LOCUS       NM_022106               5086 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 217 member B
            (FAM217B), transcript variant 1, mRNA.
ACCESSION   NM_022106
VERSION     NM_022106.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5086)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5086)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB476861.2, BC054002.1, AK074295.1, AL109928.33 and CB242399.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022106.2.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the longer isoform (1). Variants 1 and 2
            encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.243390.1,
                                           SRR1660805.168521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360816.8/ ENSP00000354056.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-658               DB476861.2         3-660
            659-3920            BC054002.1         547-3808
            3921-4454           AK074295.1         1800-2333
            4455-4462           AL109928.33        96706-96713         c
            4463-4935           CB242399.1         167-639
            4936-4936           AL109928.33        96232-96232         c
            4937-5018           CB242399.1         641-722
            5019-5086           AL109928.33        96082-96149         c
FEATURES             Location/Qualifiers
     source          1..5086
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..5086
                     /gene="FAM217B"
                     /gene_synonym="C20orf177; dJ551D2.5"
                     /note="family with sequence similarity 217 member B"
                     /db_xref="GeneID:63939"
                     /db_xref="HGNC:HGNC:16170"
     exon            1..147
                     /gene="FAM217B"
                     /gene_synonym="C20orf177; dJ551D2.5"
                     /inference="alignment:Splign:2.1.0"
     exon            148..259
                     /gene="FAM217B"
                     /gene_synonym="C20orf177; dJ551D2.5"
                     /inference="alignment:Splign:2.1.0"
     exon            260..345
                     /gene="FAM217B"
                     /gene_synonym="C20orf177; dJ551D2.5"
                     /inference="alignment:Splign:2.1.0"
     exon            346..5086
                     /gene="FAM217B"
                     /gene_synonym="C20orf177; dJ551D2.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..1501
                     /gene="FAM217B"
                     /gene_synonym="C20orf177; dJ551D2.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C20orf177; protein FAM217B"
                     /codon_start=1
                     /product="protein FAM217B isoform 1"
                     /protein_id="NP_071389.1"
                     /db_xref="CCDS:CCDS13484.1"
                     /db_xref="GeneID:63939"
                     /db_xref="HGNC:HGNC:16170"
                     /translation="MNAGPSWNKVQHSKNSSGKRQSKSQVPHASSQPRSSLTAVTQPT
                     EEKLKESISPEARRKRNPLGSRCQGASGNKLFLDFQSMKIIKENADEDSASDLSDSER
                     IPIPPSPLTPPDLNLRAEEIDPVYFDLHPGQGHTKPEYYYPNFLPSPFSSWDLRDMAL
                     LLNAENKTEAVPRVGGLLGKYIDRLIQLEWLQVQTVQCEKAKGGKARPPTAPGTSGAL
                     KSPGRSKLIASALSKPLPHQEGASKSGPSRKKAFHHEEIHPSHYAFETSPRPIDVLGG
                     TRFCSQRQTLEMRTEEKKKKSSKSTKLQRWDLSGSGSSSKVETSGHIRVPKQAAVILD
                     SADSCKASKTQAHAHPRKKGKAESCGHATVSSEKKLKTNGVKQNTYKLK"
