LOCUS       NM_138805               1245 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens FAM3 metabolism regulating signaling molecule D
            (FAM3D), mRNA.
ACCESSION   NM_138805
VERSION     NM_138805.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1245)
  AUTHORS   Zheng,T., Zhang,D., Fu,Q., Wang,M., Cheng,Z., Cao,Y., Wang,L.,
            Liu,J. and Zhao,Y.
  TITLE     DNA methylation-driven gene FAM3D promotes colorectal cancer growth
            via the ATF4-SESN2-mTORC1 pathway
  JOURNAL   Aging (Albany NY) 16 (19), 12866-12892 (2024)
   PUBMED   39388305
  REMARK    GeneRIF: DNA methylation-driven gene FAM3D promotes colorectal
            cancer growth via the ATF4-SESN2-mTORC1 pathway.
REFERENCE   2  (bases 1 to 1245)
  AUTHORS   Hu,Y., Li,J., Li,X., Wang,D., Xiang,R., Liu,W., Hou,S., Zhao,Q.,
            Yu,X., Xu,M., Zhao,D., Li,T., Chi,Y. and Yang,J.
  TITLE     Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by
            activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation
  JOURNAL   Metabolism 146, 155661 (2023)
   PUBMED   37454871
  REMARK    GeneRIF: Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by
            activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation.
REFERENCE   3  (bases 1 to 1245)
  AUTHORS   Shen,Y., Dong,Z., Fan,F., Li,K., Zhu,S., Dai,R., Huang,J., Xie,N.,
            He,L., Gong,Z., Yang,X., Tan,J., Liu,L., Yu,F., Tang,Y., You,Z.,
            Xi,J., Wang,Y., Kong,W., Zhang,Y. and Fu,Y.
  TITLE     Targeting cytokine-like protein FAM3D lowers blood pressure in
            hypertension
  JOURNAL   Cell Rep Med 4 (6), 101072 (2023)
   PUBMED   37301198
  REMARK    GeneRIF: Targeting cytokine-like protein FAM3D lowers blood
            pressure in hypertension.
REFERENCE   4  (bases 1 to 1245)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1245)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 1245)
  AUTHORS   Xu,B., Roos,J.L., Dexheimer,P., Boone,B., Plummer,B., Levy,S.,
            Gogos,J.A. and Karayiorgou,M.
  TITLE     Exome sequencing supports a de novo mutational paradigm for
            schizophrenia
  JOURNAL   Nat Genet 43 (9), 864-868 (2011)
   PUBMED   21822266
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1245)
  AUTHORS   Shimada,M., Miyagawa,T., Kawashima,M., Tanaka,S., Honda,Y.,
            Honda,M. and Tokunaga,K.
  TITLE     An approach based on a genome-wide association study reveals
            candidate loci for narcolepsy
  JOURNAL   Hum Genet 128 (4), 433-441 (2010)
   PUBMED   20677014
  REMARK    GeneRIF: Statistical analysis indicated that six genes, NFATC2,
            SCP2, CACNA1C, TCRA, POLE, and FAM3D, were associated with
            narcolepsy.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1245)
  AUTHORS   Ramachandran,P., Boontheung,P., Xie,Y., Sondej,M., Wong,D.T. and
            Loo,J.A.
  TITLE     Identification of N-linked glycoproteins in human saliva by
            glycoprotein capture and mass spectrometry
  JOURNAL   J Proteome Res 5 (6), 1493-1503 (2006)
   PUBMED   16740002
REFERENCE   9  (bases 1 to 1245)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 1245)
  AUTHORS   Zhu,Y., Xu,G., Patel,A., McLaughlin,M.M., Silverman,C., Knecht,K.,
            Sweitzer,S., Li,X., McDonnell,P., Mirabile,R., Zimmerman,D.,
            Boyce,R., Tierney,L.A., Hu,E., Livi,G.P., Wolf,B.,
            Abdel-Meguid,S.S., Rose,G.D., Aurora,R., Hensley,P., Briggs,M. and
            Young,P.R.
