LOCUS       NM_001037163            2220 bp    mRNA    linear   PRI 16-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 220 member A
            (FAM220A), mRNA.
ACCESSION   NM_001037163 XM_930588 XM_935791 XM_942732
VERSION     NM_001037163.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2220)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2220)
  AUTHORS   Ren,F., Geng,Y., Minami,T., Qiu,Y., Feng,Y., Liu,C., Zhao,J.,
            Wang,Y., Fan,X., Wang,Y., Li,M., Li,J. and Chang,Z.
  TITLE     Nuclear termination of STAT3 signaling through SIPAR
            (STAT3-Interacting Protein As a Repressor)-dependent recruitment of
            T cell tyrosine phosphatase TC-PTP
  JOURNAL   FEBS Lett 589 (15), 1890-1896 (2015)
   PUBMED   26026268
  REMARK    GeneRIF: results suggest that SIPAR terminates the activation of
            STAT3 through a dephosphorylation process that is dependent upon
            interaction with TC45 in the nucleus
REFERENCE   3  (bases 1 to 2220)
  AUTHORS   Ren,F., Su,F., Ning,H., Wang,Y., Geng,Y., Feng,Y., Wang,Y.,
            Zhang,Y., Jin,Z., Li,Y., Jia,B. and Chang,Z.
  TITLE     SIPAR negatively regulates STAT3 signaling and inhibits progression
            of melanoma
  JOURNAL   Cell Signal 25 (11), 2272-2280 (2013)
   PUBMED   23917203
REFERENCE   4  (bases 1 to 2220)
  AUTHORS   Ueda,T., Manabe,H., Tokuhiro,K., Hirose,M., Matsuoka,Y.,
            Miyagawa,Y., Tsujimura,A., Fujita,K., Wada,M., Okuyama,A.,
            Nishimune,Y. and Tanaka,H.
  TITLE     Unique alternative translation from two open reading frames on
            Acpin1 mRNA yields an acrosomal protein and a
            salivary-gland-specific protein
  JOURNAL   Int J Urol 16 (7), 639-646 (2009)
   PUBMED   19659802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009412.6, BP354450.1 and AF533707.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001037163.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.450904.1,
                                           SRR3476690.81585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            bicistronic transcript :: PMID: 19659802
            MANE Ensembl match     :: ENST00000313324.9/ ENSP00000317289.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC009412.6         121130-121137       c
            9-130               BP354450.1         15-136
            131-2220            AF533707.1         118-2207
FEATURES             Location/Qualifiers
     source          1..2220
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..2220
                     /gene="FAM220A"
                     /gene_synonym="ACPIN1; C7orf70; SIPAR; SMIM10L3"
                     /note="family with sequence similarity 220 member A"
                     /db_xref="GeneID:84792"
                     /db_xref="HGNC:HGNC:22422"
                     /db_xref="MIM:616628"
     exon            1..395
                     /gene="FAM220A"
                     /gene_synonym="ACPIN1; C7orf70; SIPAR; SMIM10L3"
                     /inference="alignment:Splign:2.1.0"
     exon            396..2220
                     /gene="FAM220A"
                     /gene_synonym="ACPIN1; C7orf70; SIPAR; SMIM10L3"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..1256
                     /gene="FAM220A"
                     /gene_synonym="ACPIN1; C7orf70; SIPAR; SMIM10L3"
                     /note="STAT3-interacting protein as a repressor; acrosomal
                     protein 1; salivary gland-specific protein SAGSIN1"
                     /codon_start=1
                     /product="protein FAM220A"
                     /protein_id="NP_001032240.1"
                     /db_xref="CCDS:CCDS34599.1"
