LOCUS       NM_001123168            2364 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 72 member A (FAM72A),
            transcript variant 1, mRNA.
ACCESSION   NM_001123168 XM_001133363 XM_001133364 XM_001133365
VERSION     NM_001123168.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2364)
  AUTHORS   Xu,Y., Hirachan,S., Shen,Y., Huang,Q., Bhandari,A. and Xia,E.
  TITLE     The pan-cancer analysis of the oncogenic role of FAM72A as a BRCA
            prognostic biomarker and immunotherapeutic target
  JOURNAL   Environ Toxicol 38 (5), 1100-1117 (2023)
   PUBMED   36757015
  REMARK    GeneRIF: The pan-cancer analysis of the oncogenic role of FAM72A as
            a BRCA prognostic biomarker and immunotherapeutic target.
REFERENCE   2  (bases 1 to 2364)
  AUTHORS   Fu,Y., Jia,X., Yuan,J., Yang,Y., Zhang,T., Yu,Q., Zhou,J. and
            Wang,T.
  TITLE     Fam72a functions as a cell-cycle-controlled gene during
            proliferation and antagonizes apoptosis through reprogramming PP2A
            substrates
  JOURNAL   Dev Cell 58 (5), 398-415 (2023)
   PUBMED   36868233
  REMARK    GeneRIF: Fam72a functions as a cell-cycle-controlled gene during
            proliferation and antagonizes apoptosis through reprogramming PP2A
            substrates.
REFERENCE   3  (bases 1 to 2364)
  AUTHORS   Bai,Y., Cao,K., Zhang,P., Ma,J. and Zhu,J.
  TITLE     Prognostic and Immunological Implications of FAM72A in Pan-Cancer
            and Functional Validations
  JOURNAL   Int J Mol Sci 24 (1), 375 (2022)
   PUBMED   36613817
  REMARK    GeneRIF: Prognostic and Immunological Implications of FAM72A in
            Pan-Cancer and Functional Validations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2364)
  AUTHORS   Feng,Y., Li,C., Stewart,J.A., Barbulescu,P., Seija Desivo,N.,
            Alvarez-Quilon,A., Pezo,R.C., Perera,M.L.W., Chan,K., Tong,A.H.Y.,
            Mohamad-Ramshan,R., Berru,M., Nakib,D., Li,G., Kardar,G.A.,
            Carlyle,J.R., Moffat,J., Durocher,D., Di Noia,J.M., Bhagwat,A.S.
            and Martin,A.
  TITLE     FAM72A antagonizes UNG2 to promote mutagenic repair during antibody
            maturation
  JOURNAL   Nature 600 (7888), 324-328 (2021)
   PUBMED   34819670
  REMARK    GeneRIF: FAM72A antagonizes UNG2 to promote mutagenic repair during
            antibody maturation.
REFERENCE   5  (bases 1 to 2364)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2364)
  AUTHORS   Heese,K.
  TITLE     The protein p17 signaling pathways in cancer
  JOURNAL   Tumour Biol 34 (6), 4081-4087 (2013)
   PUBMED   23900679
  REMARK    GeneRIF: Data indicate that p17 (p17 amyloid-beta peptide-induced
            protein; known as Ugene, LMPIP, or FAM72A/B) drives the cell cycle
            into the G0/G1 phase and enhances survival of proliferating cells.
REFERENCE   7  (bases 1 to 2364)
  AUTHORS   Wang,L.T., Lin,C.S., Chai,C.Y., Liu,K.Y., Chen,J.Y. and Hsu,S.H.
  TITLE     Functional interaction of Ugene and EBV infection mediates
            tumorigenic effects
  JOURNAL   Oncogene 30 (26), 2921-2932 (2011)
   PUBMED   21317926
  REMARK    GeneRIF: It was found that Ugene, designated herein as LMP1-induced
            protein (LMPIP), was induced, in a time-dependent manner, in
            EBV-infected peripheral blood mononuclear cells and
            LMP1-transfected 293 cells.
