LOCUS       NM_014661               5759 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 53 member B (FAM53B),
            mRNA.
ACCESSION   NM_014661 XM_374838
VERSION     NM_014661.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5759)
  AUTHORS   Zhang,C., Gu,H., Liu,D., Tong,F., Wei,H., Zhou,D., Fang,J., Dai,X.
            and Tian,H.
  TITLE     The circ_FAM53B-miR-183-5p-CCDC6 axis modulates the malignant
            behaviors of papillary thyroid carcinoma cells
  JOURNAL   Mol Cell Biochem 477 (11), 2627-2641 (2022)
   PUBMED   35598218
  REMARK    GeneRIF: The circ_FAM53B-miR-183-5p-CCDC6 axis modulates the
            malignant behaviors of papillary thyroid carcinoma cells.
REFERENCE   2  (bases 1 to 5759)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5759)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5759)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5759)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 5759)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (bases 1 to 5759)
  AUTHORS   Geisert,E.E., Lu,L., Freeman-Anderson,N.E., Templeton,J.P.,
            Nassr,M., Wang,X., Gu,W., Jiao,Y. and Williams,R.W.
  TITLE     Gene expression in the mouse eye: an online resource for genetics
            using 103 strains of mice
  JOURNAL   Mol Vis 15, 1730-1763 (2009)
   PUBMED   19727342
  REMARK    GeneRIF: Strong candidate gene for age-related macular
            degeneration, ARMS2, (human 10q26.13). Conclusion is based on a
            massive expression data set for mouse (103 strains) and joint
            analysis of RetNet database.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5759)
  AUTHORS   Thermes,V., Candal,E., Alunni,A., Serin,G., Bourrat,F. and
            Joly,J.S.
  TITLE     Medaka simplet (FAM53B) belongs to a family of novel vertebrate
            genes controlling cell proliferation
  JOURNAL   Development 133 (10), 1881-1890 (2006)
   PUBMED   16611694
REFERENCE   9  (bases 1 to 5759)
  AUTHORS   Benzinger,A., Muster,N., Koch,H.B., Yates,J.R. 3rd and Hermeking,H.
  TITLE     Targeted proteomic analysis of 14-3-3 sigma, a p53 effector
            commonly silenced in cancer
  JOURNAL   Mol Cell Proteomics 4 (6), 785-795 (2005)
   PUBMED   15778465
REFERENCE   10 (bases 1 to 5759)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068896.9, BX344666.2, AW504054.1, CA397342.1, D50930.1,
            AK127343.1 and AL513190.13.
            
            On Nov 23, 2018 this sequence version replaced NM_014661.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D50930.1, SRR7346977.2746066.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337318.8/ ENSP00000338532.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC068896.9         51362-51378         c
            18-79               BX344666.2         1-62
            80-188              AW504054.1         58-166
            189-328             CA397342.1         85-224
            329-1642            D50930.1           1-1314
            1643-3115           AK127343.1         1820-3292
            3116-5757           D50930.1           2788-5429
            5758-5759           AL513190.13        53982-53983         c
FEATURES             Location/Qualifiers
     source          1..5759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..5759
