LOCUS       NP_055679                409 aa            linear   PRI 19-SEP-2024
DEFINITION  glycosaminoglycan xylosylkinase [Homo sapiens].
ACCESSION   NP_055679
VERSION     NP_055679.1
DBSOURCE    REFSEQ: accession NM_014864.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 409)
  AUTHORS   Lei,J., Deng,H., Ran,Y., Lv,Y., Amhare,A.F., Wang,L., Guo,X.,
            Han,J. and Lammi,M.J.
  TITLE     Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in
            Patients with Osteoarthritis and Kashin-Beck Disease
  JOURNAL   Cartilage 13 (1_suppl), 818S-828S (2021)
   PUBMED   32517548
  REMARK    GeneRIF: Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2
            in Patients with Osteoarthritis and Kashin-Beck Disease.
REFERENCE   2  (residues 1 to 409)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 409)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 409)
  AUTHORS   Liu,S., Li,J., Xu,J., Liao,S., Chen,Y., Zhang,R., Tian,R. and
            Zhang,K.
  TITLE     Lack of association between PAX6/SOSTDC1/FAM20B gene polymorphisms
            and mesiodens
  JOURNAL   BMC Oral Health 19 (1), 90 (2019)
   PUBMED   31133012
  REMARK    GeneRIF: The T allele of FAM20B (rs3766626) was associated with
            susceptibility to two mesiodens
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 409)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (residues 1 to 409)
  AUTHORS   Koike,T., Izumikawa,T., Tamura,J. and Kitagawa,H.
  TITLE     FAM20B is a kinase that phosphorylates xylose in the
            glycosaminoglycan-protein linkage region
  JOURNAL   Biochem J 421 (2), 157-162 (2009)
   PUBMED   19473117
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 409)
  AUTHORS   Baxendale,H.E. and Goldblatt,D.
  TITLE     Correlation of molecular characteristics, isotype, and in vitro
            functional activity of human antipneumococcal monoclonal antibodies
  JOURNAL   Infect Immun 74 (2), 1025-1031 (2006)
   PUBMED   16428749
REFERENCE   8  (residues 1 to 409)
  AUTHORS   Nalbant,D., Youn,H., Nalbant,S.I., Sharma,S., Cobos,E., Beale,E.G.,
            Du,Y. and Williams,S.C.
  TITLE     FAM20: an evolutionarily conserved family of secreted proteins
            expressed in hematopoietic cells
  JOURNAL   BMC Genomics 6, 11 (2005)
   PUBMED   15676076
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 409)
  AUTHORS   Yavuz,S., Grammer,A.C., Yavuz,A.S., Nanki,T. and Lipsky,P.E.
  TITLE     Comparative characteristics of mu chain and alpha chain transcripts
            expressed by individual tonsil plasma cells
  JOURNAL   Mol Immunol 38 (1), 19-34 (2001)
   PUBMED   11483207
REFERENCE   10 (residues 1 to 409)
  AUTHORS   Baxendale,H.E., Davis,Z., White,H.N., Spellerberg,M.B.,
            Stevenson,F.K. and Goldblatt,D.
  TITLE     Immunogenetic analysis of the immune response to pneumococcal
            polysaccharide
  JOURNAL   Eur J Immunol 30 (4), 1214-1223 (2000)
   PUBMED   10760811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139132.16, BC051794.1 and CA844342.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB480690.1, AB007944.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263733.5/ ENSP00000263733.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     Protein         1..409
                     /product="glycosaminoglycan xylosylkinase"
                     /EC_number="2.7.1.-"
                     /note="xylose kinase; family with sequence similarity 20,
                     member B"
                     /calculated_mol_wt=46302
     Site            7..25
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O75063.1)"
     Region          188..394
                     /region_name="FAM20B_C"
                     /note="C-terminal putative kinase domain of FAM20B xylose
                     kinase; cd10470"
                     /db_xref="CDD:198461"
     Site            193
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O75063.1)"
     Site            order(282,289,309)
                     /site_type="active"
                     /note="putative catalytic residues [active]"
                     /db_xref="CDD:198461"
     Site            286..294
                     /site_type="active"
                     /note="putative catalytic loop [active]"
                     /db_xref="CDD:198461"
     Site            order(294,309)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:198461"
     Site            309..331
                     /site_type="other"
                     /note="putative activation loop"
                     /db_xref="CDD:198461"
     CDS             1..409
                     /gene="FAM20B"
                     /gene_synonym="gxk1"
                     /coded_by="NM_014864.4:339..1568"
                     /db_xref="CCDS:CCDS1328.1"
                     /db_xref="GeneID:9917"
                     /db_xref="HGNC:HGNC:23017"
                     /db_xref="MIM:611063"
ORIGIN      
        1 mklkqrvvll aillvifift kvflidnldt saanredqra fhrmmtglrv elapkldhtl
       61 qspweiaaqw vvprevypee tpelgavmha matkkiikad vgykgtqlka llileggqkv
      121 vfkpkrysrd hvvegepyag ydrhnaevaa fhldrilgfh raplvvgrfv nlrteikpva
      181 teqllstflt vgnntcfygk cyycretepa cadgdimegs vtlwlpdvwp lqkhrhpwgr
      241 tyregklarw eydesycdav kktspydsgp rlldiidtav fdylignadr hhyesfqdde
      301 gasmlilldn aksfgnpsld ersilaplyq cciirvstwn rlnylkngvl ksalksamah
      361 dpispvlsdp hldavdqrll svlatvkqct dqfgmdtvlv edrmplshl
//
