LOCUS       NM_001366318            5522 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 193 member A
            (FAM193A), transcript variant 8, mRNA.
ACCESSION   NM_001366318 XM_006713930
VERSION     NM_001366318.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5522)
  AUTHORS   Szwarc,M.M., Guarnieri,A.L., Joshi,M., Duc,H.N., Laird,M.C.,
            Pandey,A., Khanal,S., Dohm,E., Bui,A.K., Sullivan,K.D.,
            Galbraith,M.D., Andrysik,Z. and Espinosa,J.M.
  TITLE     FAM193A is a positive regulator of p53 activity
  JOURNAL   Cell Rep 42 (3), 112230 (2023)
   PUBMED   36897777
  REMARK    GeneRIF: FAM193A is a positive regulator of p53 activity.
REFERENCE   2  (bases 1 to 5522)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 5522)
  AUTHORS   Amin,M., Uhlig,H.H., Kamprad,M., Karbe,J., Osman,A.A., Grahmann,F.,
            Hummelsheim,H. and Mothes,T.
  TITLE     Neurological disease-associated autoantibodies against an unknown
            protein encoded by a RES4-22 homologous gene
  JOURNAL   Scand J Immunol 53 (2), 204-208 (2001)
   PUBMED   11169226
REFERENCE   4  (bases 1 to 5522)
  AUTHORS   Hadano,S., Ishida,Y. and Ikeda,J.E.
  TITLE     The primary structure and genomic organization of five novel
            transcripts located close to the Huntington's disease gene on human
            chromosome 4p16.3
  JOURNAL   DNA Res 5 (3), 177-186 (1998)
   PUBMED   9734812
REFERENCE   5  (bases 1 to 5522)
  AUTHORS   Hadano,S., Ishida,Y., Tomiyasu,H., Yamamoto,K., Bates,G.P. and
            Ikeda,J.E.
  TITLE     Transcript map of the human chromosome 4p16.3 consisting of 627
            cDNA clones derived from 1 Mb of the Huntington's disease locus
  JOURNAL   DNA Res 3 (4), 239-255 (1996)
   PUBMED   8946164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX322586.11, CR545473.2 and AL110117.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001366318.1.
            
            Transcript Variant: This variant (8) encodes the longest protein
            (isoform 6). This variant is inferred based on short read sequence
            data and conservation.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1968189 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000637812.2/ ENSP00000490564.1
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               BX322586.11        40143-40666         c
            525-770             CR545473.2         15663-15908         c
            771-904             AL110117.3         123638-123771       c
            905-1072            AL110117.3         122456-122623       c
            1073-1307           AL110117.3         117864-118098       c
            1308-1432           AL110117.3         109174-109298       c
            1433-1580           AL110117.3         102201-102348       c
            1581-1658           AL110117.3         91153-91230         c
            1659-1771           AL110117.3         89363-89475         c
            1772-2014           AL110117.3         88979-89221         c
            2015-2168           AL110117.3         86042-86195         c
            2169-2348           AL110117.3         85745-85924         c
            2349-2600           AL110117.3         76661-76912         c
            2601-2799           AL110117.3         59329-59527         c
            2800-3072           AL110117.3         58063-58335         c
            3073-3361           AL110117.3         55159-55447         c
            3362-3545           AL110117.3         53904-54087         c
            3546-3776           AL110117.3         52440-52670         c
            3777-4641           AL110117.3         48489-49353         c
            4642-4723           AL110117.3         32929-33010         c
            4724-5522           AL110117.3         16460-17258         c