                     /gene="FAM53B"
                     /gene_synonym="bA12J10.2; KIAA0140; smp"
                     /note="family with sequence similarity 53 member B"
                     /db_xref="GeneID:9679"
                     /db_xref="HGNC:HGNC:28968"
                     /db_xref="MIM:617289"
     exon            1..366
                     /gene="FAM53B"
                     /gene_synonym="bA12J10.2; KIAA0140; smp"
                     /inference="alignment:Splign:2.1.0"
     exon            367..618
                     /gene="FAM53B"
                     /gene_synonym="bA12J10.2; KIAA0140; smp"
                     /inference="alignment:Splign:2.1.0"
     CDS             541..1809
                     /gene="FAM53B"
                     /gene_synonym="bA12J10.2; KIAA0140; smp"
                     /note="simplet homolog; protein simplet"
                     /codon_start=1
                     /product="protein FAM53B"
                     /protein_id="NP_055476.3"
                     /db_xref="CCDS:CCDS7641.1"
                     /db_xref="GeneID:9679"
                     /db_xref="HGNC:HGNC:28968"
                     /db_xref="MIM:617289"
                     /translation="MVMVLSESLSTRGADSIACGTFSRELHTPKKMSQGPTLFSCGIM
                     ENDRWRDLDRKCPLQIDQPSTSIWECLPEKDSSLWHREAVTACAVTSLIKDLSISDHN
                     GNPSAPPSKRQCRSLSFSDEMSSCRTSWRPLGSKVWTPVEKRRCYSGGSVQRYSNGFS
                     TMQRSSSFSLPSRANVLSSPCDQAGLHHRFGGQPCQGVPGSAPCGQAGDTWSPDLHPV
                     GGGRLDLQRSLSCSHEQFSFVEYCPPSANSTPASTPELARRSSGLSRSRSQPCVLNDK
                     KVGVKRRRPEEVQEQRPSLDLAKMAQNCQTFSSLSCLSAGTEDCGPQSPFARHVSNTR
                     AWTALLSASGPGGRTPAGTPVPEPLPPSFDDHLACQEDLSCEESDSCALDEDCGRRAE
                     PAAAWRDRGAPGNSLCSLDGELDIEQIEKN"
     exon            619..673
                     /gene="FAM53B"
                     /gene_synonym="bA12J10.2; KIAA0140; smp"
                     /inference="alignment:Splign:2.1.0"
     exon            674..1446
                     /gene="FAM53B"
                     /gene_synonym="bA12J10.2; KIAA0140; smp"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..5759
                     /gene="FAM53B"
                     /gene_synonym="bA12J10.2; KIAA0140; smp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5733..5738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM53B"
                     /gene_synonym="bA12J10.2; KIAA0140; smp"
                     /note="hexamer: AATAAA"
     polyA_site      5759
                     /gene="FAM53B"
                     /gene_synonym="bA12J10.2; KIAA0140; smp"
                     /note="major polyA site"
ORIGIN      
        1 actgcacact cgcctgccgc cgccgccgca cgccgcctgc ctcctgcacg ccgccgccgc
       61 gcctagcgcc cgggcccgcg acaccgcccg ctaagcgccg ggccgagttc acgcagccgc
      121 ggtctggcgg ctccgcggcg gcggcgggtg cgggcggcct ggccggtgcc ggttaaaggg
      181 acgagttgca aacacttcag gaagtgacaa gtcgatttcc tcctccccgg gagtcgctcg
      241 tacaaagcgc tcggcgccgg caggcgagcg tgcgcgcggc ggacgcgcgg cgggcacccc
      301 ggacgacttg gcgagcgctg gcggtgacgg cgcggggtcc gcgcccggag cgccccgccg
      361 cgcacaggag ttgaccacat ttggccattt cccagaaggg ccccacccca agggtgagtg
      421 gccaatgggg agctgtttct gctgacatca attccccagg aggtactcac cccaagtctg
      481 cccaagtgaa gatggctgat acccaccctg ggatggagcc cagcgcctga ggcccttatc
