LOCUS       NM_001077498            4128 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 222 member B
            (FAM222B), transcript variant 1, mRNA.
ACCESSION   NM_001077498
VERSION     NM_001077498.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4128)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 4128)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4128)
  AUTHORS   Spiegler,S., Kirchmaier,B., Rath,M., Korenke,G.C., Tetzlaff,F., van
            de Vorst,M., Neveling,K., Acker-Palmer,A., Kuss,A.W., Gilissen,C.,
            Fischer,A., Schulte-Merker,S. and Felbor,U.
  TITLE     FAM222B Is Not a Likely Novel Candidate Gene for Cerebral Cavernous
            Malformations
  JOURNAL   Mol Syndromol 7 (3), 144-152 (2016)
   PUBMED   27587990
REFERENCE   4  (bases 1 to 4128)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057665.1, BC021228.2 and AC010761.10.
            
            On Jun 2, 2019 this sequence version replaced NM_001077498.2.
            
            Transcript Variant: This variant (1) differs in the 5' UTR, lacks
            an exon in the 5' coding region and initiates translation at an
            alternate start codon, compared to variant 3. Variants 1, 2, 4, 5,
            6, and 7 encode the same isoform (2), which is shorter and has a
            distinct N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.149768.1,
                                           SRR1803612.131232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000581407.6/ ENSP00000462419.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-597               AK057665.1         34-630
            598-2731            BC021228.2         531-2664
            2732-4128           AC010761.10        108132-109528       c
FEATURES             Location/Qualifiers
     source          1..4128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..4128
                     /gene="FAM222B"
                     /gene_synonym="C17orf63"
                     /note="family with sequence similarity 222 member B"
                     /db_xref="GeneID:55731"
                     /db_xref="HGNC:HGNC:25563"
     exon            1..109
                     /gene="FAM222B"
                     /gene_synonym="C17orf63"
                     /inference="alignment:Splign:2.1.0"
     exon            110..231
                     /gene="FAM222B"
                     /gene_synonym="C17orf63"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1838
                     /gene="FAM222B"
                     /gene_synonym="C17orf63"
                     /note="isoform 2 is encoded by transcript variant 1;
                     uncharacterized protein C17orf63; protein FAM222B"
                     /codon_start=1
                     /product="protein FAM222B isoform 2"
                     /protein_id="NP_001070966.1"
                     /db_xref="CCDS:CCDS45637.1"
                     /db_xref="GeneID:55731"
                     /db_xref="HGNC:HGNC:25563"
                     /translation="MLACLPGPGDLSFQLLSHTQMNTGLQKWDTTQKMRTAHYPTPAE
                     LDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDTSAQRYSPYPTQAATKAGLL
                     AIVKVPAKSILKDFDGTRARLLPEAIMNPPVAPYATVAPSTLAHPQAQALARQQALQH