REFERENCE   8  (bases 1 to 2364)
  AUTHORS   Nehar,S., Mishra,M. and Heese,K.
  TITLE     Identification and characterisation of the novel amyloid-beta
            peptide-induced protein p17
  JOURNAL   FEBS Lett 583 (19), 3247-3253 (2009)
   PUBMED   19755123
  REMARK    GeneRIF: this study provides an additional possible mechanism of
            neurotoxicity in Alzheimer's disease, the induction of p17(FAM72B),
            through which Abeta acts to induce apoptosis and exhibit other
            Alzheimer's disease characteristics.
REFERENCE   9  (bases 1 to 2364)
  AUTHORS   Guo,C., Zhang,X., Fink,S.P., Platzer,P., Wilson,K., Willson,J.K.,
            Wang,Z. and Markowitz,S.D.
  TITLE     Ugene, a newly identified protein that is commonly overexpressed in
            cancer and binds uracil DNA glycosylase
  JOURNAL   Cancer Res 68 (15), 6118-6126 (2008)
   PUBMED   18676834
  REMARK    GeneRIF: Using deletion constructs, the authors find that Ugene
            binds to the first 25 amino acids of the UNG2 NH(2) terminus. They
            suggest that Ugene induction in cancer may contribute to the cancer
            phenotype by interacting with the BER pathway.
REFERENCE   10 (bases 1 to 2364)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244035.3.
            
            On Jul 13, 2020 this sequence version replaced NM_001123168.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035696.2, SRR14038192.4064257.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367128.8/ ENSP00000356096.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-966               AC244035.3         151223-152188       c
            967-1044            AC244035.3         149156-149233       c
            1045-1169           AC244035.3         145101-145225       c
            1170-2364           AC244035.3         135528-136722       c
FEATURES             Location/Qualifiers
     source          1..2364
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2364
                     /gene="FAM72A"
                     /gene_synonym="LMPIP; p17; Ugene"
                     /note="family with sequence similarity 72 member A"
                     /db_xref="GeneID:729533"
                     /db_xref="HGNC:HGNC:24044"
                     /db_xref="MIM:614710"
     exon            1..966
                     /gene="FAM72A"
                     /gene_synonym="LMPIP; p17; Ugene"
                     /inference="alignment:Splign:2.1.0"
     CDS             815..1264
                     /gene="FAM72A"
                     /gene_synonym="LMPIP; p17; Ugene"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Protein FAM72A; LMP1-induced protein; latent membrane
                     protein 1-induced protein"
                     /codon_start=1
                     /product="protein FAM72A isoform 1"
                     /protein_id="NP_001116640.1"
                     /db_xref="CCDS:CCDS73016.1"
                     /db_xref="GeneID:729533"
                     /db_xref="HGNC:HGNC:24044"
                     /db_xref="MIM:614710"
                     /translation="MSTNICSFKDRCVSILCCKFCKQVLSSRGMKAVLLADTEIDLFS
                     TDIPPTNAVDFTGRCYFTKICKCKLKDIACLKCGNIVGYHVIVPCSSCLLSCNNGHFW
                     MFHSQAVYDINRLDSTGVNVLLWGNLPEIEESTDEDVLNISAEECIR"
     exon            967..1044
                     /gene="FAM72A"
