LOCUS       NM_014864               5991 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens FAM20B glycosaminoglycan xylosylkinase (FAM20B),
            transcript variant 1, mRNA.
ACCESSION   NM_014864
VERSION     NM_014864.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5991)
  AUTHORS   Lei,J., Deng,H., Ran,Y., Lv,Y., Amhare,A.F., Wang,L., Guo,X.,
            Han,J. and Lammi,M.J.
  TITLE     Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in
            Patients with Osteoarthritis and Kashin-Beck Disease
  JOURNAL   Cartilage 13 (1_suppl), 818S-828S (2021)
   PUBMED   32517548
  REMARK    GeneRIF: Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2
            in Patients with Osteoarthritis and Kashin-Beck Disease.
REFERENCE   2  (bases 1 to 5991)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5991)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5991)
  AUTHORS   Liu,S., Li,J., Xu,J., Liao,S., Chen,Y., Zhang,R., Tian,R. and
            Zhang,K.
  TITLE     Lack of association between PAX6/SOSTDC1/FAM20B gene polymorphisms
            and mesiodens
  JOURNAL   BMC Oral Health 19 (1), 90 (2019)
   PUBMED   31133012
  REMARK    GeneRIF: The T allele of FAM20B (rs3766626) was associated with
            susceptibility to two mesiodens
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5991)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 5991)
  AUTHORS   Koike,T., Izumikawa,T., Tamura,J. and Kitagawa,H.
  TITLE     FAM20B is a kinase that phosphorylates xylose in the
            glycosaminoglycan-protein linkage region
  JOURNAL   Biochem J 421 (2), 157-162 (2009)
   PUBMED   19473117
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5991)
  AUTHORS   Baxendale,H.E. and Goldblatt,D.
  TITLE     Correlation of molecular characteristics, isotype, and in vitro
            functional activity of human antipneumococcal monoclonal antibodies
  JOURNAL   Infect Immun 74 (2), 1025-1031 (2006)
   PUBMED   16428749
REFERENCE   8  (bases 1 to 5991)
  AUTHORS   Nalbant,D., Youn,H., Nalbant,S.I., Sharma,S., Cobos,E., Beale,E.G.,
            Du,Y. and Williams,S.C.
  TITLE     FAM20: an evolutionarily conserved family of secreted proteins
            expressed in hematopoietic cells
  JOURNAL   BMC Genomics 6, 11 (2005)
   PUBMED   15676076
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5991)
  AUTHORS   Yavuz,S., Grammer,A.C., Yavuz,A.S., Nanki,T. and Lipsky,P.E.
  TITLE     Comparative characteristics of mu chain and alpha chain transcripts
            expressed by individual tonsil plasma cells
  JOURNAL   Mol Immunol 38 (1), 19-34 (2001)
   PUBMED   11483207
REFERENCE   10 (bases 1 to 5991)
  AUTHORS   Baxendale,H.E., Davis,Z., White,H.N., Spellerberg,M.B.,
            Stevenson,F.K. and Goldblatt,D.
  TITLE     Immunogenetic analysis of the immune response to pneumococcal
            polysaccharide
  JOURNAL   Eur J Immunol 30 (4), 1214-1223 (2000)
   PUBMED   10760811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139132.16, BC051794.1 and CA844342.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014864.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB480690.1, AB007944.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263733.5/ ENSP00000263733.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL139132.16        60160-60204
            46-1336             BC051794.1         1-1291
            1337-5538           AL139132.16        106179-110380
            5539-5991           CA844342.1         5-457               c
