LOCUS       NP_055476                422 aa            linear   PRI 28-APR-2025
DEFINITION  protein FAM53B [Homo sapiens].
ACCESSION   NP_055476 XP_374838
VERSION     NP_055476.3
DBSOURCE    REFSEQ: accession NM_014661.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 422)
  AUTHORS   Zhang,C., Gu,H., Liu,D., Tong,F., Wei,H., Zhou,D., Fang,J., Dai,X.
            and Tian,H.
  TITLE     The circ_FAM53B-miR-183-5p-CCDC6 axis modulates the malignant
            behaviors of papillary thyroid carcinoma cells
  JOURNAL   Mol Cell Biochem 477 (11), 2627-2641 (2022)
   PUBMED   35598218
  REMARK    GeneRIF: The circ_FAM53B-miR-183-5p-CCDC6 axis modulates the
            malignant behaviors of papillary thyroid carcinoma cells.
REFERENCE   2  (residues 1 to 422)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (residues 1 to 422)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (residues 1 to 422)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (residues 1 to 422)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (residues 1 to 422)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (residues 1 to 422)
  AUTHORS   Geisert,E.E., Lu,L., Freeman-Anderson,N.E., Templeton,J.P.,
            Nassr,M., Wang,X., Gu,W., Jiao,Y. and Williams,R.W.
  TITLE     Gene expression in the mouse eye: an online resource for genetics
            using 103 strains of mice
  JOURNAL   Mol Vis 15, 1730-1763 (2009)
   PUBMED   19727342
  REMARK    GeneRIF: Strong candidate gene for age-related macular
            degeneration, ARMS2, (human 10q26.13). Conclusion is based on a
            massive expression data set for mouse (103 strains) and joint
            analysis of RetNet database.
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 422)
  AUTHORS   Thermes,V., Candal,E., Alunni,A., Serin,G., Bourrat,F. and
            Joly,J.S.
  TITLE     Medaka simplet (FAM53B) belongs to a family of novel vertebrate
            genes controlling cell proliferation
  JOURNAL   Development 133 (10), 1881-1890 (2006)
   PUBMED   16611694
REFERENCE   9  (residues 1 to 422)
  AUTHORS   Benzinger,A., Muster,N., Koch,H.B., Yates,J.R. 3rd and Hermeking,H.
  TITLE     Targeted proteomic analysis of 14-3-3 sigma, a p53 effector
            commonly silenced in cancer
  JOURNAL   Mol Cell Proteomics 4 (6), 785-795 (2005)
   PUBMED   15778465
REFERENCE   10 (residues 1 to 422)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068896.9, BX344666.2, AW504054.1, CA397342.1, D50930.1,
            AK127343.1 and AL513190.13.
            
            On May 7, 2004 this sequence version replaced NP_055476.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D50930.1, SRR7346977.2746066.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337318.8/ ENSP00000338532.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     Protein         1..422
                     /product="protein FAM53B"
                     /note="simplet homolog; protein simplet"
                     /calculated_mol_wt=45637
     Region          1..302
                     /region_name="FAM53"
                     /note="Family of FAM53; pfam15242"
                     /db_xref="CDD:464582"
     Site            118
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q14153.2)"
     Site            167
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q14153.2)"
     Site            169
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q14153.2)"
     Site            179
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q14153.2)"
     Site            212
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8BGR5; propagated from
                     UniProtKB/Swiss-Prot (Q14153.2)"
     Region          245..269
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14153.2)"
     Site            268
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q14153.2)"
     Region          281..284
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:F1QN48"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14153.2)"
     CDS             1..422
                     /gene="FAM53B"
                     /gene_synonym="bA12J10.2; KIAA0140; smp"
                     /coded_by="NM_014661.4:541..1809"
                     /db_xref="CCDS:CCDS7641.1"
                     /db_xref="GeneID:9679"
                     /db_xref="HGNC:HGNC:28968"
                     /db_xref="MIM:617289"
ORIGIN      
        1 mvmvlsesls trgadsiacg tfsrelhtpk kmsqgptlfs cgimendrwr dldrkcplqi
       61 dqpstsiwec lpekdsslwh reavtacavt slikdlsisd hngnpsapps krqcrslsfs
      121 demsscrtsw rplgskvwtp vekrrcysgg svqrysngfs tmqrsssfsl psranvlssp
      181 cdqaglhhrf ggqpcqgvpg sapcgqagdt wspdlhpvgg grldlqrsls csheqfsfve
      241 ycppsanstp astpelarrs sglsrsrsqp cvlndkkvgv krrrpeevqe qrpsldlakm
      301 aqncqtfssl sclsagtedc gpqspfarhv sntrawtall sasgpggrtp agtpvpeplp
      361 psfddhlacq edlsceesds caldedcgrr aepaaawrdr gapgnslcsl dgeldieqie
      421 kn
//
