LOCUS       NM_001012446            3557 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 221 member B
            (FAM221B), transcript variant 1, mRNA.
ACCESSION   NM_001012446
VERSION     NM_001012446.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3557)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3557)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3557)
  AUTHORS   Ridanpaa,M., van Eenennaam,H., Pelin,K., Chadwick,R., Johnson,C.,
            Yuan,B., vanVenrooij,W., Pruijn,G., Salmela,R., Rockas,S.,
            Makitie,O., Kaitila,I. and de la Chapelle,A.
  TITLE     Mutations in the RNA component of RNase MRP cause a pleiotropic
            human disease, cartilage-hair hypoplasia
  JOURNAL   Cell 104 (2), 195-203 (2001)
   PUBMED   11207361
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC146808.1, BX648702.1 and AL133410.32.
            
            On May 17, 2019 this sequence version replaced NM_001012446.3.
            
            Transcript Variant: This variant (1) is protein-coding.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000423537.7/ ENSP00000415299.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               BC146808.1         1-370
            371-391             BX648702.1         386-406
            392-1091            BC146808.1         392-1091
            1092-1092           BX648702.1         1298-1298
            1093-2931           BC146808.1         1093-2931
            2932-3557           AL133410.32        136272-136897       c
FEATURES             Location/Qualifiers
     source          1..3557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..3557
                     /gene="FAM221B"
                     /gene_synonym="C9orf128"
                     /note="family with sequence similarity 221 member B"
                     /db_xref="GeneID:392307"
                     /db_xref="HGNC:HGNC:30762"
     exon            1..270
                     /gene="FAM221B"
                     /gene_synonym="C9orf128"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1479
                     /gene="FAM221B"
                     /gene_synonym="C9orf128"
                     /note="uncharacterized protein C9orf128"
                     /codon_start=1
                     /product="protein FAM221B"
                     /protein_id="NP_001012448.2"
                     /db_xref="CCDS:CCDS43799.2"
                     /db_xref="GeneID:392307"
                     /db_xref="HGNC:HGNC:30762"
                     /translation="MEAHEIIEEPHITMDAEKHPPSKDPSAEDLQENHISESFLKPST
                     SETPLEPHTSESPLVPSPSQIPLEAHSPETHQEPSISETPSETPTYEASLDSPISVVP
                     EKHLTLPPQSRDYVCLSSSDTLKEDLSSESSSNEVPWTRRSTHLSESESLPEHCLSGP
                     SSQVQVDTTEKQEEEAGEVEKGVDASDSTAHTAQPGHQLGNTARPVFPARQTELVEVA
                     KAMHREEFGAQVNNLFQWEKDAALNAIQTGLYIGWRCPHYLWDCFRIGDESRCFCGHL
                     LREHRIISDISVPCKVSQCRCFMFCFIPSRPEEVGEFWLKRRATFDPKAWRAQCRCKH
                     SHEEHAATGPHPCRHHGCCCGCFESNFLCAACDRRWEEHETFFDTQKTRQRGGRPRGT
                     DTVSNWHRPL"
     exon            271..868
                     /gene="FAM221B"
                     /gene_synonym="C9orf128"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1012
                     /gene="FAM221B"
                     /gene_synonym="C9orf128"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1123
                     /gene="FAM221B"
                     /gene_synonym="C9orf128"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1321
                     /gene="FAM221B"
                     /gene_synonym="C9orf128"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1441
                     /gene="FAM221B"
                     /gene_synonym="C9orf128"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..3557
                     /gene="FAM221B"
                     /gene_synonym="C9orf128"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1497..1502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM221B"
                     /gene_synonym="C9orf128"
                     /note="hexamer: AATAAA"
     polyA_site      1518
                     /gene="FAM221B"
                     /gene_synonym="C9orf128"
                     /note="major polyA site"
ORIGIN      
        1 agtcaagacc ctccctcatt ggccctagac cccttgtccc tacccacttc cccaggtcat
