LOCUS       NM_001300932            1229 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 221 member A
            (FAM221A), transcript variant 4, mRNA.
ACCESSION   NM_001300932 XM_005249738
VERSION     NM_001300932.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1229)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1229)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1229)
  AUTHORS   Sakai,Y., Shaw,C.A., Dawson,B.C., Dugas,D.V., Al-Mohtaseb,Z.,
            Hill,D.E. and Zoghbi,H.Y.
  TITLE     Protein interactome reveals converging molecular pathways among
            autism disorders
  JOURNAL   Sci Transl Med 3 (86), 86ra49 (2011)
   PUBMED   21653829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY056255.1, BU958830.1, BC063130.1, AI370799.1 and BC042034.1.
            
            On May 31, 2019 this sequence version replaced NM_001300932.1.
            
            Transcript Variant: This variant (4) lacks an in-frame exon in the
            5' coding region, compared to variant 1. The encoded isoform (4) is
            shorter, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.89255.1,
                                           SRR5189667.343017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 HY056255.1         87-89
            4-408               BU958830.1         21-425
            409-902             BC063130.1         582-1075
            903-1013            AI370799.1         219-329             c
            1014-1229           BC042034.1         1145-1360
FEATURES             Location/Qualifiers
     source          1..1229
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..1229
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /note="family with sequence similarity 221 member A"
                     /db_xref="GeneID:340277"
                     /db_xref="HGNC:HGNC:27977"
     exon            1..85
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..743
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /note="isoform 4 is encoded by transcript variant 4;
                     uncharacterized protein C7orf46; protein FAM221A"
                     /codon_start=1
                     /product="protein FAM221A isoform 4"
                     /protein_id="NP_001287861.1"
                     /db_xref="CCDS:CCDS75570.1"
                     /db_xref="GeneID:340277"
                     /db_xref="HGNC:HGNC:27977"
                     /translation="MERLTLPLGGAAAVDEYLEYRRYKQHKTDLEAIPQQCPIDLPCQ
                     VTGCQCRAYLYVPLNGSQPIRCRCKHFADQHSAAPGFTCNTCSKCSGFHSCFTCACGQ
                     PAYAHDTVVETKQERLAQEKPVGQDIPYAAMGGLTGFSSLAEGYMRLDDSGIGVPSVE
                     FLESPITAVDSPFLKAFQASSSSSPETLTDVGTSSQVSSLRRPEEDDMAFFERRYQER
                     MKMEKAAKWKGKAPLPSATKPS"
     exon            86..276
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            277..483
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            484..591
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            592..674
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            675..1229
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1200..1205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /note="hexamer: AATAAA"
     polyA_site      1229
                     /gene="FAM221A"
                     /gene_synonym="C7orf46"
                     /note="major polyA site"
ORIGIN      
        1 ctttggcttc cccaccggca atggagcggt tgacgttgcc tctcggcggc gcggcggcgg
       61 tggacgagta cctggagtac cggaggtata aacaacataa aactgacttg gaagcgattc
      121 ctcagcagtg ccccattgat ctgccctgcc aagtgactgg ctgccagtgc agggcttacc
      181 tttatgtccc cttgaatggt agccagccca ttcgctgcag gtgcaaacac tttgctgatc
      241 agcacagtgc tgcgcctggc tttacatgca atacatgttc caagtgttca ggattccata
      301 gctgcttcac ttgtgcttgt ggtcagcctg catatgccca tgacacagta gtggaaacta
      361 agcaagaaag attggctcag gaaaaaccag tgggacagga cattccttat gcagccatgg
      421 gaggattaac tggtttcagc tcgctggcgg aaggctacat gcggttagat gacagtggga
      481 ttggtgtacc ttcagttgaa tttttagaat ctcccattac ggcagtagac agcccattcc
      541 taaaagcatt tcaagcatca tctagttctt ctccagaaac gttaacagat gtaggtacaa
      601 gtagtcaagt ttcttcatta aggagacctg aagaggatga tatggctttc tttgaaagac
      661 gataccagga aaggatgaaa atggaaaagg ctgctaagtg gaaaggaaaa gctccattgc
      721 catcagctac aaaaccttca tgaagactat tggagaaatt aaaaccatca tccaagtatc
      781 tttttcatgt ttatttaaat gtaataatac agtttatttt tcctgaaatt atttactttt
      841 tttttttact gtataaatgt cttttgggat gtttccttaa tttatttaaa taactaaaaa
      901 tgcctattac ttttgtcaaa actcataatt tactactttg tatgtacctt tctttctcct
      961 gacaaatgag gttattttat atgagtctgt ctgagagtac agtaaatgtt tttagtacat
     1021 aataatttaa ctgtttcagg tatttaaaaa attaaagata ttatcaaggg ttttggacaa
     1081 acatatgagc catttttttg tcattcaaaa tagtaagtta aaaacaagag aacaaaagaa
     1141 aaaaatagtt aaaatcatta atttttttat ttttcaaact ttgtaatgtt atgttttcaa
     1201 ataaaaacta tctcaaaatt ttacaacca
//