      541 atggtgatgg tcctaagtga aagcctcagc acccggggag ctgactccat tgcatgtggg
      601 accttcagcc gtgaactgca cacgccaaag aagatgagtc aaggacctac acttttctct
      661 tgtggaatta tggaaaatga cagatggcga gacctggaca ggaaatgccc tcttcagatt
      721 gaccaaccga gcaccagcat ctgggaatgc ctgcctgaaa aggacagctc actatggcac
      781 cgggaggcag tgaccgcctg cgctgtgacc agtctgatca aagacctcag catcagcgac
      841 cacaacggga acccctcagc accccctagc aagcgccagt gccgctcact gtccttctcc
      901 gatgagatgt ccagttgccg gacatcatgg aggcccttgg gctccaaagt ctggactccc
      961 gtggaaaaga gacgctgcta cagcgggggc agcgtccagc gctattccaa cggcttcagc
     1021 accatgcaga ggagttccag cttcagcctc ccttcccggg ccaacgtgct ctcctcaccc
     1081 tgcgaccagg caggactcca ccaccgattt ggagggcagc cctgccaagg ggtgccaggc
     1141 tcagccccgt gtggacaggc aggtgacacc tggagccctg acctgcaccc cgtgggagga
     1201 ggccggctgg acctgcagcg gtccctctct tgctcacatg agcagttttc ctttgtggaa
     1261 tactgtcctc cctcagccaa cagcacacct gcctcaacac cagagctggc gagacgctcc
     1321 agcggccttt cccgcagccg ctcccagccg tgtgtcctta acgacaagaa ggtcggtgtt
     1381 aaaaggcggc gccctgaaga agtgcaagag cagaggcctt ctctagacct tgccaagatg
     1441 gcacagaact gtcagacctt cagcagcctc agctgcctga gcgcagggac agaggactgc
     1501 ggtccccaga gccccttcgc ccgccacgtc agcaacacca gggcctggac cgccctgctc
     1561 tcagcctccg gcccaggggg caggaccccc gctgggaccc cggtccctga gcctcttccc
     1621 ccttccttcg acgaccacct cgcctgccag gaggacctgt cctgtgagga gtcagacagc
     1681 tgcgccctgg acgaggattg tggcaggaga gcggagccgg ctgcagcctg gcgggaccgc
     1741 ggggcccctg ggaacagcct ctgctccctg gacggcgagt tggacattga gcagatagag
     1801 aagaactgag ggggtgtggg cccaggcagg gctggggtgt gctggcatcg acagccccca
     1861 ctctgggcac taggtgggcc cttgaagggg agcccaactc gtgggcctga tgaaagcttc
     1921 ctgagtggtg tcgggtccca gagagggagc ccacctgctg cctgggggag agcctggcct
     1981 ggccgcgtca tacagcgggt gtgtcagcct ctcaccggct ccccgagcgt ggcagccacc
     2041 aggtccacag aactactgca gcccagagga cagctttgaa gtttgcgtct tttctgcctc
     2101 tttccctgtg ggatgttggg cagtctctgt tgtccccggc agagctgggc accgctctgt
     2161 atccccctgg tggtgggggc tgtcagggag ggcctggggt gggggccagg ggccatctgc
     2221 tatgtcaggg cccttcttgg cctcactcag gttcacttct ggggagtcgg ccccgcagct
     2281 tctttcactc agttttactc cgtgccttct ctcccaggtc tccctgcttc aggcttggga
     2341 aggttcggga gatgcttcct tctgtaacac cagaaccatt tggccttaat tccaatgtga
     2401 gagacagaat ccctggggtg ctggactggc cctccagagg gtaagccatg tccggagtct
     2461 cgggcccaag gaacgatttg gagggtgctt gttagggcct cccgtgttgg gtagaaattt
     2521 ggtggatctg ttggctgaaa agacggactt gcttgcctct cctacagcat ggagaggctg
     2581 accccatggc tctgccaccg ttggggcagg gttagcagat ggcagccctt ctctgtggct
     2641 gacaggtcac tgagtgataa gcatggttgg ttccggtgag tgtagggatg gcacgatacc
     2701 agggcagcct cttgaaaacg gcctcgggag acgggagctg cgagcaggtg ggcagatgag
     2761 ggccctatgc gcactcaggg gtgaagggcg tccgctggcc actctgcagg ggcccctgca
     2821 ggattccagg cacctcccgt ttgtccttga ggactgctgg ctgtaaccag ggcacatcac
     2881 ccacctcaag acaagcccac gcccttgtca gcttaggggg agcccagtcc tgagggctgc
     2941 atctctgttg taggcccagc caccggcaca aagctggatt catgctccct gcccctaccc
     3001 caccctggct cctcaccctg gggcatccga ggagcctagc cccctgaggg tttgctctcc
     3061 tctcaaggtt tgtagctcct ctccggctgc cttgcagaca ccaccacatg ggctctgctc
