LOCUS       NM_001145268            2211 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens family with sequence similarity 185 member A
            (FAM185A), transcript variant 1, mRNA.
ACCESSION   NM_001145268 XR_041062 XR_041063 XR_041064
VERSION     NM_001145268.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2211)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2211)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2211)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105052.3 and AC006477.4.
            
            On Nov 23, 2018 this sequence version replaced NM_001145268.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.81974.1,
                                           SRR1660807.22380.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000413034.3/ ENSP00000395340.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-660               AC105052.3         162740-163399
            661-770             AC105052.3         165433-165542
            771-863             AC105052.3         171595-171687
            864-1002            AC105052.3         175014-175152
            1003-1044           AC105052.3         186150-186191
            1045-1140           AC006477.4         66909-67004
            1141-1275           AC006477.4         76991-77125
            1276-2211           AC006477.4         97946-98881
FEATURES             Location/Qualifiers
     source          1..2211
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2211
                     /gene="FAM185A"
                     /note="family with sequence similarity 185 member A"
                     /db_xref="GeneID:222234"
                     /db_xref="HGNC:HGNC:22412"
     exon            1..660
                     /gene="FAM185A"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1388
                     /gene="FAM185A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM185A"
                     /codon_start=1
                     /product="protein FAM185A isoform 1"
                     /protein_id="NP_001138740.2"
                     /db_xref="CCDS:CCDS47676.1"
                     /db_xref="GeneID:222234"
                     /db_xref="HGNC:HGNC:22412"
                     /translation="MLAPCSGWELGCFRLCLRQVRLWAGAGRWACWACQARPYSSGGS
                     ERWPGSETEVPPPGPGRRTLKEWTLQVSPFGRLRARLPCHLAVRPLDPLTYPDGDRVL
                     VAVCGVEGGVRGLDGLQVKYDEDLEEMAIVSDTIHPQASVEVNAPLKFGLDIKSSGSG
                     CVKVQSIEGDNCKIETEHGTSILQSVKGQKLHVQTKGGKVICLGTVYGNIDIHASDKS
                     AVTIDKLQGSSVTVSTEDGLLKAKYLYTESSFLSSAAGDITLGSVHGNITLQSKMGNI
                     TVDSSSGCLKASTNQGAIDVYVSQLGKVELKSHKGSIIVKVPSSLQAHLQLSGKEVDV
                     NSEVHVQEMAEVRKDDVVTVTGLMNQASKREKWIKADAPKGTVSFRRQSWFQSLKLQD
                     "
     exon            661..770
                     /gene="FAM185A"
                     /inference="alignment:Splign:2.1.0"
     exon            771..863
                     /gene="FAM185A"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1002
                     /gene="FAM185A"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1044
                     /gene="FAM185A"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1140
                     /gene="FAM185A"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1275
                     /gene="FAM185A"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..2211
                     /gene="FAM185A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1468..1473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM185A"
                     /note="hexamer: TATAAA"
     polyA_site      1489
                     /gene="FAM185A"
     regulatory      2188..2193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM185A"
                     /note="hexamer: AATAAA"
     polyA_site      2211
                     /gene="FAM185A"
                     /note="major polyA site"
ORIGIN      
        1 agagctttca aatcccaact tgcccctggg gattgcgcgg ctgatgttta gaacgcctag
       61 tcaagccaac cggctcgctc ttgtttcagc aaaccctgac ttacgtctcc tatttgactt
      121 gaggcggcac agtggccaag tcgattggcc gtggcaagtg accctccctg tggctgaagt
      181 gttctgagga ctggcgagag aggcgcgcca tgcttgcccc ctgctcaggt tgggagcttg
      241 gctgcttccg tctctgtctc cgtcaggtcc gactgtgggc tggcgctggg cgctgggctt
      301 gctgggcttg ccaagccagg ccgtacagct caggtgggag cgagcgctgg cccggatcgg
      361 agactgaggt ccctccgcct ggcccggggc gccgaactct gaaggagtgg acactgcagg
      421 tgagcccgtt tggtcggctg cgggcgcggc tcccgtgcca cctggccgtg aggcccctgg
      481 accccctcac ctacccggat ggcgaccgcg tgctggtcgc ggtgtgcggc gtggagggcg
      541 gcgtgcgggg cctggacggc ctgcaggtga agtacgacga ggatctggag gagatggcca
      601 ttgtgtctga tactatccac ccccaggcgt ccgtggaggt gaacgcgccc ctgaagtttg
      661 gtttagatat caagtcatca gggtctggct gtgtaaaagt tcaaagtatt gagggtgata
      721 attgcaaaat tgaaacagag catgggacta gtatcttgca gtctgttaag ggtcaaaaat
      781 tgcatgttca aacaaaagga ggcaaagtga tctgtctggg aacagtttat ggaaatatag
      841 atattcatgc atcagataaa agtgctgtga ccatagataa actgcaggga agttctgtta
      901 ctgtatctac cgaagatggt ttgctgaaag ccaagtatct ttatacagaa tcatcatttc
      961 tgtcttctgc tgctggggat attacattag gaagtgttca tggtaatata acattacaaa
     1021 gcaagatggg taacatcaca gtagattcgt cttctggatg tctaaaagcc tcaactaatc
     1081 agggtgccat agatgtttat gtcagccaac tggggaaagt ggaattgaaa tcccataaag
     1141 gttctattat tgtcaaggtc ccatcttcac ttcaagctca tttacagtta tcagggaaag
     1201 aggttgatgt gaactcagaa gtccatgttc aggaaatggc tgaagttcgt aaagatgatg
     1261 ttgtaacagt gactggactc atgaatcaag caagcaaacg tgaaaaatgg attaaggctg
     1321 atgccccaaa aggcactgta agttttagaa ggcaaagttg gtttcagtcc ctgaaactgc
     1381 aggactaaaa ctgatttgag ttggatttat gatttttaac aatgattcgc agatctgtga
     1441 ctacaaaaat gtaaatccca ccattcatat aaaggttgaa aacaacaaat tgagaatgaa
     1501 tactggtgaa ctgttttggg aggctttttc aaaatttgtg ctttgctatt gtattcattt
     1561 tctactgctc tgtaacaaat taccacaaat ttagcagcat aaaataatac tcatttacag
     1621 ctatgtctag gttctccgct cagggaatca caaggctaga aatcaagatt ttggccaggc
     1681 tgagttctca tctggagtct ctgggaagaa atctacttcc aacttcattc agattattgg
     1741 gaaaatccag ttccttgtga ctggatgact gaggtctcca ttttcttgct ggctgtcagc
     1801 cagcaatcac tctaagcttc tagaggccac ccacatgcct tctcatgttg cccctccatc
     1861 ttcaagccag cagtgatgcg ctgagttctt ctcatgcttt gaatatctga cttcttctgc
     1921 agccagctgg aagaatatat acttttaaag ggctcacttg attaggtcag gcccacccag
     1981 gataaccttt gttttgccat ataatgtaac attcatagga gtgatggccc atcacattca
     2041 gttttcactc ccactcaagg aaaggagatt atacaaaggc atccatcatg tggggacaat
     2101 tagcttagaa ttctttataa tgtagctctc acatgacagg ttttctactt agtacctttt
     2161 atggcatcaa tgtaaattta agctgtaaat aaaaaacaaa tatgtgaagc a
//
