LOCUS       NM_014077               1463 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 32 member A (FAM32A),
            mRNA.
ACCESSION   NM_014077
VERSION     NM_014077.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1463)
  AUTHORS   Fica,S.M., Oubridge,C., Wilkinson,M.E., Newman,A.J. and Nagai,K.
  TITLE     A human postcatalytic spliceosome structure reveals essential roles
            of metazoan factors for exon ligation
  JOURNAL   Science 363 (6428), 710-714 (2019)
   PUBMED   30705154
REFERENCE   2  (bases 1 to 1463)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 1463)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   4  (bases 1 to 1463)
  AUTHORS   Chen,X., Zhang,H., Aravindakshan,J.P., Gotlieb,W.H. and Sairam,M.R.
  TITLE     Anti-proliferative and pro-apoptotic actions of a novel human and
            mouse ovarian tumor-associated gene OTAG-12: downregulation,
            alternative splicing and drug sensitization
  JOURNAL   Oncogene 30 (25), 2874-2887 (2011)
   PUBMED   21339736
  REMARK    GeneRIF: study showed that hOTAG-12b increases mRNAs of
            pro-apoptotic genes such as BAD, GADD45alpha and CIEDB, while
            inhibiting anti-apoptotic NAIP and Akt1 expression, suggesting that
            hOTAG-12b-induced apoptosis might be p53-independent
REFERENCE   5  (bases 1 to 1463)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 1463)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1463)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG749750.1 and BC000639.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014077.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1019033.1,
                                           SRR3476690.541569.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263384.12/ ENSP00000263384.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BG749750.1         30-42
            14-1463             BC000639.1         1-1450
FEATURES             Location/Qualifiers
     source          1..1463
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1463
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /note="family with sequence similarity 32 member A"
                     /db_xref="GeneID:26017"
                     /db_xref="HGNC:HGNC:24563"
                     /db_xref="MIM:614554"
     exon            1..107
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..372
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /note="ovarian tumor associated gene-12"
                     /codon_start=1
                     /product="protein FAM32A"
                     /protein_id="NP_054796.1"
                     /db_xref="CCDS:CCDS12341.1"
                     /db_xref="GeneID:26017"
                     /db_xref="HGNC:HGNC:24563"
                     /db_xref="MIM:614554"
                     /translation="MEAYEQVQKGPLKLKGVAELGVTKRKKKKKDKDKAKLLEAMGTS
                     KKNEEEKRRGLDKRTPAQAAFEKMQEKRQMERILKKASKTHKQRVEDFNRHLDTLTEH
                     YDIPKVSWTK"
     exon            108..249
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /inference="alignment:Splign:2.1.0"
     exon            250..303
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /inference="alignment:Splign:2.1.0"
     exon            304..1463
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1438..1443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /note="hexamer: AATAAA"
     polyA_site      1463
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /note="major polyA site"
ORIGIN      
        1 ggcactccag ctaccgaagc actggagagt gtcatggagg cctacgagca ggtccaaaag
       61 ggacccctga agctgaaagg cgtcgcagag ctgggagtga ccaagcggaa gaagaaaaag
      121 aaggacaaag acaaagcgaa actcctggaa gcaatgggaa cgagcaaaaa gaacgaggag
      181 gagaagcggc gcggcctgga caagcggacc ccggcccagg cggccttcga gaaaatgcag
      241 gagaagcggc aaatggaaag gatcctaaag aaggcatcca aaacccacaa gcagagagtg
      301 gaggacttca acagacacct ggacacactc acggagcatt acgacattcc caaagtcagc
      361 tggacgaagt agccgcctgc ccccagtatg gagcagcatc gagggttcgc aaaaggccac
      421 actggggttg tgtgtgtttc ctttggtata ttctggaaac atggctacac acacccttgc
      481 atcttctgct acagactgct tttcgaagct gtgtaccctc attctggaac ttgattaaag
      541 taagatcgtc cttgtactca gtttaggctt cttggcaaca tacagaagat acaccctttt
      601 cgtttggatg gaaagtttct aagtttatcc agaggtaaag cccattgtgt gtctgtgtca
      661 tgtaaaaatg ttttcacccg agttgcatgt aacgctctga ggccagccag ctgtcttctc
      721 ctggatgaga cagactccag agggtaagga gctagcgcca tggtggcctg cagtatgcag
      781 agccccgcag gacccagcgt gggcgccctt ccaagcttcc tctagctttg ggcctatgct
      841 gtcccctgca ggccctaggg aagccacttg caactatgcg gccttcagac ttcctcctca
      901 gccacctggc cactgagaca gcatagcctg ggtaacggaa cagccaccta aggcaagaat
      961 ggaacggaca caccttgctc ctttctgagc ccgtttccca aaacccccct tccaggtgct
     1021 tctaatgggt gttgccatag cagacgctgc taatgcatca cagcattctt tgaaatggaa
     1081 ccagacacag cctgcctctc aatcctcagc tgggggctcc tagcagcctc ttgtatttac
     1141 tcagagttga cacatcacac agatcctgtt tggcattcct accttacgga cgtctcaggg
     1201 gtgacaggac cagggcagag ccccggtaca aacagacaag gctgcagtca aatgggaggg
     1261 tccaggtgtc cgtgttggag ggctgggatc ttgtagggcc tgtgcgtcct ggctgaggat
     1321 caaaccacat atgttattgg gagaaacgat ttctgttgac gtagatattg aaagaataat
     1381 gaaggcagaa gagaaaaacg aagtgtggaa tttggggttg tcctgtgtaa attacacaat
     1441 aaagcaaaag tcagttattg taa
//