                     AQTLAHAPPQTLQHPQGIPPPQALSHPQSLQQPQGLGHPQPMAQTQGLVHPQALAHQG
                     LQHPHNPLLHGGRKMPDSDAPPNVTVSTSTIPLSMAATLQHSQPPDLSSIVHQINQFC
                     QTRAGISTTSVCEGQIANPSPISRSLLINASTRVSTHSVPTPMPSCVVNPMEHTHAAT
                     AALPAAGPVNLPTGISRVPTGYPSDLKPVTWNQHQLAHLQQMCSEASGTPAPGLTGKH
                     AAGRELAGPGFVGKAPAYPQELCLAQSFHLKPPLEKPTPSPPVNGMAAPLAYPNGHYF
                     QPLWNNILPTPNSDSSGSQDLAMPFHGGQPTGAPLDCAAAPGAHYRAGTGGGPVASQN
                     SLMQTVDYLSGDFQQACFREQSLAMLSKAHRAPGNRAPDPTESRSLHIQHPGYR"
     exon            232..4128
                     /gene="FAM222B"
                     /gene_synonym="C17orf63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3367..3372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM222B"
                     /gene_synonym="C17orf63"
                     /note="hexamer: AAGAAA"
     polyA_site      3402
                     /gene="FAM222B"
                     /gene_synonym="C17orf63"
                     /note="major polyA site"
     regulatory      4109..4114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM222B"
                     /gene_synonym="C17orf63"
                     /note="hexamer: AGTAAA"
     polyA_site      4128
                     /gene="FAM222B"
                     /gene_synonym="C17orf63"
                     /note="major polyA site"
ORIGIN      
        1 agtccccaca gctgcgccgg tgactgaggg gccgggcagt ggagaagtgg tggcggcggg
       61 cggcgggcgg caaaggagca gccatgaggg ccgggcccag tcaccgacct gtgagccact
      121 gccccatgtt gtgttgatgc caatctgcca tgctagcctg tctaccaggg ccaggtgacc
      181 tgtcctttca gcttctttct cacacgcaga tgaacactgg acttcagaaa tgggacacta
      241 cacagaaaat gagaactgct cactatccta ccccagccga attggatgcg tatgctaaga
      301 aggtcgcaaa caacccactg actataaaaa tcttccccaa cagtgtgaag gttccccagc
      361 ggaaacacgt tcgtcgtact gtgaacggcc tcgacacatc agcccagcgc tacagcccct
      421 acccgacaca ggctgccacc aaggcaggcc tgcttgccat tgtcaaagtg ccagccaaaa
      481 gcatactcaa ggactttgac ggcacccgag cccggttgct ccctgaggcc atcatgaacc
      541 ccccagtggc accctatgct actgtggcac ccagcacttt agcccacccc caggcccagg
      601 ctctggcccg ccagcaggcc ctgcagcatg cacagaccct ggcccatgcc cctccccaga
      661 cgctgcagca ccctcagggt atcccgccac cccaggcact gtcccaccct cagagcctcc
      721 agcagcctca gggcctgggc caccctcagc ccatggccca aacccagggc ttggtccacc
      781 ctcaggccct ggctcaccag ggtctccagc acccccacaa tcccttgctg catggaggcc
      841 ggaagatgcc agactcagat gcccccccga atgtgaccgt gtctacctca actatccccc
      901 tttcaatggc ggccactctg cagcacagcc agcctccgga cctgagtagc atcgtgcacc
      961 agatcaacca gttttgccag acgagggcag gcatcagcac tacctcagtg tgtgagggcc
     1021 agatcgccaa ccccagcccc attagtcgca gtctgctcat caatgcaagc acccgggtgt
     1081 cgacccacag cgtccccaca ccaatgcctt catgtgtggt caatcccatg gagcacaccc
     1141 acgcggccac cgccgcgttg cctgctgcag gtcctgtcaa cctgcccaca ggcatctctc
     1201 gcgtccccac tggctaccct agcgacctca agccagtcac ctggaaccag caccagctgg
     1261 cccacctaca gcagatgtgc agcgaggcta gtgggacgcc agcccctggc ctgacaggca
     1321 agcatgcggc aggacgcgag ttggcagggc ctggctttgt gggcaaggcc cctgcctacc
     1381 cgcaggaact ctgcctggcg cagtccttcc atctgaagcc acccctggaa aagccgaccc
     1441 catccccacc agtcaacggc atggcagccc cattggccta ccccaatggt cactacttcc
     1501 aacccctgtg gaacaacatt ctgcccactc ccaatagcga cagctcgggg tctcaggacc