FEATURES             Location/Qualifiers
     source          1..5991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..5991
                     /gene="FAM20B"
                     /gene_synonym="gxk1"
                     /note="FAM20B glycosaminoglycan xylosylkinase"
                     /db_xref="GeneID:9917"
                     /db_xref="HGNC:HGNC:23017"
                     /db_xref="MIM:611063"
     exon            1..205
                     /gene="FAM20B"
                     /gene_synonym="gxk1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..715
                     /gene="FAM20B"
                     /gene_synonym="gxk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..1568
                     /gene="FAM20B"
                     /gene_synonym="gxk1"
                     /EC_number="2.7.1.-"
                     /note="xylose kinase; family with sequence similarity 20,
                     member B"
                     /codon_start=1
                     /product="glycosaminoglycan xylosylkinase"
                     /protein_id="NP_055679.1"
                     /db_xref="CCDS:CCDS1328.1"
                     /db_xref="GeneID:9917"
                     /db_xref="HGNC:HGNC:23017"
                     /db_xref="MIM:611063"
                     /translation="MKLKQRVVLLAILLVIFIFTKVFLIDNLDTSAANREDQRAFHRM
                     MTGLRVELAPKLDHTLQSPWEIAAQWVVPREVYPEETPELGAVMHAMATKKIIKADVG
                     YKGTQLKALLILEGGQKVVFKPKRYSRDHVVEGEPYAGYDRHNAEVAAFHLDRILGFH
                     RAPLVVGRFVNLRTEIKPVATEQLLSTFLTVGNNTCFYGKCYYCRETEPACADGDIME
                     GSVTLWLPDVWPLQKHRHPWGRTYREGKLARWEYDESYCDAVKKTSPYDSGPRLLDII
                     DTAVFDYLIGNADRHHYESFQDDEGASMLILLDNAKSFGNPSLDERSILAPLYQCCII
                     RVSTWNRLNYLKNGVLKSALKSAMAHDPISPVLSDPHLDAVDQRLLSVLATVKQCTDQ
                     FGMDTVLVEDRMPLSHL"
     exon            716..802
                     /gene="FAM20B"
                     /gene_synonym="gxk1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..912
                     /gene="FAM20B"
                     /gene_synonym="gxk1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1084
                     /gene="FAM20B"
                     /gene_synonym="gxk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1276
                     /gene="FAM20B"
                     /gene_synonym="gxk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1336
                     /gene="FAM20B"
                     /gene_synonym="gxk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..5991
                     /gene="FAM20B"
                     /gene_synonym="gxk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5968..5973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM20B"
                     /gene_synonym="gxk1"
                     /note="hexamer: AATAAA"
     polyA_site      5991
                     /gene="FAM20B"
                     /gene_synonym="gxk1"
                     /note="major polyA site"
ORIGIN      
        1 gggtgtggga ctgccgctct gcgcggcgag aggtggcctg ggaatggccg ggccgggggt
       61 gggccggagc cgctgtggcg gcggcggcgg ctgggggcgg tgagcgcggc gtggggctgc
      121 ccctccccgg aggcggcggg ggcggccggg gccgcgccgc accgcaccgc gcgggcggcc
      181 atggagcgag cctagggccc gacaggaact gtggaaggtg catcagtgaa gaaatggacc
      241 aatgtgtata atcatggaat ctccttgcta accatcacca ccagctctcc ttaatacatg
      301 agcaagagtg ggtcagggga gaaggaaaag aggtcaacat gaagctaaag cagcgagtcg
      361 tgctgttagc aattctcctt gtcattttta tcttcaccaa agttttcctg attgacaact