                     /gene_synonym="LMPIP; p17; Ugene"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1169
                     /gene="FAM72A"
                     /gene_synonym="LMPIP; p17; Ugene"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..2364
                     /gene="FAM72A"
                     /gene_synonym="LMPIP; p17; Ugene"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgttcggtg acagacccca gcgccgactg agcctctaaa gcgacttcag ctctgcccca
       61 ccaacaccac cgcgcgcccg ggaacagccg ctccgggaag aaacctgagg ggactgcggg
      121 gggcacgagg gacagctgag ggaagggagg acgcgagaga aacagcgcga gcacgctgag
      181 ggccgggggt tgccaggaga ggggcccgcg gacccgcaga gcggaggaag gtccgggaga
      241 aaaggggcgg gacggaggag aatccgggat cgcctggcag aaaaagagaa gggagtttct
      301 gaatcctggg aagaggaggc gtgggtaggg acgcttagcc cgagatccga cagcagggaa
      361 ccggagcgct ccgggggagg ggcttaatgc tggggaaggg atgtcttaaa agaggagaag
      421 ctttaaatta gacgatcgga gaaggctgag ggaattgcta tgaaggggcg ggagctgaag
      481 tgtagaggac tcctttagac agcagaaagg gaaagccgtt gagaagttcc cttcaaactc
      541 cacctgcctc ctctccaatt caaactccac tcccttctcc aaaagttaaa aggaaagcca
      601 agtttgccac gctcccctgt tcctactcaa taaatacttc ttctactccg ccaccgggaa
      661 aacagaaaaa aaaactaatt tccttcccaa tattaggact tagaaaagct ctaggtcccg
      721 caatttgaat tttagcctag gggaatcaaa atagtaggag cattactctt gtttcctttt
      781 tcaaaatccc acacctcatc cttcctgcga cgccatgtct accaacattt gtagtttcaa
      841 ggacaggtgc gtgtccatcc tgtgttgcaa attctgtaaa caagtgctca gctctagggg
      901 aatgaaggct gttttgctgg ctgatactga aatagacctt ttctctacag acatccctcc
      961 taccaacgca gtggacttca ctggaagatg ctatttcacc aaaatctgca aatgtaaact
     1021 gaaggacatc gcatgtttaa aatgtgggaa cattgtaggt tatcatgtga ttgttccatg
     1081 tagttcctgt cttctttcct gcaacaacgg acacttctgg atgtttcaca gccaggcagt
     1141 ttatgatatt aacagactag actccacagg tgtaaacgtc ctactttggg gcaacttgcc
     1201 agagatagaa gagagtacag atgaagatgt gttaaatatc tcagcagagg agtgtattag
     1261 ataaatggaa ttatgatata tatgatatac aaactttttt ctatttaaaa atatattaat
     1321 ggatcaactt taaaattgtt agttgccagt gatctttttt ggaaaacaaa aatggggcat
     1381 ttgttgattt atttattttc cgtctctaat tagttacctc agtttgattg aagccagtga
     1441 agttgtgctt ttcctctact tctacttcct ctccccgacc tttttctgcc cagtgtaggt
     1501 gtattcttaa attcagacag gggaagattc tttcacatat cactcagtta cctcccaatc
     1561 tgggggagtt tttcttacaa cttgatacca gataccatta attttacatt cctgaataaa
     1621 ggcctagtac ccacgcatat ttcaaccatg catatatcaa gttcaaccga gttttaatag
     1681 gggattaaaa aaacaagctg ttaggtttcc atgggcactg gttctcatag gttctattgg
     1741 tgataactgc tttaacatgg agcaagagtt tgtgaatcag gaaatagaat aaattaaaat
     1801 ttaaaatata tagaggaatc ctcttgattg ctcagcatga tgttagataa atgagtttgt
     1861 cagaaaatat cagtatacgc tgtttaccaa tgttatttat ttacattctt ctaaagccat
     1921 tatggatatt gtattatgag agctaaacct aaataagtta tcctgttccc taggaccttc
     1981 tctgtaaata gtgaatttta gacgagtagt ctgtcctaaa tcttaaatag aaaaaaaact
     2041 aaagcgattt gcttaagcca ttgtacatta taaagagctg ttttgttttg ctttgctttg
     2101 ctttgttttg tttttttaaa gctgcattca gagccacaaa ggaataggaa agtagggtag
     2161 tgttggattc tggttttatg taactctaaa ataaatgtat ctctttaata tctcagttgt
     2221 agggattttg tcaataccaa agcagactga gttgtggttt tgtaaataaa gttttttcta
     2281 aaaatgacca ttcttccttt aattttttgt tatgcccaca tattgtatgt aaaaatataa
     2341 ataaatagta cttaaagtat agaa
//
