LOCUS       NM_175885               3925 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens family with sequence similarity 181 member B
            (FAM181B), mRNA.
ACCESSION   NM_175885
VERSION     NM_175885.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3925)
  AUTHORS   Marks,M., Pennimpede,T., Lange,L., Grote,P., Herrmann,B.G. and
            Wittler,L.
  TITLE     Analysis of the Fam181 gene family during mouse development reveals
            distinct strain-specific expression patterns, suggesting a role in
            nervous system development and function
  JOURNAL   Gene 575 (2 Pt 2), 438-451 (2016)
   PUBMED   26407640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC039262.1, BE858471.1, BE857184.1 and AP002796.3.
            
            On Nov 22, 2018 this sequence version replaced NM_175885.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC039262.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329203.5/ ENSP00000365295.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-587               BC039262.1         1-587
            588-597             BE858471.1         3-12                c
            598-1071            BC039262.1         598-1071
            1072-1074           BE857184.1         425-427
            1075-1538           BC039262.1         1074-1537
            1539-1861           BC039262.1         1539-1861
            1862-3925           AP002796.3         47048-49111         c
FEATURES             Location/Qualifiers
     source          1..3925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..3925
                     /gene="FAM181B"
                     /note="family with sequence similarity 181 member B"
                     /db_xref="GeneID:220382"
                     /db_xref="HGNC:HGNC:28512"
     exon            1..3925
                     /gene="FAM181B"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1416
                     /gene="FAM181B"
                     /codon_start=1
                     /product="protein FAM181B"
                     /protein_id="NP_787081.2"
                     /db_xref="CCDS:CCDS31648.1"
                     /db_xref="GeneID:220382"
                     /db_xref="HGNC:HGNC:28512"
                     /translation="MAVQAALLSTHPFVPFGFGGSPDGLGGAFGALDKGCCFEDDETG
                     APAGALLSGAEGGDVREATRDLLSFIDSASSNIKLALDKPGKSKRKVNHRKYLQKQIK
                     RCSGLMGAAPPGPPSPSAADTPAKRPLAAPSAPTVAAPAHGKAAPRREASQAAAAASL
                     QSRSLAALFDSLRHVPGGAEPAGGEVAAPAAGLGGAGTGGAGGDVAGPAGATAIPGAR
                     KVPLRARNLPPSFFTEPSRAGGGGCGPSGPDVSLGDLEKGAEAVEFFELLGPDYGAGT
                     EAAVLLAAEPLDVFPAGASVLRGPPELEPGLFEPPPAVVGNLLYPEPWSVPGCSPTKK
                     SPLTAPRGGLTLNEPLSPLYPAAADSPGGEDGRGHLASFAPFFPDCALPPPPPPHQVS
                     YDYSAGYSRTAYSSLWRSDGVWEGAPGEEGAHRD"
     regulatory      1839..1844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM181B"
                     /note="hexamer: ATTAAA"
     polyA_site      1861
                     /gene="FAM181B"
                     /note="major polyA site"
     regulatory      3900..3905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM181B"
                     /note="hexamer: ATTAAA"
     polyA_site      3925
                     /gene="FAM181B"
ORIGIN      
        1 agcgcagcga gccaggcccg gaactagtag gctgcgccgc gcgcgccgcg ccggggcggg
       61 agctgggtct gggcggcggg caggagctgg cgggggcgca cgggcagcgc tgcggacagc
      121 ccgggagccg cggcgatggc ggtgcaggcg gcgctcctca gcacgcaccc tttcgtgccc
      181 ttcggcttcg ggggctcccc ggacgggcta gggggcgcct tcggagccct ggacaagggc
      241 tgctgtttcg aggacgatga gaccggggct ccggcgggtg cgctgctgtc gggagccgaa
      301 ggaggggacg tgcgcgaggc cacccgcgat ctactcagct tcattgactc ggcgtccagc
      361 aacatcaagc tggcgctgga caagccgggc aagtcgaagc ggaaggtgaa ccaccgcaag
      421 tacctgcaga agcagatcaa gcgctgcagc ggcctcatgg gcgccgcgcc ccccggcccg
      481 ccctccccga gcgccgccga cacgccagcc aaacggccgc tggccgcccc tagcgccccg
      541 acagtcgcgg ccccggccca cggcaaggct gccccccggc gggaggcgtc gcaggccgcc
      601 gcggccgcca gcttgcaaag ccgaagtctg gccgcgctct tcgactcgct gcgccacgtc
