LOCUS       NM_001384237            3375 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens family with sequence similarity 237 member B
            (FAM237B), mRNA.
ACCESSION   NM_001384237 XR_001745268
VERSION     NM_001384237.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3375)
  AUTHORS   Li,H.Z., Wang,Y.F., Hu,W.F., Liu,Y.L., Xu,Z.G. and Guo,Z.Y.
  TITLE     Nanomolar range of FAM237B can activate receptor GPR83
  JOURNAL   Amino Acids 55 (11), 1557-1562 (2023)
   PUBMED   37689599
REFERENCE   2  (bases 1 to 3375)
  AUTHORS   Sallee,N.A., Lee,E., Leffert,A., Ramirez,S., Brace,A.D.,
            Halenbeck,R., Kavanaugh,W.M. and Sullivan,K.M.C.
  TITLE     A Pilot Screen of a Novel Peptide Hormone Library Identified
            Candidate GPR83 Ligands
  JOURNAL   SLAS Discov 25 (9), 1047-1063 (2020)
   PUBMED   32713278
  REMARK    GeneRIF: A Pilot Screen of a Novel Peptide Hormone Library
            Identified Candidate GPR83 Ligands.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002064.1.
            
            On May 11, 2021 this sequence version replaced NM_001384237.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2148874,
                              SAMEA2161674 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000692316.1/ ENSP00000509180.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               AC002064.1         113195-113577       c
            384-430             AC002064.1         112954-113000       c
            431-3375            AC002064.1         109080-112024       c
FEATURES             Location/Qualifiers
     source          1..3375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.13"
     gene            1..3375
                     /gene="FAM237B"
                     /note="family with sequence similarity 237 member B"
                     /db_xref="GeneID:107986818"
                     /db_xref="HGNC:HGNC:53217"
     exon            1..383
                     /gene="FAM237B"
                     /inference="alignment:Splign:2.1.0"
     exon            384..430
                     /gene="FAM237B"
                     /inference="alignment:Splign:2.1.0"
     exon            431..3375
                     /gene="FAM237B"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..853
                     /gene="FAM237B"
                     /note="protein FAM237B"
                     /codon_start=1
                     /product="protein FAM237B precursor"
                     /protein_id="NP_001371166.1"
                     /db_xref="CCDS:CCDS94139.1"
                     /db_xref="GeneID:107986818"
                     /db_xref="HGNC:HGNC:53217"
                     /translation="MCFATRRWFYLHLGCMMLINLVNADFEFQKGVLASISPGITKDI
                     DLQCWKACSLTLIDLKELKIEHNVDAFWNFMLFLQKSQRPGHYNVFLNIAQDFWDMYV
                     DCLLSRSHGMGRRQVMPPKYNFPQKITGGNLNVYLRE"
     regulatory      1743..1748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM237B"
                     /note="hexamer: ATTAAA"
     polyA_site      1776
                     /gene="FAM237B"
                     /note="major polyA site"
     regulatory      1850..1855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM237B"
                     /note="hexamer: AGTAAA"
     polyA_site      1871
                     /gene="FAM237B"
                     /note="major polyA site"
     regulatory      3350..3355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM237B"
                     /note="hexamer: AATAAA"
     polyA_site      3375
                     /gene="FAM237B"
ORIGIN      
        1 ctgtctcggg aaccccgcgt ggccgcagca gaaccggcag ctccacccgc ggtgagccag
       61 tgccagccag agcctcccag cgccgaagcg caccgcggcc gagacggttc cgctgagcga
      121 gcttgggcgc ccggtgagcg ctcggggtgg gtgacacagc gctgcctcgc ccagttcgcc
      181 tgcctcggga agtgggtccg ctgggcagag ggcgccctgg gcaggggtcg tccccgctga
      241 aacctctggt tcctcgtggg caggaggcgc cccgtcctcc tcccaacgag cgtagcgcac
