LOCUS       NM_001190946            2968 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 193 member B
            (FAM193B), transcript variant 3, mRNA.
ACCESSION   NM_001190946
VERSION     NM_001190946.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2968)
  AUTHORS   Xie,G., Zheng,X., Zheng,Z., Wu,R., Yao,Z., Huang,W., Sun,F., Mu,X.,
            Wu,K. and Zheng,J.
  TITLE     The ceRNA PVT1 inhibits proliferation of ccRCC cells by sponging
            miR-328-3p to elevate FAM193B expression
  JOURNAL   Aging (Albany NY) 13 (17), 21712-21728 (2021)
   PUBMED   34518442
  REMARK    GeneRIF: The ceRNA PVT1 inhibits proliferation of ccRCC cells by
            sponging miR-328-3p to elevate FAM193B expression.
REFERENCE   2  (bases 1 to 2968)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2968)
  AUTHORS   Rutz,N., Heilbronn,R. and Weger,S.
  TITLE     Interactions of cullin3/KCTD5 complexes with both cytoplasmic and
            nuclear proteins: Evidence for a role in protein stabilization
  JOURNAL   Biochem Biophys Res Commun 464 (3), 922-928 (2015)
   PUBMED   26188516
  REMARK    GeneRIF: Identification of FAM193b as KCTD5 interaction partner.
            Formation of trimeric complexes of KCTD5/cullin3 with MCM7, ZNF711
            and FAM193B.
REFERENCE   4  (bases 1 to 2968)
  AUTHORS   Picchione,F., Pritchard,C., Lagutina,I., Janke,L. and Grosveld,G.C.
  TITLE     IRIZIO: a novel gene cooperating with PAX3-FOXO1 in alveolar
            rhabdomyosarcoma (ARMS)
  JOURNAL   Carcinogenesis 32 (4), 452-461 (2011)
   PUBMED   21177767
  REMARK    GeneRIF: Expression of full length IRIZIO cDNA also cooperated with
            PAX3-FOXO1 in the transformation of Arf-/- myoblasts. Given that
            IRIZIO is expressed at increased levels in rhabdomyosarcoma, it
            might contribute to rhabdomyosarcomagenesis in humans.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ228026.1, AC139795.3, CN299723.1, DB169979.1, BC071696.1,
            AC145098.2 and AI683595.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001190946.2.
            
            Transcript Variant: This variant (3, also known as delta7/8)
            represents the shorter transcript but encodes the supported
            protein.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000514747.6/ ENSP00000422131.1
            RefSeq Select criteria    :: based on manual assertion
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BQ228026.1         23-81
            60-185              AC139795.3         76586-76711         c
            186-912             CN299723.1         3-729
            913-1195            DB169979.1         305-587
            1196-2310           BC071696.1         121-1235
            2311-2311           AC145098.2         161455-161455       c
            2312-2604           BC071696.1         1237-1529
            2605-2968           AI683595.1         5-368               c
FEATURES             Location/Qualifiers
     source          1..2968
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..2968
                     /gene="FAM193B"
                     /gene_synonym="IRIZIO"
                     /note="family with sequence similarity 193 member B"
                     /db_xref="GeneID:54540"
                     /db_xref="HGNC:HGNC:25524"
                     /db_xref="MIM:615813"
     exon            1..315
                     /gene="FAM193B"
                     /gene_synonym="IRIZIO"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2574
