LOCUS       NM_001164379            1403 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens family with sequence similarity 180 member B
            (FAM180B), transcript variant 1, mRNA.
ACCESSION   NM_001164379 XM_001716425 XM_374880 XM_941808
VERSION     NM_001164379.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1403)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104942.5 and BC065704.1.
            
            On Jan 4, 2020 this sequence version replaced NM_001164379.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065704.1, SRR3476690.965888.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000538490.3/
                                                ENSP00000443133.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC104942.5         145249-145263       c
            16-965              BC065704.1         1-950
            966-1403            BC065704.1         955-1392
FEATURES             Location/Qualifiers
     source          1..1403
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..1403
                     /gene="FAM180B"
                     /note="family with sequence similarity 180 member B"
                     /db_xref="GeneID:399888"
                     /db_xref="HGNC:HGNC:34451"
     exon            1..176
                     /gene="FAM180B"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..643
                     /gene="FAM180B"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein FAM180B; hypothetical gene supported by
                     BC065704"
                     /codon_start=1
                     /product="protein FAM180B isoform 1 precursor"
                     /protein_id="NP_001157851.1"
                     /db_xref="CCDS:CCDS91471.1"
                     /db_xref="GeneID:399888"
                     /db_xref="HGNC:HGNC:34451"
                     /translation="MAATLQFLVCLVVAICLLSGVTTTQPHAGQPMDSTSVGGGLQEP
                     EAPEVMFELLWAGLELDVMGQLHIQDEELASTHPGRRLRLLLQHHVPSDLEGTEQWLQ
                     QLQDLRKGPPLSTWDFEHLLLTGLSCVYRLHAASEAEERGRWAQVFALLAQETLWDLC
                     KGFCPQDRPPSLGSWASILDPFP"
     exon            177..247
                     /gene="FAM180B"
                     /inference="alignment:Splign:2.1.0"
     exon            248..1403
                     /gene="FAM180B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1383..1388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM180B"
                     /note="hexamer: CATAAA"
     polyA_site      1403
                     /gene="FAM180B"
                     /note="major polyA site"
ORIGIN      
        1 gcagtggaaa gttggagctg aggtgtgtgg caggcagatg agggagcaga gaactgctga
       61 acagagtgag actcagagga cgtggttgag catggctgcg accctgcagt tcctggtttg
      121 cctggtggta gccatttgtc tcctctctgg tgtgactaca acccagcccc atgcagggca
      181 gcccatggac agcaccagcg tgggaggtgg cctgcaggag ccagaggccc cggaagtgat
      241 gtttgagctg ctctgggctg ggctggagct ggatgtcatg gggcagctgc acatccagga
      301 tgaggaacta gcgtccacac acccaggccg ccgactcaga ctcctcctgc agcaccacgt
      361 gcccagtgac ttggagggca ctgagcagtg gctgcagcag ctccaggacc tgcggaaggg
      421 gcctcctctt agcacttggg actttgaaca tctgctcctc acaggcctgt cctgcgtcta
      481 ccggctccac gcagctagtg aggctgagga acggggccgc tgggcccagg tcttcgctct
      541 cctggcacag gaaacactct gggacctgtg caaaggtttc tgcccccagg accggccccc
      601 ttccctgggg tcctgggcct ccatccttga ccccttcccc tgaccctcct cttttgttct
      661 ttcacctgcc attaccccct cccatctcct cctcaacccc ccaggcagac ccatcttgcg
      721 caggggcttc tgtctggcat ctgattcttt tcaccgtgtt cagatctctg ggcttggctt
      781 gcaccctgga caccccctct ctgcttaccc cgaccagatc ttgtttccta gatcttgaga
      841 ggctaagaac ccaggctctg ggtcgcaagg agtgcgcaag gagtgggcac agagctaagg
      901 gcacgacttg caggcagtgt gtgtgtgagt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
      961 gtgtggagat caggggtcag ggttgagaag tgtgttcaag agatgctgaa gggaagctgc
     1021 cccaagtaag gcctggtcag accttccaac tcctaccctg gcagtctgtg acaggtcctg
     1081 tggaattcac aggaatcctc taggtgctga gcatcccctt ttaggcacaa ccaaggattt
     1141 ggggtctctg agcctccaag ttcccatctg ggttgggaga atcgactttt tgagttctgt
     1201 cagttggaag agtggaggga agcaggggga gggaggaaca ttatctcttt tggggtaggg
     1261 aggcaatatc tcaacaagcg tcgggtgaat acctcagagg ggggagtaag gctgggagac
     1321 caaggagaga caagcggagg tgggctggag caggtgtggc cctgattctg tgttgctctt
     1381 ctcataaaat gttctgtttc ggc
//
