LOCUS       NM_022090               2808 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 200 member C
            (FAM200C), transcript variant 2, mRNA.
ACCESSION   NM_022090 XM_371779
VERSION     NM_022090.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2808)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2808)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2808)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2808)
  AUTHORS   Hayward,A., Ghazal,A., Andersson,G., Andersson,L. and Jern,P.
  TITLE     ZBED evolution: repeated utilization of DNA transposons as
            regulators of diverse host functions
  JOURNAL   PLoS One 8 (3), e59940 (2013)
   PUBMED   23533661
REFERENCE   5  (bases 1 to 2808)
  AUTHORS   Woodard,L.E., Li,X., Malani,N., Kaja,A., Hice,R.H., Atkinson,P.W.,
            Bushman,F.D., Craig,N.L. and Wilson,M.H.
  TITLE     Comparative analysis of the recently discovered hAT transposon
            TcBuster in human cells
  JOURNAL   PLoS One 7 (11), e42666 (2012)
   PUBMED   23166581
REFERENCE   6  (bases 1 to 2808)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 2808)
  AUTHORS   Smit,A.F.
  TITLE     Interspersed repeats and other mementos of transposable elements in
            mammalian genomes
  JOURNAL   Curr Opin Genet Dev 9 (6), 657-663 (1999)
   PUBMED   10607616
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091842.3, BX487983.1, BC032603.1 and BM052679.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022090.4.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR compared to variant 1. Variants 1 and 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.766902.1,
                                           SRR1803617.248338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408953.4/ ENSP00000386184.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AC091842.3         66057-66421         c
            366-505             BX487983.1         364-503
            506-2428            BC032603.1         570-2492
            2429-2808           BM052679.1         7-386               c
FEATURES             Location/Qualifiers
     source          1..2808
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..2808
                     /gene="FAM200C"
                     /gene_synonym="Buster3; C5orf54; ZBED8"
                     /note="family with sequence similarity 200 member C"
                     /db_xref="GeneID:63920"
                     /db_xref="HGNC:HGNC:30804"
                     /db_xref="MIM:615253"
     exon            1..416
                     /gene="FAM200C"
                     /gene_synonym="Buster3; C5orf54; ZBED8"
                     /inference="alignment:Splign:2.1.0"
     exon            417..2808
                     /gene="FAM200C"
                     /gene_synonym="Buster3; C5orf54; ZBED8"
                     /inference="alignment:Splign:2.1.0"
     CDS             466..2250
                     /gene="FAM200C"
                     /gene_synonym="Buster3; C5orf54; ZBED8"
                     /note="transposon-derived Buster3 transposase-like
                     protein; zinc finger BED domain-containing protein 8;
                     protein ZBED8; zinc finger BED-type containing 8"
                     /codon_start=1
                     /product="protein FAM200C"
                     /protein_id="NP_071373.2"
                     /db_xref="CCDS:CCDS34283.1"
                     /db_xref="GeneID:63920"
                     /db_xref="HGNC:HGNC:30804"
                     /db_xref="MIM:615253"
                     /translation="MSKKRKWDDDYVRYWFTCTTEVDGTQRPQCVLCNSVFSNADLRP
                     SKLSDHFNRQHGGVAGHDLNSLKHMPAPSDQSETLKAFGVASHEDTLLQASYQFAYLC
                     AKEKNPHTVAEKLVKPCALEIAQIVLGPDAQKKLQQVPLSDDVIHSRIDEMSQDILQQ
                     VLEDIKASPLKVGIQLAETTDMDDCSQLMAFVRYIKEREIVEEFLFCEPLQLSMKGID
                     VFNLFRDFFLKHKIALDVCGSVCTDGASSMLGENSEFVAYVKKEIPHIVVTHCLLNPH
                     ALVIKTLPTKLRDALFTVVRVINFIKGRAPNHRLFQAFFEEIGIEYSVLLFHTEMRWL
                     SRGQILTHIFEMYEEINQFLHHKSSNLVDGFENKEFKIHLAYLADLFKHLNELSASMQ
                     RTGMNTVSAREKLSAFVRKFPFWQKRIEKRNFTNFPFLEEIIVSDNEGIFIAAEITLH
                     LQQLSNFFHGYFSIGDLNEASKWILDPFLFNIDFVDDSYLMKNDLAELRASGQILMEF
                     ETMKLEDFWCAQFTAFPNLAKTALEILMPFATTYLCELGFSSLLHFKTKSRSCFNLSD
