LOCUS       NM_032829               3685 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens family with sequence similarity 222 member A
            (FAM222A), mRNA.
ACCESSION   NM_032829
VERSION     NM_032829.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3685)
  AUTHORS   Tzani,A., Haemmig,S., Cheng,H.S., Perez-Cremades,D.,
            Heuschkel,M.A., Jamaiyar,A., Singh,S.A., Aikawa,M., Yu,P.B.,
            Wang,T., Sun,Y., Feinberg,M.W. and Plutzky,J.
  TITLE     FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome,
            Is a Novel Determinant of Endothelial Biology and
            Angiogenesis-Brief Report
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (1), 143-155 (2024)
   PUBMED   37942611
  REMARK    GeneRIF: FAM222A, Part of the BET-Regulated Basal Endothelial
            Transcriptome, Is a Novel Determinant of Endothelial Biology and
            Angiogenesis-Brief Report.
REFERENCE   2  (bases 1 to 3685)
  AUTHORS   Yan,T., Liang,J., Gao,J., Wang,L., Fujioka,H., Zhu,X. and Wang,X.
  CONSRTM   Alzheimer Disease Neuroimaging Initiative
  TITLE     FAM222A encodes a protein which accumulates in plaques in
            Alzheimer's disease
  JOURNAL   Nat Commun 11 (1), 411 (2020)
   PUBMED   31964863
  REMARK    GeneRIF: Study reports FAM222A as a putative brain atrophy
            susceptibility gene. The protein encoded by FAM222A is
            predominantly expressed in the CNS and is increased in brains of
            patients with Alzheimer's disease (AD) and in an AD mouse model. It
            accumulates within amyloid deposits, physically interacts with
            amyloid-beta (Abeta) via its N-terminal Abeta binding domain and
            facilitates Abeta aggregation.
            Erratum:[Nat Commun. 2022 Jul 11;13(1):4006. doi:
            10.1038/s41467-022-31711-8.. PMID: 35817794]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007834.40, DN994281.1 and BC020193.1.
            
            On Jul 9, 2019 this sequence version replaced NM_032829.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020193.1, SRR14038194.3886010.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000538780.2/ ENSP00000443292.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-557               AC007834.40        185525-186081       c
            558-560             DN994281.1         6-8
            561-976             BC020193.1         1-416
            977-977             AC007834.40        185105-185105       c
            978-3685            BC020193.1         418-3125
FEATURES             Location/Qualifiers
     source          1..3685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..3685
                     /gene="FAM222A"
                     /gene_synonym="C12orf34"
                     /note="family with sequence similarity 222 member A"
                     /db_xref="GeneID:84915"
                     /db_xref="HGNC:HGNC:25915"
     exon            1..1073
                     /gene="FAM222A"
                     /gene_synonym="C12orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1201
                     /gene="FAM222A"
                     /gene_synonym="C12orf34"
