LOCUS       NM_020447               3275 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 219 member B
            (FAM219B), transcript variant 1, mRNA.
ACCESSION   NM_020447 XM_290640
VERSION     NM_020447.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3275)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3275)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB153105.1 and AC125435.8.
            
            On Nov 23, 2018 this sequence version replaced NM_020447.4.
            
            Transcript Variant: This variant (1), along with variants 2 and 3,
            encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA407803.1, SRR1660809.234643.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357635.10/ ENSP00000350260.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-350               DB153105.1         44-393
            351-351             AC125435.8         47835-47835
            352-550             DB153105.1         395-593
            551-3275            AC125435.8         51399-54123
FEATURES             Location/Qualifiers
     source          1..3275
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1-q24.2"
     gene            1..3275
                     /gene="FAM219B"
                     /gene_synonym="C15orf17"
                     /note="family with sequence similarity 219 member B"
                     /db_xref="GeneID:57184"
                     /db_xref="HGNC:HGNC:24695"
     exon            1..265
                     /gene="FAM219B"
                     /gene_synonym="C15orf17"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..648
                     /gene="FAM219B"
                     /gene_synonym="C15orf17"
                     /note="isoform a is encoded by transcript variant 1;
                     uncharacterized protein C15orf17; protein FAM219B"
                     /codon_start=1
                     /product="protein FAM219B isoform a"
                     /protein_id="NP_065180.1"
                     /db_xref="CCDS:CCDS32295.1"
                     /db_xref="GeneID:57184"
                     /db_xref="HGNC:HGNC:24695"
                     /translation="MATAEPSGRALRLSTPGPRPSGARDRAPGAAGPPSGQIGNRALR
                     LGERTPAAVEKRGPYMVTRAPSIQAKLQKHRDLAKAVLRRKGMLGASPNRPDSSGKRS
                     VKFNKGYTALSQSPDENLVSLDSDSDGELGSRYSSGYSSAEQVNQDVSRQLLQDGYHL
                     DEIPDDEDLDLIPPKPMASSTCSCCWCCLGDSSSCTLQ"
     exon            266..353
                     /gene="FAM219B"
                     /gene_synonym="C15orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            354..431
                     /gene="FAM219B"
                     /gene_synonym="C15orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            432..480
                     /gene="FAM219B"
                     /gene_synonym="C15orf17"
                     /inference="alignment:Splign:2.1.0"
     exon            481..3275
                     /gene="FAM219B"
                     /gene_synonym="C15orf17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3257..3262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM219B"
                     /gene_synonym="C15orf17"
                     /note="hexamer: AATAAA"
     polyA_site      3275
                     /gene="FAM219B"
                     /gene_synonym="C15orf17"
                     /note="major polyA site"
ORIGIN      
        1 actctttcgc cacgggcggg gttgcaccat ccggcagggc ggggcccggc catggcgacc
       61 gcggagccca gcgggcgcgc gttgcggttg tctaccccgg gaccccggcc cagcggggct
      121 cgggaccgcg cgccgggagc tgcggggcca ccctccgggc agatcggtaa tagagccctc
      181 cgtctggggg agcgcacccc cgcggccgtg gaaaagcggg ggccatacat ggtgacgcgc
      241 gcaccctcca ttcaagccaa gctgcagaag caccgggacc tggccaaggc cgttctgcgg