     3121 tatgggaatc tggcttttag cgaatgtggc gtcttctgca aacaatagca attgggctgg
     3181 cttaggagca agtggctcat tttcccataa ggctaaaaat aactggtgcg ctcccttgtg
     3241 ttggctgaca cgcgcgttca aagcactttt gtagtcactt tgcttttgct cgtcttcatg
     3301 gacgagtgaa cgcctcgctt ctgcaggttg agtccagatg cttctcacct tctttctcct
     3361 caagaaagat gctttttggg aaacgttgtt taaatcttat ttttttacta catcaaaagg
     3421 atggtggttc aagttcccaa tatgtgggtg gcacttctta aaaatcagct ttaaggagct
     3481 ggcagaaagc ccccagcccc acagccctga gagatggtgt tgctagctca ggtggctgac
     3541 acatggggta tgccgggcac tgggcaggtc ccagagccgg ggaaccagct cacctctggt
     3601 tgctgtagct cctgccggag gcatgtctac ttgtgatccc ggacagccga acccaagagc
     3661 tggtggctct gagcagacag agacatcttg gcctgtccct gcctgggggt catggagacc
     3721 atgtcttctt agagcaaatg tggaggcggc cagggcagtt gttgggtgaa tgtggagagc
     3781 acatggccat gtcttgcccc cggagtacca ctgggcgtgg ggggtcctgg caccacatgc
     3841 ccggtgtggc cgagggcaca cagcctctat agcaggcctt cctgtggaag gcagaggcag
     3901 tgagggaggt ggacggtgcc agctgaggct gaggcatgca gcagccccca gctacctttg
     3961 cttagggctg gggtgggagg cacatggtga caggtatatg tcgtgggact ggggtgtggg
     4021 tgacctgccc tcaaaccttg cctgccacct ccccattcag gcctggtggc aggaagggac
     4081 aagctgtgga gctggctgag tcacagccac ctccccacct ccccgcaagc tggtcccatc
     4141 gaccagcaag cccagcccca gggcgcttag ggagaaatga cccagcctcc tcagaccccg
     4201 cctgcctgtc ctgtgcccac cacgcagcag tcaggggaga aaatggtggc tatcccttct
     4261 gcttagagaa agaaatggcc tttagctggt ttcatgtttg tgttttgact ggagggagta
     4321 gaccctatct ataaggtgcc accccatcat ccaagctgcc acactgcccg gagcagcctg
     4381 ttcctgcact ccaccctgct ggccccagga cttctgatct cagtcctctg ggagggaggt
     4441 tcgcctagga ggtgcccccc acattggtgt ccccatgggc agcaggcaga cagctcaccc
     4501 ccaccagcat gatggcccca gctgggggca gtggcaggag ccttactttt gtcacagcct
     4561 tgcccacaaa ccctgcctct gaggggagac tgaggaaggg cagagccaga agcaagccgt
     4621 gccaggccat ctgcctgctc atggggtcct aaagcgcggg ctaagcctgc aggaaagccg
     4681 gggcggtggg gggggcttag tgccacatgc accccactca ttccaaagcc accaaactgc
     4741 caggggctgc cgtccacccg tggggcccag gggctggggc cacagccttg ccattttcgt
     4801 tgccataccc tcttgcctta ctcgcggtgg aggccggatt tgcacgggca gacgtgcacc
     4861 tgggcccgtg gggagcttgt tctgaccaga cgtacagatt ttcattctca gaaagcctta
     4921 cttttcaacc aaatttttgt agccagtttt gtgaatttgt acactgaaag aaaatttaaa
     4981 taaaggggaa gtccacatta aaaagaaaac aaaacaaacc ctaactaact tccaaatggg
     5041 tctcctggtg cgggggcgtg agtggccgtg ccctgggtgt gctgcctgtc tgagcaagct
     5101 tccctagctg tggaaccccg ggccccctgc tgcgggctct gccttggtgt catgcctgct
     5161 gcacccccgt ttccactgac gtgccgtctg tggctatggg ggtggtcact ggaatgacgg
     5221 tcactccaga cgtcagccgg cagggatgca gcaggctggc cgcgcaccgg ggctcgggca
     5281 ccctctggcc ccacactggc aatgatgcca caccttgcca tgtccacgct gttggtcaaa
     5341 cccctctgtc atgcctcttt aaagagaaaa gaagagaaag attttttttt tttttaatgg
     5401 cagaccgaag tggagatctt gtagcctaga taggatagtc tgaccttcta gcatagtctt
     5461 tttggcaaat gatttgtgtt ttcagtgtgt ggggaagctg tcctgggggc tggggcgaca
     5521 gatagcacat aggctgtttc tggggctgca ggggcttccc tgagctggat gttgtgggtg
     5581 ttgccgtgct tcaggaagtg tggcgaccag aaagcgtaga cccggggccc agggtctgcc
     5641 cgcccctgca gcctggcctc cccgcacagg ctgtggcttg cactccagcc gctctagtct
     5701 ctcaggaatt tgcttgttac ttgtactgtg taaataaagc ttcctggttc aatacccaa
//
