LOCUS       NM_080821               2987 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens family with sequence similarity 210 member B
            (FAM210B), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_080821
VERSION     NM_080821.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2987)
  AUTHORS   Pan,X., Xu,J. and Zhou,Y.
  TITLE     Multifaceted role of FAM210B in hepatocellular carcinoma:
            Implications for tumour progression, microenvironment modulation
            and therapeutic selection
  JOURNAL   J Cell Mol Med 28 (16), e70031 (2024)
   PUBMED   39198940
  REMARK    GeneRIF: Multifaceted role of FAM210B in hepatocellular carcinoma:
            Implications for tumour progression, microenvironment modulation
            and therapeutic selection.
REFERENCE   2  (bases 1 to 2987)
  AUTHORS   Xu,Y., Gao,R., Zhang,M., Zeng,Q., Zhou,S., Zhu,G., Su,W. and
            Wang,R.
  TITLE     Mendelian randomization study on causal association of FAM210B with
            drug-induced lupus
  JOURNAL   Clin Rheumatol 43 (5), 1513-1520 (2024)
   PUBMED   38436771
  REMARK    GeneRIF: Mendelian randomization study on causal association of
            FAM210B with drug-induced lupus.
REFERENCE   3  (bases 1 to 2987)
  AUTHORS   Suzuki,C., Fujiwara,T., Shima,H., Ono,K., Saito,K., Kato,H.,
            Onodera,K., Ichikawa,S., Fukuhara,N., Onishi,Y., Yokoyama,H.,
            Nakamura,Y., Igarashi,K. and Harigae,H.
  TITLE     Elucidation of the Role of FAM210B in Mitochondrial Metabolism and
            Erythropoiesis
  JOURNAL   Mol Cell Biol 42 (12), e0014322 (2022)
   PUBMED   36374104
  REMARK    GeneRIF: Elucidation of the Role of FAM210B in Mitochondrial
            Metabolism and Erythropoiesis.
REFERENCE   4  (bases 1 to 2987)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 2987)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2987)
  AUTHORS   Sun,S., Liu,J., Zhao,M., Han,Y., Chen,P., Mo,Q., Wang,B., Chen,G.,
            Fang,Y., Tian,Y., Zhou,J., Ma,D., Gao,Q. and Wu,P.
  TITLE     Loss of the novel mitochondrial protein FAM210B promotes metastasis
            via PDK4-dependent metabolic reprogramming
  JOURNAL   Cell Death Dis 8 (6), e2870 (2017)
   PUBMED   28594398
  REMARK    GeneRIF: it was found that low expression of FAM210B was
            significantly correlated with decreased survival and enhanced
            metastasis in vivo and in vitro, and the loss of FAM210B led to an
            increased mitochondrial respiratory capacity and reduced glycolysis
            through the downregulation of pyruvate dehydrogenase kinase 4
            (PDK4).
            Erratum:[Cell Death Dis. 2019 Sep 23;10(10):707. doi:
            10.1038/s41419-019-1945-y.. PMID: 31548594]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2987)
  AUTHORS   Kondo,A., Fujiwara,T., Okitsu,Y., Fukuhara,N., Onishi,Y.,
            Nakamura,Y., Sawada,K. and Harigae,H.
  TITLE     Identification of a novel putative mitochondrial protein FAM210B
            associated with erythroid differentiation
  JOURNAL   Int J Hematol 103 (4), 387-395 (2016)
   PUBMED   26968549
  REMARK    GeneRIF: Both human and murine FAM210B are abundantly expressed in
            the later stages of erythroblast development. Moreover, the deduced
            amino acid sequence predicted that FAM210B is a membrane protein,
            and Western blot analysis demonstrated its mitochondrial
            localization. Loss-of-function analysis in erythroid cells
            suggested that FAM210B may be involved in erythroid
            differentiation.
REFERENCE   8  (bases 1 to 2987)
  AUTHORS   Palmieri,R.T., Wilson,M.A., Iversen,E.S., Clyde,M.A.,
            Calingaert,B., Moorman,P.G., Poole,C., Anderson,A.R., Anderson,S.,
            Anton-Culver,H., Beesley,J., Hogdall,E., Brewster,W., Carney,M.E.,
            Chen,X., Chenevix-Trench,G., Chang-Claude,J., Cunningham,J.M.,
            Dicioccio,R.A., Doherty,J.A., Easton,D.F., Edlund,C.K.,
            Gayther,S.A., Gentry-Maharaj,A., Goode,E.L., Goodman,M.T.,
            Kjaer,S.K., Hogdall,C.K., Hopkins,M.P., Jenison,E.L., Blaakaer,J.,
            Lurie,G., McGuire,V., Menon,U., Moysich,K.B., Ness,R.B.,
            Pearce,C.L., Pharoah,P.D., Pike,M.C., Ramus,S.J., Rossing,M.A.,
            Song,H., Terada,K.Y., Vandenberg,D., Vierkant,R.A., Wang-Gohrke,S.,
            Webb,P.M., Whittemore,A.S., Wu,A.H., Ziogas,A., Berchuck,A. and
            Schildkraut,J.M.