                     /gene="FAM193B"
                     /gene_synonym="IRIZIO"
                     /note="isoform 1 is encoded by transcript variant 3;
                     protein FAM193B"
                     /codon_start=1
                     /product="protein FAM193B isoform 1"
                     /protein_id="NP_001177875.1"
                     /db_xref="CCDS:CCDS54954.1"
                     /db_xref="GeneID:54540"
                     /db_xref="HGNC:HGNC:25524"
                     /db_xref="MIM:615813"
                     /translation="MTRRRSRPSGGAGRRERARAAGPQKPQAPEPPPPPSLEAGAGAG
                     PPEAPAEPDHDGPREDDEPNLVPGPQVPPASSQPVQTCCLLCHRERKGWEEGPSQNGL
                     VLQGEKLPPDFMPKLVKNLLGEMPLWVCQSCRKSMEEDERQTGREHAVAISLSHTSCK
                     SQSCGDDSHSSSSSSSSSSSSSSSSCPGNSGDWDPSSFLSAHKLSGLWNSPHSSGAMP
                     GSSLGSPPTIPGEAFPVSEHHQHSDLTAPPNSPTGHHPQPASLIPSHPSSFGSPPHPH
                     LLPTTPAAPFPAQASECPVAAATAPHTPGPCQSSHLPSTSMPLLKMPPPFSGCSHPCS
                     GHCGGHCSGPLLPPPSSQPLPSTHRDPGCKGHKFAHSGLACQLPQPCEADEGLGEEED
                     SSSERSSCTSSSTHQRDGKFCDCCYCEFFGHNAEKEKAQLAAEALKQANRVSGSREPR
                     PARERLLEWPDRELDRVNSFLSSRLQEIKNTVKDSIRASFSVCELSMDSNGFSKEGAA
                     EPEPQSLPPSNLSGSSEQQPDINLDLSPLTLGSPQNHTLQAPGEPAPPWAEMRGPHPP
                     WTEVRGPPPGIVPENGLVRRLNTVPNLSRVIWVKTPKPGYPSSEEPSSKEVPSCKQEL
                     PEPVSSGGKPQKGKRQGSQAKKSEASPAPRPPASLEVPSAKGQVAGPKQPGRVLELPK
                     VGSCAEAGEGSRGSRPGPGWAGSPKTEKEKGSSWRNWPGEAKARPQEQESVQPSGPAR
                     PQSLPQGKGRSRRSRNKQEKPASSLDDVFLPKDMDGVEMDETDREVEYFKRFCLDSAK
                     QTRQKVAVNWTNFSLKKTTPSTAQ"
     exon            316..558
                     /gene="FAM193B"
                     /gene_synonym="IRIZIO"
                     /inference="alignment:Splign:2.1.0"
     exon            559..793
                     /gene="FAM193B"
                     /gene_synonym="IRIZIO"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1181
                     /gene="FAM193B"
                     /gene_synonym="IRIZIO"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1380
                     /gene="FAM193B"
                     /gene_synonym="IRIZIO"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..2401
                     /gene="FAM193B"
                     /gene_synonym="IRIZIO"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2477
                     /gene="FAM193B"
                     /gene_synonym="IRIZIO"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2575
                     /gene="FAM193B"
                     /gene_synonym="IRIZIO"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2968
                     /gene="FAM193B"
                     /gene_synonym="IRIZIO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2945..2950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM193B"
                     /gene_synonym="IRIZIO"
                     /note="hexamer: GATAAA"
     polyA_site      2968
                     /gene="FAM193B"
                     /gene_synonym="IRIZIO"
                     /note="major polyA site"
ORIGIN      
        1 atattggctg ttgtcctgtg aggggagcgg tagcggcggc ggcggcggcg gcggcggcgg
       61 cggcggcggc ggcgtgtgga gcgagggagc ggcgcgagcg gcggcatgac gcggaggcgg
      121 agcaggccga gcggcggtgc gggcaggcgc gagcgggctc gggccgcggg gccgcagaag
      181 ccccaggcgc ccgagccccc gccgccgcca agcctggagg cgggagcggg tgcaggccct