      301 agaaaaggca tgctgggggc ctcgccgaac cgcccagact cttcagggaa aaggtcagtg
      361 aagtttaaca agggctatac tgctcttagc cagagtccag atgaaaacct ggtgtccctc
      421 gactctgaca gtgatgggga gctgggatcc agatactcct ccgggtattc atctgcagag
      481 caggtgaacc aggatgtgag ccggcagctg cttcaggatg ggtatcacct ggatgagatt
      541 ccagatgacg aggacttgga cctcatcccc cctaagccca tggcctcttc aacatgctcc
      601 tgctgctggt gctgtcttgg ggactcttct tcctgtaccc tccagtagac attaccctcc
      661 aaggtgggcc ctgctcacca tgaggcctac agagccctgt tggccactca tagctcacac
      721 agtgcagtga gcactgaagt cactgacccc tagaaagtga cctgcaggta gcccttacct
      781 gttgcttctc aggccagagg cccccatctg ggctgtgggc tgataggtag aattctgtag
      841 ttttcctctg ctgttggagc agagtttgga gaagtcactt taataagggc aagacagaaa
      901 attctggttc ttatggtggg tgacaaaggt ggctaaggaa aacacttgca gacagcttga
      961 ttggtatttg tcatagtgct tcagggaggc aaaaagggag ctcttgtgcc caggctgtgc
     1021 tagatagtgt tgaatggagg cagaaaatag cactttatgg tttattatag ctggcaatcc
     1081 aaaaaagaaa ctgtttgaga ccagttcgag aaattccgtt tgctctattc ttcctagctc
     1141 taagatggtt tgcaggcttg accttcaaga cagcataaag tgagtccttt tgtccctctt
     1201 caggttgcac ctgtctaact atgacaggga tcatagcagg ttgcttaatg atacagcagg
     1261 atcctggctt ccagaatccc tggacctggg gcatccccaa ctggtccaac cgtccgggtg
     1321 agtttagtga ttctggtttg cccttcccta gttagagaaa aactgctctg acatgttcat
     1381 atttatttat ttgtatttcc ttggtctggg tgagtttctt cacccagtct ttgagctaaa
     1441 gattaggtcg aaggtactgg ggctggcccc agaagcctgc agtttttatt attaccagca
     1501 gagggagcta cagggagcag tccggtgcct tcctattgtt tactttttaa acttttgaga
     1561 agtagcaatg gactcgtgag agtgggtata cagctgtgtg ggctttgtcc tagactgagg
     1621 cttacagaca ggaagggtaa gagagaccta agccagctcc tagacccttg cctgaggaaa
     1681 tcagtccacc agtgtagagg gcctcccttc actccagcat ggaccattct attgccagat
     1741 tcttctggtc acagcatggg ccttactgga tactcaggat tgggctttaa gcagacctct
     1801 gggtgtgaca cagcctcttt cagcccccag cccaaacagc agaaataggc ataatttctg
     1861 ctgtgacacc ccctacccac aaattggaga gtatatcttg ctatactcta taccaagcct
     1921 ctttctagaa tttttccaac aggttttgtt ttgttttttg gcttaactca gaaccatggt
     1981 gagcgttctg ctttgttttg ttggagacag ggtctctgtc acccaggctg gagtgcagtg
     2041 gtgtaatcac agctcactgc agcctcaacc tcccaggccc aagcagtcct cccacatggt
     2101 gagctttgaa tgggcataga cagggttccc agcccaatag tcgggattgg ggtataggtt
     2161 ctacatggga aagtatccag tctcttgctt tactcagtgt cctgtgacca ccagaggcat
     2221 gagagggaca acacactctt ttcgctctac cacaaggggt gactagaaga tgagcaagtc
     2281 taataaaaag atacggcctt atttgttatt tgtctgacaa ccatccttac gatggtaatc
     2341 ctgtgagtgc ctgatggaca tctatctttg tgtttttctc aaaccatgga aggttgagag
     2401 gaatatacag tatctggggg ctgacttact ctactagcta ggagcatcac agcagagaga
     2461 taggacagag accagagtca tgccagcttg gggtcttggg aagagaggca gatggttact
     2521 ctgttctgga atgggactct gcagctctat gcagtggcca acattctgag cactttgtgc
     2581 aaatgcttgt agagctcaag aacatctcca tccagaaccc cttccccatc tgcagagacc
     2641 atgtccaggc ctttcttgtg tctgcagagg tgaagtgcac atgtggaaag ggatcaaatg
     2701 tagcacagtg taaagaaaga cagcaacaca ggtagaggga cccagtgtgt gctgggaggt
     2761 ggctgtggaa ggtaagtata gacctacatc tctgttgggg aggtggtcag ggcagaatgg
     2821 cctgggtgtt tagcagcttc taggggtgag ggtggcagga ccccaaaacc aaggccctct
     2881 gcatcgttgt tgtaataatc agctctggca tattcagctg caactgtccc tgaagaagag
     2941 gtttctgagc tggctgaccc catgtaggag ggtgttacct tgtagaaaaa gctggaggga
     3001 cctggtggga cagtgcagtg aggcagggta gaaatggtca gttgtttagg gccagtggcc
     3061 acataccaaa ataccaccaa tgtgcccagg gccaaactgc cttaattctg agtgctgtgt
     3121 gttctgcagg tgacagtttc ctgaggagag gggtgtatcc aggcttacct cccagcagga
     3181 gtggtaccat atggtgttta tgtactactc tatagaactc ttggcttgca cttctacagc
     3241 tctgtacatt tataagaata aatgcaatca cacta
//
