LOCUS       NM_207334               2448 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens family with sequence similarity 43 member B (FAM43B),
            mRNA.
ACCESSION   NM_207334
VERSION     NM_207334.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2448)
  AUTHORS   Xu,X., Liu,R.F., Wan,B.B., Xing,W.M., Huang,J. and Han,Z.G.
  TITLE     Expression of a novel gene FAM43B repressing cell proliferation is
            regulated by DNA methylation in hepatocellular carcinoma cell lines
  JOURNAL   Mol Cell Biochem 354 (1-2), 11-20 (2011)
   PUBMED   21461611
  REMARK    GeneRIF: expression of FAM43B, regulated by methylation and
            epigenetic silencing could contribute to hepatocellular carcinoma
            tumorigenesis by regulating cell proliferation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126900.1 and BC015675.2.
            
            On Nov 22, 2018 this sequence version replaced NM_207334.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC142686.1, AK126900.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332947.6/ ENSP00000331397.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2435              AK126900.1         135-2569
            2436-2448           BC015675.2         862-874
FEATURES             Location/Qualifiers
     source          1..2448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..2448
                     /gene="FAM43B"
                     /note="family with sequence similarity 43 member B"
                     /db_xref="GeneID:163933"
                     /db_xref="HGNC:HGNC:31791"
     exon            1..2448
                     /gene="FAM43B"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..1391
                     /gene="FAM43B"
                     /codon_start=1
                     /product="protein FAM43B"
                     /protein_id="NP_997217.1"
                     /db_xref="CCDS:CCDS209.1"
                     /db_xref="GeneID:163933"
                     /db_xref="HGNC:HGNC:31791"
                     /translation="MLPWRRNKFVLVEDEAKCKAKSLSPGLAYTSLLSSFLRSCPDLL
                     PDWPLERLGRVFRSRRQKVELNKEDPTYTVWYLGNAVTLHAKGDGCTDDAVGKIWARC
                     GPGGGTKMKLTLGPHGIRMQPCERSAAGGSGGRRPAHAYLLPRITYCTADGRHPRVFA
                     WVYRHQARHKAVVLRCHAVLLARAHKARALARLLRQTALAAFSDFKRLQRQSDARHVR
                     QQHLRAGGAAASVPRAPLRRLLNAKCAYRPPPSERSRGAPRLSSIQEEDEEEEEDDAE
                     EQEGGVPQRERPEVLSLARELRTCSLRGAPAPPPPAQPRRWKAGPRERAGQAR"
     regulatory      2414..2419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM43B"
                     /note="hexamer: AATAAA"
     polyA_site      2448
                     /gene="FAM43B"
                     /note="major polyA site"
ORIGIN      
        1 ggtctgcccc actaagcagc cgccagcggc tccggcgacc caaattgcgg cggcagggac
       61 cgcggaaatc ccaccgtttg ggcttggtgg acgtccagcc cacctcaccc ccagccccgg
      121 cccctcctcg cttcccagac ggctggagac actcccggga aaagcggtcc tcagccactc
      181 ggccgccgtc cgcacctcgg ctgctggccc ggctgggcac cgggcatctg cgaagctagc
      241 cctgcctggc actgggcatc tccaggcaac gactgtcccc ggccctgccc agcttctcgc
      301 gactccaggg cggtggactt ctgcgcgcct tccctccccc ggtctcccga caggacgccg
      361 gtgagctccc tgcgccccca gcccctttcg ccgccgccgc gatgctgccc tggagacgta
      421 acaaattcgt gctggtggag gacgaggcca agtgcaaggc gaagagcctg agtccggggc
      481 tcgcctacac gtcgctgctc tccagcttcc tgcgctcctg cccggacctg ctgcccgact
      541 ggccgctgga gcgcttgggc cgtgtgttcc gcagccggcg ccagaaagtg gagctcaaca
      601 aggaggaccc gacctacacc gtgtggtacc tgggcaacgc cgtcaccctg cacgccaagg
      661 gcgacggctg caccgacgac gccgtgggca agatctgggc tcgctgcggg cctggcgggg
      721 gcactaagat gaagctgacg ctggggccgc acggcatccg catgcagccg tgcgagcgca
      781 gcgccgccgg gggttcgggg ggccgcaggc cggcgcacgc ctacctgctg ccgcgcatca
      841 cctactgcac ggcggacggg cgccacccgc gcgtcttcgc ctgggtctac cgccaccagg
      901 cgcgccacaa ggccgtggtg ctgcgctgcc acgctgtgct gctggcgcgg gcgcacaagg
      961 cgcgcgccct ggcccgcctg ctccgccaga ccgcgctggc ggccttcagc gacttcaagc
     1021 gcctgcagcg ccagagcgac gcgcgccacg tgcgccagca gcatctccgc gctgggggcg
     1081 ccgccgcctc ggtgccccgc gccccactgc gccgcctgct caatgccaag tgcgcctacc
     1141 ggccgccgcc gagcgagcgc agccgcgggg cgccgcgcct cagcagcatc caggaggagg
     1201 acgaggagga ggaggaggac gacgcggagg agcaagaggg aggagtcccc cagcgcgagc
     1261 ggccggaggt gctcagcctg gcccgggagc tgaggacgtg cagcctgcgg ggcgccccgg
     1321 cgcccccgcc gcccgcgcag ccccgccgct ggaaggccgg ccccagggag cgggcgggcc
     1381 aggcgcgctg agagccgaag gacaggactc gcagccccag gcccgacccg ccagactcac
     1441 agcctccaac cccggccctg cccgcttcgg ctgccccggc ccccggcccg tgtctccccc
     1501 gtggtctccg tgttgtccgc cccgccgcct cattttggct cagggtgatg cctgatacgc
     1561 ccttggttat tggggggtgt tcctctctcc ccacacccgg agtttcccgg gcctgccatt
     1621 gtggacccgc cccctatgct ttacacctag tctctttgcc cacagacctc ctcattccct
     1681 cccaaaacat cctctcaaga gaagggagga gaagtttcaa gaaatcagga ggggtgggtt
     1741 tggaccctgg gcagggtgga ggcagtgacc ttgcccttgg tccctctagc cttcttccct
     1801 gtgcaaaaaa aaatgaccct ggagaggcat tcttgtagga gaagaatcta gcggccgggg
     1861 agaattgggg ccgggccggc ggtgggcaga gtccgctgct atacacacag ggaggaattc
     1921 tcacgcccaa gccccgcctc tctacgcctt ggaggactcc tgtgacttca ctgctctgcc
     1981 tctggagaac actgggagag tcctaccgac gttcaaacaa caggttaggc caggtaacag
     2041 ccctgcacca ggccgctgcc cacgcctctg ccctggcacc cccaggggat tccttgccca
     2101 tcccatctct ctgcagacgg atgtgtgtgg ccccctccta ggtgccccac aaccaggacc
     2161 aagatggggc tcccaaagga ggtaaggaga acctttggca ggtgcttagg acactgacta
     2221 cctagaaagt agacgcagca gagttgctcc caagtcgagg ctcctcagag caggtgggtc
     2281 ctgacagcag tggattctcc cagcaggatg aggaaggagg gtgtgttaac caaccaaggg
     2341 agtgggcccc ccacccaggt gtctccgcaa gaccacaaaa agcccaaaga tctatgtgtc
     2401 actgatcatt gtaaataaag tggacctgct tttacagccc tgtcacta
//
