LOCUS       NM_001040710            1824 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 228 member A
            (FAM228A), mRNA.
ACCESSION   NM_001040710 XM_926573 XM_931412 XM_931416 XM_939040 XM_943992
            XM_943995 XM_943997
VERSION     NM_001040710.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1824)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1824)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1824)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1824)
  AUTHORS   Greliche,N., Germain,M., Lambert,J.C., Cohen,W., Bertrand,M.,
            Dupuis,A.M., Letenneur,L., Lathrop,M., Amouyel,P., Morange,P.E. and
            Tregouet,D.A.
  TITLE     A genome-wide search for common SNP x SNP interactions on the risk
            of venous thrombosis
  JOURNAL   BMC Med Genet 14, 36 (2013)
   PUBMED   23509962
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY022970.1, BC050462.1 and AC008073.4.
            
            On Nov 23, 2018 this sequence version replaced NM_001040710.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050462.1, SRR5189667.245105.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295150.8/ ENSP00000295150.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                HY022970.1         12-61
            51-1258             BC050462.1         1-1208
            1259-1259           AC008073.4         143213-143213
            1260-1824           BC050462.1         1210-1774
FEATURES             Location/Qualifiers
     source          1..1824
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..1824
                     /gene="FAM228A"
                     /gene_synonym="C2orf84"
                     /note="family with sequence similarity 228 member A"
                     /db_xref="GeneID:653140"
                     /db_xref="HGNC:HGNC:34418"
     exon            1..122
                     /gene="FAM228A"
                     /gene_synonym="C2orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            123..229
                     /gene="FAM228A"
                     /gene_synonym="C2orf84"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..757
                     /gene="FAM228A"
                     /gene_synonym="C2orf84"
                     /note="UPF0638 protein C2orf84"
                     /codon_start=1
                     /product="protein FAM228A"
                     /protein_id="NP_001035800.1"
                     /db_xref="CCDS:CCDS42659.1"
                     /db_xref="GeneID:653140"
                     /db_xref="HGNC:HGNC:34418"
                     /translation="MAATKTASYDEHFRPEKLREWPEPESVSLMEVLAREDIDEAVCA
                     ILFKENSIVKVTVPPFVDPLFQRQQEVDEERRTGLQCETGKRHSIKELEEIEKARLHA
                     SSPYFTFTSHCVIPKEWHKASARARSKTYKYSPEKLIYADKKQKRKEKKTADLSQAAF
                     ERQFLSSKLSQKNKVGERKGLVSRGLGRGWHAGLCSTHEQHILVPE"
     exon            230..298
                     /gene="FAM228A"
                     /gene_synonym="C2orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            299..386
                     /gene="FAM228A"
                     /gene_synonym="C2orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            387..537
                     /gene="FAM228A"
                     /gene_synonym="C2orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            538..1824
                     /gene="FAM228A"
                     /gene_synonym="C2orf84"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1802..1807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM228A"
                     /gene_synonym="C2orf84"
                     /note="hexamer: AATATA"
     polyA_site      1824
                     /gene="FAM228A"
                     /gene_synonym="C2orf84"
                     /note="major polyA site"
ORIGIN      
        1 atgcgccccg acgctcgggc ccgcgggctc ctttctccgt cgccgctcca ggacgcggcc
       61 tcgggggagc cctaccggga cggagccgcg gggcctgcga cttcccccgg agctggcctg
      121 agggattctc ctgtccatgg ctgccaccaa aactgcgagt tatgatgaac atttcaggcc
      181 agaaaagtta agagaatggc cggagcccga gtccgtttct ttaatggagg tattagctag
      241 agaagacatt gatgaagcag tatgtgcaat attatttaaa gaaaattcca ttgtgaaggt
      301 tacagtccca ccatttgttg atcctctgtt tcaaagacag caagaggtgg atgaagagag
      361 gagaactggt cttcagtgtg agacaggaaa acgacattcc ataaaagaac ttgaagaaat
      421 agagaaggcc aggctgcatg ccagctcgcc ctacttcact ttcacttcac actgtgtgat
      481 tccaaaagag tggcataaag cctctgcaag agccaggagt aaaacttaca aatacagtcc
      541 tgaaaagctc atctatgcag acaagaaaca gaaaagaaaa gagaaaaaga cggccgacct
      601 aagtcaggct gcgtttgaaa ggcagttcct ttcctcaaag ctcagccaga agaacaaagt
      661 gggtgaaaga aagggtctgg tgagcagagg cctggggcgg ggctggcatg cagggctttg
      721 cagcacccac gagcagcaca tactggttcc agaatgagcc accgccacag ccctccctgt
      781 cagacaggca cccaagggcg gaggaggcat ggcccaagaa gaagggtgtg aagaggagga
      841 gggagaaatg gcggtggcct caggctcagc actgcagctc tgacagggcc cctcgggcgg
      901 ggaagccttg catgaagaaa ctcagacaag tggtaaatgt gggacctgga ccccactttc
      961 cggagacatc ctgtccttcc gaggtgaggg ccaacctggc cacaggggct tttccccctg
     1021 agatttcttc agcgccttcg cccgggcctt tgcccttctg ccactttcct accattttcc
     1081 acttactcca tccaaactgc accaaagatg gtgttctcct tagtccacac acaactggtg
     1141 ggaagttttt gaaatgaaat ttataccaaa aaattagggc aagatgagat tttttgatat
     1201 ttaaaaggta tttttatatg taggaatttt ctgagtatgg atttcttatc cagagctcat
     1261 ggttcatttg acacagtttt cagctcctgg tctatttccc cttccattct ctccgccacg
     1321 ccctgtgccc tgaggcctga ggcgcaggac cctcccaggg aaggcctagg gggcttggtg
     1381 ggccaccgct cagctcagga cctgacagcg tcactcccac cctcaccacc acacacacag
     1441 gatgggggac tgctgctgct ttccagcctg tgagcctgga taggtatttt gtgacccagc
     1501 tcctgctcag tcccatcgct gtccccggtc tctccaggga gtaagggatt ctccgtctgt
     1561 ggtaagttac ctgtgactct tcagcagttt cctctgagca taattatatc tgagagcaca
     1621 gggagctcct cattccatgt atttttcaaa tattcaagat gtacaacgtg atgatttgct
     1681 ataggtattc attgtgaaat gtttgccaca gtcaagcttg ttgacatacc caccagctca
     1741 catttactgt tttcgtgtgt gtggtgagaa tactcacaat ctactctctg agcaaactgc
     1801 aaatatatgt tattagtaac tgta
//