  CONSRTM   Ovarian Cancer Association Consortium; Australian Cancer Study
            (Ovarian Cancer Group); Australian Ovarian Cancer Study Group
  TITLE     Polymorphism in the IL18 gene and epithelial ovarian cancer in
            non-Hispanic white women
  JOURNAL   Cancer Epidemiol Biomarkers Prev 17 (12), 3567-3572 (2008)
   PUBMED   19064572
  REMARK    GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 2987)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 2987)
  AUTHORS   Ranes-Goldberg,M.G., Hori,T., Mohan-Peterson,S. and Spits,H.
  TITLE     Identification of human pre-T/NK cell-associated genes
  JOURNAL   J Immunol 151 (10), 5810-5821 (1993)
   PUBMED   8228263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB500825.1, AK075565.1 and AL133555.1.
            
            On Nov 22, 2018 this sequence version replaced NM_080821.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ311123.1, BC017725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371384.4/ ENSP00000360437.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DB500825.1         48-54
            8-2114              AK075565.1         2-2108
            2115-2987           AL133555.1         845-1717
FEATURES             Location/Qualifiers
     source          1..2987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.2"
     gene            1..2987
                     /gene="FAM210B"
                     /gene_synonym="5A3; C20orf108; dJ1167H4.1"
                     /note="family with sequence similarity 210 member B"
                     /db_xref="GeneID:116151"
                     /db_xref="HGNC:HGNC:16102"
                     /db_xref="MIM:618722"
     exon            1..218
                     /gene="FAM210B"
                     /gene_synonym="5A3; C20orf108; dJ1167H4.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..611
                     /gene="FAM210B"
                     /gene_synonym="5A3; C20orf108; dJ1167H4.1"
                     /note="transmembrane protein C20orf108"
                     /codon_start=1
                     /product="protein FAM210B, mitochondrial"
                     /protein_id="NP_543011.2"
                     /db_xref="CCDS:CCDS13450.1"
                     /db_xref="GeneID:116151"
                     /db_xref="HGNC:HGNC:16102"
                     /db_xref="MIM:618722"
                     /translation="MAGLLALLGPAGRVGARVRPRATWLLGATAPCAPPPLALALLPP
                     RLDARLLRTARGDCRGHQDPSQATGTTGSSVSCTEEKKQSKSQQLKKIFQEYGTVGVS
                     LHIGISLISLGIFYMVVSSGVDMPAILLKLGFKESLVQSKMAAGTSTFVVAYAIHKLF
                     APVRISITLVSVPLIVRYFRKVGFFKPPAAKP"
     exon            219..394
                     /gene="FAM210B"
                     /gene_synonym="5A3; C20orf108; dJ1167H4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..2987
                     /gene="FAM210B"
                     /gene_synonym="5A3; C20orf108; dJ1167H4.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2961..2966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM210B"
                     /gene_synonym="5A3; C20orf108; dJ1167H4.1"
                     /note="hexamer: AATAAA"
     polyA_site      2987
                     /gene="FAM210B"
                     /gene_synonym="5A3; C20orf108; dJ1167H4.1"
                     /note="major polyA site"
ORIGIN      
        1 agcggcgcgg gtgctgcgcc tagctgcgca ccatggccgg gttgctggcg ttgctgggtc
       61 cggcaggcag ggtgggcgcc cgggtccggc ctcgcgccac ctggctcctg ggcgccaccg
      121 ccccctgcgc cccgccgccc ctggccctgg ccctgctccc gcccaggcta gacgcccggc
