LOCUS       NP_065904                622 aa            linear   PRI 28-APR-2025
DEFINITION  protein FAM234B [Homo sapiens].
ACCESSION   NP_065904 XP_370682
VERSION     NP_065904.1
DBSOURCE    REFSEQ: accession NM_020853.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 622)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 622)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023790.21.
            
            On Apr 26, 2005 this sequence version replaced XP_370682.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039267.1, SRR1803614.56413.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000197268.13/ ENSP00000197268.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.1"
     Protein         1..622
                     /product="protein FAM234B"
                     /calculated_mol_wt=66908
     Region          1..68
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RU67.1)"
     Site            16
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:19690332; propagated from
                     UniProtKB/Swiss-Prot (A2RU67.1)"
     Site            26
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (A2RU67.1)"
     Site            30
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (A2RU67.1)"
     Site            33
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:19690332; propagated from
                     UniProtKB/Swiss-Prot (A2RU67.1)"
     Site            62
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (A2RU67.1)"
     Site            104..124
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RU67.1)"
     CDS             1..622
                     /gene="FAM234B"
                     /gene_synonym="KIAA1467"
                     /coded_by="NM_020853.2:24..1892"
                     /db_xref="CCDS:CCDS31750.1"
                     /db_xref="GeneID:57613"
                     /db_xref="HGNC:HGNC:29288"
                     /db_xref="MIM:617838"
ORIGIN      
        1 matvlsralk lpgkkspdlg eydpltqads deseddlvln lqknggvkng ksplgeapep
       61 dsdaevaeaa kphlsevtte gypseplggl eqkaasslvs yvrtsvfllt lgismilvll
      121 caflipcppr dlhstwsrhl gsqgggdlsp leladvngdg lrdvllsfvm srngsavgvs
      181 rpaanlvcls gmngstlwss llpeeardit clelmpgsla eticlvtgth kmlsafnats
      241 gkaiwtlnpn ylsngtlaap vvvlpdlded gvrdlvvlai gelqpdlcfl lvsgrtgnpv
      301 grpvkynivg vgnligpqvy ittngavyil fgfgniqava lrdifvqaqn rdssppslqi
      361 eepewekrrs inlselidvy sdgvellqmv kapdsncsnl littrqslvl lrgqnltpyw
      421 alrlqglrsq ptpgyftddq tldfllqiqd gvgmkkmmvv dgdsgsivws yrapchmket
      481 patsavtsdq ksvflfwaeg lsaaspnsdi ilgteppslh hlyllhpafp silldlantt
      541 gtvtasevgi ndlwkdafyv trttgpsseg hpaalvvskl slrwalmegq maqlqestpk
      601 igrgelrrfl srikfveapy ei
//
