LOCUS       NM_199136               1403 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 221 member A
            (FAM221A), transcript variant 1, mRNA.
ACCESSION   NM_199136 XM_353568
VERSION     NM_199136.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1403)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1403)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1403)
  AUTHORS   Sakai,Y., Shaw,C.A., Dawson,B.C., Dugas,D.V., Al-Mohtaseb,Z.,
            Hill,D.E. and Zoghbi,H.Y.
  TITLE     Protein interactome reveals converging molecular pathways among
            autism disorders
  JOURNAL   Sci Transl Med 3 (86), 86ra49 (2011)
   PUBMED   21653829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY056255.1, BC063130.1, BC042034.1 and AI370799.1.
            
            On Nov 23, 2018 this sequence version replaced NM_199136.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063130.1, SRR5189667.198665.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344962.9/ ENSP00000342576.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                HY056255.1         87-164
            79-402              BC063130.1         78-401
            403-403             BC042034.1         469-469
            404-1076            BC063130.1         403-1075
            1077-1187           AI370799.1         219-329             c
            1188-1403           BC042034.1         1145-1360
FEATURES             Location/Qualifiers
     source          1..1403
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..1403
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /note="family with sequence similarity 221 member A"
                     /db_xref="GeneID:340277"
                     /db_xref="HGNC:HGNC:27977"
     exon            1..85
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..917
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C7orf46; protein FAM221A"
                     /codon_start=1
                     /product="protein FAM221A isoform 1"
                     /protein_id="NP_954587.2"
                     /db_xref="CCDS:CCDS5385.1"
                     /db_xref="GeneID:340277"
                     /db_xref="HGNC:HGNC:27977"
                     /translation="MERLTLPLGGAAAVDEYLEYRRIVGEDDGGKLFTPEEYEEYKRK
                     VLPLRLQNRLFVSWRSPTGMDCKLVGPETLCFCTHRYKQHKTDLEAIPQQCPIDLPCQ
                     VTGCQCRAYLYVPLNGSQPIRCRCKHFADQHSAAPGFTCNTCSKCSGFHSCFTCACGQ
                     PAYAHDTVVETKQERLAQEKPVGQDIPYAAMGGLTGFSSLAEGYMRLDDSGIGVPSVE
                     FLESPITAVDSPFLKAFQASSSSSPETLTDVGTSSQVSSLRRPEEDDMAFFERRYQER
                     MKMEKAAKWKGKAPLPSATKPS"
     exon            86..259
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            260..450
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            451..657
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            658..765
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            766..848
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1403
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1374..1379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /note="hexamer: AATAAA"
     polyA_site      1403
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /note="major polyA site"
ORIGIN      
        1 ctttggcttc cccaccggca atggagcggt tgacgttgcc tctcggcggc gcggcggcgg
       61 tggacgagta cctggagtac cggagaattg ttggtgagga tgatggaggg aaacttttta
      121 ctcctgaaga atatgaagaa tacaaaagaa aagttttacc tctgcgctta caaaacagat
      181 tatttgtgag ctggcggtca ccaacaggga tggattgtaa acttgtgggc ccagagacac
      241 tgtgtttttg tacacatagg tataaacaac ataaaactga cttggaagcg attcctcagc
      301 agtgccccat tgatctgccc tgccaagtga ctggctgcca gtgcagggct tacctttatg
      361 tccccttgaa tggtagccag cccattcgct gcaggtgcaa acactttgct gatcagcaca
      421 gtgctgcgcc tggctttaca tgcaatacat gttccaagtg ttcaggattc catagctgct
      481 tcacttgtgc ttgtggtcag cctgcatatg cccatgacac agtagtggaa actaagcaag
      541 aaagattggc tcaggaaaaa ccagtgggac aggacattcc ttatgcagcc atgggaggat
      601 taactggttt cagctcgctg gcggaaggct acatgcggtt agatgacagt gggattggtg
      661 taccttcagt tgaattttta gaatctccca ttacggcagt agacagccca ttcctaaaag
      721 catttcaagc atcatctagt tcttctccag aaacgttaac agatgtaggt acaagtagtc
      781 aagtttcttc attaaggaga cctgaagagg atgatatggc tttctttgaa agacgatacc
      841 aggaaaggat gaaaatggaa aaggctgcta agtggaaagg aaaagctcca ttgccatcag
      901 ctacaaaacc ttcatgaaga ctattggaga aattaaaacc atcatccaag tatctttttc
      961 atgtttattt aaatgtaata atacagttta tttttcctga aattatttac tttttttttt
     1021 tactgtataa atgtcttttg ggatgtttcc ttaatttatt taaataacta aaaatgccta
     1081 ttacttttgt caaaactcat aatttactac tttgtatgta cctttctttc tcctgacaaa
     1141 tgaggttatt ttatatgagt ctgtctgaga gtacagtaaa tgtttttagt acataataat
     1201 ttaactgttt caggtattta aaaaattaaa gatattatca agggttttgg acaaacatat
     1261 gagccatttt tttgtcattc aaaatagtaa gttaaaaaca agagaacaaa agaaaaaaat
     1321 agttaaaatc attaattttt ttatttttca aactttgtaa tgttatgttt tcaaataaaa
     1381 actatctcaa aattttacaa cca
//