      181 tgctccgcac ggcgcgcggg gactgccgcg gccaccagga ccccagccag gccacgggga
      241 caacaggcag cagcgtcagc tgcacagagg agaaaaagca aagcaagtca cagcaactga
      301 aaaagatttt tcaagagtat ggcactgttg gcgtgtcatt gcacattgga atctcattaa
      361 tttccttggg catattttac atggttgtgt caagtggtgt ggacatgcct gcaatcctgc
      421 tgaaactcgg atttaaagag tccctggtac agtcaaaaat ggcagcaggc acaagtacct
      481 tcgtggtggc ctatgcaatc cacaagctgt ttgcgccagt gagaatcagc attacgctag
      541 tctctgtgcc cttgattgtc agatattttc gaaaagtggg attttttaaa cctccagctg
      601 caaaacctta atgaactctt cagtcgtaca cactgaaaac ctatttcttc taaattacat
      661 gatttggatt ggttttaggg ttttagggtt gtagggtttc ttttggagag gtagggggct
      721 aattgctatg ttctcatgga taaactttgc cagcaaaaat caggcttttg aacaatttta
      781 attttttgcc tcataaattt tgtgaatgct attcattata gggcttgtat atataatcta
      841 aaatgtcagc aaggcatcgg agatgggtta acatctcaaa acaaaatagc ctacaaatgt
      901 tccttgtggg agactttggc gagggtctgt gggtaaaagc accagggggt taatcttggc
      961 tcagtttcct aaaaagcatt gattaattta actggctttt aaatatcccc ttccgctgat
     1021 atttgttgtc agctgcctac agtttaatat gcagcgttca caaaacagct gccagtgcta
     1081 caattaatga agcaaaactt aatatgtaat cacaatctaa attagcatca atactttgac
     1141 attcattaca ttggtttggg ggaagaaaag tagttctggt atgtttcatt gatccccaga
     1201 taccttccaa tctggacatg atggggctga ttccagatgg tttttctgaa atttcattaa
     1261 ggtaggtcag cgtcatttgt ctctgtttag gtaaaatata aaaaccctgc ccagtagcag
     1321 tggcatcgct tggttcctga tgcccatgtt ccagaggaat tcggatacca caaacagcta
     1381 agacaatctc agcttttctt agacaatctt ctatctcaaa cttcagacat tccagaattg
     1441 tcatgatgtt tacactgtct gagttaaaaa tcctgttcaa gaaaaaaaaa gattttgtat
     1501 cacttcttaa aaaggaatat tcatagcact tgtcacaaat agaaggcaac catgagataa
     1561 tacaagccag ggagaggctt gtattacatg acaggtgtaa ttagtctgct gagccagctt
     1621 tacccaatga agggcatatg tgttagagag attagctaag agtagaaatt cgagcataga
     1681 ggccaggtgc ggtggctcac gcctgtaatc ccagcacttt gggaggttga ggcaggcgtg
     1741 tcacttgagg ccaggagttc gagaccagcc tggccaacat gatgaaaccc cgtctctact
     1801 acaaatacaa aaattagccg ggtgtggtgg cacacgcctg tagtcccagc tactggggag
     1861 gctgaggcag cattgcttga acccaggagg tggaggttgc agtgagccaa gatcacacca
     1921 ctgcactcca gcctgggcga cagagggaga cactgtctcc aaaagaaaga aatcccagcg
     1981 tagatccaaa ctgagacact gaggcttcgt ccttatagta gtcaggagca ggcgattgaa
     2041 gtaattctgt cctgcggggt tcagcatcat gcacgttccc cctgggccat tctctgatgc
     2101 agggcacttg ctccacactc tgggaaccca gattcaccag tctgccctgt cacgtagttg
     2161 aaggagttgc atttatcttt ctggctccta attcctttaa aattacattt gttgcagaac
     2221 ctccacaagg ctaaataaaa ttacatttgt gaccatcaga gaactgaata aaccattaac
     2281 tggccatcct ggttttgcag agatcaggtt gttgacagtt cctggttgac ccacagctac
     2341 ccatgtcagt tatctccact aacatatcca agaatctttg taggacaatt tctccacctg
     2401 caaggtcttt caggtagaac tcttctttta aggcaattag cccattgcca aaaggtttta
     2461 ctgtcttaaa gctgtctttc tgagatctaa ttccaaggac ttctccacag ctaagtgaga
     2521 tgcctcacac cattaggtga tgctttggac agaacagagt attttcatct tgtgtttaaa
     2581 gcaattcctt ggcttcggct cctcaccact ttctatgcca gtctcccatt tatgtcccta
     2641 gtaatgccta tgcaaaaaaa aaaaaagaaa aaaaagaaaa actgatggtg aaacctacag
     2701 gtttaagggc ttaaatctca aactttgtta ggagtaacag gagcgtgctg agcgggcaag
     2761 caataaaaca aatcatacca aaaagccaca ttgctctctc ctaagcccca accccactcc
     2821 actcctgtgg ccaggggtcc aaacagaaaa taaccggaga agacaaggag gtcaaaggat
     2881 cagggaacta agcattatgt gaattcacca gcaagatgta cagaacgcct gtgtttacat
     2941 tgtttttatg gaactagcag aataaaacat ctattttaaa aatgaaa
//
