LOCUS       NM_014888               2455 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens FAM3 metabolism regulating signaling molecule C
            (FAM3C), transcript variant 1, mRNA.
ACCESSION   NM_014888 XM_499359
VERSION     NM_014888.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2455)
  AUTHORS   Kim,S., Oh,J., Park,C., Kim,M., Jo,W., Kim,C.S., Cho,S.W. and
            Park,J.
  TITLE     FAM3C in Cancer-Associated Adipocytes Promotes Breast Cancer Cell
            Survival and Metastasis
  JOURNAL   Cancer Res 84 (4), 545-559 (2024)
   PUBMED   38117489
  REMARK    GeneRIF: FAM3C in Cancer-Associated Adipocytes Promotes Breast
            Cancer Cell Survival and Metastasis.
REFERENCE   2  (bases 1 to 2455)
  AUTHORS   Thuya,W.L., Kong,L.R., Syn,N.L., Ding,L.W., Cheow,E.S.H.,
            Wong,R.T.X., Wang,T., Goh,R.M.W., Song,H., Jayasinghe,M.K.,
            Le,M.T., Hu,J.C., Yong,W.P., Lee,S.C., Wong,A.L., Sethi,G.,
            Hung,H.T., Ho,P.C., Thiery,J.P., Sze,S.K., Guo,T., Soo,R.A.,
            Yang,H., Lim,Y.C., Wang,L. and Goh,B.C.
  TITLE     FAM3C in circulating tumor-derived extracellular vesicles promotes
            non-small cell lung cancer growth in secondary sites
  JOURNAL   Theranostics 13 (2), 621-638 (2023)
   PUBMED   36632230
  REMARK    GeneRIF: FAM3C in circulating tumor-derived extracellular vesicles
            promotes non-small cell lung cancer growth in secondary sites.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2455)
  AUTHORS   Watanabe,N., Nakano,M., Mitsuishi,Y., Hara,N., Mano,T., Iwata,A.,
            Murayama,S., Suzuki,T., Ikeuchi,T. and Nishimura,M.
  TITLE     Transcriptional downregulation of FAM3C/ILEI in the Alzheimer's
            brain
  JOURNAL   Hum Mol Genet 31 (1), 122-132 (2021)
   PUBMED   34378027
  REMARK    GeneRIF: Transcriptional downregulation of FAM3C/ILEI in the
            Alzheimer's brain.
REFERENCE   4  (bases 1 to 2455)
  AUTHORS   Hu,X., Yuan,G., Li,Q., Huang,J., Cheng,X. and Chen,J.
  TITLE     DEAH-box polypeptide 32 promotes hepatocellular carcinoma
            progression via activating the beta-catenin pathway
  JOURNAL   Ann Med 53 (1), 437-447 (2021)
   PUBMED   33729094
  REMARK    GeneRIF: DEAH-box polypeptide 32 promotes hepatocellular carcinoma
            progression via activating the beta-catenin pathway.
REFERENCE   5  (bases 1 to 2455)
  AUTHORS   Schmidt,U., Heller,G., Timelthaler,G., Heffeter,P., Somodi,Z.,
            Schweifer,N., Sibilia,M., Berger,W. and Csiszar,A.
  TITLE     The FAM3C locus that encodes interleukin-like EMT inducer (ILEI) is
            frequently co-amplified in MET-amplified cancers and contributes to
            invasiveness
  JOURNAL   J Exp Clin Cancer Res 40 (1), 69 (2021)
   PUBMED   33596971
  REMARK    GeneRIF: The FAM3C locus that encodes interleukin-like EMT inducer
            (ILEI) is frequently co-amplified in MET-amplified cancers and
            contributes to invasiveness.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2455)
  AUTHORS   Waerner,T., Alacakaptan,M., Tamir,I., Oberauer,R., Gal,A.,
            Brabletz,T., Schreiber,M., Jechlinger,M. and Beug,H.
  TITLE     ILEI: a cytokine essential for EMT, tumor formation, and late
            events in metastasis in epithelial cells
  JOURNAL   Cancer Cell 10 (3), 227-239 (2006)
   PUBMED   16959614
  REMARK    GeneRIF: ILEI is overexpressed and/or altered in intracellular
            localization in multiple human tumors.
REFERENCE   7  (bases 1 to 2455)
  AUTHORS   Guo,J., Cheng,H., Zhao,S. and Yu,L.
  TITLE     GG: a domain involved in phage LTF apparatus and implicated in
            human MEB and non-syndromic hearing loss diseases
  JOURNAL   FEBS Lett 580 (2), 581-584 (2006)
   PUBMED   16406369
REFERENCE   8  (bases 1 to 2455)
  AUTHORS   Gronborg,M., Kristiansen,T.Z., Iwahori,A., Chang,R., Reddy,R.,
            Sato,N., Molina,H., Jensen,O.N., Hruban,R.H., Goggins,M.G.,
            Maitra,A. and Pandey,A.
