LOCUS       NM_016605               4143 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens family with sequence similarity 53 member C (FAM53C),
            transcript variant 2, mRNA.
ACCESSION   NM_016605
VERSION     NM_016605.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4143)
  AUTHORS   Miyata,Y. and Nishida,E.
  TITLE     Identification of FAM53C as a cytosolic-anchoring inhibitory
            binding protein of the kinase DYRK1A
  JOURNAL   Life Sci Alliance 6 (12), e202302129 (2023)
   PUBMED   37802655
  REMARK    GeneRIF: Identification of FAM53C as a cytosolic-anchoring
            inhibitory binding protein of the kinase DYRK1A.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4143)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 4143)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4143)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4143)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 4143)
  AUTHORS   Varjosalo,M., Keskitalo,S., Van Drogen,A., Nurkkala,H.,
            Vichalkovski,A., Aebersold,R. and Gstaiger,M.
  TITLE     The protein interaction landscape of the human CMGC kinase group
  JOURNAL   Cell Rep 3 (4), 1306-1320 (2013)
   PUBMED   23602568
REFERENCE   7  (bases 1 to 4143)
  AUTHORS   Bandyopadhyay,S., Chiang,C.Y., Srivastava,J., Gersten,M., White,S.,
            Bell,R., Kurschner,C., Martin,C., Smoot,M., Sahasrabudhe,S.,
            Barber,D.L., Chanda,S.K. and Ideker,T.
  TITLE     A human MAP kinase interactome
  JOURNAL   Nat Methods 7 (10), 801-805 (2010)
   PUBMED   20936779
REFERENCE   8  (bases 1 to 4143)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 4143)
  AUTHORS   Lai,F., Godley,L.A., Joslin,J., Fernald,A.A., Liu,J., Espinosa,R.
            3rd, Zhao,N., Pamintuan,L., Till,B.G., Larson,R.A., Qian,Z. and Le
            Beau,M.M.
  TITLE     Transcript map and comparative analysis of the 1.5-Mb commonly
            deleted segment of human 5q31 in malignant myeloid diseases with a
            del(5q)
  JOURNAL   Genomics 71 (2), 235-245 (2001)
   PUBMED   11161817
REFERENCE   10 (bases 1 to 4143)
  AUTHORS   Lai,F., Godley,L.A., Fernald,A.A., Orelli,B.J., Pamintuan,L.,
            Zhao,N. and Le Beau,M.M.
  TITLE     cDNA cloning and genomic structure of three genes localized to
            human chromosome band 5q31 encoding potential nuclear proteins
  JOURNAL   Genomics 70 (1), 123-130 (2000)
   PUBMED   11087669
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315567.1 and AC104116.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016605.2.
            
            Summary: The protein encoded by this gene belongs to the FAM53
            protein family. FAM53 protein family members bind to a
            transcriptional regulator that modulates cell proliferation.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2017].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF251040.1, SRR1660803.136210.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239906.10/ ENSP00000239906.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1373              AK315567.1         1-1373
            1374-4143           AC104116.3         75291-78060
FEATURES             Location/Qualifiers
     source          1..4143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..4143
                     /gene="FAM53C"
                     /gene_synonym="C5orf6"
                     /note="family with sequence similarity 53 member C"
                     /db_xref="GeneID:51307"
                     /db_xref="HGNC:HGNC:1336"
                     /db_xref="MIM:609372"
     exon            1..42
                     /gene="FAM53C"
                     /gene_synonym="C5orf6"