     regulatory      5059..5064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM217B"
                     /gene_synonym="C20orf177; dJ551D2.5"
                     /note="hexamer: ATTAAA"
     polyA_site      5069
                     /gene="FAM217B"
                     /gene_synonym="C20orf177; dJ551D2.5"
     polyA_site      5086
                     /gene="FAM217B"
                     /gene_synonym="C20orf177; dJ551D2.5"
                     /note="major polyA site"
ORIGIN      
        1 agctcagcca gggagctcag cggagctgcg cgcctccgcc tccagctccc ctgccgcagc
       61 gcgccgcagc cgggcgtccc cgcgcgggcg ccggagagga aggaaggctg gcagcctcgt
      121 cacgtgtccg ctgcagtcgc gaaacagttc cggtggtgag gagacctttc caaatataag
      181 aggaataaag aagtcacctc cccagctgtc atcatcttcc agcagattga gcaagaatat
      241 tttgagcact acaggaaaga cagtccatca aacccgagat gatgatcagc cacgtgattt
      301 tttcaagaag aggaataggg tgaatgaatc tcatcagaaa agcagcaata tgaatgctgg
      361 cccatcttgg aataaagtgc aacattcaaa gaattcttca ggaaaaaggc agagtaaatc
      421 ccaagtaccc cacgcttctt cccagccgag aagcagcctc acagctgtca cccagcctac
      481 tgaagaaaaa cttaaagaaa gcatttcccc ggaagcaaga cgcaaaagga atccactcgg
      541 ttccaggtgt cagggggcct cagggaataa actgtttctt gattttcagt caatgaaaat
      601 tattaaagag aatgctgatg aggacagtgc aagtgatctc tctgattcgg aaagaattcc
      661 cattcctcct tctcccctca cacctccaga tctcaatctt cgagctgaag aaattgatcc
      721 agtttacttt gatcttcacc ctggtcaggg ccatacaaaa cctgaatact attatcctaa
      781 tttccttcca tcccctttca gctcctggga cctacgagat atggccctgc ttctgaacgc
      841 agagaacaaa acggaagccg tgccccgagt gggaggactt cttgggaagt atatcgatag
      901 acttattcag cttgagtggc tgcaagtcca gactgtacag tgtgaaaaag caaagggggg
      961 caaagcaagg ccccccactg cccctgggac ctcaggggca ctgaaaagcc ctgggagaag
     1021 taagctaatt gctagtgctc tgtccaagcc actacctcac caggaagggg cttcaaagtc
     1081 aggcccttcc cgaaagaaag cttttcacca tgaagaaatc cacccatcac attatgcatt
     1141 tgagacttcc cctagaccca ttgatgtgct tggtggtacc aggttttgtt ctcagaggca
     1201 aacccttgaa atgaggacag aagaaaagaa aaagaaatca agtaagagta cgaagctgca
     1261 gcgctgggat ctgtccggca gtggaagcag ctctaaggtg gaaaccagcg gtcacattcg
     1321 agttcccaaa caggcagctg tgattctgga ctcagcagat tcctgtaagg cctccaaaac
     1381 acaagcacat gcacatccta ggaaaaaggg aaaggcagag agctgtggtc atgccactgt
     1441 atcgagtgag aaaaaactga aaacaaacgg agtaaagcaa aacacatata aactaaaata
     1501 aatatctaaa atgctgaatt gccaagacct gcaggtacct caatgttaga gcgcttccaa
     1561 aagtcaaaat actgtgaatt ttaaggaatt ttacaaatac tgacatttaa gtagttgact
     1621 ggcatttttg tccaccttta tttctaccct gagtggggtt attttcaaag ggaagtgtct
     1681 ttcaataagc ctttctttgt attgtcagtc ttaggcaaat gagagccctt tagataaaaa
     1741 ttatgtaaaa tatgtgccat ataaaggaat aaaatggcac ctctccaggg aaagtgtcag
     1801 tgaaacctca gctacagtag ccggtctgtg tagagcagct agtggtgtta cctccccatt
     1861 ttcacatgca cgtaagtata tgaaatagtg cagactgttt caaatggtgt ggaatcctaa
     1921 atgtttaaaa taaggtcctt cttgcccact ccctcgctta cttttttata aactcctcaa
     1981 gcaaaatttc tgttcatttt acccttagga gaagctttag ttcttcctca agtcagggag
     2041 tagtgagttt gtattttgag tagtcatttc tcactaagct ggttgctttc tagagagaca
     2101 gtggaatcta gtactttaat acattttctc tgacatggtt ttttttttct tttttgaggg
     2161 gcattttaaa cttagaggtg gtggtaaaac ctacttttga gttctccgaa ctgaggttaa
     2221 aataacttgc agaattttcc aaagtcaatg ggcttagcat gattactgct gtttggtggg
     2281 gctgagaatg aaatatttga cattctggaa ttgctggcat gtaaagcttc tccagagagg