      421 tagatacatc agctgccaac cgggaggacc agagggcctt tcaccgaatg atgactggct
      481 tgcgggtgga gctggcaccc aagctggacc ataccttgca gtctccctgg gagattgcag
      541 cccagtgggt ggttccccgg gaagtgtacc ctgaagagac accagagctg ggggcagtca
      601 tgcatgccat ggccaccaag aaaatcatta aagctgatgt gggttataaa gggacacagc
      661 tgaaagcctt actgatactt gaaggaggcc agaaagttgt tttcaaacct aagcggtata
      721 gccgagacca tgtggtggaa ggggaaccgt atgctggtta tgatagacac aatgcagagg
      781 tagcagcctt tcacttggac aggattctgg gtttccaccg agcccccttg gtagttggca
      841 gatttgttaa tcttcggaca gagatcaaac ctgtcgccac agagcagctg ttgagcacct
      901 tcctaactgt aggaaacaat acttgttttt atgggaagtg ctattactgc cgagaaacag
      961 aaccagcttg tgctgatgga gacataatgg agggatctgt cacactttgg cttccagatg
     1021 tgtggcctct gcagaagcac cgtcacccat ggggcaggac ttaccgagaa ggcaaattgg
     1081 ccaggtggga gtatgatgag agctactgtg atgctgtgaa gaaaacgtcc ccttatgact
     1141 ctggcccgcg cctcttggac atcattgaca cagctgtctt tgattacctg attggcaatg
     1201 ctgaccgcca tcactatgag agctttcaag atgatgaagg cgctagtatg ctcatccttc
     1261 ttgataatgc caaaagcttt gggaacccct cgctggatga aagaagcatt cttgcccctc
     1321 tctatcagtg ttgcatcatt cgggtgtcca cctggaacag actgaactac ctaaagaatg
     1381 gtgtgctaaa gtctgcctta aaatctgcca tggcccatga ccccatctcc ccagtgctct
     1441 ctgatcctca tctggacgcc gtggaccagc ggctcctgag tgtcctggcc accgtgaagc
     1501 agtgcaccga ccagtttggg atggacacag tactggtgga agacaggatg cctctctcac
     1561 acttgtaatt ctcgacacaa aataagtgaa acttcttttt acaaagatag agaaacagca
     1621 caatcaattc caaatggtat gagatggatt ggaagtggcc agcagcaagt tctggtgacg
     1681 ggacagagtg gccttggatg tctttggtat tttctgtagt agaaactaaa gcaaagacca
     1741 caagtttcag agcatggaga cattcctgct gaatcgcctt ctcacctcct cggcaattgc
     1801 tcattctagg gttgggcatc atagttggtc agtcttaatt cccatgccaa aggacaaaca
     1861 ggtgtgacat ttggatagat gaatactggg attggctctg gagcatgtgt tttgagttga
     1921 accttgcagt cctttctcta cgcccgtgga ttttgtggaa acactttgca atctctttgt
     1981 cttttttttt tttaccagaa ctagttacat tggaatgctt actgtcctac agagtggcag
     2041 caaataaaac cttgcattcc atcaagccaa aatagcacac tctgttagag gagatacatg
     2101 tttaagatag aattggaggg aaggacaaaa acagaaaaat gtttgggctt ttaagccatt
     2161 gggtagtatt gttttgatga tcttagagga gggaagaaga gagagagacc caatggtaga
     2221 accagaatca gggagatgac tgaactactg aaaaacaggt tcccttgtat ttaggatctt
     2281 aaggtgtata aaaagcaaac atgactttgc acctaagtaa attctgcatt ctcatagttg
     2341 tgtcccaatt aaccaaaaag ttgtctctag agaaaatact attacaatct aagcatgatt
     2401 ctctgtggag actaattttt tccccttttg ccaaaagcag tccttcccaa attaacaaag
     2461 caaactgaaa taataccttg aataacaggt tgcctgtggt ctctgtcatc ctcgtttctc
     2521 ttctgaaatg aatttccacc tctgccttta aggcattttt gtcactgaag ctgctgttcc
     2581 caagagatcg gcaacctttt tgtccctttc tcataagaaa gggacactcc tacaggtgag
     2641 agtgtatacc ttactctctc agataagtgg ctggacttat cttgtgattt ggggccatgg
     2701 aagattggaa acaaagattt taagccttct tctttttttc ttttttcttt tttttttgag
     2761 accaagtctc actctgttgc ccaggctgga gtgcagtggc acgatcttgg cttactgcaa
     2821 cctccgtctc ccaggttcaa gcgattctct tgcctcagcc tccagagtag ctgggattac
     2881 aggcgcccgc catcgtgccc agctaatttt tatattttta gtggagacag ggtttcgggt
     2941 ttcaccatgt tggccaggtt gatcttggac tcctgacccc aggtgatcca cctgcctcag
     3001 ccttccaaag tgctgggatt acaggcatga gccaccgtgg ccggccaaga ttttaagcct
     3061 tctgagcctt gaaattgagg aggttaaaag gaagagcctt aagattttga tttatgtcaa
     3121 atcctaattc tatcattcag tcttgtttgg agttctgaac ccatgatgtt gtattatgct
