LOCUS       NM_024581               4128 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 184 member A
            (FAM184A), transcript variant 1, mRNA.
ACCESSION   NM_024581
VERSION     NM_024581.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4128)
  AUTHORS   Piette,B.L., Alerasool,N., Lin,Z.Y., Lacoste,J., Lam,M.H.Y.,
            Qian,W.W., Tran,S., Larsen,B., Campos,E., Peng,J., Gingras,A.C. and
            Taipale,M.
  TITLE     Comprehensive interactome profiling of the human Hsp70 network
            highlights functional differentiation of J domains
  JOURNAL   Mol Cell 81 (12), 2549-2565 (2021)
   PUBMED   33957083
REFERENCE   2  (bases 1 to 4128)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4128)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4128)
  AUTHORS   Dowling,J.K., Becker,C.E., Bourke,N.M., Corr,S.C., Connolly,D.J.,
            Quinn,S.R., Pandolfi,P.P., Mansell,A. and O'Neill,L.A.J.
  TITLE     Promyelocytic leukemia protein interacts with the
            apoptosis-associated speck-like protein to limit inflammasome
            activation
  JOURNAL   J Biol Chem 289 (10), 6429-6437 (2014)
   PUBMED   24407287
REFERENCE   5  (bases 1 to 4128)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   6  (bases 1 to 4128)
  AUTHORS   Olah,J., Vincze,O., Virok,D., Simon,D., Bozso,Z., Tokesi,N.,
            Horvath,I., Hlavanda,E., Kovacs,J., Magyar,A., Szucs,M., Orosz,F.,
            Penke,B. and Ovadi,J.
  TITLE     Interactions of pathological hallmark proteins: tubulin
            polymerization promoting protein/p25, beta-amyloid, and
            alpha-synuclein
  JOURNAL   J Biol Chem 286 (39), 34088-34100 (2011)
   PUBMED   21832049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL137009.8, BC060769.1, AI457286.1, DB237883.1, AU160036.1 and
            AL132874.31.
            
            On May 17, 2019 this sequence version replaced NM_024581.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060769.1, SRR1803612.183642.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338891.12/ ENSP00000342604.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL137009.8         34115-34131         c
            18-494              BC060769.1         1-477
            495-771             AI457286.1         225-501
            772-951             BC060769.1         755-934
            952-1469            DB237883.1         7-524
            1470-4058           BC060769.1         1453-4041
            4059-4062           AU160036.1         1-4                 c
            4063-4128           AL132874.31        64449-64514         c
FEATURES             Location/Qualifiers
     source          1..4128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..4128
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /note="family with sequence similarity 184 member A"
                     /db_xref="GeneID:79632"
                     /db_xref="HGNC:HGNC:20991"
     exon            1..524
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..3788
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM184A"
                     /codon_start=1
                     /product="protein FAM184A isoform 1"
                     /protein_id="NP_078857.5"
                     /db_xref="CCDS:CCDS43499.1"
                     /db_xref="GeneID:79632"
                     /db_xref="HGNC:HGNC:20991"
                     /translation="MATPGMSWQQHYYGGSAAKFAPSPATAQLAGHSMDYSQEMHLKM
                     SKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEEL
                     DLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEE
                     IRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEK
                     AEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAES
                     LQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAE
