LOCUS       NM_145306               1073 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 241 member B
            (FAM241B), mRNA.
ACCESSION   NM_145306
VERSION     NM_145306.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1073)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1073)
  AUTHORS   Lenk,G.M., Park,Y.N., Lemons,R., Flynn,E., Plank,M., Frei,C.M.,
            Davis,M.J., Gregorka,B., Swanson,J.A., Meisler,M.H. and
            Kitzman,J.O.
  TITLE     CRISPR knockout screen implicates three genes in lysosome function
  JOURNAL   Sci Rep 9 (1), 9609 (2019)
   PUBMED   31270356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1073)
  AUTHORS   Mahajan,A., Go,M.J., Zhang,W., Below,J.E., Gaulton,K.J.,
            Ferreira,T., Horikoshi,M., Johnson,A.D., Ng,M.C., Prokopenko,I.,
            Saleheen,D., Wang,X., Zeggini,E., Abecasis,G.R., Adair,L.S.,
            Almgren,P., Atalay,M., Aung,T., Baldassarre,D., Balkau,B., Bao,Y.,
            Barnett,A.H., Barroso,I., Basit,A., Been,L.F., Beilby,J.,
            Bell,G.I., Benediktsson,R., Bergman,R.N., Boehm,B.O.,
            Boerwinkle,E., Bonnycastle,L.L., Burtt,N., Cai,Q., Campbell,H.,
            Carey,J., Cauchi,S., Caulfield,M., Chan,J.C., Chang,L.C.,
            Chang,T.J., Chang,Y.C., Charpentier,G., Chen,C.H., Chen,H.,
            Chen,Y.T., Chia,K.S., Chidambaram,M., Chines,P.S., Cho,N.H.,
            Cho,Y.M., Chuang,L.M., Collins,F.S., Cornelis,M.C., Couper,D.J.,
            Crenshaw,A.T., van Dam,R.M., Danesh,J., Das,D., de Faire,U.,
            Dedoussis,G., Deloukas,P., Dimas,A.S., Dina,C., Doney,A.S.,
            Donnelly,P.J., Dorkhan,M., van Duijn,C., Dupuis,J., Edkins,S.,
            Elliott,P., Emilsson,V., Erbel,R., Eriksson,J.G., Escobedo,J.,
            Esko,T., Eury,E., Florez,J.C., Fontanillas,P., Forouhi,N.G.,
            Forsen,T., Fox,C., Fraser,R.M., Frayling,T.M., Froguel,P.,
            Frossard,P., Gao,Y., Gertow,K., Gieger,C., Gigante,B., Grallert,H.,
            Grant,G.B., Grrop,L.C., Groves,C.J., Grundberg,E., Guiducci,C.,
            Hamsten,A., Han,B.G., Hara,K., Hassanali,N., Hattersley,A.T.,
            Hayward,C., Hedman,A.K., Herder,C., Hofman,A., Holmen,O.L.,
            Hovingh,K., Hreidarsson,A.B., Hu,C., Hu,F.B., Hui,J.,
            Humphries,S.E., Hunt,S.E., Hunter,D.J., Hveem,K., Hydrie,Z.I.,
            Ikegami,H., Illig,T., Ingelsson,E., Islam,M., Isomaa,B.,
            Jackson,A.U., Jafar,T., James,A., Jia,W., Jockel,K.H., Jonsson,A.,
            Jowett,J.B., Kadowaki,T., Kang,H.M., Kanoni,S., Kao,W.H.,
            Kathiresan,S., Kato,N., Katulanda,P., Keinanen-Kiukaanniemi,K.M.,
            Kelly,A.M., Khan,H., Khaw,K.T., Khor,C.C., Kim,H.L., Kim,S.,
