LOCUS       NM_001207073            1521 bp    mRNA    linear   PRI 14-FEB-2024
DEFINITION  Homo sapiens family with sequence similarity 181 member A
            (FAM181A), transcript variant 4, mRNA.
ACCESSION   NM_001207073
VERSION     NM_001207073.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1521)
  AUTHORS   Carapito,C., Duek,P., Macron,C., Seffals,M., Rondel,K.,
            Delalande,F., Lindskog,C., Freour,T., Vandenbrouck,Y., Lane,L. and
            Pineau,C.
  TITLE     Validating Missing Proteins in Human Sperm Cells by Targeted
            Mass-Spectrometry- and Antibody-based Methods
  JOURNAL   J Proteome Res 16 (12), 4340-4351 (2017)
   PUBMED   28891297
REFERENCE   2  (bases 1 to 1521)
  AUTHORS   Marks,M., Pennimpede,T., Lange,L., Grote,P., Herrmann,B.G. and
            Wittler,L.
  TITLE     Analysis of the Fam181 gene family during mouse development reveals
            distinct strain-specific expression patterns, suggesting a role in
            nervous system development and function
  JOURNAL   Gene 575 (2 Pt 2), 438-451 (2016)
   PUBMED   26407640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK315393.1 and BC009073.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001207073.1.
            
            Transcript Variant: This variant (4) lacks two exons from the 5'
            end but has an alternate 5' exon, compared to variant 1. The
            resulting isoform (2) has a shorter N-terminus, compared to isoform
            1. Variants 2, 3, 4 and 5 encode the same isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.248399.1,
                                           SRR3476690.88187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000556222.2/ ENSP00000451678.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-878               AK315393.1         2-879
            879-1521            BC009073.1         1010-1652
FEATURES             Location/Qualifiers
     source          1..1521
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..1521
                     /gene="FAM181A"
                     /gene_synonym="C14orf152"
                     /note="family with sequence similarity 181 member A"
                     /db_xref="GeneID:90050"
                     /db_xref="HGNC:HGNC:20491"
     exon            1..111
                     /gene="FAM181A"
                     /gene_synonym="C14orf152"
                     /inference="alignment:Splign:2.1.0"
     exon            112..1521
                     /gene="FAM181A"
                     /gene_synonym="C14orf152"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1077
                     /gene="FAM181A"
                     /gene_synonym="C14orf152"
                     /note="isoform 2 is encoded by transcript variant 4;
                     protein FAM181A"
                     /codon_start=1
                     /product="protein FAM181A isoform 2"
                     /protein_id="NP_001194002.1"
                     /db_xref="CCDS:CCDS55939.1"
                     /db_xref="GeneID:90050"
                     /db_xref="HGNC:HGNC:20491"
                     /translation="MASDSDVKMLLNFVNLASSDIKAALDKSAPCRRSVDHRKYLQKQ
                     LKRFSQKYSRLPRGLPGRAAEPYLKRGSEDRPRRLLLDLGPDSSPGGGGGCKEKVLRN
                     PYREECLAKEQLPQRQHPEAAQPGQVPMRKRQLPASFWEEPRPTHSYHVGLEGGLGPR
                     EGPPYEGKKNCKGLEPLGPETTLVSMSPRALAEKEPLKMPGVSLVGRVNAWSCCPFQY
                     HGQPIYPGPLGALPQSPVPSLGLWRKSPAFPGELAHLCKDVDGLGQKVCRPVVLKPIP
                     TKPAVPPPIFNVFGYL"
     regulatory      1492..1497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM181A"
                     /gene_synonym="C14orf152"
                     /note="hexamer: AATAAA"
     polyA_site      1521
                     /gene="FAM181A"
                     /gene_synonym="C14orf152"
                     /note="major polyA site"
ORIGIN      
        1 gcacaactgc ttccagccgg acggagctcg gccggctgcg ccggggcctg tcccaggtct
       61 gcagtgggga acctgccggg ccacgttggt ggggcctggg ccgcaccttc ggtcagctcg
      121 gtgcccttcc ttggagctgc cggccaccag cagagcctac cctcttcatg gaaagcctcg
      181 tgcagtggcc ccctggtgat ggcatccgac agtgatgtga agatgctgct gaacttcgtg
      241 aacctggcgt ccagcgacat caaggcagcc ctggataagt ccgcaccctg ccgccgctcc
      301 gtggaccatc gcaagtacct gcagaagcag ctcaagcgct tctcccagaa gtattcccgg
      361 ctcccgcggg gccttcctgg cagagctgct gagccctacc tgaaaagggg gtctgaggac
      421 cggcccagga ggctgctcct ggatttgggc cctgattcca gccccggcgg gggtgggggc
      481 tgcaaggaga aggtgctgag gaacccctac agggaggaat gtcttgctaa ggagcagctc
      541 ccacagaggc agcatccaga agctgcccag cctggccagg tgcccatgag gaaaagacag
      601 ctgcccgctt ccttctggga agagccaagg cccacccaca gctaccatgt ggggctggag
      661 gggggactgg gccccaggga gggacctccc tatgagggta agaaaaattg caagggcttg
      721 gagcccctgg gacctgagac taccctggtg tccatgtctc caagggccct ggctgaaaag
      781 gagccgctca agatgcctgg ggtctccttg gtgggccgcg tcaatgcctg gagttgctgc
      841 cccttccagt accatggaca gcccatctat ccgggccccc tgggggcact gcctcagagt
      901 cctgtcccca gcctgggcct ttggaggaag agcccagcct ttcccgggga gctggcgcac
      961 ctctgcaagg atgtggacgg cctggggcag aaggtgtgca ggcccgtggt gctgaaaccc
     1021 atccccacca agccagccgt gcccccaccc atcttcaatg tctttggcta cctctagcca
     1081 cgcggagagg gcctcagccc ccacctctgg cctgcaggag tgtcgaggtc cccgaggcgc
     1141 tctcctgtga ggaggtggct gggccacagt gtggcctctt ccgtttgtgt gcgcatggga
     1201 gtggagggca ggattggggc agggctcctc aggcagtgac ccttcagcct tgcagccttg
     1261 gaagctggga ggctggacct ggttggcccc tccccaggca ggccagggcc cagcagcttg
     1321 tcccgctgtc cctgtgcaga ccataggtac tgggatgttg cccttccttg ccttgcagtc
     1381 accccagaag ccagagagac gcatctgttt acctgccacc cactctgcga gccaatctca
     1441 gttgttgttc ttgttcttct tgttctttgt aaatattgag aaagttaaaa gaataaagac
     1501 atttcttttg gagtttccat a
//