                     /inference="alignment:Splign:2.1.0"
     exon            43..272
                     /gene="FAM53C"
                     /gene_synonym="C5orf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1373
                     /gene="FAM53C"
                     /gene_synonym="C5orf6"
                     /note="isoform 1 is encoded by transcript variant 2;
                     putative nuclear protein; protein FAM53C"
                     /codon_start=1
                     /product="protein FAM53C isoform 1"
                     /protein_id="NP_057689.1"
                     /db_xref="CCDS:CCDS4204.1"
                     /db_xref="GeneID:51307"
                     /db_xref="HGNC:HGNC:1336"
                     /db_xref="MIM:609372"
                     /translation="MITLITEQLQKQTLDELKCTRFSISLPLPDHADISNCGNSFQLV
                     SEGASWRGLPHCSCAEFQDSLNFSYHPSGLSLHLRPPSRGNSPKEQPFSQVLRPEPPD
                     PEKLPVPPAPPSKRHCRSLSVPVDLSRWQPVWRPAPSKLWTPIKHRGSGGGGGPQVPH
                     QSPPKRVSSLRFLQAPSASSQCAPAHRPYSPPFFSLALAQDSSRPCAASPQSGSWESD
                     AESLSPCPPQRRFSLSPSLGPQASRFLPSARSSPASSPELPWRPRGLRNLPRSRSQPC
                     DLDARKTGVKRRHEEDPRRLRPSLDFDKMNQKPYSGGLCLQETAREGSSISPPWFMAC
                     SPPPLSASCSPTGGSSQVLSESEEEEEGAVRWGRQALSKRTLCQRDFGDLDLNLIEEN
                     "
     exon            273..330
                     /gene="FAM53C"
                     /gene_synonym="C5orf6"
                     /inference="alignment:Splign:2.1.0"
     exon            331..1115
                     /gene="FAM53C"
                     /gene_synonym="C5orf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..4143
                     /gene="FAM53C"
                     /gene_synonym="C5orf6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4122..4127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM53C"
                     /gene_synonym="C5orf6"
                     /note="hexamer: AATAAT"
     polyA_site      4143
                     /gene="FAM53C"
                     /gene_synonym="C5orf6"
                     /note="major polyA site"
ORIGIN      
        1 agagctgctc cggccgcggc cctgggagct ggaggaaccg cgactcagca ggcatgactg
       61 gagagggaag tcccaatggt gctagaatgg tgctgcagtg gcagaagacg gctcacaagt
      121 gaggtctgga agaacaacag ggaagacatc catcatttgc tccaaagtgt gcaagtcaaa
      181 tcctggggag aatcatgata accctgatca ctgagcagct acagaagcag actctggatg
      241 agctgaaatg cacacgcttc agcatcagtc tgcctttgcc tgatcatgca gacatctcca
      301 actgtgggaa ctctttccag cttgtgtctg aaggtgcttc ctggaggggc ctgccccact
      361 gttcctgtgc tgagttccag gacagcctca acttcagcta ccatccctca ggcctgagcc
      421 tgcacctcag accacccagt cggggaaact cccccaagga gcagcccttc tcccaagtcc
      481 taagacctga gcccccagat ccagagaagc ttcctgtgcc ccctgcccct ccatccaaga
      541 ggcactgccg ctcactctca gtgcccgtgg acctgtctcg ctggcagccg gtgtggcggc
      601 ccgccccctc caagctgtgg actcccataa agcaccgggg cagtggtgga gggggtgggc
      661 cgcaggtgcc tcaccagagc cccccaaagc gggtctccag cctcaggttc ctccaagctc
      721 ccagtgcctc ttctcaatgt gccccagctc acagacccta cagccctcct ttcttcagcc
      781 tggccctggc ccaagattcc tctcgaccct gcgccgcctc ccctcaaagt ggctcctggg
      841 agagtgatgc tgagtccttg tcaccttgcc cacctcagcg ccgcttctcc ctgtcaccca
      901 gtctgggccc gcaggcaagc cgcttcttgc cctctgcccg gagctctccc gcatcctccc
      961 cagagctgcc ctggcgacct cgaggtctcc gcaaccttcc ccgaagccgc tcacagcctt
     1021 gtgatctgga tgcccgcaaa actggggtca agcggcgcca cgaggaagac ccccggcgtc
     1081 tgcggccttc gttggacttt gacaagatga atcagaaacc atactcagga ggtctttgtc
     1141 tccaagaaac agcccgggaa ggcagcagca tctctccacc atggttcatg gcctgtagcc
     1201 ccccacccct ctctgcttcc tgcagcccca ctgggggttc ctcccaggtg ctgagtgaaa
