LOCUS       NM_058186               1317 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens FAM3 metabolism regulating signaling molecule B
            (FAM3B), transcript variant 1, mRNA.
ACCESSION   NM_058186
VERSION     NM_058186.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1317)
  AUTHORS   Ma,T., Jin,L., Bai,S., Liu,Z., Wang,S., Shen,B., Cho,Y., Cao,S.,
            Sun,M.J.S., Fazli,L., Zhang,D., Wedderburn,C., Zhang,D.Y.,
            Mugon,G., Ungerleider,N., Baddoo,M., Zhang,K., Schiavone,L.H.,
            Burkhardt,B.R., Fan,J., You,Z., Flemington,E.K., Dong,X. and
            Dong,Y.
  TITLE     Loss of feedback regulation between FAM3B and androgen receptor
            driving prostate cancer progression
  JOURNAL   J Natl Cancer Inst 116 (3), 421-433 (2024)
   PUBMED   37847647
  REMARK    GeneRIF: Loss of feedback regulation between FAM3B and androgen
            receptor driving prostate cancer progression.
REFERENCE   2  (bases 1 to 1317)
  AUTHORS   Zhao,H., He,Q., Wu,X., Liang,X., Jiao,Y., Zhang,Y., Bao,S., Xu,L.,
            Hou,Y., Zhu,X. and Ding,Y.
  TITLE     Identification of rare loss-of-function variants in FAM3B
            associated with non-syndromic orofacial clefts
  JOURNAL   Genomics 115 (3), 110630 (2023)
   PUBMED   37105387
  REMARK    GeneRIF: Identification of rare loss-of-function variants in FAM3B
            associated with non-syndromic orofacial clefts.
REFERENCE   3  (bases 1 to 1317)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1317)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1317)
  AUTHORS   Song,C. and Duan,C.
  TITLE     Upregulation of FAM3B Promotes Cisplatin Resistance in Gastric
            Cancer by Inducing Epithelial-Mesenchymal Transition
  JOURNAL   Med Sci Monit 26, e921002 (2020)
   PUBMED   32442162
  REMARK    GeneRIF: Upregulation of FAM3B Promotes Cisplatin Resistance in
            Gastric Cancer by Inducing Epithelial-Mesenchymal Transition.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1317)
  AUTHORS   Yang,J., Robert,C.E., Burkhardt,B.R., Young,R.A., Wu,J., Gao,Z. and
            Wolf,B.A.
  TITLE     Mechanisms of glucose-induced secretion of pancreatic-derived
            factor (PANDER or FAM3B) in pancreatic beta-cells
  JOURNAL   Diabetes 54 (11), 3217-3228 (2005)
   PUBMED   16249448
  REMARK    GeneRIF: PANDER is secreted from 2 types of pancreatic cells,
            glucose stimulates its secretion in beta cell and primary islets
            but not in alpha-cells, it is likely cosecreted with insulin, and
            structure and conformation is vital for PANDER secretion.
REFERENCE   7  (bases 1 to 1317)
  AUTHORS   Yang,J., Gao,Z., Robert,C.E., Burkhardt,B.R., Gaweska,H.,
            Wagner,A., Wu,J., Greene,S.R., Young,R.A. and Wolf,B.A.
  TITLE     Structure-function studies of PANDER, an islet specific cytokine
            inducing cell death of insulin-secreting beta cells
  JOURNAL   Biochemistry 44 (34), 11342-11352 (2005)
   PUBMED   16114871
  REMARK    GeneRIF: Helices B and C and the second disulfide bond of PANDER
            are essential for PANDER-induced beta-cell death.
REFERENCE   8  (bases 1 to 1317)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 1317)
  AUTHORS   Zhu,Y., Xu,G., Patel,A., McLaughlin,M.M., Silverman,C., Knecht,K.,
            Sweitzer,S., Li,X., McDonnell,P., Mirabile,R., Zimmerman,D.,
            Boyce,R., Tierney,L.A., Hu,E., Livi,G.P., Wolf,B.,
            Abdel-Meguid,S.S., Rose,G.D., Aurora,R., Hensley,P., Briggs,M. and
            Young,P.R.
  TITLE     Cloning, expression, and initial characterization of a novel
            cytokine-like gene family
  JOURNAL   Genomics 80 (2), 144-150 (2002)
   PUBMED   12160727
  REMARK    GeneRIF: Localized to the islets of Langerhans.
REFERENCE   10 (bases 1 to 1317)
  AUTHORS   Reymond,A., Friedli,M., Henrichsen,C.N., Chapot,F., Deutsch,S.,
            Ucla,C., Rossier,C., Lyle,R., Guipponi,M. and Antonarakis,S.E.
  TITLE     From PREDs and open reading frames to cDNA isolation: revisiting
            the human chromosome 21 transcription map
  JOURNAL   Genomics 78 (1-2), 46-54 (2001)
   PUBMED   11707072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK125528.1, BI712971.1, BC057829.1, AY358459.1 and BF514643.1.
