LOCUS       NM_001122646            2698 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens family with sequence similarity 178 member B
            (FAM178B), transcript variant A, mRNA.
ACCESSION   NM_001122646
VERSION     NM_001122646.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2698)
  AUTHORS   Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R,
            Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T,
            Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K,
            Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T,
            Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T
            and Sugano S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   2  (bases 1 to 2698)
  AUTHORS   Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan
            HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou
            J, Hu GX, Gu J, Chen SJ and Chen Z.
  TITLE     Cloning and functional analysis of cDNAs with open reading frames
            for 300 previously undefined genes expressed in CD34+ hematopoietic
            stem/progenitor cells
  JOURNAL   Genome Res 10 (10), 1546-1560 (2000)
   PUBMED   11042152
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079395.6, BI826484.1, BC039488.1 and AK122705.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001122646.2.
            
            Transcript Variant: This variant (A) represents the longest
            transcript and encodes the longest isoform (A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1968189, SAMEA1968540
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000490605.3/ ENSP00000429896.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC079395.6         42090-42105         c
            17-425              BI826484.1         1-409
            426-749             AC079395.6         27508-27831         c
            750-1235            BC039488.1         1-486
            1236-1284           AK122705.1         99-147
            1285-2698           BC039488.1         536-1949
FEATURES             Location/Qualifiers
     source          1..2698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..2698
                     /gene="FAM178B"
                     /note="family with sequence similarity 178 member B"
                     /db_xref="GeneID:51252"
                     /db_xref="HGNC:HGNC:28036"
     exon            1..340
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..2307
                     /gene="FAM178B"
                     /note="isoform A is encoded by transcript variant A;
                     protein FAM178B"
                     /codon_start=1
                     /product="protein FAM178B isoform A"
                     /protein_id="NP_001116118.2"
                     /db_xref="CCDS:CCDS46366.2"
                     /db_xref="GeneID:51252"
                     /db_xref="HGNC:HGNC:28036"
                     /translation="MWPRLPGAGLAPQLRRQDQRLHFTGQMSHGLQMAGPQETVLALP
                     LREGVQAAATVPILLYNLEDGLSDHPLDQGPRCPARRPCSPASAPAPTSPKKPKIQAP
                     GETFPTDWSPPPVEFLNPRVLQASREAPAQRWVGVVGPQGLRRLAGELPEELEQEHLD
                     LDPKRGLALPEKLFWNTSGLSQQAAAPEFSWGGSGSYFNNLDYLLQEKREQALEQERE
                     RLLLQECLNLNSLDLDEEEVPLTPEHRMLVEKYSVSLQTIPPVHPGETVFLPRCHPLP
                     CILDSSLLKPRSHLEGLFLSSPPAQQLSFLRSGLLNILYLHMPDCPVSLLQWLFQLLT
                     WPPETSLGAFGLLWDLIVDGIFLQPDEDKHLWCPSLQEVREAFHSLGAHSPALYPLGP
                     FWHGGRVLPGEAGLNENEEQDAPQEIALDISLGHIYKFLALCAQAQPGAYTDENLMGL
                     IELLCRTSLDVGLRLLPKVDLQQLLLLLLENIREWPGKLQELCCTLSWVSDHHHNLLA
                     LVQFFPDMTSRSRRLRSQLSLVVIARMLGQQEMLPLWQEKTQLSSLSRLLGLMRPSSL
                     RQYLDSVPLPPCQEQQPKASAELDHKACYLCHSLLMLAGVVVSCQDITPDQWGELQLL
                     CMQLDRHISTQIRESPQAMHRTMLKDLATQTYIRWQELLTHCQPQAQYFSPWKDI"
     exon            341..409
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            410..831
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            832..893
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1001
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1154
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1260
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1345