      301 ccaggacacc gcgccgggac gcgctcctcg gacggcgacc agaggtcctc gactcccgcg
      361 tggcctccct cttctgcgcc cagcccaact tttttaggga ggtggcagac ggctgtgtac
      421 ggggggaaag aatatgtgtt ttgctacaag aagatggttc tatctacatt tgggctgcat
      481 gatgctgatc aatctggtta atgctgactt tgagtttcaa aaaggagtgc ttgccagcat
      541 cagcccagga atcaccaaag acattgatct ccagtgctgg aaagcttgct ctttgacatt
      601 gatagatctc aaggaactca agatagagca caatgtggat gctttttgga atttcatgtt
      661 gttcttgcaa aaatctcagc ggcctggaca ttataatgtc ttcttaaaca tagctcagga
      721 tttctgggac atgtatgtag actgcttgct ttcaagatct catggaatgg gcagaagaca
      781 ggtgatgccc cccaaatata attttccaca gaaaataaca ggaggtaatt taaatgtgta
      841 tttaagagaa tagcagttta cttttcttta aaagtcacta tttaattctt ctgatttttt
      901 tcaagttatc caacaaggta gcaaatttac catatttagt ttttttccct aaaatgatag
      961 gttttgattc tcatttttac tcattttaca ttatttacaa accacacaag ctctgactta
     1021 caattttaaa tgatcttgga atataataca ctttggtaga taattaaaat tatccttgtt
     1081 tgcccatgaa tagttcataa gaaagccatt taaccctgta attattcata ttacatttgt
     1141 tgaagaaatt ttaaacatca gacatgtatt taggcttttg aaattaattt tttcaatagg
     1201 gttgtataaa agcaggaaat ttaagagtca tattggaatg aatattaaca atttcttctt
     1261 ttaaatctta caggactaga ttttacaaaa tgagagtatt acatttaaga gaaaacatgt
     1321 aaaatacctc aagcaagatg acagcgacct gaaaacttgt atttatgagg tcaaatattt
     1381 cttgtcatag ttatacaaat tatttaatac tgataaacgt tgttttttgt tgtaattgct
     1441 ttattgctat tgaattattc caatattttc agataatttc tcaatttttt acttagaagg
     1501 tgtcttttta aagtgtcttt gttttaaaga aaacatcagt taaaaggcaa atgtgatata
     1561 ttttttagat acaatagtca atggaataaa attgtaacca attttataag gtatcttata
     1621 tattaatatt gactattaaa ctgtgccaaa actaatggca gtattatcct aaaaagtaat
     1681 atttaatgta gtatattttg tggtttctga aatgtacatt tcattaccaa gccatcttct
     1741 atattaaagt atttttctat gcattaagga ctaaaacctt tttatgttct catttttatt
     1801 gtctttgttt tgaaaaagga acaataaaca aagacagaaa cttcatttca gtaaagtaca
     1861 atttgataga atttttgtgt tagctgagtt attttttata ttgcctattt atatctcaca
     1921 tcttatttca aaaaggatgt gaagctttaa agaaatatac cgaagaaaag gaaaacatga
     1981 agtagtggag gaaattggaa cattgggaca tgaagacagg gaagtaatac aatggagtta
     2041 cggtttagat taatactttt tgaatgcatg tcgtaaaagc ctataccttt gataaagggt
     2101 gcctataaat ttggtctgtt tcccacttct cctagtgaag agggacacat gaacagtttc
     2161 aagattcaca tgcttataag aaaaaccaaa ccatatgttc aacagaggtc cagccttttc
     2221 caggacaaag aatcaatgaa aatctcaccc ataggttttc acagtggcta ccatggttta
     2281 caacactggt ttcaagtatc cttacaatga cagattctct cctttacagt ctgattccag
     2341 tacactcaaa ctcaaatata aaaagtttta aaatcggcta aaataatact gaacaagtaa
     2401 cgaactgcct gatggtttga cttgatccaa gaataagctg aattaaagga gggacgttct
     2461 ttgcattatt gaccactttc aaattctgat gatgtataga ccatttatta ggggttttat
     2521 atataaacac tcttaaaatt acattttgca tgtaatttca gggggctgca taaaccccag
     2581 gttaggaatt ttcaatatta aaggacctca tagcgttcgg caatattatt tcatataacc
     2641 aattttgcat gagtagcaga taatataaga ttgtagggct aataatttcc tagattgaaa
     2701 acttcttatc ttgccaatta agggtggatc cctaagctca gaaaatcaac tggttggagg
     2761 gtagggctaa ttaatgttct cataaaaatg accagacagc gtgtaaacat gagtgatttt
     2821 atgtccatta agcttttgat ttgtggaatt tatatgacaa ataattagtc tgatatgagt
     2881 ttttaaattt caacatattt tcatattgac actttattac tgtttagctc taatcgaaaa
     2941 gtgatgattc atttgagagg agtcacattt atgtgacagg agtaaaaagt tgagttaatc
     3001 ttgccaagaa ctttcctgtc ctttctcatc tccatattga acatctgtgt tctttatcat
     3061 taaactgctt ttggtctaaa aaaaaaaaaa tgacctgaca gctatccacc tagaattcat
     3121 ttcctgcaga ggagccgaag tggtacctag aggcagtatt acagttttcc tcaaaaaaaa
     3181 cagttctctt ttacagtctg tgggcaaatg attgaagctc aaaagttcaa tgctgtaaag
     3241 tgagaccatg tacttttagt ctaaaaaatt gttcaaccag ttgtcctcaa tcactcatag
     3301 ttgtcatgac aattttattg cagcgatgat aaacatttta gcttaaatca ataaaattag
     3361 tcttccagtt aatgg
//