       61 gccagagctc ctttgcgaag ttctgcagat atccaagtcc ccttcccaga tagcagactt
      121 tcaggcaagg catttcaaca ctcagcacct gcagctgagg cacatccaca accaagagcc
      181 tttcctccct gaggatcaac acctccccct gccatcctaa gtcaaggtct tgacctaagg
      241 acttgtaaca accaagccaa agcccagagg atggaagcac atgagatcat agaagagcct
      301 catatcacca tggatgcaga gaagcacccc ccttcaaagg acccctctgc tgaggactta
      361 caggagaacc atatctctga aagcttcttg aagccttcca cctctgagac cccgttagag
      421 ccccatacct ctgaatcccc tttggtgcca tccccttccc agatcccctt agaggcccat
      481 tcccctgaaa cccatcagga gccttccatc tctgagactc cttcagagac ccctacctat
      541 gaggcttcat tggatagtcc catctcagtg gtgccagaga aacaccttac tcttcctccc
      601 caatcacgag actatgtctg tctgtcttct tctgatactc tgaaggaaga cctctcctct
      661 gagtcttctt ccaatgaggt cccatggaca aggaggtcta cccatctctc tgaatctgag
      721 agccttccag aacactgtct ttcaggccct tcatcccagg tccaagtgga cacaaccgaa
      781 aagcaggagg aagaagcagg agaggttgaa aagggagtag atgccagtga cagcactgct
      841 cacacagccc aacctggaca ccaactaggt aacacagccc gcccagtgtt ccctgctagg
      901 cagacagagc tggtggaagt ggctaaggca atgcatagag aggagtttgg tgctcaagtg
      961 aacaatcttt tccagtggga gaaggatgca gccctgaatg ccatccagac aggtctctac
     1021 attggctggc gctgccccca ttacctatgg gactgtttcc ggattgggga tgagtccaga
     1081 tgcttttgtg gacacttgtt gagagagcac cggatcatct cagacatatc ggtgccctgc
     1141 aaggtaagcc agtgccgctg cttcatgttc tgctttatcc catcacgccc agaggaggtg
     1201 ggtgagttct ggctcaagag acgggccacc tttgacccca aggcctggag ggcccaatgt
     1261 cgctgcaaac acagccacga agaacatgca gccactgggc cccatccctg caggcatcat
     1321 ggctgttgct gcggctgttt tgagtctaat ttcctctgtg cggcctgtga ccggcgctgg
     1381 gaggaacacg agactttctt tgacacccag aagacccggc aacgaggagg aaggcctcgc
     1441 gggacagaca ctgtcagcaa ctggcacagg cctttgtgag tctggcccag atcagcaata
     1501 aaagaggagt cattggaacc tgacttggct ctatatgggg caggtagatc ccagcccagg
     1561 gagagactgc ctaataactt agagttgaca cctattagac acaggagaaa gcctggatct
     1621 ggccatctgc ctccatcaca ctcacattca agctgcctgt tgaaggaaag tggcttcaag
     1681 gaagtcaaga agggaggaag tttcaagaag gatagagtgg gaagtgatgt tagatgcagt
     1741 tggggcacca ataagataaa gactgaaaag tgtccattgg gttttgcaat tagaagatct
     1801 ttgggaacat cggagagtgc agtttcacac tggtgcagtg gaggcaggag tcaaacagca
     1861 gtgagtttca aggagtctct taaagaagct tggatgaaaa gtacaaaagt aaagtcagac
     1921 aatatccaga gggagttgtg gagtcaagga agtacttttg taggaaggaa aaggggaaga
     1981 ggccagtaga ctaaaggacc ttgaaggacc cagaagagag agaagagatg cctggtgaga
     2041 caagatccca gagatggagg aaagggatga ggtcaaagca gaggtgaagg gattttctct
     2101 ggacaggaga aacaccactt cctatgacca agacgaagga agaggatgga gccttcctag
     2161 agtttcaggg aacaagaacc tgtggaagtt cccctctgat ggcttctata tgccctgtga
     2221 agtaggagat aaggccaatg gctggggtcc aggggaagag ggataagagt agggagcagg
     2281 agacaagaag agaaagggga aggtttggga aggctaatgt agggaactgg agaaaaacct
     2341 catcagtggg tagttcagga ttcgggcaca gttggaagtg agaacctagt tagagaagca
     2401 gagaatccaa atatttaatg ggttgatgat gtgagggtgt cagggaggaa gatcaggaaa
     2461 actaagcaaa agaaggcatg aggatgtgaa gggagcatac agcaccaata gggaaagaaa
     2521 gtgatgccag gaggcaaatg acagattgaa aaagggagca gtcaaaggaa gagaagtctc
     2581 taatgaggta cagtagcaga cgtaggggca ggggttggag tacaagagac agtgttcaga
     2641 ggctgcagag cataacatct ttcagatgag ggcaagtgaa ggtgataagt gcttgaagta
     2701 gagaaaactg tgggccaagg atcaaaatca gtgaatgtgg gaagtcacaa gggagtccat
     2761 aggttcttat gggagtagga gattccagca ctaatgggct ctgtgaaccc aggcaagtca
     2821 ctgtccctct ttaggctgag tttctggacc tgtaaaacag gaataacctc tgtgttgcct
     2881 actttctatg agaaccaaag aaataactaa tttcaaagtg ctttgtatcc acctatcctc
     2941 cagactggct tccttcctct tcctagatcc cagatccact tatctctcgc ccttctccag
     3001 ggcaactcta gggtctccca gtgtcccaga ggcaccacag agaactgcag cctctggggc
     3061 ccagagaaga ggccattcta catttcctca caattagggg ggccatctgt tcctccaagg
     3121 gaaggaatgc aatctggact gctaggatcc ctggggaaaa tcacagaatc aaatgtctgc
     3181 cctttagagg agaaaggatt ttctaacaat aatatagcta tacaaaagag attgttatat
     3241 ctctagaagc aaagttcccc aacagtggtt atatgcccca tgataaccat tcacctaaaa
     3301 ctaattcaac taatagtcaa caatagagtt aggattacta tgataaactc attgaaggaa
     3361 ataataagca gccaatacaa actatattta cgtagactgt aaaaatatga aaaattgatt
     3421 acacatgggt tagtatcata tgcaatacat attacatatt atgaaaaaaa gacaggaaac
     3481 accaaatgtt attcattcaa caattactga ccacctatat gtatcaggtc atgtgtttaa
     3541 aaaaaaaaaa aagaaaa
//