  TITLE     Cloning, expression, and initial characterization of a novel
            cytokine-like gene family
  JOURNAL   Genomics 80 (2), 144-150 (2002)
   PUBMED   12160727
  REMARK    GeneRIF: A cytokine-like protein found in placenta
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358677.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138805.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB105189.1, AY358677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2152798
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358781.7/ ENSP00000351632.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1245              AY358677.1         75-1319
FEATURES             Location/Qualifiers
     source          1..1245
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.2"
     gene            1..1245
                     /gene="FAM3D"
                     /gene_synonym="EF7; OIT1"
                     /note="FAM3 metabolism regulating signaling molecule D"
                     /db_xref="GeneID:131177"
                     /db_xref="HGNC:HGNC:18665"
                     /db_xref="MIM:608619"
     exon            1..199
                     /gene="FAM3D"
                     /gene_synonym="EF7; OIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..250
                     /gene="FAM3D"
                     /gene_synonym="EF7; OIT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..912
                     /gene="FAM3D"
                     /gene_synonym="EF7; OIT1"
                     /note="cytokine-like protein EF-7; protein FAM3D;
                     Oncoprotein-induced transcript 1; family with sequence
                     similarity 3 member D"
                     /codon_start=1
                     /product="protein FAM3D precursor"
                     /protein_id="NP_620160.1"
                     /db_xref="CCDS:CCDS2893.1"
                     /db_xref="GeneID:131177"
                     /db_xref="HGNC:HGNC:18665"
                     /db_xref="MIM:608619"
                     /translation="MRVSGVLRLLALIFAIVTTWMFIRSYMSFSMKTIRLPRWLAASP
                     TKEIQVKKYKCGLIKPCPANYFAFKICSGAANVVGPTMCFEDRMIMSPVKNNVGRGLN
                     IALVNGTTGAVLGQKAFDMYSGDVMHLVKFLKEIPGGALVLVASYDDPGTKMNDESRK
                     LFSDLGSSYAKQLGFRDSWVFIGAKDLRGKSPFEQFLKNSPDTNKYEGWPELLEMEGC
                     MPPKPF"
     exon            251..358
                     /gene="FAM3D"
                     /gene_synonym="EF7; OIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..382
                     /gene="FAM3D"
                     /gene_synonym="EF7; OIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..500
                     /gene="FAM3D"
                     /gene_synonym="EF7; OIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..559
                     /gene="FAM3D"
                     /gene_synonym="EF7; OIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..610
                     /gene="FAM3D"
                     /gene_synonym="EF7; OIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..695
                     /gene="FAM3D"
                     /gene_synonym="EF7; OIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..822
                     /gene="FAM3D"
                     /gene_synonym="EF7; OIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1245
                     /gene="FAM3D"
                     /gene_synonym="EF7; OIT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1218..1223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM3D"
                     /gene_synonym="EF7; OIT1"
                     /note="hexamer: ATTAAA"
     polyA_site      1245
                     /gene="FAM3D"
                     /gene_synonym="EF7; OIT1"
                     /note="major polyA site"
ORIGIN      
        1 aacactccgt ctcaccctct gggcccactg catctagagg agggccgtct gtgaggccac
       61 tacccctcca gcaactggga ggtgggactg tcagaagctg gcccagggtg gtggtcagct
      121 gggtcaggga cctacggcac ctgctggacc acctcgcctt ctccatcgaa gcagggaagt
      181 gggagcctcg agccctcggg tggaagctga ccccaagcca cccttcacct ggacaggatg
      241 agagtgtcag gtgtgcttcg cctcctggcc ctcatctttg ccatagtcac gacatggatg
      301 tttattcgaa gctacatgag cttcagcatg aaaaccatcc gtctgccacg ctggctggca
      361 gcctcgccca ccaaggagat ccaggttaaa aagtacaagt gtggcctcat caagccctgc
      421 ccagccaact actttgcgtt taaaatctgc agtggggccg ccaacgtcgt gggccctact
      481 atgtgctttg aagaccgcat gatcatgagt cctgtgaaaa acaatgtggg cagaggccta
      541 aacatcgccc tggtgaatgg aaccacggga gctgtgctgg gacagaaggc atttgacatg
      601 tactctggag atgttatgca cctagtgaaa ttccttaaag aaattccggg gggtgcactg
      661 gtgctggtgg cctcctacga cgatccaggg accaaaatga acgatgaaag caggaaactc
      721 ttctctgact tggggagttc ctacgcaaaa caactgggct tccgggacag ctgggtcttc
      781 ataggagcca aagacctcag gggtaaaagc ccctttgagc agttcttaaa gaacagccca
      841 gacacaaaca aatacgaggg atggccagag ctgctggaga tggagggctg catgcccccg
      901 aagccatttt agggtggctg tggctcttcc tcagccaggg gcctgaagaa gctcctgcct
      961 gacttaggag tcagagcccg gcaggggctg aggaggagga gcagggggtg ctgcgtggaa
     1021 ggtgctgcag gtccttgcac gctgtgtcgc gcctctcctc ctcggaaaca gaaccctccc
     1081 acagcacatc ctacccggaa gaccagcctc agagggtcct tctggaacca gctgtctgtg
     1141 gagagaatgg ggtgctttcg tcagggactg ctgacggctg gtcctgagga aggacaaact
     1201 gcccagactt gagcccaatt aaattttatt tttgctggtt ttgaa
//