FEATURES             Location/Qualifiers
     source          1..5522
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..5522
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /note="family with sequence similarity 193 member A"
                     /db_xref="GeneID:8603"
                     /db_xref="HGNC:HGNC:16822"
                     /db_xref="MIM:620037"
     exon            1..524
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..4817
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /note="isoform 6 is encoded by transcript variant 8;
                     protein FAM193A"
                     /codon_start=1
                     /product="protein FAM193A isoform 6"
                     /protein_id="NP_001353247.1"
                     /db_xref="CCDS:CCDS93467.1"
                     /db_xref="GeneID:8603"
                     /db_xref="HGNC:HGNC:16822"
                     /db_xref="MIM:620037"
                     /translation="MSPADAKRGAKRRKNKRGGGGGSGGGNGGASSGKAGPAAALRGS
                     QAAGLAAPGSAAGLVGGAAAANGPLGAGASAGGAAPGGYFETPFSFGMNHRTPPYPAG
                     DYCLLCRSERKDSSFLESGIKTASKLALSMAPKGNSVLHLPLWVCPDCRRTVEKEERH
                     GGLDQPVSQDFLLHSSLGGSQPEAGSGGRLALGAQTLPSDTACSCEACSERREISAEA
                     DREPQQLQNYWSEVRYTVRCIYRQAGTPLADDQDQSLVPDKEGVKELVDRLCERDPYQ
                     LYQRLEQQAREYVLEMKVRLLRQLSAAAKVKAPSGLQGPPQAHQFISLLLEEYGALCQ
                     AARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGTT
                     THDTCSEDTYSTLLQRYQRSEEELRRVAEEWLECQKRIDAYVDEQMTMKTKQRMLTED
                     WELFKQRRFIEEQLTNKKAVTGENNFTDTMRHMLSSRLSMPDCPNCNYRRRCACDDCS
                     LSHILTCGIMDPPVTDDIHIHQLPLQVDPAPDYLAERSPPSVSSASSGSGSSSPITIQ
                     QHPRLILTDSGSAPTFCSDDEDVAPLSAKFADIYPLSNYDDTEVVANMNGIHSELNGG
                     GENMALKDESPQISSTSSSSSEADDEEADGESSGEPPGAPKEDGVLGSRSPRTEESKA
                     DSPPPSYPTQQAEQAPNTCECHVCKQEASGLTPSAMTAGALPPGHQFLSPEKPTHPAL
                     HLYPHIHGHVPLHTVPHLPRPLIHPTLYATPPFTHSKALPPAPVQNHTNKHQVFNASL
                     QDHIYPSCFGNTPEWNSSKFISLWGSEVMNDKNWNPGTFLPDTISGSEILGPTLSETR
                     PEALPPPSSNETPAVSDSKEKKNAAKKKCLYNFQDAFMEANKVVMATSSATSSVSCTA
                     TTVQSSNSQFRVSSKRPPSVGDVFHGISKEDHRHSAPAAPRNSPTGLAPLPALSPAAL
                     SPAALSPASTPHLANLAAPSFPKTATTTPGFVDTRKSFCPAPLPPATDGSISAPPSVC
                     SDPDCEGHRCENGVYDPQQDDGDESADEDSCSEHSSSTSTSTNQKEGKYCDCCYCEFF
                     GHGGPPAAPTSRNYAEMREKLRLRLTKRKEEQPKKMDQISERESVVDHRRVEDLLQFI
                     NSSETKPVSSTRAAKRARHKQRKLEEKARLEAEARAREHLHLQEEQRRREEEEDEEEE
                     EDRFKEEFQRLQELQKLRAVKKKKKERPSKDCPKLDMLTRNFQAATESVPNSGNIHNG
                     SLEQTEEPETSSHSPSRHMNHSEPRPGLGADGDAADPVDTRDSKFLLPKEVNGKQHEP
                     LSFFFDIMQHHKEGNGKQKLRQTSKASSEPARRPTEPPKATEGQSKPRAQTESKAKVV
                     DLMSITEQKREERKVNSNNNNKKQLNHIKDEKSNPTPMEPTSPGEHQQNSKLVLAESP
                     QPKGKNKKNKKKKGDRVNNSIDDVFLPKDIDLDSVDMDETEREVEYFKRFCLDSARQT
                     RQRLSINWSNFSLKKATFAAH"
     exon            525..770
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            771..904
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1072
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1307
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1432
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1580
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1658
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1771
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..2014
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2168
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2348
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2600
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2799
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..3072
