca gcagaggagt gtattagata aatggaatta tgatatatat
     1321 gatatacaaa cttttttcta tttaaaaata tattaatgga tcaactttaa aattgttagt
     1381 tgccagtgat cttttttgga aaacaaaaat ggggcatttg ttgatttatt tattttccgt
     1441 ctctaattag ttacctcagt ttgattgaag ccagtggagt tgtgcttttc ctctacttct
     1501 acttcctctc ccccaccttt ttctgcccag tgtaggtgta ttcttaaatt cagacgggaa
     1561 gattctttca catatcactc agttacctcc caatctgggg gagtttttct tacaacttga
     1621 taccagatac cattaatttt acattcctga ataaaggcct agtacccacg catatttcaa
     1681 ccatgcatat atcaagttca actgagtttt aataggggat taaaaaaaca agctgttagg
     1741 tttccatggg cactggttct cataggttct attggtgata actgctttaa catggagcaa
     1801 gagtttgtga atcaggaaat agaataaatt aaaatttaaa atatatagag gaatcctctt
     1861 gattgctcag catgatgtta gataaatgag tttgtcagaa aatatcagta tacgctgttt
     1921 accaatgtta tttatttaca ttcttctaaa gccattatgg atattgtatt atgagagcta
     1981 aacctaaata agttatcctg ttccctagga ccttctctgt aaatagtgaa ttttagacga
     2041 gtagtctgtc ctaaatctta aatagaaaaa aaactaaagc gatttgctta agccattgta
     2101 cattataaag agctgttttg ttttgctttg ctttgctttg ttttgttttt ttaaagctgc
     2161 attcagagcc acaaaggaat aggaaagtag ggtagtgttg gattctggtt ttatgtaact
     2221 ctaaaataaa tgtatctctt taatatctca gttgtaggga ttttgtcaat accaaagcag
     2281 actgagttgt ggttttgtaa ataaagtttt ttctaaaaat gaccattctt cctttaattt
     2341 tttgttatgc ccacatattg tatgtaaaaa tataaataaa tagtacttaa agtata
//
