LOCUS       NM_205855               1774 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens family with sequence similarity 180 member A
            (FAM180A), transcript variant 1, mRNA.
ACCESSION   NM_205855 XM_371955 XM_374531
VERSION     NM_205855.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1774)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
REFERENCE   2  (bases 1 to 1774)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 1774)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL597791.1, BC137311.1, BI040280.1, BU617005.1 and AC091736.2.
            
            On Nov 23, 2018 this sequence version replaced NM_205855.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.156878.1, AY358803.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338588.8/ ENSP00000342336.3
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AL597791.1         34-227
            195-851             BC137311.1         1-657
            852-852             BI040280.1         108-108             c
            853-1453            BC137311.1         659-1259
            1454-1768           BU617005.1         18-332              c
            1769-1774           AC091736.2         64969-64974         c
FEATURES             Location/Qualifiers
     source          1..1774
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1774
                     /gene="FAM180A"
                     /gene_synonym="UNQ1940"
                     /note="family with sequence similarity 180 member A"
                     /db_xref="GeneID:389558"
                     /db_xref="HGNC:HGNC:33773"
     exon            1..309
                     /gene="FAM180A"
                     /gene_synonym="UNQ1940"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..755
                     /gene="FAM180A"
                     /gene_synonym="UNQ1940"
                     /note="HWKM1940; protein FAM180A"
                     /codon_start=1
                     /product="protein FAM180A precursor"
                     /protein_id="NP_995327.1"
                     /db_xref="CCDS:CCDS5841.1"
                     /db_xref="GeneID:389558"
                     /db_xref="HGNC:HGNC:33773"
                     /translation="MHWKMLLLLLLYYNAEASMCHRWSRAVLFPAAHRPKRSSSLPLN
                     PVLQTSLEEVELLYEFLLAELEISPDLQISIKDEELASLRKASDFRTVCNNVIPKSIP
                     DIRRLSASLSSHPGILKKEDFERTVLTLAYTAYRTALSHGHQKDIWAQSLVSLFQALR
                     HDLMRSSQPGVPP"
     exon            310..410
                     /gene="FAM180A"
                     /gene_synonym="UNQ1940"
                     /inference="alignment:Splign:2.1.0"
     exon            411..1084
                     /gene="FAM180A"
                     /gene_synonym="UNQ1940"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1774
                     /gene="FAM180A"
                     /gene_synonym="UNQ1940"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1741..1746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM180A"
                     /gene_synonym="UNQ1940"
                     /note="hexamer: AATAAA"
     polyA_site      1774
                     /gene="FAM180A"
                     /gene_synonym="UNQ1940"
                     /note="major polyA site"
ORIGIN      
        1 agttccccaa tcccagagag cgtcaaatga agagaggtac cgactcctgt cccacccagg
       61 acgcagcctt cagcctccag ccttctgagg cagagtaggc atttctgcac gtctgcaaaa
      121 ggaagggagg gaagcactcc atcatctcac tgggaagaac ggcacgggca tacctgcagc
      181 tactggggtt ccactgggct tgagggtcga tttttcacct tttgaaggac aagatgcatt
      241 ggaagatgtt gctgcttctg ctgttgtatt acaatgctga ggcttctatg tgccacaggt
      301 ggagcagggc tgtgctcttc cctgccgccc accggccaaa gaggtcctca tcactgccat
      361 tgaacccagt cctgcagacc tccctggagg aggtggagct gctctacgag ttcctgctgg
      421 ccgaacttga gatcagccct gacctgcaga tctccatcaa ggacgaggag ctggcctcct
      481 tgcggaaggc ctcagacttc cgcaccgtct gcaacaacgt catccccaag agcatcccag
      541 acatccgccg gctcagcgcc agcctctcca gccaccctgg catcctcaag aaagaagact
      601 ttgaaaggac agtgctgacc ctggcctaca cagcctaccg cacagccctg tcccacggcc
      661 atcagaagga catctgggcg cagtccctcg ttagcctctt ccaggccctg aggcacgact
      721 tgatgcgctc ctcacagccg ggagtacctc cctgagagac tggcccacac caggacctca
      781 gagcagggac cagcacagta atccagaaag tcttcattct ctactccatt tacagagacc
      841 agcaacaaaa ctcttaccgc tgacacagag cagcagagat caaacagtaa ccccgatgct
      901 cttttctcct tgtagtttcc tggaagacac atctgattca tgccatcatg tgacctgggc
      961 tggaagaaag ggctggaatg gtcattcaag acgcctccat gggcagaatg gtttgcctat
     1021 ggcaggcaga attctgatat gcttcaaccc agagcagtgg ccacacactc aagagtgaga
     1081 acaggcgtga gccaccgtgc ctggcccagg atctaaaaac tttctaagtt tcctccatcg
     1141 ttggcatcct cacagctatc tccaatgtca ctcaagagac atcaacagac atttaactgc
     1201 tgcagacttc attgctctgt cacctcacct tgaatctaac aaatcaaagt atttctgcag
     1261 gtccaatggt ctaaaatcaa atgcttgtta aatgactttt tacaacaccc cttactttcc
     1321 taatccattt caatcttatt ttttttattg tggtaaaaaa cacatcaggt aaaatgtacc
     1381 atcttaacca tttttaagca tatggtacag cagtgttaac tccatgcatg ttgtgaaaca
     1441 gacccccgga actttctcat cttgtaattc tgaagttcta tacccaccga acaactcctc
     1501 ttttcccctt ccccctgcct gccccagctc ttggcaccat tattctgctt tctgtttttg
     1561 agagtctgac tacttaagat acctcataca agcgggatct ggcttacatt tcttgagcat
     1621 tgtattctgg aaaagtgttt ccttcctctg aaaaatgggt agagttctga aggagaacta
     1681 ctggtcttat tgtacacttg ctgtacctat ttttatttaa caaatattca tctatggtat
     1741 aataaagatg tcatgattga gttgctcact ggaa
//