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3361
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3545
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3776
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..4641
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            4642..4723
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     exon            4724..5522
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5471..5476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /note="hexamer: ATTAAA"
     polyA_site      5522
                     /gene="FAM193A"
                     /gene_synonym="C4orf8; RES4-22"
                     /note="major polyA site"
ORIGIN      
        1 atccctttcc ccttgtgtcc gccatattgg actctaactc tggtcagccg cggcgccggg
       61 actgtggact cgcggttcct cccgcccagc ggcctgcccc gcagctcccg cccgccccag
      121 ccctccccga cccggacgcg accccgcgca gcgccccccg gctggccgga gcgcccgccg
      181 ccgcggccgc ctcagcctcc ccgccttccc cgccctccgc cgccgcccgc ggcccccgcg
      241 cccgctctgc gcccctctcc ccgcccgcca tgagcccagc cgacgccaag cgcggggcca
      301 agcgccggaa gaacaagcgg ggcggcggcg gcggctcggg cgggggtaac ggcggcgcga
      361 gcagcggcaa ggccggcccg gcggcggcgc tgcgcggttc ccaggccgcg ggcctggcgg
      421 ccccgggcag cgcggcaggc ctggtgggcg gcgcggcggc ggccaacggg cctctcggcg
      481 cgggcgcgag cgcgggcggc gccgcccccg gaggctactt cgagactcct tttagttttg
      541 gcatgaatca taggacacca ccctaccctg ctggggatta ttgtcttctg tgcagaagtg
      601 aacggaaaga ctcatcattc ttagagagtg gaattaagac tgcgagcaaa ttggcccttt
      661 ccatggctcc caagggcaac agcgtgctgc acctgccact gtgggtgtgc ccggactgcc
      721 gcaggaccgt ggagaaggag gagaggcatg gcggccttga ccagccagtg agccaagatt
      781 ttcttcttca ctcctcgctt ggtggctccc agccagaggc cggcagtggt gggaggctcg
      841 ctctgggtgc acagacgctg ccttcagaca ccgcatgctc gtgcgaggcc tgcagtgagc
      901 gcagagaaat ttcggcagag gcggaccggg aacctcagca gctgcagaac tactggtcag
      961 aagtgcgcta cacggtgcgc tgcatctacc gccaggcagg aaccccgctg gcagatgacc
     1021 aggaccagtc tctggtgcct gacaaggagg gagtgaagga gctcgtggat aggctctgcg
     1081 agagggaccc ctaccagctg taccagcgtc tggaacagca agctcgagag tatgtgctgg
     1141 agatgaaggt ccgcctgctc cggcagctgt cggctgcggc caaggtgaag gcaccatctg
     1201 gcctgcaggg cccgccgcaa gcgcaccagt tcatctccct cctgcttgag gagtacggcg
     1261 ccctctgcca ggccgcacgc tccatcagca ccttccttgg cactctggaa aatgaacact
     1321 tgaaaaagtt ccaagtgacg tgggaactgc ataataaaca cctgtttgaa aatctggtct
     1381 tttcggagcc acttcttcag agcaacttgc ccgcactggt gtcacagatc aggctaggaa
     1441 ccaccacaca cgacacctgc agtgaggaca catacagtac cttgctgcag aggtaccagc
     1501 gttccgagga ggagctgcgc agagtcgccg aggagtggct ggagtgccag aagaggatcg
     1561 acgcctatgt cgacgagcag atgacaatga aaaccaagca gcgcatgtta acagaagact
     1621 gggagctttt taaacaaaga agattcattg aagaacagtt aaccaataag aaagcagtta
     1681 ctggcgagaa caacttcaca gacaccatga ggcacatgtt atcgtcccgg ctgagcatgc
     1741 ccgactgccc caactgcaac tacaggagaa gatgtgcttg cgatgactgc agtctctcac
     1801 acatcctcac gtgtggtatc atggaccccc ccgtcactga tgacatccac attcaccagc
     1861 tcccacttca agtggatcct gctcctgact atcttgctga gaggagcccg cccagtgtgt
     1921 catctgcaag ctcggggtcc ggctccagct ctcccatcac aattcagcag caccccaggc
     1981 tcatcctcac agacagtggc tcggcaccaa ctttttgtag tgatgatgaa gatgttgcac
     2041 cattgtcagc caaatttgct gatatttatc cattgagtaa ttatgatgat accgaggtgg
     2101 tggccaacat gaatggaatc cacagcgaat tgaatggtgg cggggaaaac atggccctga
     2161 aggatgagtc tcctcagata agcagtacca gcagtagttc ctcagaagct gatgatgaag
     2221 aagcggacgg cgagagtagt ggggagcccc caggggcccc gaaggaagat ggagtgctgg
     2281 gaagcaggag ccccaggaca gaggagagca aagcagacag tccaccccca tcctacccaa
     2341 cacagcaggc tgaacaagct ccaaacactt gtgaatgtca tgtttgtaag caggaagctt
     2401 ctggactgac accatctgca atgacagccg gagcccttcc tcctggccat cagttcttga
     2461 gcccagagaa gcccacacac cctgcactgc acctttaccc tcacatccat ggacatgtgc