                     NNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQAT
                     QMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAK
                     RTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKL
                     QMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGL
                     GSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE
                     EEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAA
                     RDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQH
                     QQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIE
                     MEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSID
                     ISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRI
                     RSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVS
                     LEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVNRETNFNK
                     VFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLDPIPNSP
                     VHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFTF"
     exon            525..1379
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1515
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1697
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1895
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2018
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2180
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2302
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2453
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2666
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2820
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2948
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3133
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3280
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3398
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3503
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3706
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..4128
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4040..4045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /note="hexamer: AATAAA"
     polyA_site      4061
                     /gene="FAM184A"
                     /gene_synonym="C6orf60"
                     /note="major polyA site"
ORIGIN      
        1 agcctcgccg agtcctcggt gcgggctgcg agcgggaccc gcggagctgc gctgtcctcg
       61 acgcctccgc caggcgcggg ccgaggagcc tccaagagct ggcccggccc ccggccgccg
      121 ccgcccaacc ccgggcatct gccccgcgcc gttgtccccg cggcttcggg ccggcgggac
      181 cgccccgtcc cttccagggg tgacccgggg gtcgcgggtg ggacggcgcc tgcggccgag
      241 tctggggggc gccgggtgtc gggtcgggaa gcggccgccg cgactcttgc ctcccgggcg
      301 tcgttgctcc acgggcctgc ctccacccgc ggggacaggt gccccggctg gggtctgttg
      361 ggaagatggc gaccccgggc atgagctggc agcagcacta ttacggcggc tcggcggcca
      421 aattcgcgcc ctcgccggcc accgcacagc tggctgggca cagcatggac tacagccagg
      481 agatgcacct gaaaatgagc aagaaaatcg cccagctcac caaggtaata tatgctttaa
      541 acactaaaaa tgatgagcat gaatctgcaa ttcaagccct caaagatgct catgaagaag
      601 aaattcaaca aattcttgct gaaacaagag aaaaaatatt gcagtataaa agcaaagtaa
      661 cagaggagct agaccttaga agaaagattc aagttttaga atcatcatta gaagatcaca
      721 taaaaatgaa gcagcaggct ttgacagaat ttgaagctta taagcacaga gttgaggaca
      781 tgcaactttg tgcagaagcc cagcatgtcc aacgcatagt gaccatgtct agagaagtcg
      841 aagagattag aaggaaattt gaagaaaaat tacggagctt tggacaactt caagtacagt
      901 ttgaaaaaga caaacgattg gcattggaag acttgcaagc tgctcacaga cgggagatac
      961 aagagctatt gaagtcacag caggatcaca gtgcctcagt aaataaaggc caggaaaagg
     1021 cagaggaact acacagaatg gaggtggagt ccctaaacaa aatgcttgag gagctaagac
     1081 ttgaacggaa gaaactaatt gaggattatg aaggcaagtt gaataaagct cagtcctttt