            Kim,Y.J., Kinnunen,L., Klopp,N., Kong,A., Korpi-Hyovalti,E.,
            Kowlessur,S., Kraft,P., Kravic,J., Kristensen,M.M., Krithika,S.,
            Kumar,A., Kumate,J., Kuusisto,J., Kwak,S.H., Laakso,M., Lagou,V.,
            Lakka,T.A., Langenberg,C., Langford,C., Lawrence,R., Leander,K.,
            Lee,J.M., Lee,N.R., Li,M., Li,X., Li,Y., Liang,J., Liju,S.,
            Lim,W.Y., Lind,L., Lindgren,C.M., Lindholm,E., Liu,C.T., Liu,J.J.,
            Lobbens,S., Long,J., Loos,R.J., Lu,W., Luan,J., Lyssenko,V.,
            Ma,R.C., Maeda,S., Magi,R., Mannisto,S., Matthews,D.R., Meigs,J.B.,
            Melander,O., Metspalu,A., Meyer,J., Mirza,G., Mihailov,E.,
            Moebus,S., Mohan,V., Mohlke,K.L., Morris,A.D., Muhleisen,T.W.,
            Muller-Nurasyid,M., Musk,B., Nakamura,J., Nakashima,E., Navarro,P.,
            Ng,P.K., Nica,A.C., Nilsson,P.M., Njolstad,I., Nothen,M.M.,
            Ohnaka,K., Ong,T.H., Owen,K.R., Palmer,C.N., Pankow,J.S.,
            Park,K.S., Parkin,M., Pechlivanis,S., Pedersen,N.L., Peltonen,L.,
            Perry,J.R., Peters,A., Pinidiyapathirage,J.M., Platou,C.G.,
            Potter,S., Price,J.F., Qi,L., Radha,V., Rallidis,L., Rasheed,A.,
            Rathman,W., Rauramaa,R., Raychaudhuri,S., Rayner,N.W., Rees,S.D.,
            Rehnberg,E., Ripatti,S., Robertson,N., Roden,M., Rossin,E.J.,
            Rudan,I., Rybin,D., Saaristo,T.E., Salomaa,V., Saltevo,J.,
            Samuel,M., Sanghera,D.K., Saramies,J., Scott,J., Scott,L.J.,
            Scott,R.A., Segre,A.V., Sehmi,J., Sennblad,B., Shah,N., Shah,S.,
            Shera,A.S., Shu,X.O., Shuldiner,A.R., Sigurdsson,G., Sijbrands,E.,
            Silveira,A., Sim,X., Sivapalaratnam,S., Small,K.S., So,W.Y.,
            Stancakova,A., Stefansson,K., Steinbach,G., Steinthorsdottir,V.,
            Stirrups,K., Strawbridge,R.J., Stringham,H.M., Sun,Q., Suo,C.,
            Syvanen,A.C., Takayanagi,R., Takeuchi,F., Tay,W.T., Teslovich,T.M.,
            Thorand,B., Thorleifsson,G., Thorsteinsdottir,U., Tikkanen,E.,
            Trakalo,J., Tremoli,E., Trip,M.D., Tsai,F.J., Tuomi,T.,
            Tuomilehto,J., Uitterlinden,A.G., Valladares-Salgado,A.,
            Vedantam,S., Veglia,F., Voight,B.F., Wang,C., Wareham,N.J.,
            Wennauer,R., Wickremasinghe,A.R., Wilsgaard,T., Wilson,J.F.,
            Wiltshire,S., Winckler,W., Wong,T.Y., Wood,A.R., Wu,J.Y., Wu,Y.,
            Yamamoto,K., Yamauchi,T., Yang,M., Yengo,L., Yokota,M., Young,R.,
            Zabaneh,D., Zhang,F., Zhang,R., Zheng,W., Zimmet,P.Z.,
            Altshuler,D., Bowden,D.W., Cho,Y.S., Cox,N.J., Cruz,M., Hanis,C.L.,
            Kooner,J., Lee,J.Y., Seielstad,M., Teo,Y.Y., Boehnke,M.,
            Parra,E.J., Chambers,J.C., Tai,E.S., McCarthy,M.I. and Morris,A.P.
