LOCUS       NM_152647               3316 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 227 member B
            (FAM227B), transcript variant 1, mRNA.
ACCESSION   NM_152647
VERSION     NM_152647.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3316)
  AUTHORS   Porcu,E., Medici,M., Pistis,G., Volpato,C.B., Wilson,S.G.,
            Cappola,A.R., Bos,S.D., Deelen,J., den Heijer,M., Freathy,R.M.,
            Lahti,J., Liu,C., Lopez,L.M., Nolte,I.M., O'Connell,J.R.,
            Tanaka,T., Trompet,S., Arnold,A., Bandinelli,S., Beekman,M.,
            Bohringer,S., Brown,S.J., Buckley,B.M., Camaschella,C., de
            Craen,A.J., Davies,G., de Visser,M.C., Ford,I., Forsen,T.,
            Frayling,T.M., Fugazzola,L., Gogele,M., Hattersley,A.T.,
            Hermus,A.R., Hofman,A., Houwing-Duistermaat,J.J., Jensen,R.A.,
            Kajantie,E., Kloppenburg,M., Lim,E.M., Masciullo,C., Mariotti,S.,
            Minelli,C., Mitchell,B.D., Nagaraja,R., Netea-Maier,R.T.,
            Palotie,A., Persani,L., Piras,M.G., Psaty,B.M., Raikkonen,K.,
            Richards,J.B., Rivadeneira,F., Sala,C., Sabra,M.M., Sattar,N.,
            Shields,B.M., Soranzo,N., Starr,J.M., Stott,D.J., Sweep,F.C.,
            Usala,G., van der Klauw,M.M., van Heemst,D., van Mullem,A.,
            Vermeulen,S.H., Visser,W.E., Walsh,J.P., Westendorp,R.G., Widen,E.,
            Zhai,G., Cucca,F., Deary,I.J., Eriksson,J.G., Ferrucci,L.,
            Fox,C.S., Jukema,J.W., Kiemeney,L.A., Pramstaller,P.P.,
            Schlessinger,D., Shuldiner,A.R., Slagboom,E.P., Uitterlinden,A.G.,
            Vaidya,B., Visser,T.J., Wolffenbuttel,B.H., Meulenbelt,I.,
            Rotter,J.I., Spector,T.D., Hicks,A.A., Toniolo,D., Sanna,S.,
            Peeters,R.P. and Naitza,S.
  TITLE     A meta-analysis of thyroid-related traits reveals novel loci and
            gender-specific differences in the regulation of thyroid function
  JOURNAL   PLoS Genet 9 (2), e1003266 (2013)
   PUBMED   23408906
REFERENCE   2  (bases 1 to 3316)
  AUTHORS   Teumer,A., Rawal,R., Homuth,G., Ernst,F., Heier,M., Evert,M.,
            Dombrowski,F., Volker,U., Nauck,M., Radke,D., Ittermann,T.,
            Biffar,R., Doring,A., Gieger,C., Klopp,N., Wichmann,H.E.,
            Wallaschofski,H., Meisinger,C. and Volzke,H.
  TITLE     Genome-wide association study identifies four genetic loci
            associated with thyroid volume and goiter risk
  JOURNAL   Am J Hum Genet 88 (5), 664-673 (2011)
   PUBMED   21565293
REFERENCE   3  (bases 1 to 3316)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057362.1, BC048125.1, BG182490.1 and AC022306.6.