     2521 ctttgcacac tgttccacac ctgccacgcc ctctcatcca ccccaccttg tatgcaacgc
     2581 cccccttcac acacagtaag gctttaccgc cagcacctgt tcagaatcac acaaataagc
     2641 atcaggtatt caatgcatct cttcaagacc atatttatcc gagctgtttt gggaatactc
     2701 cagagtggaa tagttctaaa tttataagtc tttggggatc agaagtgatg aatgataaga
     2761 actggaatcc tggcactttc ttgccagata caatttctgg gagtgaaata ttagggccaa
     2821 cactctcaga aacaagaccg gaagcccttc cacctccatc tagcaatgaa acacctgcag
     2881 tctcggatag taaagagaaa aagaatgctg caaaaaagaa atgtttatac aatttccaag
     2941 atgctttcat ggaagcaaat aaagttgtca tggccacgtc atcagccacg tcctctgtgt
     3001 cctgcacagc taccacagtg cagtccagca acagccagtt cagagtgtca tccaagagac
     3061 ctccttcagt aggtgacgtg tttcatggca tcagcaagga ggaccacaga cactcggccc
     3121 cagccgcccc gaggaatagc cccacgggct tggcccccct cccagcgctc tcgcctgctg
     3181 cgctgtcacc tgctgcgctc tcacctgcct ccacacctca ccttgcaaat cttgcagccc
     3241 catcattccc caaaacagca accacaactc ctgggtttgt ggacacacgc aagagtttct
     3301 gtcctgcacc cctacccccg gccacagatg gctccattag cgcccctcca agtgtctgca
     3361 gtgaccctga ctgcgaaggg caccgctgcg agaatggtgt ctacgaccca cagcaggatg
     3421 atggggacga gagtgcagat gaggacagct gctctgagca cagctccagc acctcgacct
     3481 ccaccaacca gaaggagggc aagtactgcg actgctgcta ctgcgaattc tttgggcacg
     3541 gcgggcctcc agctgcacca acaagtagaa attatgcaga aatgagggaa aagcttcgct
     3601 tacggctgac caagaggaaa gaggagcaac ctaaaaaaat ggaccagatc tcagaaaggg
     3661 aaagcgtcgt tgaccatcgg agggtggagg atttgttgca gtttataaat agctccgaaa
     3721 ccaaaccagt gagcagcacg cgtgcagcga agcgagcaag gcataagcaa aggaagctgg
     3781 aggagaaagc tcgcctagaa gcagaggcca gggcccggga gcacctgcac ctccaggagg
     3841 agcagaggcg gcgggaggag gaggaggatg aggaagaaga ggaggatcgt ttcaaggagg
     3901 aatttcagcg gcttcaggag cttcagaagc taagagctgt aaaaaagaag aagaaggaga
     3961 ggccaagtaa agactgcccc aagttggaca tgctcactag aaatttccag gcagcaacag
     4021 agtctgttcc taactctgga aacatccaca atggctcact agagcaaact gaagaaccag
     4081 aaacctcttc tcactcccca tccaggcata tgaaccactc agagcccagg ccagggctag
     4141 gggctgatgg ggatgctgca gaccccgtcg acaccagaga ctccaaattt ctcctcccca
     4201 aggaggtgaa tgggaagcag catgagccac tctctttttt cttcgacatc atgcagcacc
     4261 ataaagaagg aaatggcaag cagaagctga ggcagaccag caaggccagc agcgagccag
     4321 cgaggaggcc cacagagccc cccaaggcca cagaggggca gtccaagccc cgggcccaga
     4381 ctgagtcaaa ggctaaggtg gtcgacctca tgtccatcac agagcagaaa agagaggaga
     4441 gaaaagtcaa cagtaataac aataacaaaa agcagctgaa ccacatcaag gacgaaaagt
     4501 caaacccaac ccctatggag cccacctctc ccggtgagca tcagcagaac agcaagctgg
     4561 tgctggcaga gtcccctcag ccaaagggca agaacaagaa aaataagaag aagaaaggag
     4621 acagagtcaa caattcaatt gatgatgtct ttctacctaa agatattgac ctagacagtg
     4681 tggatatgga tgagacagag agggaagtgg aatatttcaa aaggttctgc ttggattctg
     4741 ctagacagac ccgacaaaga ctgtctatca actggtccaa ttttagcttg aaaaaagcca
     4801 cctttgctgc ccactgaatg aggactccct ggagagggac acgcgagagg caggccaggc
     4861 tgcaccaccc caagagccac gcccctcgct ggcgccccag agccgtggtg cttgccaagg
     4921 gctgtgcgga gctggtgctg cctgaaaccc cagaccgaga agttgatgct cggcccacgc
     4981 cgttagctcg tgtgcgtgta gtctgtgcgt gagactcctt cgattgtagc tctgtgctgt
     5041 cggattggaa cagtagttcc cgccaagtcc tcccaccacc gcggcctcgg aggcctgggc
     5101 cgtggccaga taggagtttg catcatccac gtggctccgt tgcctctgca ttgcgccctg
     5161 tcctgtcatg tgtcctcacc ggggtatcgg ccgtcactca gctctcctgt gcccctgcgt
     5221 ctcaccctag gcgggctggg cggggcaggc ctcctttgtt ctccacaatc tactgtctcc
     5281 gagtgtacac gttgcgctgt ttgtgtttga tccccctgac ttgtagccag cttgtgtaag
     5341 atcccttgca gaacgagaaa gttaaaaaca agcccaccca gtactcacac catcaagtct
     5401 gttatagagt gtacgactgt attaacacgg aggcctgcct ggctactttt ttaacatatt
     5461 gttaagtaat attaaaatca tgtctttctt tttgaaagat ggaatacatt agtacagcag
     5521 ga
//
