LOCUS       NM_152352               4210 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens family with sequence similarity 210 member A
            (FAM210A), transcript variant 2, mRNA.
ACCESSION   NM_152352
VERSION     NM_152352.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4210)
  AUTHORS   Wang,Y. and Yue,F.
  TITLE     FAM210A: An emerging regulator of mitochondrial homeostasis
  JOURNAL   Bioessays 46 (10), e2400090 (2024)
   PUBMED   39159484
  REMARK    Review article
REFERENCE   2  (bases 1 to 4210)
  AUTHORS   Yu,J., Li,W., Hou,G.J., Sun,D.P., Yang,Y., Yuan,S.X., Dai,Z.H.,
            Yin,H.Z., Sun,S.H., Huang,G., Zhou,W.P. and Yang,F.
  TITLE     Circular RNA cFAM210A, degradable by HBx, inhibits HCC
            tumorigenesis by suppressing YBX1 transactivation
  JOURNAL   Exp Mol Med 55 (11), 2390-2401 (2023)
   PUBMED   37907737
  REMARK    GeneRIF: Circular RNA cFAM210A, degradable by HBx, inhibits HCC
            tumorigenesis by suppressing YBX1 transactivation.
REFERENCE   3  (bases 1 to 4210)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 4210)
  AUTHORS   Tanaka,K.I., Xue,Y., Nguyen-Yamamoto,L., Morris,J.A., Kanazawa,I.,
            Sugimoto,T., Wing,S.S., Richards,J.B. and Goltzman,D.
  TITLE     FAM210A is a novel determinant of bone and muscle structure and
            strength
  JOURNAL   Proc Natl Acad Sci U S A 115 (16), E3759-E3768 (2018)
   PUBMED   29618611
  REMARK    GeneRIF: Genetic variation near FAM210A, a gene of previously
            unknown function, was strongly associated with both appendicular
            and whole body lean mass, as well as bone mineral density.
REFERENCE   5  (bases 1 to 4210)
  AUTHORS   Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
            Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
            Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
            Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
            Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
            Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
            Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
            Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
            Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
            Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
            Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
            Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
            Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
            van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
            Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
            Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
            Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
            Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
            Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
            Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
            Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
            Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
            Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
            Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
            Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
            Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
            Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
            Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
            Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
            Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
            McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
            Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
            Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
            Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
            Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
            Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
            Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
            Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
            Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
  TITLE     Genome-wide meta-analysis identifies 56 bone mineral density loci
            and reveals 14 loci associated with risk of fracture
  JOURNAL   Nat Genet 44 (5), 491-501 (2012)
   PUBMED   22504420
