LOCUS       NM_001145710            1369 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens family with sequence similarity 228 member B
            (FAM228B), transcript variant 1, mRNA.
ACCESSION   NM_001145710 XR_040244 XR_040245 XR_040246
VERSION     NM_001145710.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1369)
  AUTHORS   Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z.,
            Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S.,
            McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J.,
            Dunham,I., Hill,D.E. and Vidal,M.
  TITLE     hORFeome v3.1: a resource of human open reading frames representing
            over 10,000 human genes
  JOURNAL   Genomics 89 (3), 307-315 (2007)
   PUBMED   17207965
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008073.4, CN395744.1, BC029459.1 and BM969566.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001145710.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.222392.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000615575.5/ ENSP00000482482.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC008073.4         75550-75560
            12-594              CN395744.1         13-595
            595-595             AC008073.4         98885-98885
            596-610             CN395744.1         597-611
            611-831             BC029459.1         480-700
            832-832             AC008073.4         113635-113635
            833-1050            BC029459.1         702-919
            1051-1051           BM969566.1         336-336             c
            1052-1369           BC029459.1         921-1238
FEATURES             Location/Qualifiers
     source          1..1369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..1369
                     /gene="FAM228B"
                     /note="family with sequence similarity 228 member B"
                     /db_xref="GeneID:375190"
                     /db_xref="HGNC:HGNC:24736"
     exon            1..65
                     /gene="FAM228B"
                     /inference="alignment:Splign:2.1.0"
     exon            66..196
                     /gene="FAM228B"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1072
                     /gene="FAM228B"
                     /note="isoform a is encoded by transcript variant 1;
                     UPF0638 protein B; protein FAM228B"
                     /codon_start=1
                     /product="protein FAM228B isoform a"
                     /protein_id="NP_001139182.1"
                     /db_xref="CCDS:CCDS74491.1"
                     /db_xref="GeneID:375190"
                     /db_xref="HGNC:HGNC:24736"
                     /translation="MKNVDSDDLVTGTLPKLKSSKEWLEPKPLCFMEVLAKEDTEAAI
                     QSILYKENSVIKELDKYLQHHAFLNARRKEMLYKRWVDCVADPLQKKIIEKVCSHKKI
                     KKRRQGELDGFLKHVNKKGNAFIEHYDPKEYDPFYMSKKDPNFLKVTIPPFHDPLKKA
                     QYDKDNEKRTLLQCETGKIYSIKEFKEVEKVQLHSRFPQISNSRHFITPNEWLKLPTR
                     YIESEFCRRRRLKVKVNFNDCSFDLKPLARAPYLLESQEEEKTVIYKNKGSSFLEREP
                     LCYQEGNNPSAKEAISEGYFSSLSLSQEREEDQDGSPSPRLGLLKLEL"
     exon            197..265
                     /gene="FAM228B"
                     /inference="alignment:Splign:2.1.0"
     exon            266..457
                     /gene="FAM228B"
                     /inference="alignment:Splign:2.1.0"
     exon            458..538
                     /gene="FAM228B"
                     /inference="alignment:Splign:2.1.0"
     exon            539..626
                     /gene="FAM228B"
                     /inference="alignment:Splign:2.1.0"
     exon            627..783
                     /gene="FAM228B"
                     /inference="alignment:Splign:2.1.0"
     exon            784..891
                     /gene="FAM228B"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1029
                     /gene="FAM228B"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1086
                     /gene="FAM228B"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1369
                     /gene="FAM228B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1345..1350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM228B"
                     /note="hexamer: AATAAA"
     polyA_site      1369
                     /gene="FAM228B"
                     /note="major polyA site"
ORIGIN      
        1 ggactcgctg tggaacccgc ggcgcagggg gcggagtgct cgcgcggcgc tgcgtccggg
       61 agacgttttt ccaggggcat tgttatttgt gaccacaatg aaaaatgtag acagtgatga
      121 tctggtaact ggcacacttc ccaagctcaa gagctcaaaa gaatggttgg agcccaagcc
      181 cctttgtttt atggaggttt tagctaaaga agatactgag gcagctattc aatcaatatt
      241 atacaaagaa aattctgtaa ttaaggaact agataagtat ttacaacatc atgccttctt
      301 aaatgcaaga agaaaggaga tgttatataa aagatgggtt gactgtgtgg cagatcctct
      361 tcagaagaaa attatagaaa aagtttgctc acataagaag attaaaaaaa ggaggcaagg
      421 ggaattagat ggctttttaa aacatgtaaa taaaaaggga aatgcattta tagaacatta
      481 tgatccaaaa gagtatgatc ccttttatat gagcaagaag gaccccaatt ttctgaaggt
      541 taccatccca ccatttcatg accctttgaa aaaagcacaa tatgacaagg ataacgaaaa
      601 aagaactctt cttcagtgtg agactggcaa aatatattca ataaaggaat tcaaagaagt
      661 tgagaaggtt cagctgcatt ccagattccc acaaatttct aattcaaggc actttataac
      721 tccaaacgag tggctgaaac tgcctacaag atacatagaa agtgaatttt gtagaaggag
      781 aaggttaaag gtgaaagtga attttaatga ctgtagtttt gatttgaaac ctttggcaag
      841 agctccttat cttttggaat cccaggaaga agaaaaaaca gttatttaca aaaacaaagg
      901 gtcatccttt ctagaaagag aaccgctgtg ctatcaggag ggaaataatc caagtgccaa
      961 agaggccatc tctgaagggt atttttcttc cttgagcctc agccaggaac gggaggaaga
     1021 ccaggatggg tctccctccc cgcgtttggg gctgctgaag ctggagctat aagaaagaag
     1081 agggaggttt cagcaaccaa ggagcacaca ccctgatcct tgattggtga aaggatacac
     1141 aaaatcaggc tgcttcagag gaagtcatct gctcacagga atcagggtga aggccaagga
     1201 cggcactcaa gaattgtcct gtctctaaaa aaaaagcatc tgcaacgaac ttcctttaat
     1261 ttttgagttc agtgtctgtg ataattaaga aatggcaata ccatgtattt tccccagaag
     1321 ttaagaaata ttgctgaacg aaccaataaa aataattaca gctccctca
//