     1261 gcgaagagga ggaggagggg gctgtgcggt ggggtcggca ggcgctgagc aagcggacac
     1321 tgtgccagcg ggactttggg gacctggact tgaatttgat tgaggaaaac taaaactgag
     1381 aggctacttc ctggggccac acagactgac tctctcatgg ctactaacaa gtgtcgagtc
     1441 cccaaggctg ggggccgagc ctgggaatgg gggtgagtgg agggctccga ctcagggcag
     1501 ctggaaatct tctcgctcca gcaagctcga ccatgccaag agactggccg ggacaagata
     1561 aacggagctg gtggcgggag ggacagcccc agagcagacc cttcctatgg cggccctgag
     1621 tgtgagtatc cctgccacca agagagcaat gggcagggaa ggaaggggtc tgccgacccc
     1681 agctcgggga atttcactag cccctttgct tcaaagggca cttgtgtctt agaatttggc
     1741 cagggtgggg ggttgagtca gcctcctcag agaaactgcg tgagagtgtg tgcgtgcatg
     1801 ggagtgtact tgtggaaagg tgtgtttgcg tagccttagg gaaggaaggc aattgctcct
     1861 taacagcaga gtatcatgat acccccagga tcttgagttt tttacaggat gttgggtttg
     1921 ctcaaggagt caagaggagg gcaccaagtt ttcctttttt ctaaatagct ctggaaccag
     1981 gcttgtaatc catagcatca ccgactctgc aaaggatttc attttggggt acagcagggt
     2041 gttttaagtg ctgtgacttc agctaatgat cttttcttca gccccacccc ctccccacta
     2101 gctcgatcta gtatattggg gaatgcaggt ggggggtgtc accatatttt ttctgagctg
     2161 gccttttttt ctcatcagat tgtccaggct atattccacc tgcctctttt gccctcttga
     2221 gtagagttgc acacagcaca tgggcaactg aagcagggtt gaggggctct ctctctctct
     2281 cctctgctga tgggaccctt ttcccctcac cctctgccct tctaagtcat agactaggta
     2341 ggaaggccct atattggtcc ccagcatcta ctgaggcaga cctgcaacag aagtggcatt
     2401 cagtccccag cagacatggg tgagctcacc ccagcactgc tgttgggaag gtgactgcag
     2461 gaaaccaatt cttacaagat ccaggcccag cctttttgac ctgcttgaga gggaagaagg
     2521 ggtgtttagc atttaatagt ttgcttgtct tccactcctg ccaggaagtg tttatttgcc
     2581 tctaattggg cctgagagac catagggagg ttggggctca ctgagggatt ggctgaggat
     2641 gtataaagca aaggctgtga gaagcagttg ggagtttggt tgtcattgga ttgaatttac
     2701 ttttttgttt ctcacccgca acttgagcca ggacagctgg tccaagtggc cacagtgatg
     2761 ggtttaagta ccttggtagg gctggcacca gtggaaacac atactgaagc tgccaccaca
     2821 atagcttgtg aggttttatc cagctgtggt tagaccctgc atgaccaaat ttgacctgcc
     2881 cttgtttatg gcaagaaggg catttttctc ttcaatttcc agggtttcct aggacccagt
     2941 tcctcatgta agggaggaag accaaggtct ttgtgttttc ttcctcatgg aattgaacct
     3001 gacattttct ggatctcctg catgtcagga gcatcagtga ggcttcagcc tcctcgtctc
     3061 cactccagag aggaggtggc tatgtcttct taagcctctg gccctcagag gctcctccct
     3121 atctcctggc tagttaccac taggctacca ggtctctagg ggcctgagag aggccctcta
     3181 gagaatccag ggaaactgtg agcccaggag ttgcccatct atggtttcat tcctcccctg
     3241 gctcttctcc ctcttcaggc cataatttcc ctggtgccaa tttcttttcc tcctggggca
     3301 tcctcatccc agggctctct gctgtagatt ggctgtgcca gcttccaaca ggttactggc
     3361 aatgccagtg agtttctgta ggccctaagc tgaagaagtg aggcagtgat tctgcctcca
     3421 tcctggtttc cccaaagccc cagggcacca tccttagggg agaaggtcta cagttatcat
     3481 tattttaatt ccattacttt cagtctggaa aactaagcta gtcagaactg tcatcttgct
     3541 tcccaatcta agaacctgtg gccctggaac acttttcaag aattggttca ttttgcttta
     3601 cacagtagat ctgttccaac agttctgtgt aaaccaaatg ctatttttca atgcatttgg
     3661 actgctgacc atttaaaagc agcctatgat tgcttctttt tgtaaagcaa gcaacctccc
     3721 tccactttag ctgttttgac tatttgaatt ttcacatatt gggcttaccc agagtggagc
     3781 acacctccag ggcatgtggc tgacactggg tcaatgtctg catctgtgct gtgtgtgtag
     3841 tgtggttggc cagtaggtga gtatccctgt gtgtgtgagt gaagccactc cccaggctgg
     3901 tgctctcctc ctgtgcccag tgactgccca gtggcagctc agctgccctt cactcccacc
     3961 tgctgccaaa gtccctgtgc taatgggatt acaaatacaa aaagtggaaa aaaattttcg
     4021 taaactttgt tttatattaa aagaaaaatc cataagtctg tgtgtgttaa acatgaggtt
     4081 ctgcctctgt ggctgtgttt gaaaaaataa agttttatta gaataatcca ttttcccaag
     4141 caa
//