     1141 atgaacgtga gcttgatact ttgaaaaggt cacagctttt tacagcagaa agcctacagg
     1201 ccagcaaaga aaaggaagct gatcttagaa aagaatttca gggacaagaa gcaattttac
     1261 gaaaaactat aggaaaatta aagacagagt tacagatggt acaggatgaa gctggaagtc
     1321 ttcttgacaa atgccaaaag cttcagacgg cacttgccat agcagagaac aatgttcagg
     1381 ttcttcaaaa acagcttgat gatgccaagg agggagaaat ggccctatta agcaagcaca
     1441 aagaagtgga aagtgagcta gcagctgcca gagaacgttt acaacagcaa gcttcagatc
     1501 ttgtcctcaa agctagtcat attggaatgc ttcaagcaac tcaaatgacc caggaagtta
     1561 caattaaaga tttagaatca gaaaaatcga gagtcaatga gagattatct caacttgaag
     1621 aggaaagagc ttttttgcga agcaaaaccc aaagtctgga tgaagagcag aagcaacaga
     1681 ttctagaact ggagaagaaa gtaaatgaag caaagagaac tcagcaagaa tattatgaaa
     1741 gggaacttaa aaacctgcaa agtagattgg aagaggaggt gactcaatta aacgaggccc
     1801 attctaagac tttggaagaa ttagcttgga agcaccatat ggcaattgaa gctgtccaca
     1861 gtaatgcaat tagggataag aaaaaactgc aaatggattt ggaagaacaa cataacaaag
     1921 ataaactaaa cctggaagag gataaaaatc agcttcaaca agagctagaa aacctaaagg
     1981 aagtactgga agacaagttg aatacagcca atcaagagat tggccacctc caagatatgg
     2041 taaggaaaag tgaacaaggt cttggctctg cagaaggact tattgctagt cttcaggact
     2101 cccaggaaag gcttcagaat gagcttgact tgactaaaga cagcctaaag gagaccaagg
     2161 atgctctatt aaatgtggag ggtgagctag aacaagaaag gcaacagcat gaagaaacaa
     2221 ttgctgccat gaaagaagaa gagaagctca aagtggacaa aatggcccat gacttagaaa
     2281 ttaagtggac tgaaaatctt agacaagagt gttctaaact tcgtgaagag ttaaggcttc
     2341 aacatgaaga ggataagaag tcagcaatgt ctcaactttt gcagttgaaa gatcgagaga
     2401 aaaatgcagc aagagattca tggcagaaga aagtagaaga tctcttaaac cagatttcct
     2461 tgctgaaaca gaatctggag atacagcttt cccagtctca gacttctttg caacaactgc
     2521 aagcccagtt tacgcaagaa cgacagcggc ttacgcaaga gcttgaagaa ttagaggagc
     2581 aacatcagca aagacacaaa tcattaaaag aagcacatgt ccttgcattt caaactatgg
     2641 aagaggaaaa ggaaaaggag caaagagctc ttgaaaatca tttacaacag aagcattctg
     2701 cagagcttca atcactaaaa gatgcacaca gagagtcaat ggagggcttc cggatagaaa
     2761 tggaacagga acttcagact cttcggtttg aattagaaga tgaaggaaag gctatgcttg
     2821 cttccttgcg ctcagaactc aaccatcaac atgcagctgc aattgatttg ttacggcata
     2881 atcatcatca agaattggca gctgctaaaa tggaattaga gagaagcata gacatcagca
     2941 gaagacagag taaggagcac atatgtagaa ttacagatct acaagaggaa ttaagacaca
     3001 gagagcatca catctctgaa ttggataagg aggttcagca ccttcatgag aatataagtg
     3061 ccctaaccaa agaactggaa tttaagggga aagaaattct cagaatacga agtgaatcta
     3121 accaacagat aaggttgcat gaacaagatt taaacaagag acttgaaaaa gagttggatg
     3181 tcatgacagc agaccacctc agagagaaaa atatcatgcg ggcagatttt aataagacta
     3241 acgagctact caaggaaata aatgccgctt tacaagtgtc attagaagaa atggaagaaa
     3301 aatatctaat gagagaatca aaaccagaag atatacagat gattacagaa ttaaaagcca
     3361 tgcttacaga aagagaccag atcataaaga aactaattga ggataataag ttttatcagc
     3421 tggaattagt caatcgagaa actaacttca acaaagtgtt taactcaagt cctactgttg
     3481 gtgttattaa tccattggct aagcaaaaga agaagaatga taaatcacca acaaacaggt
     3541 ttgtgagtgt tcccaatcta agtgctctgg aatctggtgg agtgggcaat ggacatccta
     3601 accgcctgga tcccattcct aattctccag tccacgatat tgagttcaac agcagcaaac
     3661 cacttccaca gccagtgcca cctaaagggc ccaagacatt tttgagtcct gctcagagtg
     3721 aagcttctcc agtggcttct ccagatcccc agcgccagga gtggtttgcc cggtacttca
     3781 cattctgaaa gaattgtgtt ggcacagctc tgtatagact gttactaaga gcatgacttt
     3841 atacagattg ttatgtaaat aggctttcct atgtcaaaca ctgtgaatga gaaagtattt
     3901 gtctctccaa cttgaaaatg cactgtattt cctgtgatat ttattggaat cattctataa
     3961 ggtactatat tatgtgtgta attataactg ttatttttat ttgagatgga agagtcttta
     4021 acctttgtaa ttactgcata ataaattttg ttagaatcaa acaatgcttt ttattttttt
     4081 ctacgtttgc tttaattttt aaatattttt taattccagg taagactt
//