  TITLE     Biomarker discovery from pancreatic cancer secretome using a
            differential proteomic approach
  JOURNAL   Mol Cell Proteomics 5 (1), 157-171 (2006)
   PUBMED   16215274
REFERENCE   9  (bases 1 to 2455)
  AUTHORS   Mauri,P., Scarpa,A., Nascimbeni,A.C., Benazzi,L., Parmagnani,E.,
            Mafficini,A., Della Peruta,M., Bassi,C., Miyazaki,K. and Sorio,C.
  TITLE     Identification of proteins released by pancreatic cancer cells by
            multidimensional protein identification technology: a strategy for
            identification of novel cancer markers
  JOURNAL   FASEB J 19 (9), 1125-1127 (2005)
   PUBMED   15985535
REFERENCE   10 (bases 1 to 2455)
  AUTHORS   Zhu,Y., Xu,G., Patel,A., McLaughlin,M.M., Silverman,C., Knecht,K.,
            Sweitzer,S., Li,X., McDonnell,P., Mirabile,R., Zimmerman,D.,
            Boyce,R., Tierney,L.A., Hu,E., Livi,G.P., Wolf,B.,
            Abdel-Meguid,S.S., Rose,G.D., Aurora,R., Hensley,P., Briggs,M. and
            Young,P.R.
  TITLE     Cloning, expression, and initial characterization of a novel
            cytokine-like gene family
  JOURNAL   Genomics 80 (2), 144-150 (2002)
   PUBMED   12160727
  REMARK    GeneRIF: A cytokine-like protein found in almost all tissues.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079401.8 and AC006364.4.
            
            On Nov 23, 2018 this sequence version replaced NM_014888.2.
            
            Summary: This gene is a member of the family with sequence
            similarity 3 (FAM3) family and encodes a secreted protein with a GG
            domain. A change in expression of this protein has been noted in
            pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.227477.1,
                                           SRR1803614.175681.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359943.8/ ENSP00000353025.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC079401.8         3481-3627           c
            148-201             AC006364.4         120595-120648       c
            202-306             AC006364.4         116548-116652       c
            307-336             AC006364.4         109748-109777       c
            337-460             AC006364.4         108938-109061       c
            461-519             AC006364.4         101768-101826       c
            520-570             AC006364.4         100535-100585       c
            571-655             AC006364.4         97681-97765         c
            656-782             AC006364.4         88781-88907         c
            783-2455            AC006364.4         86516-88188         c
FEATURES             Location/Qualifiers
     source          1..2455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.31"
     gene            1..2455
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /note="FAM3 metabolism regulating signaling molecule C"
                     /db_xref="GeneID:10447"
                     /db_xref="HGNC:HGNC:18664"
                     /db_xref="MIM:608618"
     exon            1..147
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /inference="alignment:Splign:2.1.0"
     exon            148..201
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..872
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /note="predicted osteoblast protein; interleukin-like EMT
                     inducer; protein FAM3C; interleukin-like
                     epithelial-mesenchymal transition inducer; family with
                     sequence similarity 3 member C"
                     /codon_start=1
                     /product="protein FAM3C precursor"
                     /protein_id="NP_055703.1"
                     /db_xref="CCDS:CCDS5782.1"
                     /db_xref="GeneID:10447"
                     /db_xref="HGNC:HGNC:18664"
                     /db_xref="MIM:608618"
                     /translation="MRVAGAAKLVVAVAVFLLTFYVISQVFEIKMDASLGNLFARSAL
                     DTAARSTKPPRYKCGISKACPEKHFAFKMASGAANVVGPKICLEDNVLMSGVKNNVGR
                     GINVALANGKTGEVLDTKYFDMWGGDVAPFIEFLKAIQDGTIVLMGTYDDGATKLNDE
                     ARRLIADLGSTSITNLGFRDNWVFCGGKGIKTKSPFEQHIKNNKDTNKYEGWPEVVEM
                     EGCIPQKQD"
     exon            202..306
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /inference="alignment:Splign:2.1.0"