                     DIRVAISKKVPRFSDIIEQKLQLQQKSL"
     regulatory      2407..2412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM200C"
                     /gene_synonym="Buster3; C5orf54; ZBED8"
                     /note="hexamer: AATAAA"
     polyA_site      2428
                     /gene="FAM200C"
                     /gene_synonym="Buster3; C5orf54; ZBED8"
     regulatory      2787..2792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM200C"
                     /gene_synonym="Buster3; C5orf54; ZBED8"
                     /note="hexamer: AATAAA"
     polyA_site      2808
                     /gene="FAM200C"
                     /gene_synonym="Buster3; C5orf54; ZBED8"
                     /note="major polyA site"
ORIGIN      
        1 ggagaacccg gatggaaccc gggcctggct gaggcggagg ttgttgcgga tgcttctctc
       61 tccaggcgca ccgcagattc ctgcccgggg gttggacccg aggaaccgcc gtctctactg
      121 gttccgacgg ccagaggctg ggccctaggc tgagcggaga gtgggactgg agcctgaaac
      181 gggcgcctaa aagaagcccg tgcatcccat aggcctgcgc ctcaggcttg gagacgggcg
      241 ggcggagacc gcgctgagtc tttttttttt ttttcctagc agctggcgtt cttatctcac
      301 ccgggaggct gtaaaaatct ccgtccttaa cagtaacacc atcaggtcct atcagttaag
      361 agctgcttgt tatttgcatg cattcttata attaaatctc ctaacaaccc tgtaagcaaa
      421 attctgtggc atctctggaa tactacctga gaatttttgt gtgccatgtc gaagaaacgc
      481 aaatgggatg atgactatgt tcgctactgg ttcacctgta caacggaagt agatggaact
      541 cagcgtccac agtgtgtgtt gtgtaactca gtattttcaa atgctgacct cagaccatca
      601 aaactgtcag accattttaa cagacagcat ggtggtgtag ctgggcatga tctcaatagc
      661 ctgaagcata tgccagcacc atctgatcag agtgaaacct tgaaagcatt tggagttgca
      721 tctcatgagg atactttatt acaagcatcg tatcaatttg cgtatttatg tgccaaggag
      781 aagaatcctc atacagtagc tgaaaagtta gtgaaacctt gtgcactgga aatagcacaa
      841 atagttttgg gaccagatgc acaaaaaaag cttcagcagg tacccttatc agatgatgtg
      901 atccattcta gaattgatga aatgagccag gatatcttac agcaagttct agaagatatc
      961 aaagccagtc ctcttaaagt gggtattcag cttgctgaga caactgacat ggatgactgc
     1021 agtcagctaa tggcatttgt gcgctatata aaagaaagag agatcgtaga agaatttctc
     1081 ttctgtgaac cattgcagct atccatgaaa ggaatagatg tgttcaatct cttcagagac
     1141 ttctttctga agcataagat agcacttgat gtatgtggct ctgtttgtac tgatggtgcc
     1201 tcctctatgc taggagaaaa ttccgagttt gttgcctacg tgaaaaaaga gatacctcat
     1261 atcgtagtta cacattgttt attgaatcct catgcacttg tcataaagac attgcctaca
     1321 aaactgaggg atgctctgtt tactgtggtg agggtaataa atttcatcaa agggagagct
     1381 ccaaatcatc gcctatttca ggctttcttt gaagaaattg gcatagaata tagtgtcctc
     1441 cttttccata ctgaaatgag gtggctttcc cgaggccaaa tacttactca catttttgaa
     1501 atgtatgaag aaataaatca gtttcttcac cacaagagca gtaatttagt tgatggcttt
     1561 gaaaataaag agtttaaaat tcacctagca taccttgcag atttattcaa acacttaaat
     1621 gaactcagtg catctatgca gaggactggg atgaacacag tatcagctag agagaagtta
     1681 tctgcttttg ttaggaagtt tccattttgg caaaaacgaa ttgagaaaag aaattttacc
     1741 aattttcctt ttcttgaaga aataattgtt tcagataatg aaggcatatt cattgcagct
     1801 gaaataacac tgcatctgca acaattgagc aacttcttcc atggatattt ttccattgga
     1861 gatcttaatg aggcaagtaa atggatattg gatccatttc tttttaatat cgattttgtt
     1921 gatgatagtt atttaatgaa aaatgatctt gctgaattac gagctagtgg ccaaatccta
     1981 atggaatttg agacaatgaa gcttgaggat ttctggtgtg cccaattcac agcatttcca
     2041 aacctggcaa agacagctct agaaatcctt atgccatttg caactacata cctttgtgag
     2101 ttgggatttt catcactttt acatttcaaa acaaagtcca gaagctgctt taatctgagt
     2161 gatgatatcc gtgtggctat ttcaaaaaaa gttcctcgtt tctcggacat cattgaacaa
     2221 aagctacagc tacagcagaa gtcactgtaa gctgatatac ttttttaatg aataatttca
     2281 atcttaatat cattgtaaaa ttaagctgta attctgtctc tttcatattt atgatatact
     2341 gaattctatg tctaaaaaac ttaagaactt taattttgaa tgaggcatgt gaaaatatgt
     2401 tttgagaata aaaacacagc agaaaagatt aagtactact gcctagttgc tatcatgaga
     2461 ttttcccaat tctaagtatc tgtttaacct gttcgtgtgg tatatgaaaa agatacctaa
     2521 gcactagaat atccagctaa atggtgcaat aggctaggaa ttgagccagg agaaaagaga
     2581 agatatccca gaagtcaaaa aggcaaaatg aaagattgag ttcgcccgtc tttgttatgg
     2641 agaggttaat gaaatcagaa gaggattatg aaatataatg ggaaaaggaa tgatctggct
     2701 tatgtaagac ttacttttaa atatactctt tggagttagt ctcacaatgt ccattcccct
     2761 agctcctgtg ctatgaatat catattaata aatagcctaa tatattaa
//