                     /inference="alignment:Splign:2.1.0"
     CDS             1120..2478
                     /gene="FAM222A"
                     /gene_synonym="C12orf34"
                     /note="aggregatin"
                     /codon_start=1
                     /product="protein FAM222A"
                     /protein_id="NP_116218.2"
                     /db_xref="CCDS:CCDS9133.1"
                     /db_xref="GeneID:84915"
                     /db_xref="HGNC:HGNC:25915"
                     /translation="MLACLQRTQNAPGQHLACPSKSLELRKCEAVASAMHSSRYPSPA
                     ELDAYAEKVANSPLSIKIFPTNIRVPQHKHLSRTVNGYDTSGQRYSPYPQHTAGYQGL
                     LAIVKAAVSSSSTAAPAGPAKSVLKSAEGKRTKLSPAAVQVGIAPYPVPSTLGPLAYP
                     KPPEAPAPPPGLPAAATAASVIPLPGRGLPLPPSNLPSIHSLLYQLNQQCQAPGAAPP
                     ACQGMAIPHPSPAKHGPVPSFPSMAYSAAAGLPDCRKGTELGQGATQALTLAGAAKPA
                     GYADSGLDYLLWPQKPPPPPPQPLRAYSGSTVASKSPEACGGRAYERASGSPLNCGVG
                     LPTSFTVGQYFAAPWNSVLVTPTSDCYNPAAAVVVTELGPGAARELAGPPADALSGLP
                     SKSVCNTSVLSSSLQSLEYLINDIRPPCIKEQMLGKGYETVAVPRLLDHQHAHIRLPV
                     YR"
     exon            1202..3685
                     /gene="FAM222A"
                     /gene_synonym="C12orf34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3668..3673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM222A"
                     /gene_synonym="C12orf34"
                     /note="hexamer: AAGAAA"
     polyA_site      3685
                     /gene="FAM222A"
                     /gene_synonym="C12orf34"
                     /note="major polyA site"
ORIGIN      
        1 agtcgggcca gagcggagca gcgggcagga ctgcctggcc ggctgctccg cggagaggct
       61 gcgcgcgccg gccgggggag gcggacagcc gggcccggcg cctgtggggc gcggcgcgcg
      121 gcacccgggc ctgagaccag gcgaggcgcc ggcgcgcgcc agacggcgcg aggctgcggc
      181 cccgggagcc cccgcgcgcc gcccggggcc atgggcgcgt gagagcccag cgcgcgcggc
      241 ccctgctgcg gcttgcgagc tcgcacaccc ggtgcacagt cccccgggcc gtcctcgtgt
      301 ccgtcctgcg ccactgggat cggctgtttc tcagcgccga ggcccccgag gctgcatccg
      361 agcttgcgtc gcccgctgcc gccgccgccg ccgctgccgc cgccgctgtt cgccggcttc
      421 ccctcccccc acacccgggg ctcagagcag gaggaggagg ggccggtgca ttctcgccgc
      481 tgttctttgc aacctgcagg ggccggtgta tgtccggcga ggagccgggg ccgctgcggg
      541 tgcgtgcaac ccccgaagga gacaatccct ccacctcggg gcgaacccgg gggctgcaag
      601 ccgcgggcgg gcgggcgagc gagaggaagc aacaaagaca ggctgcagct ggggctggcg
      661 aaaggggccg cggccgccgg gctcccagcg cgggcggaga gggcgccctg ggagcggcgc
      721 gggccgagct gcagccttga gcggggcccc gaggggaggc gcagcgccgc ccgccggacg
      781 tggcgatcac gggccccggc gaagatgcgt cgcctgagcg cccgcgcggc ccccgtccgg
      841 ggcgggcgtg acccctgctg aacggagacc tcccctcccc cccgacttcg gacggcgcag
      901 gccggcgcca ggatagccct caccgacagc gccccttccc acccggagag aggcatcgac
      961 ccccaaggag ggcttcgtca ggcagcctct gccactcctg catggctgcg acccgtcgag
     1021 cggagcgtcg tggtagctga gacctggtgc ccttcgacgg cctggctgat ccgggaccca
     1081 gtcgcagagc gcaccccact ggggaccccc agctcagcca tgctggcctg tctgcagagg
     1141 acccagaacg ccccgggcca acacctggcc tgcccgagca agagcctgga gctgcgcaag