            
            On May 17, 2019 this sequence version replaced NM_058186.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF375989.1, AY358459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357985.7/ ENSP00000350673.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               AK125528.1         70-363
            295-498             BI712971.1         324-527
            499-861             BC057829.1         488-850
            862-1021            AY358459.1         797-956
            1022-1317           BF514643.1         145-440
FEATURES             Location/Qualifiers
     source          1..1317
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..1317
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /note="FAM3 metabolism regulating signaling molecule B"
                     /db_xref="GeneID:54097"
                     /db_xref="HGNC:HGNC:1253"
                     /db_xref="MIM:608617"
     exon            1..98
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..787
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; pancreatic derived factor; D21M16SJHU19e;
                     cytokine-like protein 2-21; protein FAM3B; family with
                     sequence similarity 3 member B"
                     /codon_start=1
                     /product="protein FAM3B isoform a precursor"
                     /protein_id="NP_478066.3"
                     /db_xref="CCDS:CCDS13671.1"
                     /db_xref="GeneID:54097"
                     /db_xref="HGNC:HGNC:1253"
                     /db_xref="MIM:608617"
                     /translation="MRPLAGGLLKVVFVVFASLCAWYSGYLLAELIPDAPLSSAAYSI
                     RSIGERPVLKAPVPKRQKCDHWTPCPSDTYAYRLLSGGGRSKYAKICFEDNLLMGEQL
                     GNVARGINIAIVNYVTGNVTATRCFDMYEGDNSGPMTKFIQSAAPKSLLFMVTYDDGS
                     TRLNNDAKNAIEALGSKEIRNMKFRSSWVFIAAKGLELPSEIQREKINHSDAKNNRYS
                     GWPAEIQIEGCIPKERS"
     exon            99..242
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /inference="alignment:Splign:2.1.0"
     exon            243..366
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /inference="alignment:Splign:2.1.0"
     exon            367..425
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /inference="alignment:Splign:2.1.0"
     exon            426..476
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /inference="alignment:Splign:2.1.0"
     exon            477..564
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /inference="alignment:Splign:2.1.0"
     exon            565..697
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /inference="alignment:Splign:2.1.0"
     exon            698..1317
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      803..808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /note="hexamer: AGTAAA"
     regulatory      822..827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /note="hexamer: AACAAA"
     polyA_site      827
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /note="major polyA site"
     polyA_site      838
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
     regulatory      910..915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /note="hexamer: AATGAA"
     polyA_site      935
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /note="major polyA site"
     regulatory      1002..1007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
                     /note="hexamer: AATGAA"
     polyA_site      1026
                     /gene="FAM3B"
                     /gene_synonym="2-21; C21orf11; C21orf76; ORF9; PANDER;
                     PRED44"
ORIGIN      
        1 cttcctgacc caggggctcc gctggctgcg gtcgcctggg agctgccgcc agggccagga
       61 ggggagcggc acctggaaga tgcgcccatt ggctggtggc ctgctcaagg tggtgttcgt
      121 ggtcttcgcc tccttgtgtg cctggtattc ggggtacctg ctcgcagagc tcattccaga
      181 tgcacccctg tccagtgctg cctatagcat ccgcagcatc ggggagaggc ctgtcctcaa
      241 agctccagtc cccaaaaggc aaaaatgtga ccactggact ccctgcccat ctgacaccta
      301 tgcctacagg ttactcagcg gaggtggcag aagcaagtac gccaaaatct gctttgagga
      361 taacctactt atgggagaac agctgggaaa tgttgccaga ggaataaaca ttgccattgt
      421 caactatgta actgggaatg tgacagcaac acgatgtttt gatatgtatg aaggtgataa
      481 ctctggaccg atgacaaagt ttattcagag tgctgctcca aaatccctgc tcttcatggt
      541 gacctatgac gacggaagca caagactgaa taacgatgcc aagaatgcca tagaagcact
      601 tggaagtaaa gaaatcagga acatgaaatt caggtctagc tgggtattta ttgcagcaaa
      661 aggcttggaa ctcccttccg aaattcagag agaaaagatc aaccactctg atgctaagaa
      721 caacagatat tctggctggc ctgcagagat ccagatagaa ggctgcatac ccaaagaacg
      781 aagctgacac tgcagggtcc tgagtaaatg tgttctgtat aaacaaatgc agctggaatc
      841 gctcaagaat cttatttttc taaatccaac agcccatatt tgatgagtat tttgggtttg
      901 ttgtaaacca atgaacattt gctagttgta tcaaatcttg gtacgcagta tttttatacc
      961 agtattttat gtagtgaaga tgtcaattag caggaaacta aaatgaatgg aaattcttaa
     1021 agggaatgat gtgattcaag ctggaaagag ggttgggaga aacagcttgt ccaggtggag
     1081 ctatgttatg atcagatcga agtgtgaccc ctgtgtggtc cagacagccc tgcagagaga
     1141 aaacctttat tccattatca ccaagcacct cctagtttcc gacagtcatc tccttctgct
     1201 gggagaatta gcagcagttc agggggctta tgttatgtcc ttgttcaact caacttgagc
     1261 tcttgaactc ctcctgtggg cctgtgaatg tattcattca ttccacaact ctgggtg
//