     3181 tctttctcct cttagcactc tcaaatttca ggtttgtaaa acacagtttt tgttttgtgt
     3241 tctggcaaag tgatctcaac atgtaagtag ttgcagtaaa acacaggggc aaaggaagac
     3301 aggcctgatg tgcccactca tctatggact cagagctgtg tgctttgctc ctgcatcttg
     3361 ttgaggtgct gttccagctt tgcatttctg tcaagtagag gcgaatatat aaacagtgtg
     3421 gttgaataca tttaatgcca gccattggaa actagtttta ggcaaccact ctcaaaaaca
     3481 gctttagaat ttatgcccag ttttcttgca ttgaaagata actgagtaat aacctgtaac
     3541 tatttttaaa tggcatgaaa ttaggaaact tttgtacatt ttatatacat tttgagatga
     3601 acagaacaat gggctgagtt ataaaaagcg tgtattgaat ttaagaagac agactagcac
     3661 aaaacacaga attcgtgtta accaaaggag gcattgattt cagttttaag gctactcagt
     3721 gttgtgtgtc cagggaaatt cacagctcag tatgagaata ccttggttag tgctcaccca
     3781 caagcttcca ggagccagct gggaggagac aataggaaga gatgtcatct ctgctctccc
     3841 tgtaaatgtt agttgaacta agttatggat ttgtggtctt tcaaatacat gacgccttta
     3901 gtatgccaca ctgaaatgaa taagaagtct tctgaaactg ggaacttcat aacattgaag
     3961 gcagaagatt ctgctaagga aaaaagcagg caggaaagaa aatgtctcat cctttcttga
     4021 aagcatttgc agaaaatata tcatttcatt ttattcccat ctgttttcaa actcgtgatc
     4081 ttaaaaggca ttctgatgat aaatttagaa ttttcatcta taaaatttag aactctaatc
     4141 cataaagtta gaattgagct aatagagtgg tatgacatgg cactaaaaat ataaattttt
     4201 gttgtaagtc aggattggag taagctggaa aagtatgttt aggcaaatct tggagaaaac
     4261 caaccataaa cttacagctc taaaattcag aaagccctaa aatttcaaac actgtttgaa
     4321 agaagaggtg ggggccgggt gccgtggctc atgcctgtca tcccagcatt tgggaggctg
     4381 aggcaggcag atcacctgag gccaggagtt cgagaccagc ctggctggct agcatggtga
     4441 gaccgtctct actaaaaatg caaaaattaa cagggcacgg tggcatgcgc ctgtagtccc
     4501 agctactcgg gaggctgagg caggagaatc acttgaatcc aggaggcgaa ggttgcagtg
     4561 agctgagatt gtgctgctgc actccagcct gggagacaga gcgagactct gtcttaaaaa
     4621 aaaaaaaagg aggtgaattt ttttttaagt tttgtaacac tgtcctactt tatttattag
     4681 aatctaaggc tgttacaatc aagtcgttgc agggtttgga tcagctgtaa gttaggtatg
     4741 cctaccaaac atccaaaggt agacgtggag acattttaat actacaaaac taggaaaatc
     4801 agaactcatg gccatttcct gccctcctcc aacttgttaa aacatgttta ttctaaagtt
     4861 cgaatggata aatttgagta taaaggtttt gttataaaac tgttctttag tgtaaggctg
     4921 cattgtgggt ttgggggaaa tgtaaataat tttctgtgta aaacaaattc ataggatctg
     4981 atttgctcag agtattattc aagaatgtat taataaggca ttgccccctg tttgcactca
     5041 gggttaatat gtcaaatgaa atttaagaag gaaatggaag aattcaggta cattaattgc
     5101 atattatttt gggaaagatg agtcctatac gtggcaattt ttcaatgtca tctgaagcca
     5161 gcattatctt ccaaagaaat cgatcttttt tttctaaaaa aaaaaaatgc ttttgccttc
     5221 ccttcccttc ccatccgcca tatttcttca gcctttcttc tcgatcaccc gtgtattctt
     5281 tgaccagtaa atgaccacac ctcaatgatg gtaaaacagc atcatcagta agctatctta
     5341 tatgcctcat cctgtgagtt tgagcttcag gaaacatgag taaaagtata tgtaatgtat
     5401 atagtcgtat atgtattcta gcaagaaaaa catatttatt ttgacaaagg ggaacactga
     5461 ctttctgaag gattcagaaa gaaccttagt gaaaggttct cagtctctga gagtggaccc
     5521 taattaacat aaagaccatt catcagcgaa taactactga gcaactctag tgtgccagca
     5581 caggccagac atactagtga gccaggcaca tctggccttg ggaaactcat cctacagggg
     5641 aaggccagtt tttttccctt caattcctca agtctgggtg gtgacaaggt aggggctagg
     5701 tactggacta ccacaggttt ttaggaacta aggtgtttct cataaacaca aaatgttggg
     5761 tgaaactggg aacaactact cagaagctca tttatttgct taaatggaaa gtgtgggagc
     5821 cactaccctc tcttttgatc tgccaaggat ttcctctcag agctgttgca cagacagaga
     5881 ttgtacttgg taagatacca aacaagacag atatggatct aaatttctaa tgtgttctat
     5941 gggtttcaat tctgaaaaaa gaaaatgaat aaagatttta ataaatattg a
//