     1201 tgcgaggcgg tggccagcgc catgcattcc tcccgctacc cgagcccagc agaactggac
     1261 gcctatgccg agaaggtggc caacagcccg ctgtccatca agatcttccc caccaacatc
     1321 cgtgtgcccc agcacaagca cctcagccgc acagtcaatg gctatgacac cagtggccag
     1381 cgctacagcc cctacccaca gcacaccgct ggctaccagg gccttctggc cattgtcaag
     1441 gccgcggttt cctcctccag cacggccgca ccagctgggc ccgccaaaag tgtgctcaag
     1501 agcgccgagg gcaagcggac caagctgtca ccggccgccg tgcaggtggg cattgcgccc
     1561 tacccagtgc ccagcactct gggtcccttg gcctacccca agccacctga ggcgcctgct
     1621 ccaccacccg gcctgcccgc agccgccact gccgcctccg tcatccccct gccgggccgg
     1681 ggcctgcccc tgccaccttc caacctgccc tccatccaca gcctcctgta ccagctcaac
     1741 cagcagtgcc aggccccggg cgccgcaccc cctgcctgcc agggcatggc tattccccat
     1801 cccagccctg ccaagcacgg cccagtgccc agcttcccca gcatggccta ctcggctgca
     1861 gccggtctgc ccgactgccg gaaaggcact gagctgggcc agggagccac ccaagccttg
     1921 acgttggctg gggccgccaa gcctgcaggg tacgcagaca gcggcctgga ttacctgctg
     1981 tggccgcaga aaccgccccc accgccgccc cagccactgc gtgcctacag tgggagcacg
     2041 gtggccagca agtcccctga ggcttgcggg ggccgggcat acgagcgggc cagcgggtca
     2101 cccctcaact gtggcgtggg gctgcccacc agcttcaccg taggccagta ctttgcggcc
     2161 ccgtggaaca gtgtgctggt gacacccacc agcgactgct acaacccagc ggcggcggtg
     2221 gtggtcacgg agctggggcc gggggcagcc cgggagctgg ctgggccccc tgcagatgcc
     2281 ctctcgggcc tgcccagcaa gagtgtgtgc aacacatcgg tgctgagcag cagcctgcag
     2341 tcactggagt atctcatcaa cgacatccgg ccgccctgca tcaaggagca gatgctgggc
     2401 aagggctatg agacggtggc cgtgccccgg ctactcgacc accagcatgc ccacatccgc
     2461 ctacccgtct acagataagg cctgccctgc ggacatacgg acatgcggac agggcgcaga
     2521 gccgggaggc aggccgcaga acagggtggg cggctcgcag gggcgctcag ccccaccctg
     2581 tgcctgctga tgcccacagg ggagccaggc tggctgccgc ctcgctgtgg ccggatggag
     2641 ggtggcaggg caacctcaca taccaaggcc cctccccacc atcggttgcc ccaggacaca
     2701 gtgagggcct gggggcagcc actgacgccc atgccttcct ttatctaagc tggcagaggc
     2761 agggagagag aaaccactca aaaacaggaa tggttctttc tgggcctcct gggacagggg
     2821 cccaggccaa ggtggggtgc aggaggaaac aggcgcacca gagtcagggt gggggcaggg
     2881 cagccccccc aggggtcagg cagctgtgtc tccccacact ggctccccag tattctggaa
     2941 aaggggtaca ggaggccgat aggaagtcac tgggcccaaa gtgtctcccc accagccagg
     3001 tgaagaccac tctgacagag gctccaggga ctataccagt ccccctgttc ctccttcccc
     3061 tacccccacc attccttcct aacacagagt tgcaccccca tccccattct ccaaaccctg
     3121 gactaccata ttcccccttc cctccaatac atcttatagg gctgctgggt acagttgttc
     3181 aggctgtgca ctgcacaagg gcaccttgtc caaggagaca ccactttcac ccaaacttgt
     3241 atatttatta caattttctg catcttgagg aaggggcgtc attttcctgt tcgcacaaag
     3301 gcaccacagg ggctaacagt gggcctgcaa tcttagatcc catccttgcc ttcttcgagg
     3361 gatctcttgg gaccctcctg gttttaactg ggaggcccag accaactcct ttcctgcaaa
     3421 ccaccctcca aggcctgtcc cacacgatca aggcagggaa agataggcag gagtcccctc
     3481 acgaagtcct caagtcctgg cccctctggc gctctggaag cggtactgta tctctctcca
     3541 aggcctggtc aagcactaag tgcatttaca aatctctgag aatgtttttt ttatactaaa
     3601 attgaccatt atattctact gtgagaagtg cagtctgcac tatattgttt taaaaacgaa
     3661 gagaaagaag aaaaaggaaa acaca
//
