LOCUS       NM_001184940            3645 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens family with sequence similarity 219 member A
            (FAM219A), transcript variant 1, mRNA.
ACCESSION   NM_001184940
VERSION     NM_001184940.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3645)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096350.1, AK299882.1, AL356494.13 and BC025348.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001184940.1.
            
            Summary: The protein encoded by this gene has homologs that have
            been identified in mouse, macaque, etc organisms. Multiple
            alternatively spliced transcript variants that encode different
            protein isoforms have been described for this gene. [provided by
            RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299882.1, CD366572.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651358.1/ ENSP00000499069.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               AK096350.1         1-367
            368-982             AK299882.1         363-977
            983-3603            AL356494.13        64629-67249         c
            3604-3645           BC025348.1         2961-3002
FEATURES             Location/Qualifiers
     source          1..3645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..3645
                     /gene="FAM219A"
                     /gene_synonym="C9orf25"
                     /note="family with sequence similarity 219 member A"
                     /db_xref="GeneID:203259"
                     /db_xref="HGNC:HGNC:19920"
     exon            1..367
                     /gene="FAM219A"
                     /gene_synonym="C9orf25"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..865
                     /gene="FAM219A"
                     /gene_synonym="C9orf25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C9orf25; protein FAM219A"
                     /codon_start=1
                     /product="protein FAM219A isoform 1"
                     /protein_id="NP_001171869.1"
                     /db_xref="CCDS:CCDS55304.1"
                     /db_xref="GeneID:203259"
                     /db_xref="HGNC:HGNC:19920"
                     /translation="MMEEIDRFQVPTAHSEMQPLDPAAASISDGDCDAREGESVAMNY
                     KPSPLQVKLEKQRELARKGSLKNGSMGSPVNQQPKKNNVMARTRLVVPNKGYSSLDQS
                     PDEKPLVALDTDSDDDFDMSRYSSSGYSSAEQINQDLNIQLLKDGYRLDEIPDDEDLD
                     LIPPKSVNPTCMCCQATSSTACHIQ"
     exon            368..467
                     /gene="FAM219A"
                     /gene_synonym="C9orf25"
                     /inference="alignment:Splign:2.1.0"
     exon            468..570
                     /gene="FAM219A"
                     /gene_synonym="C9orf25"
                     /inference="alignment:Splign:2.1.0"
     exon            571..651
                     /gene="FAM219A"
                     /gene_synonym="C9orf25"
                     /inference="alignment:Splign:2.1.0"
     exon            652..706
                     /gene="FAM219A"
                     /gene_synonym="C9orf25"
                     /inference="alignment:Splign:2.1.0"
     exon            707..3645
                     /gene="FAM219A"
                     /gene_synonym="C9orf25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3624..3629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM219A"
                     /gene_synonym="C9orf25"
                     /note="hexamer: ATTAAA"
     polyA_site      3645
                     /gene="FAM219A"
                     /gene_synonym="C9orf25"
                     /note="major polyA site"
ORIGIN      
        1 gagtcaccgc agtggctgag ctgctgacag gaggcggcag cggagtagga ggcgaggcaa
       61 gacctgcggc tcggcccggc cacagccgcg gtagtgctag gcaagcccac ggagtcacgc
      121 cggcctcagc cagtctgcga acctctcgcc cccgcccacc cctgcatccg cccggcccct
      181 gcccgcccga gtggtccggg gaggcctagt ctgcaccacc cgccgggctc ctggggccgc
      241 cgccccgcgc ggtcctgtcg gcgtccgcgg ccgcgcccgg cccctggccc gctcgcccgc
      301 cggcaccatg atggaggaga tcgaccggtt ccaggtgccc accgcgcact cggagatgca