            
            On May 17, 2019 this sequence version replaced NM_152647.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057362.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299338.11/ ENSP00000299338.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               AK057362.1         102-462
            362-836             BC048125.1         467-941
            837-1889            AK057362.1         938-1990
            1890-1893           BG182490.1         14-17               c
            1894-3316           AC022306.6         80387-81809         c
FEATURES             Location/Qualifiers
     source          1..3316
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..3316
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /note="family with sequence similarity 227 member B"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
     exon            1..119
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            120..242
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1718
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM227B"
                     /codon_start=1
                     /product="protein FAM227B isoform 1"
                     /protein_id="NP_689860.2"
                     /db_xref="CCDS:CCDS32237.1"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
                     /translation="MAGQRTCQRRSSRAGPGKMQEPPKSIEEFLKFQNWDYWPREIHF
                     RDDDKWSCTLKKIKEDSSFVSIYTHLWENVPRIFEALLIMESKLKEYSLILQNHTSEI
                     FKWKSMISETSSYRKLERYGEFLKKYHKKKKIMLSDEMETEKNIEGCSFTGFKANELT
                     QLPRHLDAEQIYLFILKAHNFDERVFKIWKTHFLSEASIALLHDSFWWWFLHKFRPDR
                     ENQDCLFDRISESYVTLFMSIPLSRKDAFFQIYPDCLAQAIYATFHEAFPESSYLFND
                     EFKEDLGNNIFLWCSGLKPQKGFWIHWKLKELSTTTIHGSKKAPAKSVKERIADSQEH
                     ISTSIDFNIIKILNNPRAYTLPISKEESRLSRLATKSHYSSTGPEFNRVLFNFGGQSP
                     LILYYLKMHELAGISKAPKKTKIKLTKIFQEPLPAPTYRDVIKEAKRQFARNQKDFRI
                     LQAKATKKPHEVKQDFEKFLHKLRSEAEIERECVASLSSSSSSSPSSTDNYNFEEEEY
                     "
     exon            243..296
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            297..528
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            529..596
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            597..632
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            633..737
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            738..836
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            837..938
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1065
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1203
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1301
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1462
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1540
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1610
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..3316
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1866..1871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /note="hexamer: AATAAA"
     polyA_site      1893
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /note="major polyA site"
     regulatory      3269..3274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /note="hexamer: AATAAA"
     polyA_site      3289
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
     regulatory      3297..3302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /note="hexamer: ATTAAA"
     polyA_site      3316
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
ORIGIN      
        1 gcgttcgtcc gggacccgcc tcaagcctcg cagcctttca cccagtttcc tcccgattct
       61 tgctgggaca acaaaattgg gaagcggttc tcgaaacata ctgtcaaggc gtagttgcat
      121 ttggtcgccc aactcacatt gaagcctaag acccagctga tttctcttca tttctgcaaa
      181 gttactgtac catggcaggc caacgaacat gtcaaaggag gagcagcaga gctggccccg
