LOCUS       NM_032039               2909 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 234 member A
            (FAM234A), transcript variant 1, mRNA.
ACCESSION   NM_032039
VERSION     NM_032039.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2909)
  AUTHORS   Ding,K., de Andrade,M., Manolio,T.A., Crawford,D.C.,
            Rasmussen-Torvik,L.J., Ritchie,M.D., Denny,J.C., Masys,D.R.,
            Jouni,H., Pachecho,J.A., Kho,A.N., Roden,D.M., Chisholm,R. and
            Kullo,I.J.
  TITLE     Genetic variants that confer resistance to malaria are associated
            with red blood cell traits in African-Americans: an electronic
            medical record-based genome-wide association study
  JOURNAL   G3 (Bethesda) 3 (7), 1061-1068 (2013)
   PUBMED   23696099
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2909)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 2909)
  AUTHORS   Teckchandani,A., Toida,N., Goodchild,J., Henderson,C., Watts,J.,
            Wollscheid,B. and Cooper,J.A.
  TITLE     Quantitative proteomics identifies a Dab2/integrin module
            regulating cell migration
  JOURNAL   J Cell Biol 186 (1), 99-111 (2009)
   PUBMED   19581412
REFERENCE   4  (bases 1 to 2909)
  AUTHORS   Wollscheid,B., Bausch-Fluck,D., Henderson,C., O'Brien,R., Bibel,M.,
            Schiess,R., Aebersold,R. and Watts,J.D.
  TITLE     Mass-spectrometric identification and relative quantification of
            N-linked cell surface glycoproteins
  JOURNAL   Nat Biotechnol 27 (4), 378-386 (2009)
   PUBMED   19349973
  REMARK    Erratum:[Nat Biotechnol. 2009 Sep;27(9):864]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN262982.1, AC004754.1, AL136542.1 and BC032112.2.
            
            On Nov 23, 2018 this sequence version replaced NM_032039.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.258763.1,
                                           SRR1660805.192324.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399932.8/ ENSP00000382814.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                CN262982.1         276-288
            14-14               AC004754.1         1509-1509
            15-2281             AL136542.1         3-2269
            2282-2909           BC032112.2         2250-2877
FEATURES             Location/Qualifiers
     source          1..2909
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2909
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /note="family with sequence similarity 234 member A"
                     /db_xref="GeneID:83986"
                     /db_xref="HGNC:HGNC:14163"
     exon            1..37
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /inference="alignment:Splign:2.1.0"
     exon            38..143
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /inference="alignment:Splign:2.1.0"
     exon            144..444
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1835
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /note="protein ITFG3; integrin alpha FG-GAP repeat
                     containing 3"
                     /codon_start=1
                     /product="protein FAM234A"
                     /protein_id="NP_114428.1"
                     /db_xref="CCDS:CCDS10402.1"
                     /db_xref="GeneID:83986"
                     /db_xref="HGNC:HGNC:14163"
                     /translation="MLDHKDLEAEIHPLKNEERKSQENLGNPSKNEDNVKSAPPQSRL
                     SRCRAAAFFLSLFLCLFVVFVVSFVIPCPDRPASQRMWRIDYSAAVIYDFLAVDDING
                     DRIQDVLFLYKNTNSSNNFSRSCVDEGFSSPCTFAAAVSGANGSTLWERPVAQDVALV
                     ECAVPQPRGSEAPSACILVGRPSSFIAVNLFTGETLWNHSSSFSGNASILSPLLQVPD
                     VDGDGAPDLLVLTQEREEVSGHLYSGSTGHQIGLRGSLGVDGESGFLLHVTRTGAHYI
                     LFPCASSLCGCSVKGLYEKVTGSGGPFKSDPHWESMLNATTRRMLSHSSGAVRYLMHV
                     PGNAGADVLLVGSEAFVLLDGQELTPRWTPKAAHVLRKPIFGRYKPDTLAVAVENGTG
                     TDRQILFLDLGTGAVLCSLALPSLPGGPLSASLPTADHRSAFFFWGLHELGSTSETET
                     GEARHSLYMFHPTLPRVLLELANVSTHIVAFDAVLFEPSRHAAYILLTGPADSEAPGL
                     VSVIKHKVRDLVPSSRVVRLGEGGPDSDQAIRDRFSRLRYQSEA"
     exon            445..561
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /inference="alignment:Splign:2.1.0"
     exon            562..753
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /inference="alignment:Splign:2.1.0"
     exon            754..884