      661 cccgggggtg ccgagccggc ggggggtgag gtggctgcgc cggcggccgg gctaggaggt
      721 gcgggcactg ggggcgcggg aggggacgtg gcaggccccg cgggggccac ggcgatccca
      781 ggggccagga aggtcccgct gcgggcacgc aatctgcctc cgtccttctt cacggagccg
      841 tcccgggcag gcggcggcgg gtgtggcccg tcggggccgg acgtgagctt gggcgacctg
      901 gagaagggcg cggaggccgt ggagttcttt gagctgctgg ggcccgacta cggcgccggc
      961 acggaggcgg cagtcttgct tgccgccgag cctctcgacg tgttccccgc cggagcctcc
     1021 gtactgcggg gacccccgga gctggagccc ggcctctttg agccgccgcc ggcagtggtg
     1081 ggaaacctac tgtaccccga gccctggagc gtcccgggct gctccccgac caaaaagagc
     1141 cccctgactg ccccccgcgg cggcttgacc ttgaacgagc ccttgagccc cctgtacccc
     1201 gccgctgcgg attctcccgg cggggaggac gggcggggcc atttggcctc tttcgccccc
     1261 ttctttccag actgcgccct gcccccgccg ccgccgcccc atcaggtgtc ctacgattac
     1321 agcgcgggct acagccgcac cgcctattcc agcctttgga gatccgacgg ggtttgggaa
     1381 ggggcgccgg gggaggaggg ggcgcaccgg gactgacttc gaggcacgct tcccttcatt
     1441 agagacggct gtggagagcg ccgcgcctcc gtgggtttct cctaaatctg aagaacgatg
     1501 ggaaaatgca cgtggagatg aaaccagatt tttaaaaatt caattaataa aagcaacttc
     1561 agaaaaaaga gatgaagacg agttggggat tgtttaatca caacctcaag tgttaaaaca
     1621 aaaacaaaca aacacgtttg taggttctta ctggaccaga ggagtcaaga aaccaagatg
     1681 gtttggggta tggggtgggg acggcaaaag gggtaagagc tggcttctgt agccacctgt
     1741 cccttctatt tttcagcgaa ggtcagtgta tttagtgtaa ttaccccttc taaacagtgt
     1801 cctagtccct cccttccctc tccttgagtg cattttgaat taaagcctat attgaaaaga
     1861 atggaggtga gacttactga tttgggtgtt ttcttacagg acggttttcc gtctggtcgc
     1921 ttagctttgt taggtgagcc tgtggctgag ggaggaggcc ggtggtccac tgctgacctc
     1981 ctgtgcttgt ccttgggtag ggttctcttc tgtcacggtt taactctttt ttctgcccgc
     2041 ttcctgcttc catctccctc cacccttatc acagtcccag tgcttacttt ccttctttct
     2101 ttgcctggcc tctcattatt ctatttcttt cggccggctt ttcttgcaca tctcttttgt
     2161 aggagactta aatttggcaa acctgggttc catttctctc ctgtcttttc cccattttcc
     2221 agccactttg ggagggagag ggtgggcaaa ctgtaacctc tttgtatcaa ttttcgtgat
     2281 ctgagagggt gaagacggta atgttcttct actcacttca caactggttg ggtagctcag
     2341 agggaaataa gtaaaatgtc ttgaggctgt ggcagtgctt gattggttct gctgtgtata
     2401 tataaatggt ttctacacac ggaaacagag ttgtgagtcc catgcctttt ttggcggggg
     2461 gctatctact tgcctggtga ttgccctttc ccttacaagc tgtacatcct ctttaccatc
     2521 cctccttctc tccttccaca gctccccttc cacctctgtt ggtttctgcc tccctttgtt
     2581 tcctcagtcc ttatacccac actctcccca cggaagggca taaagaaagg tgtgaagttt
     2641 ccaaaggaat ttctgttccc tgaatagcag gtctgatgaa tggaatctga aggggctctg
     2701 cagggaggag tatgatctgt tgtccgaggg agatttgggg aaaaagaaat atttttacca
     2761 gccatgaatg tggcagagag gacacatggc accaataggt tggttaaggg gcaggggagg
     2821 aaagactggt gggaagtgag cagctggagg gaaaagagga gcccttggtg ctgtagaact
     2881 gcggggagaa aggcatgaag agagcaacgc ccagaacatc tgagtgagag gctgccttct
     2941 gatgatgctg caaaggagag ctgcttggct tcaaggcacc caggattgat tgcaggaata
     3001 tctggatgtg agttagttga aaaccgagtg ttaccgcaag aggtgtaaaa atccaggttc
     3061 atgtttgcac acatcaaaag tattgtgata ttttcataaa agaatttctg gaaaaaatga
     3121 gtattaacca atggtagatg caactttaaa tgctatcagt aagtcatttt cttctgaata
     3181 aagcctttct taagaaagca ccacaggaaa tagaacgagt actgttaatg atgaaaagaa
     3241 cttttgcaac tccagaaagc taatgtctat tggatttctt ccaaagtggt taaaggtgat
     3301 taattccatt gtgctaacag aatattactt aataacgatt taatttgtct aaactgttgt
     3361 gaatacaatc caggatacac ttgcacagta ggaaaacatt aataaccctg tgactgttac
     3421 taagactata gtgtcattgt aatgtttctt aattctcctc tcctttctta cctagtgtag
     3481 taaaacaggt tatctctctc ctactgtttt gcttgctata cgtttaatta ataataatat
     3541 caacattgtt tccgcatccc aggcatttaa gctaactcac tgagcctctt aatattgcca
     3601 tgatgtaggt gcttgatact gtttggatct gtgtccctag ccaaatgtca tctctaattg
     3661 taatccccac atgtcgaggg aggtcctagt ggaaggtgat tggatcatgg gggtggtttc
     3721 ctccatgctg ttcttgtgat agtgagggag ttctcatgag atctgatggt tataaagtgt
     3781 ggcacttcct tgctatctct ctctcctgcc accatgtaag acgtgccttc ctgctgcttc
     3841 accttctgcc atgattgtaa gtttcatgag gcctcccagc catgtggaac tgtgagtcaa
     3901 ttaaacctct ttcatttata aatta
//