      361 gccgctggac ccagccgccg cctccatctc tgacggagac tgtgacgccc gggagggtga
      421 gtcagtagcc atgaattaca aaccatcccc gctccaagtg aagctggaga agcagcggga
      481 gctggcccgg aagggctccc tgaagaatgg cagcatgggt agccctgtca accagcaacc
      541 caagaagaac aatgtcatgg cccgaacaag gctggtcgtc cccaataaag gctactcctc
      601 acttgaccag agccctgatg agaagccact ggtagccctt gacacggaca gcgatgatga
      661 ctttgacatg tctagatact cctcctccgg ctactcctct gctgagcaga tcaaccaaga
      721 tttgaacatc cagctgctga aggacggcta ccggttagat gagatccccg acgacgagga
      781 cctagacctc atccccccca agtccgtgaa ccccacgtgc atgtgctgcc aggccacgtc
      841 ctccaccgcc tgccacattc agtagcgggc ggggccactg cggtcgccgg ggcggggccg
      901 ccaagggccg ggtaggacgg gcagaggccg accccttccc agctcgtctg cctgcccccg
      961 gccccgcgcc cctacagccg ccaacctcgt ataacagtca ttgcttcctc ctatggtagg
     1021 acgtgtacct ctgtgtgttc atggagctgg agaaaccaaa actgggtctc tctccacccg
     1081 ggagctgagg aggggtgggg gccgtttgtt cagttacctg ggggaacctc acccagcacc
     1141 ctgccccgct tcccagggct ggccaagaga gaagactgga cggcagggag gtcaacatta
     1201 acgagtgggg ggatcacaaa gccaggggct tggccccacc ccagcgaagc catgaactcc
     1261 caagccccgg cctcagccta accaggaaag gggctcggag ggagaaaggc ccagggcagt
     1321 ggggacgggt cccagcacct cggagccccc ttcacacgcc ccctaccggc ccatgtttct
     1381 atttgcattt ccccctcctc agatgggaag cctggcaaag ctgcccaacc gggtagtgcc
     1441 cctcacccat cggatcactg ccttcttcct cctcttgccc cattcacccg cttccttgca
     1501 ctctgggagt ggggcagggt aaggtgggcc ttacagacag gctgaggttt gggtggtgtg
     1561 atctgtccta attggcccct caccaatgca tctatctgtc tgccaccagc ccaccccacc
     1621 ctgcccccac cctcacccac gcttctgctc attggtctca atcccagcct ggaagcaggg
     1681 agtaaggctg gactccaatg gcccattccc ctcaccccag cccaagacgt gggaggctgc
     1741 ttcccagtaa gaatccagga gcaagctttg gtgaatccag tgggctgagt ggctctatgg
     1801 atgtggttgt ttggatgtgg tagggagtgc ttagcagaat gtgtgtgtat ctctgaggct
     1861 gtcagggggt gggtgggtgt gtgtctctgt tggacctgtc tctcctcagt ctattcctgt
     1921 catagatgtg ggtgtccctg gtagggaagt gcctgtgtgg tctgtttaca gtgcagaagg
     1981 cggctcagca gtgcaatggg ctgacagcct tggaccggga gtcagaagcc tgggttctgg
     2041 ttgtagctct ggcccctccc tgtgatcttc aacaagccac ttgctttctc tcgtcttcag
     2101 tttcctcaac tagaaaatga acagcagctg aaattatgtt gaagatcctt ttatacctga
     2161 aagagtttct tcatagaaat ttctgtggtg gggagggggc aatctctgtg tgtctcagta
     2221 tacctaaagg ttggggtggg gcggagttgt gtgtctctgt agaaaggcga aggggcagtt
     2281 cctatcagga ctgtgtatgt ctgagcacat gtggctctgt ttgggattac gtgtttgtct
     2341 gtgaatgtgt gtgtgtgttg gagggttgtc tattgtgtgt ggctgtatag ggtgtctgta
     2401 gatcaagatg tgtatacagc tgcttctgct attgctggtt tgggggaggg gactggaaag
     2461 ctgagactga aaatcaagag ggaagaggtg aggaaggccc acccctgggg ctgggcagtg
     2521 tagacctgcc accgtgtgaa gaaaaatgaa agcacagata gcctaagact gcacaggcct
     2581 gtgcccacat accttatagc acaggcccag gtggatcatc tcatgctaac accccacatg
     2641 tgctggtgga tccactccca tggatccact cacatgctgc aggcatgcag tagactcacc
     2701 cacagcccac tctctggaca ccaatcctgg gaggtgggag ctggaatggg gagcaatgag
     2761 aggagggagt gagactgttg gcttaggaag ggtggtacct ctccctgcat catacccagg
     2821 aactgccagc tccaaaatat tggggtacag ctcaccaccc cccactccgc caacccattc
     2881 ctacctcctc tagtgcaggg acccaagtta gatgatgaga aaatgccaaa caaagggagg
     2941 caaggacaga gaaggtacct gcaggaccca caaggcccat actggccccc atctgaaccc
     3001 acctctccca cccagatcaa catcccccca acccctgtgc ccccatcatc tggaccccag
     3061 agccagccct cccactacca ccaccaccac cccggggctc cttggctcac ctttctagaa
     3121 catgggtacc tcctcttttt gggggctcat ttagactgct gcctttgctg ctgacttgca
     3181 gtgtgactcg ggcccattgt tcaatctctg tggccctgag acaccaggga aaatctcccc
     3241 ccccacagga catactagtt ccctggcagg caagggcttc caactgaggc agtgcatgtg
     3301 tggcagagag aggcaggaag ctggcagtgg cagcttctgt gtctagggag gggtgtggct
     3361 ccctccttcc ctgtctggga ggttggaggg aagaatctag gccttagctt gccctcctgc
     3421 cacccttccc cttgtagata ctgccttaac actccctcct ctctcagctg tggctgccac
     3481 ccagccaggt ttctccgtgc tcactaattt atttccagga aggtgtgtgg aagacatgag
     3541 ccgtgtataa tatttttttt aacattttca ttgcagtatt gaccatcatc cttggttgtg
     3601 tatcgtgtaa cacaaataat gatattaaaa gcatcaaaca agcca
//