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1017
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1147
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1288
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1364
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1520
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1623
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..2909
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2882..2887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /note="hexamer: AATAAA"
     polyA_site      2909
                     /gene="FAM234A"
                     /gene_synonym="C16orf9; gs19; ITFG3"
                     /note="major polyA site"
ORIGIN      
        1 gccagcggcg cggtcgggtg agaggccgcg gcggcaggtc cacctgggct tgcgaaggca
       61 cagattcccc gtccacagct cacgaccaga tgcaccagca ggagtccaca tcgaggacgt
      121 cctccgggca ctcccacgac cagtgaccag gagttaaact ttgggatgtg cccgtgatgt
      181 tggaccacaa ggacttagag gccgaaatcc accccttgaa aaatgaagaa agaaaatcgc
      241 aggaaaatct gggaaatcca tcaaaaaatg aggataacgt gaaaagcgcg cctccacagt
      301 cccggctctc ccggtgccga gcggcggcgt tttttctttc attgtttctc tgcctttttg
      361 tggtgttcgt cgtctcattc gtcatcccgt gtccagaccg gccggcgtca cagcgaatgt
      421 ggaggataga ctacagtgcc gctgttatct atgactttct ggctgtggat gatataaacg
      481 gggacaggat ccaagatgtt ctttttcttt ataaaaacac caacagcagc aacaatttca
      541 gccgatcctg tgtggacgaa ggcttttcct ctccctgcac ctttgcagct gctgtgtcgg
      601 gggccaacgg cagcacgctc tgggagagac ctgtggccca agacgtggcc ctcgtggagt
      661 gtgctgtgcc ccagccaaga ggcagtgagg caccttctgc ctgcatcctg gtgggcagac
      721 ccagttcttt cattgcagtc aacttgttca caggggaaac cctgtggaac cacagcagca
      781 gcttcagcgg gaatgcgtcc atcctgagcc ctctgctgca ggtgcctgat gtggacggcg
      841 atggggcccc agacctgctg gttctcaccc aggagcggga ggaggttagt ggccacctct
      901 actccggcag caccgggcac cagattggcc tcagaggcag ccttggtgtg gacggggaaa
      961 gtggcttcct ccttcacgtc accaggacag gtgcccacta catcctcttt ccctgcgcaa
     1021 gctccctctg cggctgctct gtgaagggtc tctacgagaa ggtgaccggg agcggcggcc
     1081 cgttcaagag tgacccgcac tgggagagca tgctcaatgc caccacccgc aggatgcttt
     1141 cccacagctc tggagcagtg cgctacctga tgcatgtccc agggaacgcc ggtgcagatg
     1201 tgcttcttgt gggctcagag gccttcgtgc tgctggacgg gcaggagctg acgcctcgct
     1261 ggacacccaa ggcagcccat gtcctgagaa aacccatctt cggccgctac aaaccagaca
     1321 ccttggctgt agccgttgaa aacggaactg gcaccgacag acagatcctg tttctggacc
     1381 ttggcactgg agccgtcctg tgtagcctag ccctcccgag cctccctggg ggtccactgt
     1441 ccgccagcct gccgaccgca gaccaccgct cagccttctt cttctggggc ctccacgagc
     1501 tggggagcac cagcgagacg gagaccgggg aggcccggca cagcctgtac atgttccacc
     1561 ccaccctgcc gcgcgtgctg ctggagctgg ccaatgtctc tacccacatt gtcgcctttg
     1621 acgccgtcct gtttgagcca agccgccacg ccgcctacat ccttctgaca ggcccggcag
     1681 actcagaggc acccggcctg gtctctgtga tcaagcacaa ggtgcgggac cttgtcccaa
     1741 gcagcagggt ggtccgcctg ggtgagggtg ggccagacag tgaccaagcc atcagggacc
     1801 ggttctcccg gctgcggtac cagagtgagg cgtagaggca cgccagccag agcctgtgga
     1861 gagactccgc ctgctgacac taaacgtcct gggaagtggg cccttccctg ggtctctgca
     1921 ctgactcccc cactcctgac cctggtgatg gtcgccactg ggcagcagca gccttaccag
     1981 tcctccatga tcacacccag ggacctgcat gggtgagggg acaccctggg cctctctccc
     2041 gcccagcatc ctccctgagt ccccacacag ggcctcactc tgcaccccac cagggtcccg
     2101 ctcacaccag gcagccttca tagtggtctc cctggccacc ttgggcagag ctgggtcatg
     2161 cagcacccca tccttacccg gtgccctctc cttgccagct tctccccagg ccagagcggc
     2221 catcgcgtag aaagaaccag ggtgtccccg ggacaggccg tcccccaccc catcctgtag
     2281 aagtccattc cccttttccc tcctgtgctc tgtcccccaa ggagtcatgg aactcagggt
     2341 actgggcctc aacgggaacc tgagacagct ccagcttcgc agcccttccc ggagctacag
     2401 ggggatcctc tagcatgggg ggtgtgactt ggttcctttg accaggtcct gtgaggaagc
     2461 ctggagcaag ggtctccccc agcaggatgg gtggggcctg ctctggagct gagcccgtgg
     2521 ccgctcacag gtgtccttag tggtgttgca gctgtctact ggctgcatgt gctgtgaata
     2581 tcccaaggaa ctggctgtgg aatgcgtgtt tgggtcagtc tgtgccctct cagtagacac
     2641 tggagctgct ctgtccctga agaggccccg tgccccaggc atggcaagcg cctgcctctc
     2701 cccttccggt gctcacacgc ccacgccgtg ccacccgatg caggactcac ctctgtgcct
     2761 tgctgctcct gaggcccaag ggcagccatg gtgctctgta ctgctcgggc cgcccaggtc
     2821 acagagcctg agcttcgtag ccaaagcagc ctgatgaccc acccaccaag gaagaaagca
     2881 gaataaacat ttttgcactg cctgaaaaa
//