     exon            307..336
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /inference="alignment:Splign:2.1.0"
     exon            337..460
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /inference="alignment:Splign:2.1.0"
     exon            461..519
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /inference="alignment:Splign:2.1.0"
     exon            520..570
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /inference="alignment:Splign:2.1.0"
     exon            571..655
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /inference="alignment:Splign:2.1.0"
     exon            656..782
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /inference="alignment:Splign:2.1.0"
     exon            783..2455
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1305..1310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /note="hexamer: ATTAAA"
     polyA_site      1324
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /note="major polyA site"
     polyA_site      2455
                     /gene="FAM3C"
                     /gene_synonym="GS3786; ILEI"
                     /note="major polyA site"
ORIGIN      
        1 acttgccggg gtgaggggca gccggaggag tccgagagga agcggaggcg cgagctggag
       61 gcggcggctc ccgtcggcct ccggcaggac tgagcgctgg gaggccggaa ggcgggcgcg
      121 cgcggcggag aggcgggcgg gaggccggag catattaatg aaaagtgcca taaactgaaa
      181 aaccaaacat gagggtagca ggtgctgcaa agttggtggt agctgtggca gtgtttttac
      241 tgacatttta tgttatttct caagtatttg aaataaaaat ggatgcaagt ttaggaaatc
      301 tatttgcaag atcagcattg gacacagctg cacgttctac aaagcctccc agatataagt
      361 gtgggatctc aaaagcttgc cctgagaagc attttgcttt taaaatggca agtggagcag
      421 ccaacgtggt gggacccaaa atctgcctgg aagataatgt tttaatgagt ggtgttaaga
      481 ataatgttgg aagagggatc aatgttgcct tggcaaatgg aaaaacagga gaagtattag
      541 acactaaata ttttgacatg tggggaggag atgtggcacc atttattgag tttctgaagg
      601 ccatacaaga tggaacaata gttttaatgg gaacatacga tgatggagca accaaactca
      661 atgatgaggc acggcggctc attgctgatt tggggagcac atctattact aatcttggtt
      721 ttagagacaa ctgggtcttc tgtggtggga agggcattaa gacaaaaagc ccttttgaac
      781 agcacataaa gaacaataag gatacaaaca aatatgaagg atggcctgaa gttgtagaaa
      841 tggaaggatg catcccccag aagcaagact aatggaaatg tggagagaat tgaagaaagc
      901 gcactttcac tcttaatggg agagctataa atggcagagc tatgtgtaaa tattttaaga
      961 gcatgcagcc atcttggtgt gtgcatgagt attgtctctt ttgatatcag gattatttat
     1021 tgctaacgta aatagatagc attgtaaata atcatcacaa tgatcaaatc actgaaccat
     1081 gtctccgcac atttccctaa aagtacaatg tttagactgc tatggtaata catattttaa
     1141 attctaaaag catacacaat gtgtaactga atggtttgtg aaaaatatat tgatatatat
     1201 actagttgct atgaaaatat catggaataa tagggatttt agggtggata ctttattttc
     1261 ttttatgttt ctatatgttg cgttgtgatg acattatctt ttaaattaaa aagagatttg
     1321 gctagttgtg tgtgtaatgt tactttacag tccgactctc ctgatgtacc tcttttcatg
     1381 atctttttct ttccttccca agaaactgag gaatgtttaa tatgaaaaca tacatcggat
     1441 atgtgaaaag cacaacaaaa ttcttaatgt acacagtaaa aaagtaaata tataaatgta
     1501 gatggcattt aggaccacag cttgctggat ttgtgttagc tatgggaata acttgatttt
     1561 gtataagcta tttagagtga ggctggaggt ggcagcttca cagaactgga gaaccaggcc
     1621 aagtcccctc cccaacctaa ttaggtcatt caggacagct aagtcagtat atttagagca
     1681 atactagcat acgtttttct taattgttat cagcattgac caagtggttt ggaaggaggc
     1741 atgctttaat atcacaataa ttttgatttg taaaccaaga aattaatcct gtgtttatct
     1801 aacttcataa tagcaattat tgcccgaagc tatagtggca tatttacaaa agttcttatt
     1861 actgggcgga ctgataacat ttaaaaaata attgtgtttg accccaaatg actttatacc
     1921 caattctaca taaaaatata gaagatctat ctttttttgt taccttcaga tgttcactaa
     1981 ataactcagt ttttaagcag aagttttcag ggcattaaat atatgttgtg tatgaagtat
     2041 ctcaaactgg aacataaatt tagtgatcaa actgccattc acagtgtaag gcagcactta
     2101 aatttcgaac ctaaagttta gatgcattgt ataaaaaaac ctaaaagcag tatctgttat
     2161 ttagctgtaa accaagttgg aagctattcg gataatttct taaatattga tgaactttgg
     2221 agtactgttt cttccttcaa actgaatgta attaattcat gaataaatgc accttatatg
     2281 tttaaacaat ctttgtatac ttttgggatt tttggtgctt atatgctaaa tcacattcag
     2341 catgtgtatt ttgacattta aaatacttcc ctcaattctg taaattaaaa gaatagttat
     2401 tttacagttc cagggattgt gaaataaatg ttgcagtttt ttaaaataat gaaaa
//
