LOCUS       NM_173563               2176 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 217 member A
            (FAM217A), mRNA.
ACCESSION   NM_173563
VERSION     NM_173563.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2176)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2176)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL033383.26 and BC039349.1.
            
            On May 17, 2019 this sequence version replaced NM_173563.2.
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039349.1, BM559565.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274673.8/ ENSP00000274673.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AL033383.26        52788-53073         c
            287-622             BC039349.1         307-642
            623-2176            AL033383.26        42303-43856         c
FEATURES             Location/Qualifiers
     source          1..2176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.2"
     gene            1..2176
                     /gene="FAM217A"
                     /gene_synonym="C6orf146"
                     /note="family with sequence similarity 217 member A"
                     /db_xref="GeneID:222826"
                     /db_xref="HGNC:HGNC:21362"
     exon            1..286
                     /gene="FAM217A"
                     /gene_synonym="C6orf146"
                     /inference="alignment:Splign:2.1.0"
     exon            287..380
                     /gene="FAM217A"
                     /gene_synonym="C6orf146"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1847
                     /gene="FAM217A"
                     /gene_synonym="C6orf146"
                     /note="uncharacterized protein C6orf146"
                     /codon_start=1
                     /product="protein FAM217A"
                     /protein_id="NP_775834.2"
                     /db_xref="CCDS:CCDS4489.1"
                     /db_xref="GeneID:222826"
                     /db_xref="HGNC:HGNC:21362"
                     /translation="MGRRNENCANSLRVSNISQENLSHWNLDSEVPVSENKNLPAGRD
                     GAAGGKINKNYLEIPVEQLMLEPNLSVHSQKSTQNSKQGIFQLWNCPLNEGSTIEKRE
                     FKKSSVETGFNVINHPIRVFTLNHPLTIASVDKQVGPYPGLPMPLGLCWPYADGDFFK
                     NRNEIHVSSCSTIENNDGETLPAPNWNLKHGNSSVEENFTDESDLSENEKTNDTLLSY
                     FKKVDLNLKPETIKNVEEPFTEEPNEVFPYPDFLPPPFSALDLHNLALSKSDNWKVTV
                     DPAETSVEHLITRLLELERLQHMTIQKERPRLQTTFCTPAVTERPSSSKATPKVRQPK
                     LCDSLSLQIPCVDKSQEKSKNNSGSCKLEQNALKRNWSNAGKYRWNSRPLSLKSSSTP
                     KQLIETYDKNPKSSILSPCQELSFKPTIGHTNQSMVKMVSTRCLPWRSPMPVSPIPLT
                     FPENQKEEIKAPKRNFGTKKKLYRQNIVLNRPFSIQKLNCLSPSLIAKDKCCSPIEQK
                     "
     exon            381..465
                     /gene="FAM217A"
                     /gene_synonym="C6orf146"
                     /inference="alignment:Splign:2.1.0"
     exon            466..479
                     /gene="FAM217A"
                     /gene_synonym="C6orf146"
                     /inference="alignment:Splign:2.1.0"
     exon            480..554
                     /gene="FAM217A"
                     /gene_synonym="C6orf146"
                     /inference="alignment:Splign:2.1.0"
     exon            555..622
                     /gene="FAM217A"