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4210)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA573992.1, DA895646.1, BU189118.1, AP001010.4 and AA602175.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152352.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.241640.1,
                                           SRR1803615.13708.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651643.1/ ENSP00000498370.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               DA573992.1         35-151
            118-566             DA895646.1         122-570
            567-961             BU189118.1         188-582
            962-3977            AP001010.4         168773-171788       c
            3978-4210           AA602175.1         9-241               c
FEATURES             Location/Qualifiers
     source          1..4210
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.21"
     gene            1..4210
                     /gene="FAM210A"
                     /gene_synonym="C18orf19; HsT2329"
                     /note="family with sequence similarity 210 member A"
                     /db_xref="GeneID:125228"
                     /db_xref="HGNC:HGNC:28346"
                     /db_xref="MIM:617975"
     exon            1..230
                     /gene="FAM210A"
                     /gene_synonym="C18orf19; HsT2329"
                     /inference="alignment:Splign:2.1.0"
     exon            231..731
                     /gene="FAM210A"
                     /gene_synonym="C18orf19; HsT2329"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1077
                     /gene="FAM210A"
                     /gene_synonym="C18orf19; HsT2329"
                     /note="uncharacterized protein C18orf19"
                     /codon_start=1
                     /product="protein FAM210A"
                     /protein_id="NP_689565.2"
                     /db_xref="CCDS:CCDS11866.1"
                     /db_xref="GeneID:125228"
                     /db_xref="HGNC:HGNC:28346"
                     /db_xref="MIM:617975"
                     /translation="MQWNVPRTVSRLARRTCLEPHNAGLFGHCQNVKGPLLLYNAESK
                     VVLVQGPQKQWLHLSAAQCVAKERRPLDAHPPQPGVLRHKQGKQHVSFRRVFSSSATA
                     QGTPEKKEEPDPLQDKSISLYQRFKKTFRQYGKVLIPVHLITSGVWFGTFYYAALKGV
                     NVVPFLELIGLPDSVVSILKNSQSGNALTAYALFKIATPARYTVTLGGTSVTVKYLRS
                     HGYMSTPPPVKEYLQDRMEETKELITEKMEETKDRLTEKLQETKEKVSFKKKVE"
     exon            732..843
                     /gene="FAM210A"
                     /gene_synonym="C18orf19; HsT2329"
                     /inference="alignment:Splign:2.1.0"
     exon            844..4210
                     /gene="FAM210A"
                     /gene_synonym="C18orf19; HsT2329"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1861..1866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM210A"
                     /gene_synonym="C18orf19; HsT2329"
                     /note="hexamer: ATTAAA"
     polyA_site      1891
                     /gene="FAM210A"
                     /gene_synonym="C18orf19; HsT2329"
                     /note="major polyA site"
     regulatory      3383..3388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM210A"
                     /gene_synonym="C18orf19; HsT2329"
                     /note="hexamer: AGTAAA"
     polyA_site      3407
                     /gene="FAM210A"
                     /gene_synonym="C18orf19; HsT2329"
     regulatory      4186..4191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM210A"
                     /gene_synonym="C18orf19; HsT2329"
                     /note="hexamer: AATAAA"
     polyA_site      4210
                     /gene="FAM210A"
                     /gene_synonym="C18orf19; HsT2329"
ORIGIN      
        1 agaagcttca ctgagcgggc actggaggtc gcgagcacgt tgctagtggg cgcggctggc
       61 ggggccgggg gcggcagggg gctagcgtcc ggctgagccc ggcgggttcc tgcacgcgga
      121 cccacgcttt gtcgggctgc tctgctgagt gacaccgccg tggcatccga ggagctgtgg
      181 tccagcctgc gcggcgggaa gcggcggcgg cggctccagc gtcctaagag aagctgaaac
      241 ctatcaacac tcttcaaaat gcaatggaat gtaccacgga ctgtatctcg actggcacgc
      301 aggacatgct tggaaccaca taatgctggt ctctttggac actgtcaaaa tgtaaaggga
      361 cctttacttt tatacaatgc tgaatccaaa gtggttttgg tacaaggccc tcaaaaacaa
      421 tggttgcatt tatctgctgc ccagtgtgtt gcaaaggaaa ggaggccatt ggatgctcat
      481 ccaccccaac caggagtcct tcgccataag caagggaagc aacatgtttc attcaggagg
      541 gttttttcat ccagtgccac agctcaggga actccggaaa aaaaggaaga gcctgatcct
      601 ttgcaagaca aatctattag tctttatcaa cgattcaaga agacatttag acagtatgga
