LOCUS       NM_001382368             608 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 240 member C
            (FAM240C), transcript variant 2, mRNA.
ACCESSION   NM_001382368 NR_135767 XR_241445 XR_251308 XR_430642
VERSION     NM_001382368.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 608)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   2  (bases 1 to 608)
  AUTHORS   Hillier,L.D., Lennon,G., Becker,M., Bonaldo,M.F., Chiapelli,B.,
            Chissoe,S., Dietrich,N., DuBuque,T., Favello,A., Gish,W.,
            Hawkins,M., Hultman,M., Kucaba,T., Lacy,M., Le,M., Le,N.,
            Mardis,E., Moore,B., Morris,M., Parsons,J., Prange,C., Rifkin,L.,
            Rohlfing,T., Schellenberg,K., Bento Soares,M., Tan,F.,
            Thierry-Meg,J., Trevaskis,E., Underwood,K., Wohldman,P.,
            Waterston,R., Wilson,R. and Marra,M.
  TITLE     Generation and analysis of 280,000 human expressed sequence tags
  JOURNAL   Genome Res 6 (9), 807-828 (1996)
   PUBMED   8889549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131097.6, BX108328.1, HY129633.1 and AA193593.1.
            
            On May 1, 2020 this sequence version replaced NR_135767.1.
            
            Transcript Variant: This variant (2) encodes the longer isoform
            (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI743188.1, BX108328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404031.6/ ENSP00000490626.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC131097.6         112542-112561       c
            21-39               BX108328.1         6-24
            40-229              BX108328.1         26-215
            230-473             HY129633.1         251-494
            474-608             AA193593.1         6-140               c
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..608
                     /gene="FAM240C"
                     /note="family with sequence similarity 240 member C"
                     /db_xref="GeneID:285095"
                     /db_xref="HGNC:HGNC:54200"
     exon            1..107
                     /gene="FAM240C"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..383
                     /gene="FAM240C"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein FAM240C"
                     /codon_start=1
                     /product="protein FAM240C isoform 2"
                     /protein_id="NP_001369297.1"
                     /db_xref="CCDS:CCDS92996.1"
                     /db_xref="GeneID:285095"
                     /db_xref="HGNC:HGNC:54200"
                     /translation="MVGKNMSKSLTLKNPGRVAYDSGGIKMFWEKKIEHHARHLQNED
                     IRVRRSALNKLRVGWAEQLEGRNKMLQGPGRCPDRVPEATESLHTKDKKAA"
     exon            108..256
                     /gene="FAM240C"
                     /inference="alignment:Splign:2.1.0"
     exon            257..608
                     /gene="FAM240C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      587..592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM240C"
                     /note="hexamer: AATAAA"
     polyA_site      608
                     /gene="FAM240C"
                     /note="major polyA site"
ORIGIN      
        1 aacagagagc ggcaggcgag atacaggcgt gcaccccgga gaggacaggc tgaggaccct
       61 caacagagac aggaaaacct gcccgtcact gagaaatggt tggaaaaaac atgagtaaaa
      121 gcctcactct taagaatcct ggaagagtag catacgattc aggcgggata aagatgtttt
      181 gggagaaaaa aatcgagcat cacgcaagac acctgcagaa cgaggacatc agggttcgca
      241 gaagcgctct gaacaagctc cgcgtgggat gggctgagca gctggagggg aggaacaaga
      301 tgctgcaggg cccagggaga tgcccagaca gggtcccgga ggccactgag tccctccaca
      361 ccaaggacaa gaaggcggcc tgagggccca cgagctccag actctgcatg agcttccgga
      421 gggtcatgga gaaggaacac cacgcgtggg gtccaagcat ccacgccaga gttcacagga
      481 tcttcatcat ggaaatggcc cgcacctcgc tgaccccgta ataatcccac ctcggggtcc
      541 acgctgcagc agagtcccag ggttctctag cgcatctctg gtgcccaata aaacctaagt
      601 caattgga
//