     2341 caccccaggg aaatcactct ttacaatttg taaaggaagg gcctgtaaaa ggatcaaaac
     2401 acatggacct acattcagtg taatagttac aaagttactg atttgggttc cacaccctgt
     2461 ggtccttagt caaaaataat gatctgtttc agtttgcaag agcaggattt tattattttg
     2521 cttggggtga ggggcgggag agtggaatat gagtaaggtt gctgaatgaa ttctaaactc
     2581 gcttatctgg tcttcaggct tcccaactct ctccaagcct tcttatttca ctgcagttaa
     2641 ataacatctt cttgttccta tagttgtgct gtgagttttc tgttcatatt tgcgcagtgt
     2701 attttaatac ggcccatgtc attatagttg attttatccc tttaaacaat tactgtattt
     2761 gtttttgacg tagaggtttc aattttttca ccttgggggc aaatgaaaaa cttggcattt
     2821 ttcatttggg aacatataat agcttgtaaa cttttcagac agcagtaaat gtctgaaaaa
     2881 atatcaaaaa cagcataaag acaagattat gtagctctaa ttatacgtat ataattataa
     2941 aaaacaatgt gcaagggtta tattttaagg tcttttaaaa tctgattttg atcataccaa
     3001 atgacataat attttttatg gtagcctttt actttcaaga cttaattttc agacttgtac
     3061 aagttccttc ttacattctt tccctctcac accatcctac tggagaaagc atacttttat
     3121 gctaagatct tactttaagc tttttatgtg aacaaaagat gtacatatag taagtattac
     3181 ttccgtagtc ctcaaattta ctataacttt tgtacttagt atatgtttta tatttggaaa
     3241 acagcactac gcttagtttt cctgtagttc ctgagtgatg tctgtgtgtt ccttgcctgc
     3301 ccttttttgt gagcacagat tagtctgtta tccatggctg gcacttcact tatgatcctt
     3361 tctctgctag atttttatgc agctctctat gaagtttcat ggcccataga tattcaaaag
     3421 caagatattc tatacatatg tgtatatgta tatatactcc ttatgttaat actaaagtgt
     3481 ttatgctgag ttgctgcctt tccccgtcat gtatccatgt gcatgctctt agagaccttg
     3541 aatggttgag ggtaaagtga tttattagta attctacttg ccttgtgtat gtctgagctg
     3601 aaaacaatcg tgattaagaa atttagaggt ggctgggcgt ggtggctcac gcctgtaatc
     3661 ccagcacttt gggaggccga ggcaggcgga tcacctgagg tcgggagttc aagaccagcc
     3721 tgaccaacat ggagaaaccc tgtctccact aaaaatacaa aattagccgg gtgtggtggt
     3781 gcatgcctgt aatcccagct actcggaagt ttgagacgag aatctcttga acccgggagg
     3841 cggaggttgt ggtgagccaa gatcgtgcca ttgcactcca gcctgggcaa caagagggaa
     3901 actccgtttc aaaaaaaaaa gaaaaagaaa gaaattgaga agtaacgcct cataatattt
     3961 gttcccagct ttttaaattg aagctggttg cataatctgg ggaatagtca taatttcatg
     4021 tgttatacag tttaaaaagc ctgcaaaagt gactttgctt gtttactttc tgcctcagat
     4081 tgactatttt aaccaatatt gtcacgacta gatcatagct cctagtgaat aacatgaggt
     4141 gttttaaagt taggtctatt acagaattaa cataagcaca attttaattt tatgatatct
     4201 gatatgccta tctaatacat cttaatgcat taaatgctgc agataagaat cttgctattt
     4261 ttcaagtaga caacattaga aagttgaatc atgaactcat tcaattcatc aagtcaaaag
     4321 cactgagtgt tttgctagtc tagtgacatg ggttattgta tttccgagaa gtgcctctca
     4381 tttctgggga gttgtttaca tataccctgc atttaaacca attaaaacaa tccaagtttc
     4441 tttaaaaaaa aaaagaaaaa gaaaaagaaa aagaaaaata ttttaggctt agaattatct
     4501 aatggaaaaa atgtaaaaaa gtacaaaaat gaactaaaag tatatcagta tttgcagtat
     4561 ttgctgtgat tacttaggtt tagactttct caacttctta gatgactaaa tgggctgaag
     4621 acttgtaact aacttgaata ggatagactt cataccctgt gacaaaaagg atggggaaga
     4681 gaatatcatt ggtcttgcca tatacctcct agctaaaagg aaaatggttt gtagttgttc
     4741 ttgggcctac tgtgttgctt ttcagaagga cataagactt tctactttat ctgatatgga
     4801 tatcgtctac ttcctcattc ctttatgctc acttatggag tagttacata gaaatataac
     4861 tcttggtggt actgtatttt aaggtaattc agaagcagta tgtattattt atgtacatgt
     4921 acaggacacc attcaaaatg gcttgaaaat attcagcatg tttgttattt gctgttatat
     4981 tgtatgttta gttttgtatg tgataaacag aattgatgta agtttttgtg gacttgaatt
     5041 tctccttcct tgagatcaat taaacagcag aaaaatattg tctgga
//