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1460
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1554
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1731
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1829
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1917
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2043
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2121
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2274
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2698
                     /gene="FAM178B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2679..2684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FAM178B"
                     /note="hexamer: ATTAAA"
     polyA_site      2698
                     /gene="FAM178B"
                     /note="major polyA site"
ORIGIN      
        1 gcacttggcc ggcgagctcc ccagctggcg gcggcggcgg ctgtgagctg gccgcttggt
       61 ttggagtcgg aactcaatcc ccagaactgg atctttaggt tccacgttgg cggccctgga
      121 tctagggacg caactcttgg ggtcctccca ctgcgccgcc tggggagcct gctcctgctt
      181 cctttcccgg ctagctggcc ccgtcctctg aggccgtgcg aattcccgcc accctccctc
      241 accccggagc cctgcccttc ccgccctatg tggccaaggc ttccaggtgc gggcctcgct
      301 ccacaactca ggaggcagga tcagcggctc cattttacag gacagatgtc ccacggcttg
      361 cagatggctg ggccccagga gacggtgcta gcccttcctc tgagagaagg ggtgcaggct
      421 gccgccaccg tgcccatcct cctgtacaac ctggaggatg gcttgtcaga ccatcccctg
      481 gaccaggggc cccgctgccc tgcccggcgg ccctgcagcc ctgcctcggc tccagctccc
      541 acatcgccaa agaagcccaa gatacaggca cctggggaaa cgtttcccac tgactggagc
      601 cccccgcccg tggaattcct caacccgagg gtgctgcagg ccagtcggga ggccccggcc
      661 cagaggtggg tgggtgtggt gggcccccag ggcctgagga gactggctgg tgagctgccc
      721 gaggagttgg agcaggaaca cctggacttg gacccgaaga ggggcctggc cttgccagag
      781 aagctgttct ggaacacgtc aggcctgagc cagcaggctg cggccccaga gttttcctgg
      841 gggggctcag gaagctactt caacaacctg gactacttac tgcaggagaa gagggaacag
      901 gccctggagc aggagcgaga gaggctgctt ctgcaggagt gtctcaatct caactccttg
      961 gatcttgatg aagaggaagt gccactcaca cccgagcaca ggatgctggt ggaaaagtac
     1021 tcagtgtccc tgcagaccat cccgccggtc catccaggtg agactgtgtt tctgcccagg
     1081 tgtcaccccc tgccatgcat cctggactcc tcactcctga agccacgcag ccacctggaa
     1141 gggctgttcc tcagctcccc gccagcccaa cagctctcct tcctgcgcag tggcctcctg
     1201 aacatcctct acctgcacat gcctgactgc ccggtatccc tgctccagtg gctgttccag
     1261 ctgctgacat ggcctccaga aacatctttg ggagcctttg gtcttctgtg ggatctcatt
     1321 gtggatggaa tcttccttca gcctgatgaa gacaagcacc tgtggtgccc ctcactgcaa
     1381 gaagtcaggg aggcattcca cagcctgggt gcccacagtc ctgccctgta ccctctgggg
     1441 cccttttggc acggtggcag ggtgcttcca ggcgaggctg gcctgaatga gaatgaggag
     1501 caggacgctc cccaagagat tgccttggac atcagcctgg gccacatcta caagtttctg
     1561 gcgctgtgtg cccaggccca gccgggggcc tacactgatg agaacctcat gggactgatt
     1621 gagctgctgt gccgcaccag cctggacgtg gggctccgcc tgctgcccaa agttgacctc
     1681 cagcagcttc tcctcttgct cctggagaac atccgggagt ggccagggaa gctccaggaa
     1741 ctgtgctgca ccctgagctg ggtgtctgac caccaccaca acctgctggc cctcgtgcag
     1801 ttcttcccag acatgacctc ccggagcagg cggcttcgaa gccagctcag ccttgtggtc
     1861 attgctcgaa tgctgggcca gcaggagatg ctccctctct ggcaagagaa gacccagctg
     1921 tcctcgctca gccggctcct gggcctcatg aggccatcat ctctcaggca atacctggac
     1981 tctgtgccct tgccaccctg ccaggagcaa cagccaaagg ctagtgccga gctagaccac
     2041 aaggcctgct acctgtgcca cagcttgctg atgctggccg gggtagttgt tagctgccag
     2101 gacatcactc cagaccagtg gggcgagctg cagctgctgt gcatgcagtt ggaccgccac
     2161 atcagcacgc agatccggga gagcccccag gccatgcacc gcaccatgct caaggacctg
     2221 gctacccaga cctacatccg ttggcaggag ctgctgaccc actgccagcc ccaggcccag
     2281 tatttcagcc cctggaaaga catctaaagg gacagggtca gggcagccca gggctcctgg
     2341 cttcagcagg aagtgaacag gctcagggaa ctggaggaag cgaagcatca aggccagagg
     2401 aggccacatg ctgaccagcc tgatgaggca agagcctgcc cctgccaccg ccccgacccc
     2461 tctcctctct gcaagagcct gcctctgcca ccgccccgac cccctctcct ctcagcaagg
     2521 gatgggcctc tctgcctcgc ccacccctca gccctcctcc cagccatctc ctcttcccta
     2581 aggcctctgt ctccatagct ctggtttccc tgggcctcag tcctccccac cctccttcct
     2641 ctgtctccct gtcactaatg tgaggtttct ttgtgcacat taaagtcttc tttcagca
//