      661 aaagttctga ttccagtgca tctaataact tctggtgttt ggtttggaac attttattat
      721 gcagccttga aaggagtgaa tgtcgttcct tttctagaac tcattgggtt acctgacagt
      781 gtggtaagca tcctgaaaaa ctcccagagt ggaaatgccc tcacagcata tgccttgttt
      841 aagattgcaa cacctgctcg gtataccgtg actttgggag gaacatctgt cactgtgaag
      901 tatctgcgca gtcatggcta catgtccacg ccgccacccg tcaaggagta tctgcaggac
      961 aggatggaag agacaaagga gcttatcaca gagaaaatgg aagaaacaaa agatagactc
     1021 actgaaaagt tacaagaaac caaagaaaaa gtttccttta agaaaaaagt ggaataaggt
     1081 gccttatata gcagtataga aaattcctgc actttaaccc tttggaaact atgggcaaag
     1141 atacatgtgt ctgattattt ttttggttag ttgccgaaat atactagttc tctgagggtt
     1201 aaagaagtaa aatacctttt taaagttaaa tatcactaga aaaatcagtg ttattacaag
     1261 ggaagaaatg aacccagttt aagaatttgc catcagtagc agtattaagc agtggttaat
     1321 gtcttagaag tcagacttct ttttcaaggt cttcagaacc acacttgatt tctgttttgt
     1381 tgcagctgta attgacacat actaggcagc tgactccttg aatatccagt gtgacccata
     1441 aaatagtctg ttaataccgg atcttaattt ttatgttatt cattaagatt ttaactatat
     1501 tcagtacgta atttggagac aaactagcat catcaaaact gcctgtaaat aaggtgttta
     1561 gtctttctat aaaaacagaa tagagcagtt acctaccagt taaaatatct tatatgaaga
     1621 aaatagaata aagatccagt catatatgta aataagatgt actgattgta cgtaaatgaa
     1681 aaatggaccc tttaaaaatt atttttacct gaagcttgtc ataatttttt taaagcaaat
     1741 atatatatgg tgatggtact tttcaaagtg tgtattagtg gtgatcacct caaacataaa
     1801 cctctgttgt gaatcatttg tgtccttttc aactgtcttt cagaggaaag gtaaaaaatc
     1861 attaaacctt aaattcattg ttaaaatcaa atatttgtca gcagtaactc aagctcatgg
     1921 ttctcaagca gaaaaaggtt tgggagacta aaaatggagt caggttttca tggagactgc
     1981 taactccttg gggtagacat gggccttgcc tcagcaaacc agtgcaattt cccaatgtct
     2041 tagtttcaga attcatgctg atttcattat ggagtaaagt tttaaattgt ggctgctgct
     2101 ttttgtctta cattgaaggg aaatatcctt gtttgagcat tctacttgat tttttttttt
     2161 tttttttttt tttttgagac ggagcctccc tctctctctc ccagactgga gtgcaatggt
     2221 acaatctcgg ctcactgcat cctctgcctc ccaggttcaa gtgatcctcc cgcctcagct
     2281 ttccaagtag ctgggagtat aagcgtgtgc caccacactc agctaatttt tgtattttta
     2341 gtggaggtgg agtttcacca tgttagccag gctagtctcc aactcctgac ctcagcctcc
     2401 cgagtagctg ggactacagg cgcccaccac cacgcccagc taattttttt gtatttttag
     2461 tagagatggg gtttcaccat cttaacaaag ctatcattaa atcatttgct tgtaatgaaa
     2521 ttcagccgtt gtcagctgtg agcgttgcgg ggctggtggg gtgtgtttga gtatgtaagt
     2581 gtctatttcc tgtgctctaa cagtgactat ttcagttcta acccttcaat tgctaattgg
     2641 atgagggaat ggcctcttag attgtccttg ttttgactta tctgctaagg cgagagaatg
     2701 tctgggtttg ccacacagtc ccgcagggac ccctgctctt tgccaggatt tttatatcaa
     2761 gtacttagtt tggccaaatt tagagtatag tttaaagggg aaaaaaagtt tgtatttgat
     2821 gagtctaatt actatattag aatgcttttt aaatgaatat gctgtgattg gaatctcttc
     2881 ttgggggccg gggagagtgc tgagagatgc agctgtgtct ctgctctctg cagtcttggg
     2941 caggcagcac cgctgtctcc tgatacagag ggttgaatgc actgcttcac attgatgcca
     3001 cattttcaaa tctaaacatg attaacatgt tttttaagta tttatcaaat aattcacatt
     3061 tttgcaggtt taagtgctgt tttttaagat attaaacatg ttccttgttt cttttttctt
     3121 tttaaccact ggagactatg tgaaaatctt gtgttatatg gaatttttct aaaacaattt
     3181 ccttttactt ttcatgttgc atattttcca gtggggataa attggaggtt cttattacta
     3241 ataatcctga aactaaaatt tgcttttcct gcatagacat cttttgttag tccatttgag
     3301 ttttgttgcc atccagtttc atgatcatgt tgtgttagtc taatagacaa tgagttactg
     3361 cttgaatgat atgaaattct ctagtaaaaa atgctctgaa gatgtgagaa gctctgttgt
     3421 attacttggc accaggaatg ttacaaaaat gttgttgcta gcatattgct aacctagtcc
     3481 ttaagtttca gggattcctg taatatgttg agtttggagt attaatagca ggctaacaga
     3541 atacagtacc aatatgccaa gttaaataat tgagaatata tacagtatag tttgctatgt
     3601 ataatagacc tcatttcatt tacagtacac ctcacacttg ggattaattc acctataacc
     3661 tctgtgaact gcgagtgctc ggcagaagca gccctgtgtc ttacatgtct acatttatat
     3721 ttatatttat atttattttt ttgagacaga gtctcactct gtcacccagg ctagagtgca
     3781 gtggcatgat catagctcac ttgcgtcttg aactcctggc tcaagtgatc ctcccacctc
     3841 agcctgctga gtagctggga ctacaggtgc acaccaccat gcctggctaa aggcatgtct
     3901 gcatttatgc gaggtgtgtt gaccgggtgg ggagggagct aggactgaga ttcgcctgtg
     3961 taaaatgcac aaaaagggtt tgctaagcaa attgatattt gaaatgaaag atggattagg
     4021 tgagagactt agtttattca ggaataagag caaaaccaac cacatcaaaa aatgtatttc
     4081 actgagacag ccttttgtac atacagcagg gtgctgttta cagatttcaa gaaaggagaa
     4141 aaagaatgct tatactgaga ttacctacct cccagtagtg aaaataataa atttatccct
     4201 tgaaatataa
//
