LOCUS       NM_001102659            1223 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens family with sequence similarity 237 member A
            (FAM237A), mRNA.
ACCESSION   NM_001102659 XM_117266 XM_937259
VERSION     NM_001102659.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1223)
  AUTHORS   Li,H.Z., Wang,Y.F., Shao,X.X., Liu,Y.L., Xu,Z.G., Wang,S.L. and
            Guo,Z.Y.
  TITLE     FAM237A, rather than peptide PEN and proCCK56-63, binds to and
            activates the orphan receptor GPR83
  JOURNAL   FEBS J 290 (13), 3461-3479 (2023)
   PUBMED   36853120
REFERENCE   2  (bases 1 to 1223)
  AUTHORS   Sallee,N.A., Lee,E., Leffert,A., Ramirez,S., Brace,A.D.,
            Halenbeck,R., Kavanaugh,W.M. and Sullivan,K.M.C.
  TITLE     A Pilot Screen of a Novel Peptide Hormone Library Identified
            Candidate GPR83 Ligands
  JOURNAL   SLAS Discov 25 (9), 1047-1063 (2020)
   PUBMED   32713278
  REMARK    GeneRIF: A Pilot Screen of a Novel Peptide Hormone Library
            Identified Candidate GPR83 Ligands.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010731.3.
            
            On Jul 13, 2020 this sequence version replaced NM_001102659.2.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            CDS exon combination :: BG217192.1, BG215574.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2145743, SAMN03465403 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000441223.4/ ENSP00000490802.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC010731.3         52059-52154
            97-518              AC010731.3         53799-54220
            519-1223            AC010731.3         58233-58937
FEATURES             Location/Qualifiers
     source          1..1223
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.3"
     gene            1..1223
                     /gene="FAM237A"
                     /note="family with sequence similarity 237 member A"
                     /db_xref="GeneID:200726"
                     /db_xref="HGNC:HGNC:52388"
     exon            1..96
                     /gene="FAM237A"
                     /inference="alignment:Splign:2.1.0"
     exon            97..518
                     /gene="FAM237A"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..652
                     /gene="FAM237A"
                     /note="protein FAM237A"
                     /codon_start=1
                     /product="protein FAM237A precursor"
                     /protein_id="NP_001096129.1"
                     /db_xref="CCDS:CCDS82560.1"
                     /db_xref="GeneID:200726"
                     /db_xref="HGNC:HGNC:52388"
                     /translation="MADPGNRGGIHRPLSFTCSLLIVGMCCVSPFFCHSQTDLLALSQ
                     ADPQCWESSSVLLLEMWKPRVSNTVSGFWDFMIYLKSSENLKHGALFWDLAQLFWDIY
                     VDCVLSRNHGLGRRQLVGEEEKISAAQPQHTRSKQGTYSQLLRTSFLKKKELIEDLIS
                     MHVRRSGSSVIGKVNLEIKRK"
     exon            519..1223
                     /gene="FAM237A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1204..1209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM237A"
                     /note="hexamer: AATAAA"
     polyA_site      1223
                     /gene="FAM237A"
                     /note="major polyA site"
ORIGIN      
        1 ctctccacgc gttcgaggga acccggaagg ggccaggcgg gtgagtgcgg agggaagccc
       61 ttgtgccatc tgggagtaga gccgccgagt caggagtttt agggccatgg ctgatcctgg
      121 gaacagagga gggatccacc gccccttgag cttcacctgc tccctgctca ttgtgggaat
      181 gtgctgtgta tctcctttct tctgccatag ccagacagac ttgctggctc ttagccaagc
      241 tgatcctcag tgctgggaat cctcctcagt gcttctcctg gaaatgtgga aacctcgcgt
      301 ttccaacact gtttcaggct tctgggattt tatgatctac ctgaagtcat ctgagaactt
      361 gaagcatgga gcactgtttt gggatctggc ccaactcttc tgggacatct atgtggactg
      421 tgtgctctct aggaaccatg gcttaggaag gaggcaattg gttggagagg aagagaaaat
      481 ctcagcagcg cagccacagc acacaaggag taaacaaggt acatattctc agctcctaag
      541 gacctccttc ctaaagaaga aagagttgat tgaagatttg ataagcatgc atgtgcgtag
      601 gagtgggtct agtgtcattg gaaaagtgaa cctggaaata aagagaaaat aaattgaact
      661 cggagctaat tcatgccttg gaattaaata tacatatata taacattttt cttaactatt
      721 gattatttat ttattttaaa tggtgggaat gcccagagat aaatatgaac ccaaattctc
      781 tcagtatact aatttaaagc tgccttctat tatttattta tttattttag gctgctagca
      841 tgtttcttct aatggtgaca ttactgccag tctatcccac agtctaaagg agttaaataa
      901 cttccagaga tgacttgagg attctttgta ttcatttaat agttcatttt gggatgcttg
      961 acatgttaat aaactagtgt gccatacatt taacttgaat acactgcatg gcttccaaga
     1021 cttcaaccac tggattgctt atgcacaggc acataaggga ctacattttg gaattactag
     1081 ttactgacaa tctatgatat ctgaatcttg tttgacagca tatttttgaa tactgaatga
     1141 agcaaaaagt aaaacaaaac aaaaaactgg caaataaagc attcttctaa tgaaaacaaa
     1201 attaataaaa gctctggacc cca
//