                     /gene_synonym="C6orf146"
                     /inference="alignment:Splign:2.1.0"
     exon            623..2176
                     /gene="FAM217A"
                     /gene_synonym="C6orf146"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2159..2164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM217A"
                     /gene_synonym="C6orf146"
                     /note="hexamer: AATAAA"
     polyA_site      2176
                     /gene="FAM217A"
                     /gene_synonym="C6orf146"
                     /note="major polyA site"
ORIGIN      
        1 ggtggggaag cccgcggagc cgcagccccg gccccggaag gtctctctgg gccccgggcc
       61 cgactcccac ccctgcgccg gcccgcgggc ttcgcaggcc ctgcactgcc gaccgggctg
      121 cgctcaaggc cgccagccgc ccgccgccct ctttgtcccc ccgctgcagg aaggccgcgg
      181 cagagggggc gccctccaag ccgtcagcca cgcacgcgga ggcgctcggg cctcggggcg
      241 gcgcaccggg agagcacgcc ggggaggaca cgtgggcctt cgcgcggatt ttaaggaaac
      301 agagcaacag ctacaacaaa atggggagaa gaaatgagaa ctgtgctaac agcctacgtg
      361 tgtcaaacat ctctcaggag aacttatctc actggaattt ggattcagaa gtacctgttt
      421 ctgaaaataa aaacctccca gctggaaggg atggagcagc aggtggcaaa attaacaaga
      481 actatttgga aattccagtg gagcaactga tgctagaacc taatttgtcg gtgcatagtc
      541 aaaaaagtac acagaatagt aaacaaggga tctttcaatt atggaattgt cctcttaatg
      601 aaggaagtac catagagaag agggaattca aaaaatcttc agtggaaact ggctttaatg
      661 taatcaatca tcctataagg gtcttcactc tgaaccaccc attaacaatt gcttcagttg
      721 ataagcaagt tggtccttac cctggactgc caatgccatt aggtctctgc tggccctatg
      781 ctgatggaga cttttttaag aacagaaatg agattcatgt tagttcatgt tcaactatag
      841 aaaacaatga tggtgaaaca ttacctgctc caaattggaa tttgaaacat ggaaacagca
      901 gtgtggaaga aaatttcaca gatgaaagtg atttatcaga aaatgagaag acaaatgata
      961 ctttactcag ctattttaaa aaggtggacc tgaacttgaa gccagaaaca ataaaaaatg
     1021 ttgaggaacc tttcaccgag gagccaaatg aagtatttcc atatcctgat tttctccctc
     1081 ctcctttcag tgctctagac ttgcacaatt tagccctctc caaatctgac aattggaaag
     1141 tgacagtgga ccctgcagaa acctctgttg aacacttgat aactcgttta ctggaactag
     1201 aacgattaca acatatgact attcaaaaag agaggccaag actacaaacg actttctgta
     1261 ctccagcagt tactgaacga ccctcttcct ccaaagctac accaaaagtg agacagccaa
     1321 aactttgcga ctctttgagt cttcagatac cttgtgtaga taaaagtcaa gaaaaaagta
     1381 aaaacaactc tggttcttgt aagcttgaac aaaatgcttt aaaacggaat tggagcaatg
     1441 ctggcaaata tagatggaat tctagaccac tgtctctaaa aagttcttcc accccaaaac
     1501 aattgattga aacttatgat aagaatccca aaagttctat tttaagtcca tgccaagaac
     1561 tctcattcaa acctactatt ggccatacaa atcaatcaat ggttaaaatg gtctccacaa
     1621 gatgtctgcc atggaggtct ccaatgccag tttcacctat acctctgact tttcccgaaa
     1681 atcagaagga agaaattaag gcaccgaaga gaaactttgg gaccaaaaag aaactttacc
     1741 gacaaaatat agtgttgaat agaccattct ctattcagaa gctaaactgt ttgtcgcctt
     1801 cccttattgc taaggataag tgctgctcac ccattgaaca aaaataactc ttttctttca
     1861 tacatctcaa tgtgaacaca tctactctaa gaagcccaac taagatatgg ttaattattc
     1921 caagacacag gtactattaa cagtccccca aaatcaccaa acagttgctt gatgtgatat
     1981 ggagtagaac ttgtgaaaag cactgctgag atgtctatat ataaacccac aggcttctat
     2041 actgacatat ttcacaatct tttgcatgtt gtgtttcaag taaatggttc acttggtaga
     2101 ctattctatt caaaaggcta ctcttttttc agtgattgtt ttccagtata attccatcaa
     2161 taaatggtat aattga
//