      241 ccggaggcgc cggcggagcc cgaccacgac ggccccaggg aggatgacga acccaacctg
      301 gtgcccggcc cgcaggtccc ccccgcctcc agccagcctg tgcagacttg ctgcctgctg
      361 tgtcaccggg aacgcaaagg ctgggaagaa ggcccttctc aaaatggact ggtgttgcag
      421 ggtgagaagc tgccccctga cttcatgcca aagctcgtca agaatctcct aggcgagatg
      481 cctctgtggg tctgccagag ttgccgaaag agcatggagg aagatgaaag gcagacaggt
      541 cgagaacatg cagtggcgat ctccttgtca cacacatcct gcaaatcaca gtcttgtgga
      601 gatgactctc attcgtcctc gtcttcctcc tcatcatcct catcctcgtc ctcctcttcc
      661 tgccctggga actcgggaga ctgggatcct agctcgttcc tgtcggcaca taagctctcg
      721 ggcctctgga attccccaca ttccagtggg gccatgccag gcagctctct tgggagtcct
      781 cctaccatcc ccggtgaggc tttccccgtc tcggagcacc accagcactc agacctcact
      841 gctcccccta acagccccac cggccaccac ccgcagccag catctctaat cccgtctcac
      901 cccagctcct ttggctcccc accccaccca cacctgctgc ccaccacccc ggcagcacct
      961 ttccctgccc aggcttcaga gtgccctgtt gctgctgcca ctgcccccca cactccaggg
     1021 ccatgtcaga gctcccatct accctccacc agcatgccgc tcctgaagat gcccccacca
     1081 ttctcggggt gcagccaccc ctgcagcggg cactgtggtg ggcactgcag tgggcctctc
     1141 ctcccacccc cgagctctca gccactccct agcactcaca gggatcccgg gtgcaagggg
     1201 cacaagtttg cacacagtgg cctggcttgc cagctgcccc agccctgcga ggcagatgag
     1261 gggctgggtg aggaagagga tagcagctct gagcgaagct cctgcacctc atcctccacc
     1321 caccagagag atgggaagtt ctgtgactgc tgctactgtg agttcttcgg ccacaatgcg
     1381 gaaaaggaga aggcccagtt ggcagcagaa gctctaaagc aggcaaatcg tgtttctgga
     1441 agccgggagc caaggcctgc cagggagagg ctcttggagt ggcccgaccg ggaactggat
     1501 cgggtcaaca gcttcctgag cagccgtctg caggagatca aaaacactgt caaagactcc
     1561 atccgtgcca gcttcagtgt gtgtgagctc agcatggaca gcaatggctt ctctaaggag
     1621 ggggctgctg agcctgagcc tcagagtcta cccccctcaa acctcagtgg ctcctcagag
     1681 cagcagcctg acatcaacct tgacctgtcc cctttgactt tgggctcccc tcagaaccac
     1741 acgttacaag ctccaggcga gccagcccca ccatgggcag aaatgagagg cccccaccca
     1801 ccatggacag aggtgagggg gccccctccc ggtatcgtcc ccgagaacgg gctcgtgagg
     1861 agactcaaca ccgtgcccaa cctatcccgg gtgatctggg tcaagacacc caagccgggc
     1921 taccccagct ccgaggagcc aagctcaaag gaagttccca gttgcaagca ggagctgcct
     1981 gagcctgtgt cctcaggtgg gaagccacag aagggcaaga ggcagggcag tcaggccaag
     2041 aagagcgagg caagcccagc cccccggccc ccagccagcc tagaggttcc cagtgccaag
     2101 ggccaggtcg ctggccccaa gcagccaggc agggtcctag agcttcccaa agtaggcagc
     2161 tgtgctgagg ctggagaggg gagccggggg agccggccag gaccaggttg ggctggcagt
     2221 cccaaaactg agaaggagaa gggcagctcc tggcgaaact ggccaggcga ggccaaggca
     2281 cggcctcagg agcaggagtc tgtgcagccc tcaggcccag caaggccaca gagcttgccc
     2341 cagggcaagg gccgcagccg ccggagccgc aacaagcagg agaagccagc ctcctccttg
     2401 gacgatgtgt tcctgcccaa ggacatggac ggggtggaga tggatgagac tgaccgagag
     2461 gtggagtact ttaagaggtt ctgtttggat tctgcaaagc agactcgtca gaaagttgct
     2521 gtgaactgga ccaacttcag cctcaagaaa accactccta gcacagctca gtgaggccct
     2581 gcccaggctg agctgcttca gggcgtcctg aggccctgac tgccagctga aggcgtataa
     2641 tttttccctc cgtgtgcccc acctacccgt ccaagaccct ctgtgctccc caccatcctg
     2701 gaccaaccaa aagctgaacg gatgccacac tgtgctgggg ccccttgacc tcagcagagc
     2761 cgcttcctgg tgctacgcag cctccacact cagagcccgt ggactgggct ggcctaaggg
     2821 ccagggctga tggtactgct ggcccaacac tgctctcttt gtgtttggtt tttttgtttt
     2881 tgtttttatt ttgttttttt ccaattcttt acttttgata ctgtgaagat ctttcgtgcc
     2941 gaaagataaa gcaacatttg gacacaga
//