     1561 ttgccatgcc gttccacggt gggcagccca caggtgcacc cctcgactgt gcggcagctc
     1621 ccggggccca ctaccgagca gggaccgggg gcggtccagt ggcaagccag aacagcttga
     1681 tgcaaacagt ggattaccta agtggggatt tccaacaggc ctgcttccga gaacagagcc
     1741 tggccatgct gagcaaggcc caccgagccc ctggcaaccg agcccccgat cccacagaga
     1801 gtcgaagtct tcatattcag cacccagggt atagataggt agccctgctg ccctccacgt
     1861 gcaacacatc atacatcacc ctcctaggtt tagtctttta agtaactgga tagtttcaaa
     1921 gtttcactgc tccagtgtga tcattcttag atgtctaaga aagggaattt ggtgggatct
     1981 aagtggggac agaaggggtc ctctcgtcct cccctccagc aacttttggt tttatgttag
     2041 aacctaaccc taagcccagg cttttctctc cactgactgc ctgtcagcta gtctctccac
     2101 cttggccatt tccagccagc tcccacccat cttttcttga atctcttcct gtttccctta
     2161 ggacgactga ggtgtgggct gacggaatgc cctagttgag gtagtatagg tgctcaggcc
     2221 cctaatccag acctctacct gttgctaccc cccttcccct ccctccagga ctaagaagca
     2281 agatttccca ggtgctctga aagctaatta cttactcatc gaaggatctc aaatcaaagc
     2341 tgacccagtc ttcatatcct tcaagttcct ttccattcct caaggctttg ttttgtgtct
     2401 atattgatcc cacagccact gcacttgccc ttgccacact tgatctcaag ggcatcttgg
     2461 aagtatttga ccatttcttg agatatgggg ggaaaaagtc tttgtattgg catcttggtt
     2521 ccagactccc ctttccaaac ctagaaaaat acagtgacct ttgagcatac ccaagatccc
     2581 tttctcactg ttgcctgtcc cctaactcac ctccccacag cccctatcct ttccccctca
     2641 acaaaaacaa aatctacctt acttgaggaa ttaggtaggt aaggaatgat cacattggag
     2701 tttgggatta aaaacaccaa aaaaaaaaaa atgcatttgg ttctctctac actggctaag
     2761 aatattgctc tacactgtaa gttttaaacg ttacgtttct gtatgaatgt agtgtgggtt
     2821 tgagtagcat tgtgtgtgag tggccccaca ggtacattca ccctctagtg cagcccctca
     2881 gtttaatgaa ggaaaaaaaa acaaacacaa agccttaagc tctttgagta cttcctttac
     2941 caaatgagca tggttctaac acctggagct gggcctacat tggaaacaag cccctcctgc
     3001 cctctgtcca ttcttagagc ataccttcat ccactccatg ctcagcacgt ctcatcccaa
     3061 gcgacaatta gttggctaga aacacttttc tgtaatttta aacttagact gttttgttac
     3121 aaatttttgc accattctgt taaagatgca gaattgggct tttttatttt ttacagatga
     3181 aataagccct tacctttcct cttgtctctg gggaatgtca gctgatggtt cttatttaag
     3241 gttttgcatt ttgttcacta tccactactg ttcgttagcc agaaattctc tagtgatctg
     3301 aagcaatgtg actgaagacc agttttaagt tatgtgttgg caagttgcct tatatttaaa
     3361 aggaaaaaga aaaaaaaaaa agcctgattg tgttatgcca aatgatagca acatgaagtc
     3421 ctaatttatt gttcccaatt gttttcctgc cgtctgtgaa cactggtacc tccctgtcct
     3481 gatcccccag gagcacctgt agcttctgac tcaatgcctt ctccgaaggt gttggccgcc
     3541 atctcaccca gggccctctt ccagttcctg cttttctgag tcagatttaa agagcaccac
     3601 tgtcttcccc ctaccccttg cttgatctcc aaagcagata ttcttgctgt attttttttt
     3661 cctccccaat acctctccct gaaaggtgag ctgctatttt aggaaactgg accagacacc
     3721 aacttggggg ctttaagtca aacaacctca aacccatctc ttcctgtgta ggggtgcaag
     3781 cctctgaagc tctcactccc acccttagtc tgcatggaaa atgtactgtg atccccctgc
     3841 ccccaactgc cctcgccttt ggtgtgagat gttccttctt tcggagttca gcctgagtcc
     3901 ctctcccctc tgccagccaa cccccagcca gcaataaggg tccaagccag ggcctcctct
     3961 ccacactccc tgtctccatc ctacactacc ctagggaata cctggattcc ccattctatc
     4021 cacatactgt agcattcatt ctccatctct ctcacctcac ctgtggtggt ttatgggtgt
     4081 gatggggttt ttaagattat tataaaccag taaaaataag aaaacctc
//