                     /db_xref="GeneID:84792"
                     /db_xref="HGNC:HGNC:22422"
                     /db_xref="MIM:616628"
                     /translation="MRDRRGPLGTCLAQVQQAGGGDSDKLSCSLKKRMPEGPWPADAP
                     SWMNKPVVDGNSQSEALSLEMRKDPSGAGLWLHSGGPVLPYVRESVRRNPASAATPST
                     AVGLFPAPTECFARVSCSGVEALGRRDWLGGGPRATDGHRGQCPKGEPRVSRLPRHQK
                     VPEMGSFQDDPPSAFPKGLGSELEPACLHSILSATLHVYPEVLLSEETKRIFLDRLKP
                     MFSKQTIEFKKMLKSTSDGLQITLGLLALQPFELANTLCHS"
     regulatory      2201..2206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM220A"
                     /gene_synonym="ACPIN1; C7orf70; SIPAR; SMIM10L3"
                     /note="hexamer: AATAAA"
     polyA_site      2220
                     /gene="FAM220A"
                     /gene_synonym="ACPIN1; C7orf70; SIPAR; SMIM10L3"
                     /note="major polyA site"
ORIGIN      
        1 aggctgcgcg gccaggctgg tacaggcggc tgctcgcgga ggcacttctc cgagcgtgac
       61 gtgcggactc cgctccactg cggcccgccc gcccgccggt ctagccgccg cctccttcgc
      121 tccctgagca cgccaggcga gggtcagctg ccggggcgac gcggcgcgga gagggcgggc
      181 gggggggctg tgggagcgcc ggtctctata tggcggcggc tctgtcgggc ctggctgtcc
      241 ggctctcgcg ctcggccgcc gcccgctcct atggggtctt ctgcaagggg ctgactcgca
      301 cgctgctcat cttcttcgac ctggcctggc ggctgcgtat caacttcccc tacctctaca
      361 tcgtggcttc catgatgctc aacgtccgcc tgcaggttca tattgagatc cattgaaggc
      421 cctcccagac tgacgaaggc gtgacctcag gcccaccgca tccaagaaca cgaagcatga
      481 gggacagaag agggcccctc ggcacctgcc tggcacaagt gcagcaggcc ggaggaggtg
      541 actcggacaa actatcatgc agccttaaga aaagaatgcc ggagggccct tggcctgcag
      601 atgcaccctc ctggatgaat aagcctgtgg ttgatggaaa ttcacaaagt gaggcattat
      661 cactggaaat gagaaaggat ccgagcgggg ctggcctctg gcttcacagt ggcggcccag
      721 tgcttccata tgtgagagaa tcagtaagaa gaaatccagc ctcagcagcc actccgagca
      781 cagccgtggg tttgttccct gctccaacag agtgttttgc tcgggtgtcc tgcagtggtg
      841 ttgaagctct ggggcggcga gactggctgg gaggagggcc cagggccact gacggccaca
      901 gaggacagtg ccccaaagga gagcctcggg tgtcacgact gccacgccat caaaaagtgc
      961 cggaaatggg aagttttcag gatgacccac caagtgcttt tcccaagggt ctgggctctg
     1021 agttggaacc cgcttgcctg cactccatcc tgtctgcaac gctgcacgtg tatcccgaag
     1081 tgctcctgag tgaggagaca aaacgcattt tccttgaccg tttaaagccc atgttttcaa
     1141 agcaaacaat agaattcaag aaaatgctta aaagcacctc agatggtctg cagataacac
     1201 tggggttact ggctctgcaa ccttttgaat tagcaaatac attatgccat agttaaggta
     1261 caagcagaac aataccaata gattaatttt aagagttgtc ttagaatgat ttctttcgca
     1321 ttaagtctgg atgcaaactg tgcagccctt aggttcctgc tgtagttttg tacgacctgg
     1381 cagacttaaa gtaaattgag tttaaattca aagccagttg atgcggaagg aacttttttg
     1441 gcatgtgtta aattgtgctt taaaagacat ataaagaatt gggaaacatt tcaggagacg
     1501 atcatagcct gtataaatac cagattagaa catacggatt taccatgaag ttctgtcttc
     1561 aacatccatt ctaaagggct actgtcccaa atcctgtgtg tccttttgac ttgtctgatc
     1621 acccaatgga agtggatact tgtaaagtct acaccactgt acttggcgtt aaatcttgct
     1681 gaattcgtgg taagctgtta ccatgtctac attttgtaga atgattttgg tctgcagcaa
     1741 aattcgattt cacttctcat acccctttcc ttccacttga aatgcaattt agacagaggc
     1801 cctgtggtga aagttgcaat attaagttta cctttagaag atcccttctc aaactcagaa
     1861 ccctagcagt gttaccttaa acaaaaatga gctcgagaaa aaagtagctc agttacagag
     1921 aagcaaatcg agttatttcc cacataaaaa gtttcccaga ttctaagaat tgcagtatcc
     1981 tgtaccctaa aatttttcaa ggtgactcct gttgtcgtct gttgataact ttaataaagg
     2041 tcatttaagg acataagttt ttaaagactc ccaaagtgaa acttaaacat tttcgggatt
     2101 atcgattgca tatatcagtt tatgctgtgt gctgaattac tatgccatgt gctattttag
     2161 tgtttgggga aaatgaaaaa taaaatttgt tctttagctt aataaatatg tcttatttta
//