  CONSRTM   DIAbetes Genetics Replication And Meta-analysis (DIAGRAM)
            Consortium; Asian Genetic Epidemiology Network Type 2 Diabetes
            (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D)
            Consortium; Mexican American Type 2 Diabetes (MAT2D) Consortium;
            Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in
            muylti-Ethnic Samples (T2D-GENES) Consortium
  TITLE     Genome-wide trans-ancestry meta-analysis provides insight into the
            genetic architecture of type 2 diabetes susceptibility
  JOURNAL   Nat Genet 46 (3), 234-244 (2014)
   PUBMED   24509480
REFERENCE   4  (bases 1 to 1073)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1073)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   6  (bases 1 to 1073)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB465414.1, BC013587.1, CK903062.1 and DB339258.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145306.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.215453.1,
                                           SRR3476690.271195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373279.6/ ENSP00000362376.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DB465414.1         1-11
            12-277              BC013587.1         1-266
            278-599             CK903062.1         217-538
            600-1073            DB339258.1         3-476               c
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..1073
                     /gene="FAM241B"
                     /gene_synonym="C10orf35"
                     /note="family with sequence similarity 241 member B"
                     /db_xref="GeneID:219738"
                     /db_xref="HGNC:HGNC:23519"
     exon            1..67
                     /gene="FAM241B"
                     /gene_synonym="C10orf35"
                     /inference="alignment:Splign:2.1.0"
     exon            68..135
                     /gene="FAM241B"
                     /gene_synonym="C10orf35"
                     /inference="alignment:Splign:2.1.0"
     exon            136..266
                     /gene="FAM241B"
                     /gene_synonym="C10orf35"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..536
                     /gene="FAM241B"
                     /gene_synonym="C10orf35"
                     /note="uncharacterized protein C10orf35"
                     /codon_start=1
                     /product="protein FAM241B"
                     /protein_id="NP_660349.1"
                     /db_xref="CCDS:CCDS7295.1"
                     /db_xref="GeneID:219738"
                     /db_xref="HGNC:HGNC:23519"
                     /translation="MVRILANGEIVQDDDPRVRTTTQPPRGSIPRQSFFNRGHGAPPG
                     GPGPRQQQAGARLGAAQSPFNDLNRQLVNMGFPQWHLGNHAVEPVTSILLLFLLMMLG
                     VRGLLLVGLVYLVSHLSQR"
     exon            267..1073
                     /gene="FAM241B"
                     /gene_synonym="C10orf35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1066..1071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM241B"
                     /gene_synonym="C10orf35"
                     /note="hexamer: AGTAAA"
     polyA_site      1073
                     /gene="FAM241B"
                     /gene_synonym="C10orf35"
                     /note="major polyA site"
ORIGIN      
        1 aggtgggagg aaaccgcctg gagccgccgg gagtggacgc cgccgaggcc cggagtcgcg
       61 cctgcagaca cagcatctac tcagcgtggg tcacctctgt gaacatcact gactgcaagc
      121 ctccctcaat ttctggtgca gcccatcagg gacccacagc gcctgggagg atggtgcgga
      181 tcttggccaa tggggaaatc gtgcaggatg acgacccccg agtgaggacc actacccagc
      241 caccaagagg tagcattcct cgacagagct tcttcaacag gggccatggt gctcccccag
      301 ggggtcctgg cccccgccag cagcaggcag gtgccaggct gggtgctgct cagtccccct
      361 tcaatgacct caaccggcag ctggtgaaca tgggctttcc gcagtggcat cttggcaacc
      421 atgctgtgga gccggtgacc tccatcctgc tcctcttcct gctcatgatg cttggtgttc
      481 gtggcctcct cctggttggc cttgtctacc tggtgtccca cctgagtcag cggtgacctc
      541 tgagggctga taggggtggg tttgttgaga gggacttgct gggccttggt gtgagagcag
      601 gcatatttgg aggggatctg gtggtgcctt gaaggtatga tcagagaggg gaccacaggt
      661 gtgtgtttcc cctttgtgtt aagcgtgagg cagagggaga cgttagtcca gcatttccaa
      721 agtgtgggtg ggtccgttgg ttcccaagat acttttaggt ggtatggggc ctgcattaag
      781 tggcacaaaa tcagagcaag aaagcgatgc ccttcccaat tctctcaatc cttttatgcc
      841 gagaagatct cagctggatg ccaacatgtt ccgatgcctg tggaagacat gccgacgtct
      901 cctctgccta gggagcagga cttgggctta gggcaggtgg aaaaaattcc agactttttt
      961 agcactgttt ttgttttaat ggtatatttt tattggctac tttattgttt aggacaagtg
     1021 gtagtggcat tctatttatt gtgacctttt caataaatag atttaagtaa aaa
//