      241 ggaaaatgca agaacctcca aagagcattg aagaattctt aaagtttcaa aattgggatt
      301 attggccaag ggaaatccat tttagagatg atgataaatg gtcatgcact ctgaaaaaaa
      361 taaaagaaga tagttcattt gtttcaattt atacacacct atgggaaaat gttcctcgaa
      421 tatttgaagc acttttgatc atggaatcaa aattaaagga atattcactt attttgcaaa
      481 accacacctc tgaaatattt aagtggaaaa gcatgatttc tgagacaagt tcttatagaa
      541 aattggaacg atatggggaa tttctaaaga agtaccataa gaaaaaaaag ataatgcttt
      601 cagatgaaat ggagacagag aagaatatag agggttgcag cttcacagga ttcaaagcaa
      661 atgaacttac tcagctaccc agacatttgg atgctgaaca aatttatctt tttattttaa
      721 aagcccataa ttttgatgaa agagttttta aaatctggaa gactcatttt ctctcagaag
      781 cctccattgc tcttttgcat gactcctttt ggtggtggtt tctccataaa tttaggcctg
      841 acagagaaaa ccaagattgc ttattcgata gaatttcaga aagttatgtg acacttttca
      901 tgagcatacc tctaagtcga aaggatgcat tttttcagat atatcctgat tgtttggcac
      961 aagccatata tgcaacgttc catgaagcat ttccagaatc gagttacctc tttaatgatg
     1021 aatttaaaga agatctaggg aataacattt ttctttggtg ttcaggttta aaacctcaaa
     1081 aaggcttttg gatccactgg aaactgaaag aactctccac aaccaccatt catggtagca
     1141 aaaaagcacc tgcaaaatca gtaaaggaaa gaattgcaga cagtcaagaa catatatcaa
     1201 ctagtatcga cttcaatatt ataaagattc tgaacaaccc aagagcatat acgttgccca
     1261 tatccaagga agaatcaaga ttatcaagac tagcaacaaa gtcgcactat agtagtactg
     1321 gtccagagtt taatcgtgtt ctcttcaatt ttggaggtca gagtccattg attttatatt
     1381 atcttaagat gcatgagctg gctggtattt ccaaagcacc taagaaaacc aagattaaac
     1441 tcactaagat attccaggaa ccactacctg ctccaacata ccgtgatgtt ataaaggagg
     1501 caaaaagaca atttgcaagg aaccaaaagg attttaggat actccaagca aaggctacca
     1561 agaaacctca tgaagtgaaa caggactttg agaagttcct acataaactg cgttccgaag
     1621 ctgaaattga gagagaatgt gtggcatcac tatcgtcatc atcatcatca tcaccatcat
     1681 caacagacaa ctacaacttt gaggaagaag aatactaaga gaaaccagaa atgaactcta
     1741 ttcaagaata atgcatacaa ttcagtggta tcagtttaat tgtaacaata tatttaattc
     1801 aagtccaatc catgtaatca gtattaagag tgtgttttac cattcatctt taaaatcttc
     1861 aaatcaataa atctcagtaa gttattctta aaagatctgt ccaagcatga tcttggctct
     1921 taatagtaaa accatatttt aagatggaaa aagaatcatt atgaagcata gagagctttc
     1981 aaccatttct ttgaaaatat atcttgatat aatagcaacc gttcatcata atacaaaaca
     2041 gaaggaagat taatttactg tggcacagaa agtcctgcca attcctaagt gccctaagta
     2101 gtttctctca gactttttac attttttcag gcctcaagca aaaccaaagc cccacctcca
     2161 ggtttggtag caaacaaact ttgcttctcc ggtgctaagc ttccatcact cctctggtaa
     2221 taagctttgt gcacatttgc tagaaagctg ggcagcttgt ccgcaggtac cattgatact
     2281 gtgcagcctc cccatcctgc tccagtaagt cgtgaccctt gagccccaaa cttcctaaaa
     2341 cagtgaggaa aaaaatatta gaacctataa atgaaaatac aagggatttg cttggtgttt
     2401 gtagaacaca tagcctatct aagttctaag aagaaaatac atgcggggtt tttaggtgtc
     2461 atcaaacatt ttaggacatt aagacattta tactgtttca gagagtgatt tggaattttt
     2521 tcattgtatc taaatctagt ccctggtttt gactccaagt ggtaagtcaa cagtactcct
     2581 cccatttcat gactggcaat aacccactgt aatattgatt ccataaagta gccacttgaa
     2641 gagttgtata gcaagcttac acgtaaatca ggaaggaggc gttaagataa aacaggcaat
     2701 ggtaaaagaa atgtaggcaa ccctgaatca gaaggtcact ccaaatgagg acaaatcaaa
     2761 atttaaaatg tacagtctta tacaagtttt ccccaatggc tatttcagct gcattcttaa
     2821 ggccgggctg tttcaaagaa gaatcagtcc cctagaacag atagcctagt tcactgaata
     2881 aacttatcaa caaaaagcgt gttattaaac tccaggttgg gtcggtggtt ggttgaatct
     2941 ctaatggaaa attaaccaag cctttccaca aagcagaggg cagtccctag aggtccacac
     3001 caccttccct gtgccttctg gagctagtct gattattgga ctcagaagtt gacatcagat
     3061 gagatatatc tgattgggat gacaacaact atataaagga ccacacagct agagttaatt
     3121 ttagttactg taaaccaggc acagtttcaa acctaagatt tcaaccaaag tgaaaggccc
     3181 tatcacaatg tacacagatc acttagcttt aaaagatgca atttatcctg acacgaaagt
     3241 taacatgtac ttacaattaa ttcttcttaa taaaattcac tccaaattac tagtggatta
     3301 aaggctctat gattaa
//
